scholarly journals A note on the impact of a behavioral side-effect of vaccine failure on the spread of a contagious disease

2021 ◽  
Vol 46 ◽  
pp. 100929
Author(s):  
G.S. Harari ◽  
L.H.A. Monteiro
Keyword(s):  
Side Effect ◽  
Vaccine Failure ◽  
Contagious Disease ◽  
The Impact

Fatigue

2019 ◽  
pp. 132-139
Author(s):  
Edith O’Neil-Page ◽  
Grace E. Dean ◽  
Paula R. Anderson
Keyword(s):  
End Of Life ◽  
Side Effect ◽  
Healthcare Providers ◽  
Self Care ◽  
Significant Others ◽  
Daily Activities ◽  
Course Of Disease ◽  
Cancer Related Fatigue ◽  
Care Requirements ◽  
The Impact

Individuals suffering from chronic or malignant disease may experience overwhelming and debilitating symptoms of extensive tiredness or sleepiness or an inability to meet daily self-care requirements and maintain personal interaction with significant others. However, they may be unable to verbalize the impact of fatigue on their daily activities. Fatigue is both personal and communal, affecting all aspects of life. Fatigue is often unrecognized by family and healthcare providers or is accepted as a “side effect” of disease and treatment. Cancer-related fatigue affects all aspects of life, at all ages, and may remain unacknowledged by healthcare providers. Yet with recognition and intervention, fatigue can be successfully managed throughout the course of disease, recovery, or through end of life.

The Impact of Prescribed Medication on Swallowing: An Overview

2010 ◽  
Vol 19 (4) ◽  
pp. 98-102 ◽  
Author(s):  
Louise Gallagher
Keyword(s):  
Side Effects ◽  
Best Practices ◽  
Side Effect ◽  
Team Member ◽  
Assessment Process ◽  
Valuable Resource ◽  
Speech Language Pathologists ◽  
Swallowing Difficulties ◽  
The Impact

Dysphagia clinicians are aware that best practices guidelines recommend a medications review as part of the assessment process. This article aims to review the literature to date regarding the impact that medications may have on the physiology of swallowing. It is important to consider the side effects of all medications, not only medications listing swallowing difficulties as a known side effect. Medications that impact upon arousal, awareness, and xerostomia should also be considered as part of a comprehensive dysphagia evaluation. Speech-language pathologists should consider the pharmacist an integral dysphagia team member and a valuable resource.

Impact of cetuximab on chemoradiation use in older patients with locally advanced head and neck cancer.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 6594-6594 ◽  
Author(s):  
Shrujal S. Baxi ◽  
Eric Jeffrey Sherman ◽  
Coral L Atoria ◽  
Nancy Y. Lee ◽  
David G. Pfister ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Side Effect ◽  
Locally Advanced ◽  
Definitive Treatment ◽  
Side Effect Profile ◽  
Advanced Head ◽  
The Impact ◽  
Over Time

6594 Background: The benefit of chemoradiation (CTRT) in the treatment of locally advanced head and neck cancer (LAHNC) declines in older and sicker patients. In 2006, the FDA approved cetuximab in LAHNC. Cetuximab with radiation has a perceived lower side effect profile compared to standard chemotherapies used in CTRT. Our objective was to examine the impact of cetuximab on the use of CTRT in elderly patients with LAHNC. Methods: We identified adults aged 66 and older diagnosed with LAHNC between 1999 and 2007 in the Surveillance Epidemiology and End Results (SEER)-Medicare linked database. Treatment was categorized as CTRT or other based on Medicare claims within 6 months of diagnosis. We excluded patients who did not receive definitive treatment. In patients who had CTRT, we identified use of cetuximab based on drug-specific billing codes. We assessed trends in the use of CTRT over the entire study period and in the use of cetuximab since 2006. We examined the influence of age and comorbidity on the likelihood of receiving CTRT before and after 2006 adjusting for clinical and demographic factors. Results: We identified 4,809 patients with LAHNC. One-fourth were ≥80 years and almost a fifth had a Charlson comorbidity score (CCS) of ≥2. Overall more than 20% of patients received CTRT. The use of CTRT more than tripled over time, from 10% of patients diagnosed in 1999 to 38% in 2007 (p<0.0001 for trend). Of the 336 patients who had CTRT since 2006, 45% received cetuximab. Prior to 2006, patients ≥80 years or those with a CCS of ≥2 were significantly less likely to be treated with CTRT compared to younger patients or those with a CCS of 0. In patients diagnosed in 2006 or later, age and comorbidity no longer predicted the likelihood of receiving CTRT. Conclusions: In this population-based cohort of older adults, the use of CTRT increased substantially over time. The availability of cetuximab, with a perceived gentler side effect profile, may have increased the use of CTRT, especially in older and sicker patients. [Table: see text]

Determining the impact of chemotherapy-induced peripheral neuropathy: A survey of cancer survivors.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e24080-e24080
Author(s):  
Eva Battaglini ◽  
David Goldstein ◽  
Susanna Park
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Peripheral Neuropathy ◽  
Side Effects ◽  
Cancer Survivors ◽  
Side Effect ◽  
Functional Disability ◽  
Health Conditions ◽  
The Impact

e24080 Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a major yet poorly understood side effect of cancer treatment, leading to symptoms including numbness, tingling and pain. It can lead to cessation of effective treatment, long-term functional disability and reduced quality of life. Despite this, there is currently little understanding of its impact. Methods: The aim of the study was to investigate the impact of neurotoxic chemotherapy side effects on the lives of cancer survivors. Data was collected via an online survey covering demographics, cancer diagnosis and treatment, CIPN and other side effects of chemotherapy, using standardised measures to assess comorbidities, quality of life, physical activity, pain and CIPN symptoms. Results: Data was analysed from 986 respondents who were treated with neurotoxic therapies (83% female, 16% male), with mean age 59 years ( SD 10.7 years). A majority of respondents were treated for breast cancer (59%), 14% for colorectal cancer and 11% for multiple myeloma. Chemotherapy types received included paclitaxel (32%), docetaxel (32%) and oxaliplatin (13%), and respondents completed treatment a mean of 3.6 years ago. The majority of respondents (80%) reported experiencing neuropathic symptoms after finishing chemotherapy, with 77% reporting current CIPN. Those with CIPN reported functional impacts, with 23% reporting moderate to severe problems with hand function and 28% reporting moderate to severe walking difficulties. CIPN was second most commonly rated as the treatment side effect having the greatest impact, following fatigue. Respondents with high levels of current CIPN symptoms had poorer quality of life, more comorbid health conditions, higher BMI and more often received multiple neurotoxic chemotherapies than those with low levels of CIPN symptoms. In addition, respondents who reported meeting government physical activity guidelines had lower CIPN and higher quality of life scores than those who did not meet the guidelines. Regression analyses investigating the association between quality of life and clinical and sociodemographic characteristics resulted in a model with comorbid health conditions, CIPN symptoms, years since treatment, age and physical activity as significant predictors of quality of life. Conclusions: These findings suggest that CIPN has a lasting impact on cancer survivors, leading to decreases in quality of life, often occurring alongside poorer general health. This impact supports the need for further research to improve assessment, prevention and treatment.

scholarly journals Impact of Pharmacist Counselling on Clozapine Knowledge

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Ciara Ní Dhubhlaing ◽  
Ailish Young ◽  
Laura J. Sahm
Keyword(s):  
Side Effects ◽  
Patient Information ◽  
Side Effect ◽  
Information Sources ◽  
Knowledge Score ◽  
University Hospital ◽  
Patient Knowledge ◽  
Specific Knowledge ◽  
The Impact ◽  
Improve Patient

Clozapine is the only antipsychotic with evidence for efficacy in treatment of resistant schizophrenia but it carries a high side effect burden. Patient information is provided but may be poorly retained. This study aims to examine the impact of pharmacist counselling upon patient knowledge of clozapine. Outpatients, aged 18 years and over, attending St. Patrick’s University Hospital, Dublin, participated in this study between June and August 2015. The intervention consisted of pharmacist counselling on two occasions one month apart. Knowledge was assessed using a 28-point checklist devised from the currently available clozapine patient information sources, at baseline and after each counselling session. Ethics approval was obtained. Twenty-five participants (40% female; mean age 45.1 years, SD 9.82; 64% unemployed, 28% smokers) showed an improvement in knowledge scores of clozapine from baseline to postcounselling on each occasion with an overall improvement in knowledge score, from baseline to postcounselling at one month, of 39.43%; p<0.001. This study adds to the evidence that interventions involving pharmacist counselling can improve patient knowledge, whilst the specific knowledge gained relating to recognition of side effects may help patients towards more empowerment regarding their treatment.

scholarly journals Job change and self-control of waste pickers: evidence from a field experiment in the Philippines

2018 ◽  
Vol 9 (2) ◽  
pp. 22-35
Author(s):  
Hide-Fumi Yokoo ◽  
Maki Ikuse ◽  
Aries Roda D. Romallosa ◽  
Masahide Horita
Keyword(s):  
Developing Countries ◽  
Side Effects ◽  
Field Experiment ◽  
Side Effect ◽  
The Philippines ◽  
Self Control ◽  
Informal Workers ◽  
Negative Side ◽  
The Impact ◽  
Waste Pickers

Environmental policies may have a negative side effect on employment, often in a specific industry in the short run. Workers in regulated industries can be affected by losses in job-specific human capital. The informal sectors in developing countries are often associated with environmental pollution and thus targeted by such policies. Welfare loss due to this side effect can be problematic in developing countries, since they often lack safeguarding schemes, including unemployment insurance. Inducing workers in informal sectors to change their jobs can mitigate these negative side effects. This study examines efficient methods of inducing informal workers to change jobs. An alternative job is offered to informal workers at a dumpsite in the Philippines and whether changing the scheme of wage payment increases the acceptance of the offer is examined. The impacts of changing payment schemes are evaluated by using a randomized field experiment. The sampled 112 waste pickers each randomly receive one of four offers for an alternative job, and the number of those who accept the offer is observed to evaluate the impact of less frequent payment (i.e., once every three days instead of daily). Piece rates and fixed wages are also compared. Those offered less frequent payment are more likely to accept the job offer compared with those offered daily payment. This preferred payment scheme can mitigate the side effects of environmental policy and workers’ self-control problem related to savings, while minimizing moral hazard.

scholarly journals The impact of chronic mild hypoxia on cerebrovascular remodelling; uncoupling of angiogenesis and vascular breakdown

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Sebok K. Halder ◽  
Richard Milner
Keyword(s):  
Blood Vessels ◽  
Side Effect ◽  
Vascular Perfusion ◽  
Vascular Leak ◽  
Unwanted Side Effect ◽  
Endothelial Proliferation ◽  
Junction Protein ◽  
Temporary Closure ◽  
The Impact ◽  
Mild Hypoxia

Abstract Background Chronic mild hypoxia (CMH, 8% O2) stimulates robust vascular remodelling in the brain, but it also triggers transient vascular disruption. This raises the fundamental question: is the vascular leak an unwanted side-effect of angiogenic remodelling or is it a pathological response, unrelated to endothelial proliferation, in which declining oxygen levels trigger endothelial dysfunction? Methods To answer this question, mice were exposed to CMH (8% O2) for periods up to 14 days, after which, brain tissue was examined by immunofluorescence (IF) to determine which type of blood vessel (arteriole, capillary or venule) was most commonly associated with endothelial proliferation and vascular leak and how this correlated with tight junction protein expression. Vascular perfusion was examined using DiI. Data were analysed using one-way analysis of variance (ANOVA) followed by Tukey’s multiple comparison post-hoc test. Results The following was observed: (1) most endothelial proliferation and extravascular fibrinogen leak occurred in capillaries and to a lesser degree in venules, (2) much to our surprise, endothelial proliferation and extravascular fibrinogen leak never colocalized, (3) interestingly however, endothelial proliferation was strongly associated with an intravascular fibrinogen staining pattern not seen in stable blood vessels, (4) DiI perfusion studies revealed that angiogenic vessels were adequately perfused, suggesting that fibrinogen retention in angiogenic vessels is not due to temporary closure of the vessel, but more likely because fibrinogen is retained within the vessel wall, (5) bromodeoxyuridine (BrdU) labelling as a means to more permanently label proliferating endothelial cells, confirmed lack of any connection between endothelial proliferation and extravascular fibrinogen leak, while (6) in contrast, proliferating microglia were detected within extravascular leaks. Conclusions Taken together, our findings support the concept that in the short-term, hypoxia-induced endothelial proliferation triggers transient fibrinogen deposition within the walls of angiogenic blood vessels, but no overt vascular leak occurs in these vessels. Importantly, endothelial proliferation and extravascular fibrinogen leaks never co-localize, demonstrating that extravascular leak is not an unwanted side-effect of angiogenic endothelial proliferation, but rather a dysfunctional vascular response to hypoxia that occurs in a distinct group of non-angiogenic blood vessels.

scholarly journals Quantifying Model Form Uncertainty of Epidemic Forecasting Models from Incidence Data

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Nicholas Hengartner ◽  
Paul Fenimore
Keyword(s):  
Time Series ◽  
Model Misspecification ◽  
Disease Model ◽  
Parametric Models ◽  
Incidence Data ◽  
Force Of Infection ◽  
Model Form ◽  
Contagious Disease ◽  
The Impact ◽  
Non Parametric

ObjectiveWe present a mathematical framework for non-parametric estimation of the force of infection, together with statistical upper and lower confidence bands. The resulting estimates allow to assess how well simpler models, such as SEIR, fit the observed time series of incidence data.IntroductionUncertainty Quantification (UQ), the ability to quantify the impact of sample-to-sample variations and model misspecification on predictions and forecasts, is a critical aspect of disease surveillance. While quantifying the impact of stochastic uncertainty in the data is well understood, quantifying the impact of model misspecification is significantly harder. For the latter, one needs a "universal model" to which more restrictive parametric models are compared too.MethodsThis talk presents a useful modeling framework for time series of incidence data from contagious diseases that enables one to identify and quantify the impact of model form uncertainty. Specifically, we propose to focus on estimating the timedependent force of infection. The latter is a universal parameters for all contagious disease model. Using a machine learning technique for estimating monotone functions, i.e., isotonic regression and its variants, one can estimate the force ofinfection without addtional assumptions. We note that most contagious disease model do satisfy this monotonicity assumption, due to a combination of factors: depletion of susceptibles, implementation of mitigation strategies, behavior change, etc. Comparing the resulting "non-parametric" estimate with parametric estimates, obtained by fitting an SEIR for example, can reveal model deficiencies and help quantify model form uncertainties.Finally, we discuss how ideas from "strict bound theory" can be used to develop upper and lower uncertainty bands for force of infection that acknowledge the intrinsic stochasticity in the data.ResultsWe demonstrate the application of the methodology to weekly Influenza Like Illness (ILI) incidence data from France andcompare the results to fitted SIR and SEIR models. This comparison can be seen as a nonparametric goodness of fit test, providing one with tools to do simple model selection.ConclusionsWe present a novel and flexible model to statistically describe the force of infection as a function of time. Comparing the fit to incidence data of that model with the fit of simpler parametric models enables the quantification of model form uncertainty and associated model selection.

scholarly journals ANTIRETROVIRAL SIDE EFFECT ON ADHERENCE IN PEOPLE LIVING WITH HIV AIDS AT DR. KARIADI GENERAL REFFERAL HOSPITAL SEMARANG CENTRAL JAVA

2019 ◽  
Vol 8 (2) ◽  
pp. 79 ◽  
Author(s):  
Gede Arya Bagus Arisudhana ◽  
Muchlis Achsan Udji Sofro ◽  
Untung Sujianto
Keyword(s):  
Health Care ◽  
Side Effects ◽  
Side Effect ◽  
People Living With Hiv ◽  
Drug Adherence ◽  
Cross Sectional ◽  
Central Java ◽  
Living With Hiv ◽  
The Impact ◽  
Hiv Aids

Background: Antiretroviral (ARV) therapy is a lifelong treatment in people living with HIV/AIDS (PLWHA). Adherence is the key to the effectiveness of antiretroviral therapy. ARV have side effects that may affect patient adherence.Purpose: The purpose of this study was to examine the impact of ARV side effects on drug adherence in PLWHA.Methods: This study used cross-sectional approach. Sample size in this study was 78 consist of people who were recruited by purposive sampling. These subjects received ARV therapy in Tropical Disease and Infection Polyclinic at General Hospital of Dr. Kariadi SemarangResult : Result showed that eta2 is 0,525625. It means that ARV side effect has impact on ARV adherence. Most of the side effects reported by the respondents were nausea and dizziness. Some respondents also reported experiencing weakness, difficult to concentrate, and diarrhea. Conclusion : Side effects have impact on patient’s ARV therapy adherence. Therefore health care provider for PLWHA should be able to recognize and concern on ARV side effect management. 

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