Surface coating prolongs the degradation and maintains the mechanical strength of surgical suture in vivo

Human saphenous vein (hSV) and synthetic grafts are commonly used conduits in vascular grafting, despite high failure rates. Decellularising hSVs (D-hSVs) to produce vascular scaffolds might be an effective alternative. We assessed the effectiveness of a detergent-based method using 0% to 1% sodium dodecyl sulphate (SDS) to decellularise hSV. Decellularisation effectiveness was measured in vitro by nuclear counting, DNA content, residual cell viability, extracellular matrix integrity and mechanical strength. Cytotoxicity was assessed on human and porcine cells. The most effective SDS concentration was used to prepare D-hSV grafts that underwent preliminary in vivo testing using a porcine carotid artery replacement model. Effective decellularisation was achieved with 0.01% SDS, and D-hSVs were biocompatible after seeding. In vivo xeno-transplantation confirmed excellent mechanical strength and biocompatibility with recruitment of host cells without mechanical failure, and a 50% patency rate at 4-weeks. We have developed a simple biocompatible methodology to effectively decellularise hSVs. This could enhance vascular tissue engineering toward future clinical applications.

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Development of a Cell‐Loading Microrobot with Simultaneously Improved Degradability and Mechanical Strength for Performing In Vivo Delivery Tasks

Advanced Intelligent Systems ◽

10.1002/aisy.202100052 ◽

2021 ◽

pp. 2100052

Author(s):

Tanyong Wei ◽

Junyang Li ◽

Liushuai Zheng ◽

Cheng Wang ◽

Feng Li ◽

...

Keyword(s):

Mechanical Strength ◽

Cell Loading ◽

A Cell ◽

In Vivo Delivery

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Preliminary experience with a novel model assessing In vivo mechanical strength of bone grafts and substitute materials

Calcified Tissue International ◽

10.1007/bf00298999 ◽

1995 ◽

Vol 57 (1) ◽

pp. 64-68 ◽

Cited By ~ 11

Author(s):

K. R. Hamson ◽

J. M. Toth ◽

J. B. Stiehl ◽

K. L. Lynch

Keyword(s):

Mechanical Strength ◽

Bone Grafts ◽

Substitute Materials ◽

Novel Model

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Structure Optimization on FEM Biomechanical Model of Bioabsorable Pure Magnesium Skin Staple

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.1049-1050.511 ◽

2014 ◽

Vol 1049-1050 ◽

pp. 511-514

Author(s):

Yong Hua Lao ◽

Yue Shan Huang ◽

Wei Rong Li ◽

Ying Jun Wang

Keyword(s):

Stainless Steel ◽

Mechanical Strength ◽

316L Stainless Steel ◽

Mechanical Performance ◽

Structure Optimization ◽

Biomechanical Model ◽

Pure Magnesium ◽

Structural Deformation ◽

Medical Implants ◽

Surgical Suture

Skin Stapler is an alternative instrument, which makes surgy easily and quickly and owns fine-looking effect without scars after the wound healed, to traditional surgical suture for the wound skin sewing. Magnesium recently is considered to develop medical implants because of its beneficial biocompatibility and bioabsorability. Due its less mechanical strength than traditional 316L stainless steel used in common staple, this paper try to optimize the structure of pure magnesium skin staple by FEM models and simulation as so to assure its biomechanical safty. Using ADINA software, two staples with different pre-bended shoulders and the traditional staple without shoulder are modeling to analyze its stress and plastical strain during structural deformation under load. The results, not only of pure magnesium models but also of 316L stainless steel models, showed that the shoulders optimization on staple structure has important role in its mechanical performance. The research increases the possibility of bioabsorable magnesium material application on medical skin staple.

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In vivo degeneration and the fate of inorganic nanoparticles

Chemical Society Reviews ◽

10.1039/c5cs00699f ◽

2016 ◽

Vol 45 (9) ◽

pp. 2440-2457 ◽

Cited By ~ 228

Author(s):

Neus Feliu ◽

Dominic Docter ◽

Markus Heine ◽

Pablo del Pino ◽

Sumaira Ashraf ◽

...

Keyword(s):

Surface Coating ◽

Inorganic Nanoparticles

Nanoparticles comprise of a core, a surface coating, and a corona of adsorbed biomolecules, of which all parts can have a different fate.

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Surgical Suture Assembled with Tadalafil/Polycaprolactone Drug-Delivery for Vascular Stimulation Around Wound: Validated in a Preclinical Model

Biointerface Research in Applied Chemistry ◽

10.33263/briac105.63176327 ◽

2020 ◽

Vol 10 (5) ◽

pp. 6317-6327 ◽

Cited By ~ 1

Keyword(s):

Wound Healing ◽

Tensile Strength ◽

Drug Release ◽

Study Groups ◽

Preclinical Model ◽

Surgical Suture ◽

Electrospinning Method ◽

Hematoxylin And Eosin ◽

Improve Wound Healing

In this study, a novel Polycaprolactone suture assembled with Tadalafil was investigated to improve wound healing processes via vascular stimulation. Tadalafil/Polycaprolactone (TP) suture was developed by the electrospinning method. The designed suture was characterized by SEM, mechanical properties assessments, tensile strength measurements and the drug release study. For in vivo tests, rats were classified into two study groups. An incision was made on their back skin and they were sutured with TP suture and Polycaprolactone suture as control. Rats were sacrificed at 7 days following surgery for histopathological examinations with Hematoxylin and Eosin staining. Results of Tensile test demonstrated that the lowest tensile strength belonged to 3 and 4 % wt and the highest tensile strength belonged to 1 and 2 % wt of TP suture. The rate of Tadalafil release showed that the highest drug release was related to 3 and 4% wt which were about 125 to 210 μg during 15 days. The histopathology revealed that the number of blood vessels, collagen fibers, fibroblast, polymorphonuclear leukocytes, and epithelization was remarkable in Tadalafil/Polycaprolactone group during 7-day. A novel Tadalafil/Polycaprolactone suture improved the processes of wound healing by releasing the Tadalafil drug around the sutured wound and can be used in medical applications.

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Poly(glycerol sebacate)-modified polylactic acid scaffolds with improved hydrophilicity, mechanical strength and bioactivity for bone tissue regeneration

RSC Advances ◽

10.1039/c5ra13334c ◽

2015 ◽

Vol 5 (97) ◽

pp. 79703-79714 ◽

Cited By ~ 27

Author(s):

Hengsong Shi ◽

Qi Gan ◽

Xiaowei Liu ◽

Yifan Ma ◽

Jun Hu ◽

...

Keyword(s):

Mechanical Strength ◽

Bone Tissue ◽

Polylactic Acid ◽

Tissue Regeneration ◽

Biomedical Engineering ◽

Bone Tissue Regeneration ◽

Engineering Applications

Polylactic acid (PLA) has been extensively researched in biomedical engineering applications due to its superior mechanical strength and biocompatibility in vivo.

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