Sun Exposure Guidelines and Serum Vitamin D Status in Denmark: The StatusD Study

AbstractObjectiveTo assess vitamin D status among Cypriot adolescents and investigate potential determinants including BMI and body fat percentage (BF%).DesignParticipants had cross-sectional assessments of serum vitamin D, physical activity, dietary vitamin D intake and sun exposure. Linear and logistic regression models were used to explore the associations of vitamin D with potential predictors.SettingHospitals, Cyprus, November 2007–May 2008.SubjectsAdolescents (n 671) aged 16–18 years.ResultsMean serum vitamin D was 22·90 (sd 6·41) ng/ml. Only one in ten children had sufficient levels of vitamin D (≥30 ng/ml), while the prevalence of vitamin D deficiency (12–20 ng/ml) and severe deficiency (<12 ng/ml) was 31·7 % and 4·0 %, respectively. Lower vitamin D was associated with winter and spring season, female gender, reduced sun exposure in winter and darker skin. Participants with highest BMI and BF% when compared with a middle reference group had increased adjusted odds of vitamin D insufficiency (OR = 3·00; 95 % CI 1·21, 7·45 and OR = 5·02; 95 % CI 1·80, 13·97, respectively). A similar pattern, although not as strong, was shown for vitamin D deficiency with BF% (OR = 1·81; 95 % CI 1·04, 3·16) and BMI (OR = 1·51; 95 % CI 0·85, 2·67). Participants in the lowest BMI and BF% groups also displayed compromised vitamin D status, suggesting a U-shaped association.ConclusionsVitamin D deficiency in adolescence is very prevalent in sunny Cyprus, particularly among females, those with darker skin and those with reduced sun exposure in winter. Furthermore, vitamin D status appears to have a U-shaped association with adiposity measures.

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Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women

Nutrients ◽

10.3390/nu13113747 ◽

2021 ◽

Vol 13 (11) ◽

pp. 3747

Author(s):

María José Toribio ◽

Feliciano Priego-Capote ◽

Beatriz Pérez-Gómez ◽

Nerea Fernández de Larrea-Baz ◽

Emma Ruiz-Moreno ◽

...

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Premenopausal Women ◽

Sun Exposure ◽

Individual Characteristics ◽

Vitamin D Metabolites ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Nulliparous Women ◽

Diagnostic Center

The most representative indicator of vitamin D status in clinical practice is 25(OH)D3, but new biomarkers could improve the assessment of vitamin D status and metabolism. The objective of this study is to investigate the association of serum vitamin D metabolites and vitamin D metabolite ratios (VMRs) with potentially influential factors in premenopausal women. This is a cross-sectional study based on 1422 women, aged 39–50, recruited from a Madrid Medical Diagnostic Center. Participants answered an epidemiological and a food frequency questionnaire. Serum vitamin D metabolites were determined using an SPE–LC–MS/MS platform. The association between participant’s characteristics, vitamin D metabolites, and VMRs was quantified by multiple linear regression models. Mean 25(OH)D3 concentration was 49.2 + 18.9 nmol/L, with greater deficits among obese, nulliparous, dark-skinned women, and with less sun exposure. A lower R2 ratio (1,25(OH)2D3/25(OH)D3) and a higher R4 (24,25(OH)2D3/1,25(OH)2D3) were observed in nulliparous women, with high sun exposure, and those with low caloric intake or high consumption of calcium, vitamin D supplements, or alcohol. Nulliparous women had lower R1 (25(OH)D3/Vit D3) and R3 (24,25(OH)2D3/25(OH)D3), and older women showed lower R3 and R4. Vitamin D status modified the association of the VMRs with seasons. VMRs can be complementary indicators of vitamin D status and its endogenous metabolism, and reveal the influence of certain individual characteristics on the expression of hydroxylase enzymes.

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A genomewide association study identified CYP2J2 as a gene controlling serum vitamin D status in beef cattle1,2

Journal of Animal Science ◽

10.2527/jas.2012-6020 ◽

2013 ◽

Vol 91 (8) ◽

pp. 3549-3556 ◽

Cited By ~ 8

Author(s):

E. Casas ◽

R. J. Leach ◽

T. A. Reinhardt ◽

R. M. Thallman ◽

J. D. Lippolis ◽

...

Keyword(s):

Vitamin D ◽

Association Study ◽

Serum Vitamin ◽

Vitamin D Status ◽

Genomewide Association Study ◽

Serum Vitamin D ◽

Genomewide Association

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Influence of serum vitamin D status on severe sarcopenia among female patients with rheumatoid arthritis: the KURAMA database

10.21203/rs.3.rs-697981/v1 ◽

2021 ◽

Author(s):

Hiroto Minamino ◽

Masao Katsushima ◽

Mie Torii ◽

Wataru Yamamoto ◽

Yoshihito Fujita ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Vitamin D ◽

Muscle Mass ◽

Gait Speed ◽

Serum Vitamin ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Increased Risk ◽

Vitamin D Levels ◽

High Prevalence

Abstract Sarcopenia is an age-related disease with an increased risk of mortality. It is emerging that low serum vitamin D (25(OH)D) affects the sarcopenic state in general, but in rheumatoid arthritis (RA), these associations are not understood although the prevalence of vitamin D insufficiency is high in RA. We conducted a cross-sectional study of older female outpatients from our cohort (KURAMA) database. We measured skeletal muscle mass, handgrip strength, and gait-speed to diagnose severe sarcopenia. The serum 25(OH)D concentration was measured using electrochemiluminescence immunoassay. A total of 156 Patients (sarcopenia:44.9%, severe sarcopenia: 29.5%, and without sarcopenia: 25.6%) were enrolled. Classification of vitamin D status at a cutoff point of median 25(OH)D concentration revealed that low 25(OH)D status was associated with a high prevalence of severe sarcopenia and with low measured values of muscle mass, handgrip, and gait-speed. Furthermore, multiple regression analysis identified that low 25(OH)D status was associated with a high prevalence of severe sarcopenia (OR 6.00; 95% CI 1.99–18.08). In components of sarcopenia, both low physical performance and muscle mass were associated with low 25(OH) status. In conclusion, vitamin D levels are associated with severe sarcopenia and its components, and modification of vitamin D status including vitamin D supplementation may play a role in improving sarcopenia in RA.

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Does the evidence for an inverse relationship between serum vitamin D status and breast cancer risk satisfy the Hill criteria?

Dermato-Endocrinology ◽

10.4161/derm.20449 ◽

2012 ◽

Vol 4 (2) ◽

pp. 152-157 ◽

Cited By ~ 25

Author(s):

Sharif B. Mohr ◽

Edward D. Gorham ◽

John E. Alcaraz ◽

Christopher I. Kane ◽

Caroline A. Macera ◽

...

Keyword(s):

Breast Cancer ◽

Vitamin D ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Inverse Relationship ◽

Serum Vitamin ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Hill Criteria ◽

The Hill

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Bone Mineral Density and Serum Vitamin D Status in Parkinson's Disease: Are the Stage and Clinical Features of the Disease Important?

Neurology India ◽

10.4103/0028-3886.325366 ◽

2021 ◽

Vol 69 (4) ◽

pp. 1145

Author(s):

MahmoodDhahir Al-Mendalawi

Keyword(s):

Bone Mineral Density ◽

Parkinson’S Disease ◽

Vitamin D ◽

Parkinson's Disease ◽

Clinical Features ◽

Bone Mineral ◽

Serum Vitamin ◽

Vitamin D Status ◽

Mineral Density ◽

Serum Vitamin D

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Bone mineral density and serum vitamin D status in Parkinson's disease: Are the stage and clinical features of the disease important?

Neurology India ◽

10.4103/0028-3886.283755 ◽

2020 ◽

Vol 68 (2) ◽

pp. 394 ◽

Cited By ~ 2

Author(s):

ErhanArif Ozturk ◽

Ibrahim Gundogdu ◽

Burak Tonuk ◽

Ebru Umay ◽

BilgeGonenli Kocer ◽

...

Keyword(s):

Bone Mineral Density ◽

Parkinson’S Disease ◽

Vitamin D ◽

Parkinson's Disease ◽

Clinical Features ◽

Bone Mineral ◽

Serum Vitamin ◽

Vitamin D Status ◽

Mineral Density ◽

Serum Vitamin D

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Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women

Nutrients ◽

10.3390/nu12103176 ◽

2020 ◽

Vol 12 (10) ◽

pp. 3176

Author(s):

Sharon M. Anderson ◽

Andrea R. Thurman ◽

Neelima Chandra ◽

Suzanne S. Jackson ◽

Susana Asin ◽

...

Keyword(s):

Vitamin D ◽

Reproductive Tract ◽

Serum Vitamin ◽

Female Reproductive Tract ◽

High Dose ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Hiv 1

While vitamin D insufficiency is known to impact a multitude of health outcomes, including HIV-1, little is known about the role of vitamin D-mediated immune regulation in the female reproductive tract (FRT). We performed a pilot clinical study of 20 women with circulating 25(OH)D levels <62.5 nmol/L. Participants were randomized into either weekly or daily high-dose oral vitamin D supplementation groups. In addition to serum vitamin D levels, genital mucosal endpoints, including soluble mediators, immune cell populations, gene expression, and ex vivo HIV-1 infection, were assessed. While systemic vitamin D levels showed a significant increase following supplementation, these changes translated into modest effects on the cervicovaginal factors studied. Paradoxically, post-supplementation vitamin D levels were decreased in cervicovaginal fluids. Given the strong correlation between vitamin D status and HIV-1 infection and the widespread nature of vitamin D deficiency, further understanding of the role of vitamin D immunoregulation in the female reproductive tract is important.

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Low Serum Vitamin D is Independently Associated with Acute Ischemic Stroke

Medicine Today ◽

10.3329/medtoday.v30i1.35564 ◽

2018 ◽

Vol 30 (1) ◽

pp. 34-37

Author(s):

Md Mahabubul Islam Majumder ◽

Md Nazmul Hasan Chowdhury ◽

Ashiqur Rahman Khan ◽

Tarek Ahmed ◽

Saleh Ahmed

Keyword(s):

Vitamin D ◽

Ischemic Stroke ◽

Acute Stroke ◽

Acute Ischemic Stroke ◽

Serum Vitamin ◽

Multivariate Logistic Regression Analysis ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Low Serum

Low serum vitamin D levels have been associated with various vascular diseases. Very little is known its association with acute stroke in Bangladeshi population. We therefore sought to assess whether low serum 25- hydroxyvitamin D, a marker of vitamin D status is associated with acute stroke. We performed a prospective study in Comilla Medical Collage, Comilla, from November 2016 to November 2017. All the patients diagnosed as acute ischemic stroke on the basis of CT scan or MRI of brain. Patients were eligible for inclusion if they were admitted with onset of symptoms within 24 hours. Estimation of 25(OH)D level was done at presentation. The patients were stratified by vitamin D status, >30 as vitamin D sufficient, vitamin D 20-20.9 as insufficient and finally vitamin D<20 as deficient. Multivariate logistic regression analysis revealed that out of the desired 7 variables, smoking, hypertension and low serum vitamin D were found independent predictors for acute stroke with ORs being 1.44, 4.23 and 2.39 respectively. Vitamin D deficiency represents an important risk factor for acute stroke and it might play a causal role in the development adverse events associated with stroke.Medicine Today 2018 Vol.30(1): 34-37

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