Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women

The most representative indicator of vitamin D status in clinical practice is 25(OH)D3, but new biomarkers could improve the assessment of vitamin D status and metabolism. The objective of this study is to investigate the association of serum vitamin D metabolites and vitamin D metabolite ratios (VMRs) with potentially influential factors in premenopausal women. This is a cross-sectional study based on 1422 women, aged 39–50, recruited from a Madrid Medical Diagnostic Center. Participants answered an epidemiological and a food frequency questionnaire. Serum vitamin D metabolites were determined using an SPE–LC–MS/MS platform. The association between participant’s characteristics, vitamin D metabolites, and VMRs was quantified by multiple linear regression models. Mean 25(OH)D3 concentration was 49.2 + 18.9 nmol/L, with greater deficits among obese, nulliparous, dark-skinned women, and with less sun exposure. A lower R2 ratio (1,25(OH)2D3/25(OH)D3) and a higher R4 (24,25(OH)2D3/1,25(OH)2D3) were observed in nulliparous women, with high sun exposure, and those with low caloric intake or high consumption of calcium, vitamin D supplements, or alcohol. Nulliparous women had lower R1 (25(OH)D3/Vit D3) and R3 (24,25(OH)2D3/25(OH)D3), and older women showed lower R3 and R4. Vitamin D status modified the association of the VMRs with seasons. VMRs can be complementary indicators of vitamin D status and its endogenous metabolism, and reveal the influence of certain individual characteristics on the expression of hydroxylase enzymes.

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Association of serum vitamin D status with dietary intake and sun exposure in adults

Clinical Nutrition ESPEN ◽

10.1016/j.clnesp.2019.09.008 ◽

2019 ◽

Vol 34 ◽

pp. 23-31 ◽

Cited By ~ 1

Author(s):

Ioannis Dimakopoulos ◽

Emmanuella Magriplis ◽

Anastasia-Vasiliki Mitsopoulou ◽

Dimitra Karageorgou ◽

Ioanna Bakogianni ◽

...

Keyword(s):

Vitamin D ◽

Dietary Intake ◽

Serum Vitamin ◽

Sun Exposure ◽

Vitamin D Status ◽

Serum Vitamin D

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Association of vitamin D with adiposity measures and other determinants in a cross-sectional study of Cypriot adolescents

Public Health Nutrition ◽

10.1017/s1368980013003480 ◽

2014 ◽

Vol 18 (1) ◽

pp. 112-121 ◽

Cited By ~ 11

Author(s):

Ourania Kolokotroni ◽

Anna Papadopoulou ◽

Panayiotis K Yiallouros ◽

Vasilios Raftopoulos ◽

Christiana Kouta ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Reference Group ◽

Serum Vitamin ◽

Sun Exposure ◽

Dietary Vitamin ◽

Vitamin D Status ◽

Fat Percentage ◽

Cross Sectional ◽

Serum Vitamin D

AbstractObjectiveTo assess vitamin D status among Cypriot adolescents and investigate potential determinants including BMI and body fat percentage (BF%).DesignParticipants had cross-sectional assessments of serum vitamin D, physical activity, dietary vitamin D intake and sun exposure. Linear and logistic regression models were used to explore the associations of vitamin D with potential predictors.SettingHospitals, Cyprus, November 2007–May 2008.SubjectsAdolescents (n 671) aged 16–18 years.ResultsMean serum vitamin D was 22·90 (sd 6·41) ng/ml. Only one in ten children had sufficient levels of vitamin D (≥30 ng/ml), while the prevalence of vitamin D deficiency (12–20 ng/ml) and severe deficiency (<12 ng/ml) was 31·7 % and 4·0 %, respectively. Lower vitamin D was associated with winter and spring season, female gender, reduced sun exposure in winter and darker skin. Participants with highest BMI and BF% when compared with a middle reference group had increased adjusted odds of vitamin D insufficiency (OR = 3·00; 95 % CI 1·21, 7·45 and OR = 5·02; 95 % CI 1·80, 13·97, respectively). A similar pattern, although not as strong, was shown for vitamin D deficiency with BF% (OR = 1·81; 95 % CI 1·04, 3·16) and BMI (OR = 1·51; 95 % CI 0·85, 2·67). Participants in the lowest BMI and BF% groups also displayed compromised vitamin D status, suggesting a U-shaped association.ConclusionsVitamin D deficiency in adolescence is very prevalent in sunny Cyprus, particularly among females, those with darker skin and those with reduced sun exposure in winter. Furthermore, vitamin D status appears to have a U-shaped association with adiposity measures.

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Sun Exposure Guidelines and Serum Vitamin D Status in Denmark: The StatusD Study

Nutrients ◽

10.3390/nu8050266 ◽

2016 ◽

Vol 8 (5) ◽

pp. 266 ◽

Cited By ~ 17

Author(s):

Louise Hansen ◽

Anne Tjønneland ◽

Brian Køster ◽

Christine Brot ◽

Rikke Andersen ◽

...

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Sun Exposure ◽

Vitamin D Status ◽

Serum Vitamin D

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Does the serum vitamin d status and its possible effect on serum anti-müllerian hormone levels predict fertility in premenopausal women?

Journal of Human Reproductive Sciences ◽

10.4103/jhrs.jhrs_234_20 ◽

2021 ◽

Vol 0 (0) ◽

pp. 0

Author(s):

OyinkansolaIslamiyat Lawal

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Premenopausal Women ◽

Vitamin D Status ◽

Hormone Levels ◽

Serum Vitamin D

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AB0915 BONE MINERAL DENSITY AND FRACTURE FREQUENCY IN PREMENOPAUSAL WOMEN WITH RHEUMATIC DISEASES

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.2740 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1759.2-1759

Author(s):

N. Toroptsova ◽

O. Dobrovolskaya ◽

O. Nikitinskaya ◽

N. Demin ◽

A. Smirnov ◽

...

Keyword(s):

Bone Mineral Density ◽

Vitamin D ◽

Lumbar Spine ◽

Serum Vitamin ◽

Premenopausal Women ◽

Healthy Controls ◽

C Reactive Protein ◽

Mineral Density ◽

Serum Vitamin D ◽

Reactive Protein

Background:The onset of the disease in young and middle age is typical for rheumatic diseases (RDS), but most studies on osteoporosis were conducted in patients (pts) older than 50 years, which included postmenopausal women.Objectives:To assess bone mineral density (BMD), fracture frequency and the factors associated with low BMD in premenopausal women with RDs.Methods:160 women (median age, 36 [29; 43] years): 120 pts with RDs (43 rheumatoid arthritis (RA), 53 systemic sclerosis (SSc) and 24 psoriatic arthritis (PsA)) and 40 age-matched healthy controls were enrolled in the study. We performed a dual-energy X-ray absorptiometry (DXA, Hologic Discovery A, USA) to measure BMD in lumbar spine, femoral neck and total hip. BMD decreasing grade was evaluated by the Z-score <-2SD. All pts were interviewed using a unified questionnaire including assessment of daily dietary calcium intake. Serum vitamin D, C-reactive protein and erythrocyte sedimentation rate (ESR) measurements were done.Results:25% pts with RDs and only 8% healthy controls have low BMD (p=0.02). RA, SSc and PsA pts had low BMD in 37%, 21% and 13%, respectively, that was more often than in healthy women (p=0.004, p=0.046 and p= 0.081, respectively). 9,3% RA pts and 7,5% SSc pts had low energy fractures. BMD of RDs pts in all areas of measurement demonstrated a direct correlation with height, weight, body mass index, and serum vitamin D concentration and an inverse correlation with the cumulative dose of glucocorticoids. Also, proximal femur BMD inversely correlated with RDs duration. BMD of femoral neck and total hip inversely correlated with C-reactive protein level in SSc pts. In RA women we found a direct correlation between lumbar spine and femur neck BMD and ESR.Conclusion:25% of premenopausal women with RDs had reduced BMD and needed monitoring and osteoporosis prevention, while 9.3% pts with RA and 7.5% women with SSc needed anti-osteoporotic treatment.Disclosure of Interests:None declared

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A genomewide association study identified CYP2J2 as a gene controlling serum vitamin D status in beef cattle1,2

Journal of Animal Science ◽

10.2527/jas.2012-6020 ◽

2013 ◽

Vol 91 (8) ◽

pp. 3549-3556 ◽

Cited By ~ 8

Author(s):

E. Casas ◽

R. J. Leach ◽

T. A. Reinhardt ◽

R. M. Thallman ◽

J. D. Lippolis ◽

...

Keyword(s):

Vitamin D ◽

Association Study ◽

Serum Vitamin ◽

Vitamin D Status ◽

Genomewide Association Study ◽

Serum Vitamin D ◽

Genomewide Association

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Serum Vitamin D Metabolites in Colorectal Cancer Patients Receiving Cholecalciferol Supplementation: Correlation with Polymorphisms in the Vitamin D Genes

Hormones and Cancer ◽

10.1007/s12672-013-0139-9 ◽

2013 ◽

Vol 4 (4) ◽

pp. 242-250 ◽

Cited By ~ 15

Author(s):

Josephia R. Muindi ◽

Araba A. Adjei ◽

Zengru R. Wu ◽

Isabel Olson ◽

Huayi Huang ◽

...

Keyword(s):

Colorectal Cancer ◽

Vitamin D ◽

Cancer Patients ◽

Serum Vitamin ◽

Vitamin D Metabolites ◽

Serum Vitamin D ◽

Cholecalciferol Supplementation ◽

Colorectal Cancer Patients

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Assessment of Vitamin D Metabolism in Patients with Cushing’s Disease in Response to 150,000 IU Cholecalciferol Treatment

Nutrients ◽

10.3390/nu13124329 ◽

2021 ◽

Vol 13 (12) ◽

pp. 4329

Author(s):

Alexandra Povaliaeva ◽

Viktor Bogdanov ◽

Ekaterina Pigarova ◽

Artem Zhukov ◽

Larisa Dzeranova ◽

...

Keyword(s):

Vitamin D ◽

Cushing’S Disease ◽

Serum Vitamin ◽

Urinary Free Cortisol ◽

Cushing's Disease ◽

Control Group ◽

Vitamin D Metabolites ◽

Vitamin D Metabolism ◽

Serum Vitamin D ◽

Free Cortisol

In this study we aimed to assess vitamin D metabolism in patients with Cushing’s disease (CD) compared to healthy individuals in the setting of bolus cholecalciferol treatment. The study group included 30 adults with active CD and the control group included 30 apparently healthy adults with similar age, sex and BMI. All participants received a single dose (150,000 IU) of cholecalciferol aqueous solution orally. Laboratory assessments including serum vitamin D metabolites (25(OH)D3, 25(OH)D2, 1,25(OH)2D3, 3-epi-25(OH)D3 and 24,25(OH)2D3), free 25(OH)D, vitamin D-binding protein (DBP) and parathyroid hormone (PTH) as well as serum and urine biochemical parameters were performed before the intake and on Days 1, 3 and 7 after the administration. All data were analyzed with non-parametric statistics. Patients with CD had similar to healthy controls 25(OH)D3 levels (p > 0.05) and higher 25(OH)D3/24,25(OH)2D3 ratios (p < 0.05) throughout the study. They also had lower baseline free 25(OH)D levels (p < 0.05) despite similar DBP levels (p > 0.05) and lower albumin levels (p < 0.05); 24-h urinary free cortisol showed significant correlation with baseline 25(OH)D3/24,25(OH)2D3 ratio (r = 0.36, p < 0.05). The increase in 25(OH)D3 after cholecalciferol intake was similar in obese and non-obese states and lacked correlation with BMI (p > 0.05) among patients with CD, as opposed to the control group. Overall, patients with CD have a consistently lower 25(OH)D3/24,25(OH)2D3 ratio, which is indicative of a decrease in 24-hydroxylase activity. This altered activity of the principal vitamin D catabolism might influence the effectiveness of cholecalciferol treatment. The observed difference in baseline free 25(OH)D levels is not entirely clear and requires further study.

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Influence of serum vitamin D status on severe sarcopenia among female patients with rheumatoid arthritis: the KURAMA database

10.21203/rs.3.rs-697981/v1 ◽

2021 ◽

Author(s):

Hiroto Minamino ◽

Masao Katsushima ◽

Mie Torii ◽

Wataru Yamamoto ◽

Yoshihito Fujita ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Vitamin D ◽

Muscle Mass ◽

Gait Speed ◽

Serum Vitamin ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Increased Risk ◽

Vitamin D Levels ◽

High Prevalence

Abstract Sarcopenia is an age-related disease with an increased risk of mortality. It is emerging that low serum vitamin D (25(OH)D) affects the sarcopenic state in general, but in rheumatoid arthritis (RA), these associations are not understood although the prevalence of vitamin D insufficiency is high in RA. We conducted a cross-sectional study of older female outpatients from our cohort (KURAMA) database. We measured skeletal muscle mass, handgrip strength, and gait-speed to diagnose severe sarcopenia. The serum 25(OH)D concentration was measured using electrochemiluminescence immunoassay. A total of 156 Patients (sarcopenia:44.9%, severe sarcopenia: 29.5%, and without sarcopenia: 25.6%) were enrolled. Classification of vitamin D status at a cutoff point of median 25(OH)D concentration revealed that low 25(OH)D status was associated with a high prevalence of severe sarcopenia and with low measured values of muscle mass, handgrip, and gait-speed. Furthermore, multiple regression analysis identified that low 25(OH)D status was associated with a high prevalence of severe sarcopenia (OR 6.00; 95% CI 1.99–18.08). In components of sarcopenia, both low physical performance and muscle mass were associated with low 25(OH) status. In conclusion, vitamin D levels are associated with severe sarcopenia and its components, and modification of vitamin D status including vitamin D supplementation may play a role in improving sarcopenia in RA.

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