Transdermal sensing: in-situ non-invasive techniques for monitoring of human biochemical status

2021 ◽  
Vol 71 ◽  
pp. 198-205
Author(s):  
Kenta Iitani ◽  
Sai Sathish Ramamurthy ◽  
Xudong Ge ◽  
Govind Rao
Heritage ◽  
2020 ◽  
Vol 3 (3) ◽  
pp. 858-874
Author(s):  
Susanna Bracci ◽  
Donata Magrini ◽  
Rachele Manganelli del Fà ◽  
Oana Adriana Cuzman ◽  
Barbara Mazzei

The Lot Sarcophagus is one of the most relevant funerary sculptures of late antiquity (mid-4th century AC). Some of the remarkable aspects are the following (i) it is still preserved in situ; (ii) most of the carved scenes are rarities or unicum; (iii) not all the sculpture work has been completed, which allows us to analyse the executive process; (iv) many traces of polychromy have remained. This paper is focused on the characterization of the residual polychromy by using in-situ non-invasive techniques. Furthermore, few micro samples were taken, to be analysed in laboratory to study the composition of some deposits and to define if a preparatory layer was present under the coloured layer. The data showed that the very rich polychromy of the Lot Sarcophagus was made of Egyptian blue, yellow ochre, and three different types of red: two inorganics (red ochre and cinnabar), and one organic-based (madder lake). Furthermore, some decorations, completely vanished and no longer visible to the naked eye, have been rediscovered, also providing details on the construction phases. During the project, the 3D model of the sarcophagus was acquired, which afterwards was used to map the results of the diagnostic campaign.


2020 ◽  
Vol 53 (6) ◽  
pp. 2915-2920
Author(s):  
Yinghong Wang ◽  
Qiangqiang Pei ◽  
Shanlong Yang ◽  
Qinglin Guo ◽  
Heather Viles

Author(s):  
Juan Antonio Martínez Hermoso ◽  
María José Ayora Cañada ◽  
Ana Domínguez Vidal ◽  
◽  

The chapel of the QH31 funerary complex (Sarenput II) was excavated directly into the rock, like the rest of the hypogea of the necropolis of Qubbet el-Hawa. However, in the chapel there are some outstanding elements that, probably, were elaborated independently of the excavation works in situ, to be located in the planned place as an integral part of the burial equipment, and the general design of the chapel. These elements include, for example, the three pairs of Osiride statues in the corridor, the four pillars in the offering chamber, and the slabs with which they built the sanctuary of the statue of the grave’s owner. As these elements were found coated so as to make their surfaces suitable for decoration, it is very difficult to determine the stone with which they were made. During the last campaign (2018), in situ analysis with non-invasive techniques, such as X-ray Fluorescence, has allowed determining its chemical composition. In addition, some stone fragments found during the excavations carried out since 2008 by the Qubbet el-Hawa project (University of Jaén), have been analyzed, such as the wig of the decapitated statue on the north wall of the corridor, and the fragment belonging to the right jamb of the façade of the sanctuary housing the statue. The results of the analysis seem to indicate that these elements were made from a very similar sandstone to that of the excavation itself and not with silicified sandstone (quartzarenite), which was also very abundant at Qubbet el-Hawa. Besides, these studies show several differences in composition between the stone employed for the construction of the sanctuary, and other elements such as the Osiride statues. Finally, the slab on the floor of the sanctuary, on which the statue of Sarenput was placed, was made of imported limestone.


2013 ◽  
Vol 548 ◽  
pp. 239-246 ◽  
Author(s):  
Amélia Dionísio ◽  
Edite Martinho ◽  
Carlos Grangeia ◽  
Fernando Almeida

Today experts agree that precise damage diagnosis is the key to comprehensive characterization, interpretation, rating and prediction of stone damage. It provides vital information for monument conservation and sustainable preservation. Better understanding of the stones used in monuments and the factors, processes and characteristics involved in stone decay is therefore essential to the sustainable preservation of cultural heritage. A frequent and major obstacle to studying stone decay in monuments is the impossibility of touching or obtaining samples for study in the laboratory or even in-situ. The aim of this paper is to present the results of three non-invasive geophysical (3-D electrical resistivity and seismic refraction) and geochemical (soluble salts typology and distribution) techniques, that were used to diagnose stone damage in case studies involving Portuguese cultural heritage. Different techniques were applied based on decay typology or observed phenomena.


2015 ◽  
Vol 3 (9) ◽  
pp. 1831-1845 ◽  
Author(s):  
Diogo Mata ◽  
Filipe J. Oliveira ◽  
Miguel A. Neto ◽  
Manuel Belmonte ◽  
Alexandre C. Bastos ◽  
...  

Cell functions were controlledin situby an efficient mechanism of delivering electrical stimuli involving conductive biomaterials and non-invasive techniques.


2020 ◽  
pp. 71-74
Author(s):  
M.M. Melnyk ◽  
◽  
S.V. Nespradko ◽  
I.V. Goncharuk ◽  
M.V. Marchenko ◽  
...  

The objective: analyse the effectiveness of diagnosis and treatment for early cervical cancer. Materials and methods. Analysed 107 cases of women’s disease on CIN ІІІ, cancer in situ, they were on treatment in National cancer institute and Kyiv dictrict cancer dispensary from 2010 till 2015 years. Results. Diagnosed percent relapse CIN ІІІ, cancer in situ contain 4.57% uninvasive and invasive form – 0.94%. Conclusion. According diagnostic CIN ІІ and CIN ІІІ is recommended to do treatment conization and dynamic dispensary observation. Are making complex program of infection HPV16, 18. In appering of margins resection some elements of tumor after wider conization by forms of cancer in situ. Many of expansive burns in cervical glands, in making of reproductive function, going disease (nodel leiomyoma of corpus uteri etc). In perspective is accept the notion of looking after and screening research of considering infection HPV16, 18 on CIN І, CIN ІІ. Key words: cervical cancer, сancer in situ, CIN І–ІІІ, diagnostic, treatment, conization.


2019 ◽  
Vol 19 (2) ◽  
pp. 105-111
Author(s):  
Nadia Shafei ◽  
Mohammad Saeed Hakhamaneshi ◽  
Massoud Houshmand ◽  
Siavash Gerayeshnejad ◽  
Fardin Fathi ◽  
...  

Background: Beta thalassemia is a common disorder with autosomal recessive inheritance. The most prenatal diagnostic methods are the invasive techniques that have the risk of miscarriage. Now the non-invasive methods will be gradually alternative for these invasive techniques. Objective: The aim of this study is to evaluate and compare the diagnostic value of two non-invasive diagnostic methods for fetal thalassemia using cell free fetal DNA (cff-DNA) and nucleated RBC (NRBC) in one sampling community. Methods: 10 ml of blood was taken in two k3EDTA tube from 32 pregnant women (mean of gestational age = 11 weeks), who themselves and their husbands had minor thalassemia. One tube was used to enrich NRBC and other was used for cff-DNA extraction. NRBCs were isolated by MACS method and immunohistochemistry; the genome of stained cells was amplified by multiple displacement amplification (MDA) procedure. These products were used as template in b-globin segments PCR. cff-DNA was extracted by THP method and 300 bp areas were recovered from the agarose gel as fetus DNA. These DNA were used as template in touch down PCR to amplify b-globin gen. The amplified b-globin segments were sequenced and the results compared with CVS resul. Results: The data showed that sensitivity and specificity of thalassemia diagnosis by NRBC were 100% and 92% respectively and sensitivity and specificity of thalassemia diagnosis by cff-DNA were 100% and 84% respectively. Conclusion: These methods with high sensitivity can be used as screening test but due to their lower specificity than CVS, they cannot be used as diagnostic test.


2020 ◽  
Vol 16 (2) ◽  
pp. 138-152
Author(s):  
Bingren Zhang ◽  
Chu Wang ◽  
Chanchan Shen ◽  
Wei Wang

Background: Responses to external emotional-stimuli or their transitions might help to elucidate the scientific background and assist the clinical management of psychiatric problems, but pure emotional-materials and their utilization at different levels of neurophysiological processing are few. Objective: We aimed to describe the responses at central and peripheral levels in healthy volunteers and psychiatric patients when facing external emotions and their transitions. Methods: Using pictures and sounds with pure emotions of Disgust, Erotica, Fear, Happiness, Neutral, and Sadness or their transitions as stimuli, we have developed a series of non-invasive techniques, i.e., the event-related potentials, functional magnetic resonance imaging, excitatory and inhibitory brainstem reflexes, and polygraph, to assess different levels of neurophysiological responses in different populations. Results: Sample outcomes on various conditions were specific and distinguishable at cortical to peripheral levels in bipolar I and II disorder patients compared to healthy volunteers. Conclusions: Methodologically, designs with these pure emotions and their transitions are applicable, and results per se are specifically interpretable in patients with emotion-related problems.


2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Andy Sombke ◽  
Carsten H. G. Müller

Abstract Background The jointed appendage is a key novelty in arthropod evolution and arthropod legs are known to vary enormously in relation to function. Among centipedes, the ultimate legs always are distinctly different from locomotory legs, and different centipede taxa evolved different structural and functional modifications. In Geophilomorpha (soil centipedes), ultimate legs do not participate in locomotion and were interpret to serve a sensory function. They can be sexually dimorphic and in some species, male ultimate legs notably appear “hairy”. It can be assumed that the high abundance of sensilla indicates a pronounced sensory function. This study seeks for assessing the sensory diversity, however, documents the surprising and unique case of an extensive glandular epithelium in the ultimate legs of three phylogenetically distant species. Results The tightly aggregated epidermal glands with stalked ducts – mistakenly thought to be sensilla – were scrutinized using a multimodal microscopic approach comprising histology as well as scanning and transmission electron microscopy in Haplophilus subterraneus. Hence, this is the first detailed account on centipede ultimate legs demonstrating an evolutionary transformation into a “secretory leg”. Additionally, we investigated sensory structures as well as anatomical features using microCT analysis. Contrary to its nomination as a tarsus, tarsus 1 possesses intrinsic musculature, which is an indication that this podomere might be a derivate of the tibia. Discussion The presence and identity of ultimate leg associated epidermal glands with stalked ducts is a new discovery for myriapods. A pronounced secretory as well as moderate sensory function in Haplophilus subterraneus can be concluded. The set of characters will improve future taxonomic studies, to test the hypotheses whether the presence of these specialized glands is a common feature in Geophilomorpha, and that tarsus 1 may be a derivate of the tibia. As the number of epidermal glands with stalked ducts is sexually dimorphic, their function might be connected to reproduction or a sex-specific defensive role. Our results, in particular the unexpected discovery of ‘glandular hairs’, may account for a striking example for how deceptive morphological descriptions of epidermal organs may be, if based on non-invasive techniques alone.


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