Tantalum and its derivatives in orthopedic and dental implants: Osteogenesis and antibacterial properties

2021 ◽  
Vol 208 ◽  
pp. 112055
Author(s):  
Xu Wang ◽  
Boyu Ning ◽  
Xibo Pei
Keyword(s):  
Dental Implants ◽  
Antibacterial Properties

scholarly journals Carbon Nanomaterials Modified Biomimetic Dental Implants for Diabetic Patients

Nanomaterials ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2977
Author(s):  
Renjini Vijay ◽  
Jayanti Mendhi ◽  
Karthika Prasad ◽  
Yin Xiao ◽  
Jennifer MacLeod ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Dental Implants ◽  
Structural Changes ◽  
Carbon Nanomaterials ◽  
Antibacterial Properties ◽  
Diabetic Patients ◽  
Crucial Issue ◽  
Biomimetic Materials ◽  
Dental Clinics ◽  
Healing Phase

Dental implants are used broadly in dental clinics as the most natural-looking restoration option for replacing missing or highly diseased teeth. However, dental implant failure is a crucial issue for diabetic patients in need of dentition restoration, particularly when a lack of osseointegration and immunoregulatory incompetency occur during the healing phase, resulting in infection and fibrous encapsulation. Bio-inspired or biomimetic materials, which can mimic the characteristics of natural elements, are being investigated for use in the implant industry. This review discusses different biomimetic dental implants in terms of structural changes that enable antibacterial properties, drug delivery, immunomodulation, and osseointegration. We subsequently summarize the modification of dental implants for diabetes patients utilizing carbon nanomaterials, which have been recently found to improve the characteristics of biomimetic dental implants, including through antibacterial and anti-inflammatory capabilities, and by offering drug delivery properties that are essential for the success of dental implants.

scholarly journals Silicon Nitride (Si3N4) Implants: The Future of Dental Implantology?

2017 ◽  
Vol 43 (3) ◽  
pp. 240-244 ◽  
Author(s):  
Zahi Badran ◽  
Xavier Struillou ◽  
Francis J Hughes ◽  
Assem Soueidan ◽  
Alain Hoornaert ◽  
...  
Keyword(s):  
Silicon Nitride ◽  
Dental Implants ◽  
Dental Implant ◽  
Clinical Success ◽  
Treatment Options ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Future Research ◽  
Success Rates ◽  
Biological Performance

For decades titanium has been the preferred material for dental implant fabrication, with mechanical and biological performance resulting in high clinical success rates. These have been further enhanced by incremental development of surface modifications aimed at improving speed and degree of osseointegration and resulting in enhanced clinical treatment options and outcomes. However, increasing demand for metal-free dental restorations has also led to the development of ceramic-based dental implants, such as zirconia. In orthopedics, alternative biomaterials, such as polyetheretherketone or silicon nitride, have been used for implant applications. The latter is potentially of particular interest for oral use as it has been shown to have antibacterial properties. In this article we aim to shed light on this particular biomaterial as a future promising candidate for dental implantology applications, addressing basic specifications required for any dental implant material. In view of available preclinical data, silicon nitride seems to have the essential characteristics to be a candidate for dental implants material. This novel ceramic has a surface with potentially antimicrobial properties, and if this is confirmed in future research, it could be of great interest for oral use.

scholarly journals Bio-Functional Coating on Ti6Al4V Surface Produced by Using Plasma Electrolytic Oxidation

Metals ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1124
Author(s):  
Aqmar Zakaria ◽  
Hamdi Shukor ◽  
Masahiro Todoh ◽  
Kamaruzaman Jusoff
Keyword(s):  
Dental Implants ◽  
Plasma Electrolytic Oxidation ◽  
Energy Dispersive Spectrometer ◽  
Antibacterial Properties ◽  
Functional Surface ◽  
Functional Coating ◽  
Fluoridated Hydroxyapatite ◽  
Coating Surface ◽  
Electrolytic Oxidation ◽  
Plasma Electrolytic

One way to improve the biofunctionality of titanium alloys is by implementing plasma electrolytic oxidation (PEO) to incorporate bioactive elements such as fluoridated hydroxyapatite, into surface coatings of orthopaedic and dental implants. Hydroxyapatite (HAp) is known as a bioactive coating while fluorapatite (FAp) has an antibacterial effect that would enhance the bio-functionality and reduce the failure rate of orthopaedic and dental implants. The purpose of this study was to develop fluoridated hydroxyapatite as a bio-functional coating on Ti6Al4V with electrolyte containing trisodium orthophosphate, potassium hydroxide, and calcium fluoride. The coating surface and cross-section morphologies were evaluated, and the species in the electrolyte solution were found, and irregular micropores shapes were observed by field emission scanning electron microscopy (FESEM) and energy dispersive spectrometer (EDS). The phase composition of the coating surface containing TiO2 (anatase and rutile), tricalcium orthophosphate, HAp, and FAp was characterized by X-ray diffractometer (XRD). The adhesive strength of the coating was analysed by a micro-scratch test. Simulated body fluid (SBF) immersion test was performed to investigate the bioactivity of the coating. In this study, we demonstrated that the PEO technique has a good potential to develop bio-functional surface modifications that can affect the chemical composition and roughness of the coating surface. The FAp coating may provide insights for subsequent bioactive coatings while improving the antibacterial properties for orthopaedic and dental implants. Future work shall investigate the optimal amount of fluoride in the coating layer that obtains excellent results without causing adverse effects on adjacent tissue.

scholarly journals Antibacterial Properties of Triethoxysilylpropyl Succinic Anhydride Silane (TESPSA) on Titanium Dental Implants

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 773
Author(s):  
Judit Buxadera-Palomero ◽  
Maria Godoy-Gallardo ◽  
Meritxell Molmeneu ◽  
Miquel Punset ◽  
Francisco Javier Gil
Keyword(s):  
Dental Implants ◽  
Photoelectron Spectroscopy ◽  
Succinic Anhydride ◽  
Human Fibroblasts ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Sodium Titanate ◽  
Adhesion Assay ◽  
Vitro Effect

Infections related to dental implants are a common complication that can ultimately lead to implant failure, and thereby carries significant health and economic costs. In order to ward off these infections, this paper explores the immobilization of triethoxysilylpropyl succinic anhydride (TESPSA, TSP) silane onto dental implants, and the interaction of two distinct monospecies biofilms and an oral plaque with the coated titanium samples. To this end, titanium disks from prior machining were first activated by a NaOH treatment and further functionalized with TESPSA silane. A porous sodium titanate surface was observed by scanning electron microscopy and X-ray photoelectron spectroscopy analyses confirmed the presence of TESPSA on the titanium samples (8.4% for Ti–N-TSP). Furthermore, a lactate dehydrogenase assay concluded that TESPSA did not have a negative effect on the viability of human fibroblasts. Importantly, the in vitro effect of modified surfaces against Streptococcus sanguinis, Lactobacillus salivarius and oral plaque were studied using a viable bacterial adhesion assay. A significant reduction was achieved in all cases but, as expected, with different effectiveness against simple mono-species biofilm (ratio dead/live of 0.4) and complete oral biofilm (ratio dead/live of 0.6). Nevertheless, this approach holds a great potential to provide dental implants with antimicrobial properties.

Silver nanoparticle-loaded hydroxyapatite coating: structure, antibacterial properties, and capacity for osteogenic induction in vitro

RSC Advances ◽  
2016 ◽  
Vol 6 (11) ◽  
pp. 8549-8562 ◽  
Author(s):  
Bo Tian ◽  
Wei Chen ◽  
Yufeng Dong ◽  
John V. Marymont ◽  
Yong Lei ◽  
...  
Keyword(s):  
Dental Implants ◽  
Silver Nanoparticle ◽  
Antibacterial Properties ◽  
Hydroxyapatite Coating ◽  
Infection Prophylaxis ◽  
Coating Structure ◽  
Osteogenic Induction

AgNP-HAC has the potential to be used on the surfaces of orthopedic and dental implants for infection prophylaxis.

scholarly journals Dental Implants with Anti-Biofilm Properties: A Pilot Study for Developing a New Sericin-Based Coating

Materials ◽  
2019 ◽  
Vol 12 (15) ◽  
pp. 2429 ◽  
Author(s):  
Paolo Ghensi ◽  
Elia Bettio ◽  
Devid Maniglio ◽  
Emiliana Bonomi ◽  
Federico Piccoli ◽  
...  
Keyword(s):  
Dental Implants ◽  
Vapor Phase ◽  
Biological Activities ◽  
Bacterial Colonization ◽  
Antibacterial Properties ◽  
Intermediate Step ◽  
Implant Surface ◽  
Oh Groups ◽  
Bacterial Inhibition ◽  
Dental Implant Surface

Aim: several strategies have been tested in recent years to prevent bacterial colonization of dental implants. Sericin, one of the two main silk proteins, possesses relevant biological activities and also literature reports about its potential antibacterial properties, but results are discordant and not yet definitive. The aim of this study was to evaluate the effectiveness of different experimental protocols in order to obtain a sericin-based coating on medical grade titanium (Ti) able to reduce microbial adhesion to the dental implant surface. Materials and Methods: different strategies for covalent bonding of sericin to Ti were pursued throughout a multi-step procedure on Ti-6Al-4V disks. The surface of grade 5 Ti was initially immersed in NaOH solution to obtain the exposure of functional -OH groups. Two different silanization strategies were then tested using aminopropyltriethoxysilane (APTES). Eventually, the bonding between silanized Ti-6Al-4V and sericin was obtained with two different crosslinking processes: glutaraldehyde (GLU) or carbodiimide/N-Hydroxy-succinimide (EDC/NHS). Micro-morphological and compositional analyses were performed on the samples at each intermediate step to assess the most effective coating strategy able to optimize the silanization and bioconjugation processes. Microbiological tests on the coated Ti-6Al-4V disks were conducted in vitro using a standard biofilm producer strain of Staphylococcus aureus (ATCC 6538) to quantify the inhibition of microbial biofilm formation (anti-biofilm efficacy) at 24 hours. Results: both silanization techniques resulted in a significant increase of silicon (Si) on the Ti-6Al-4V surfaces etched with NaOH. Differences were found between GLU and EDC/NHS bioconjugation strategies in terms of composition, surface micro-morphology and anti-biofilm efficacy. Ti-6Al-4V samples coated with GLU-bound sericin after silanization obtained via vapor phase deposition proved that this technique is the most convenient and effective coating strategy, resulting in a bacterial inhibition of about 53% in respect to the uncoated Ti-6Al-4V disks. Conclusions: The coating with glutaraldehyde-bound sericin after silanization in the vapor phase showed promising bacterial inhibition values with a significant reduction of S. aureus biofilm. Further studies including higher number of replicates and more peri-implant-relevant microorganisms are needed to evaluate the applicability of this experimental protocol to dental implants.

scholarly journals A comparative study on the microstructural and antibacterial properties of Laser - textured and SLA dental implants.

2021 ◽  
Vol 14 (3) ◽  
pp. 222-225
Author(s):  
Ronald Motzfeld ◽  
Cristian Covarrubias ◽  
Leyla Gómez ◽  
Fabiola Bastias ◽  
Miguel Maureira
Keyword(s):  
Comparative Study ◽  
Dental Implants ◽  
Antibacterial Properties

scholarly journals Overview of Nanoparticle Coating of Dental Implants for Enhanced Osseointegration and Antimicrobial Purposes

2017 ◽  
Vol 20 ◽  
pp. 148 ◽  
Author(s):  
Feridoun Parnia ◽  
Javad Yazdani ◽  
Vahid Javaherzadeh ◽  
Solmaz Maleki Dizaj
Keyword(s):  
Dental Implants ◽  
Scientific Literature ◽  
Antibacterial Properties ◽  
Significant Progress ◽  
Biological Fixation ◽  
Coating Materials ◽  
Tissue Integration ◽  
Implant Coating ◽  
Implant Coatings

PURPOSE: Nanomaterials are suitable candidates for coating of titanium based (Ti-based) dental implants due to their unique properties. The objective of this article is to summarize the application of nanoparticles as Ti-based implant coating materials in order to control and improve the implant success rate with focus on enhanced osseointegration and antimicrobial purposes. METHOD: This review was conducted using electronic databases and MeSH keywords to detect associated scientific literature published in English. RESULTS: The reviewed articles exhibited that a significant progress in research has occurred in the case of nanomaterial-based coatings for dental implants. Coating of Ti surfaces with nanoparticles can improve soft tissue integration and osteogeneration that leads to improved fixation of implants. Furthermore, osteoconductive nanoparticles induce a chemical bond with bone to attain good biological fixation for implants. Surface modification of implants using antibacterial properties can also decrease the potential for infection, and certainly, present improve clinical outcomes. CONCLUSIONS: Considering the reported success, more clinically and in vivo information on the nanoparticle-based implant coatings will add to the successful application of the device in the clinic. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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