Sleep in post-menopausal women: Differences between early and late post-menopause

2009 ◽  
Vol 145 (1) ◽  
pp. 81-84 ◽  
Author(s):  
Helena Hachul ◽  
Lia Rita Azeredo Bittencourt ◽  
José Maria Soares ◽  
Sergio Tufik ◽  
Edmund Chada Baracat
Keyword(s):  
Menopausal Women ◽  
Post Menopause ◽  
Post Menopausal

scholarly journals Phyto-oestrogens and bone health

2008 ◽  
Vol 67 (2) ◽  
pp. 184-195 ◽  
Author(s):  
Véronique Coxam
Keyword(s):  
Hormone Replacement Therapy ◽  
Bone Loss ◽  
Replacement Therapy ◽  
Bone Health ◽  
Hormone Replacement ◽  
Early Period ◽  
Long Duration ◽  
Menopausal Women ◽  
Post Menopause ◽  
Post Menopausal

As oestrogen deficiency is the main cause in the pathogenesis of osteoporosis hormone-replacement therapy remains the mainstay for prevention. However, prophylaxis by hormone-replacement therapy is limited. Phyto-oestrogens, which are weakly-oestrogenic compounds present in plants, deserve particular mention because emerging data support the suggestion that they may prevent bone loss associated with the menopause. In the past few years extensive research using animal models has provided convincing data to indicate a significant improvement in bone mass or other end points following feeding with soyabean. Moreover, observational studies relate the lower incidence of osteoporosis among women in the Eastern world to a diet rich in phyto-oestrogens. However, it is not valid to extrapolate to the Western situation. The varied clinical trials that have been published suggest that isoflavones reduce bone loss in women in the early period post menopause, but a definitive result requires more investigations of the effect of phyto-oestrogens on bone health that have substantial sample size and are of long duration. In addition, the clinical efficacy of soya foods in preventing osteopenia depends on their intestinal metabolism. Thus, phyto-oestrogens are a source for putative innovative dietary health intervention for post-menopausal women. However, more data are necessary, particularly in relation to their effect on the risk of fracture.

scholarly journals STUDY OF CALCIUM, PHOSPHORUS AND ACID PHOSPHATASE IN PRE-AND POST-MENOPAUSAL WOMEN

2020 ◽  
Vol 4 (5) ◽  
Author(s):  
Gangaram Bhadarge ◽  
Badade ZG ◽  
Rahul Kadam
Keyword(s):  
Acid Phosphatase ◽  
Phosphorus Acid ◽  
T Score ◽  
Menopausal Women ◽  
The World ◽  
Calcium Phosphorus ◽  
Post Menopause ◽  
Post Menopausal ◽  
One Year ◽  
Hazard Factor

Introduction: More than 75 million individuals overall experience the ill effects of osteoporosis of which 80 % for example 44 million are postmenopausal ladies. Osteoporosis is second just to cardiovascular disease as a main medicinal services issue, as per the World Health Organization. Around the world, the lifetime hazard for ladies to have an osteoporotic break is 30 – 40%. Menopauseis one of the most significant physiological occasions; it is identified with the suspension of ovarian capacity and the finish of conceptive cycle. The occurrence of osteoporosis in postmenopausal ladies keeps on expanding with continuously maturing populaces. Pre-menopause refers to a ladies' regenerative or rich life, from the main menstrual period to the last. Post-menopause is characterized as the time after menopause, in any event one year without a period. Osteoporosisis a dynamic infection which prompts the exhaustion in the bone structure with loss of bone mineral thickness (BMD) expanding the hazard factor of breaks throughout the years. High danger of creating osteoporosis is described by low BMD and shows a disintegration of the smaller scale engineering with the BMD is the consequence of a harmony between bone resorption because of osteoclasts and bone arrangement because of osteoblasts, during an on-going renovating process. Aim: Study of Calcium, Phosphorus, Acid Phosphatase and BMD T score in Pre-and Post-Menopausal Women. Material and Methods: The present study includes total 100 subjects that include 50 pre-menopausal women (age 35 to 45 years) and 50 post -menopause women (age 46 to 60 years).  Blood samples were collected from the subjects were obtained for Calcium, Phosphorus and Acid Phosphatase from Medicine /Orthopaedics/ Obstetrics and Gynaecology Wards. Conclusion: Menopause is one of the most significant physiological occasions: it is identified with the end of ovarian capacity and the finish of conceptive cycle. The rate of osteoporosis in postmenopausal ladies keeps on expanding with continuously maturing populaces. Pre-menopause alludes to a lady's regenerative or prolific life, from the principal menstrual period to the last. Post-menopause is the time after menopause, in any event one year without a period. Beginning stage of menopause builds hazard for some postmenopausal wellbeing inconveniences, for example, osteoporosis, ischemic ailment, and ovarian malignancy, though later menopause is a hazard factor for endometrial and bosom disease. Abbreviation: Menopause, Osteoporosis, BMD T score, Calcium, Phosphorus, Acid phosphatase.

Abstract 029: Menopause Alters The Gut Microbiome In Hispanic/Latina Women Of The Hispanic Community Health Study/Study Of Latinos (HCHS/SOL), With Implications For Metabolic Syndrome

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Brandilyn Peters-samuelson ◽  
Juan Lin ◽  
Qibin Qi ◽  
Carmen R Isasi ◽  
Yasmin Mossavar-Rahmani ◽  
...  
Keyword(s):  
Gut Microbiome ◽  
Cardiometabolic Risk ◽  
Disease Risk ◽  
Self Report ◽  
Microbiome Composition ◽  
Microbiome Diversity ◽  
Menopausal Women ◽  
Younger Men ◽  
Post Menopause ◽  
Post Menopausal

Introduction: During menopause, women experience an increase in cardiometabolic risk factors, thought to relate to aging and loss of endogenous estrogen. Menopause may also influence the gut microbiome, which plays a role in cardiometabolic risk. However, the menopause-microbiome relationship has not been examined in a large study and implications for disease are unknown. Hypothesis: Menopause alters gut microbiome composition, which may affect post-menopausal disease risk. Methods: Menopause was defined by self report of 12 months of amenorrhea, not due to surgery or other non-natural causes. Shotgun sequencing was used on stool from 2370 participants (301 pre-menopausal women; 1072 post-menopausal women; 997 men). Between pre- and post-menopausal women and age-matched men, we compared microbiome diversity, composition, and taxa. Results: Pre-menopausal women had higher gut microbiome diversity than post-menopausal women and men (all p<0.05, Figure 1a). Post-menopausal women also differed in overall microbiome composition from pre-menopausal women (p=0.005), while older and younger men did not differ from each other (p=0.70) (Figure 1b). We identified differentially abundant taxa between post- and pre-menopausal women, including class Betaproteobacteria and its genus Sutterella (enriched in post-menopause), and genera Shigella and Escherichia (depleted in post-menopause); associations were similar in comparisons of men vs. women, though the taxa did not differ between older and younger men (Figure 1c). In post-menopausal women, higher abundance of Shigella and Escherichia was associated with impaired fasting glucose (≥100 mg/dL or diabetes treatment) (Figure 1d). Conclusions: Menopause is associated with a gut microbiome more similar to that of men, perhaps related to the common condition of a low estrogen state. In HCHS/SOL, menopause was associated with depletion of gut pathogens, which were related to increased diabetes risk. These findings require confirmation in other racial/ethnic groups.

scholarly journals The Importance of Being a ‘Lark’ in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus?

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3762
Author(s):  
Luigi Barrea ◽  
Claudia Vetrani ◽  
Barbara Altieri ◽  
Ludovica Verde ◽  
Silvia Savastano ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Diseases ◽  
Increased Risk ◽  
Menopausal Women ◽  
Post Menopause ◽  
Post Menopausal

Chronotype is defined as the behavioral manifestation of circadian rhythms related to the external light–dark cycle. Evening chronotype has been associated with an increased risk of developing cardiometabolic diseases in obesity. Menopause is a lifestage associated with an increased risk of developing cardiometabolic diseases and a change in circadian rhythmicity compared to pre-menopause. However, the prevalence of chronotype categories in menopause and their role in determining menopause-related cardiometabolic risk, mostly in obesity, have not been investigated. Thus, we aimed to investigate the prevalence of chronotype categories in post-menopausal women with obesity and their role in menopause-related cardiometabolic risk. In this cross-sectional study we enrolled 49 pre-menopausal and 74 post-menopausal women with obesity. Anthropometric parameters, lifestyle habits, adherence to the Mediterranean Diet (MD), sleep quality, chronotype and the presence of type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD) were studied. No significance differences were detected in terms of lifestyle and adherence to the MD between pre- and post-menopausal women. Chronotype was classified as morning in 66 (53.6%), evening in 20 (16.3%) and intermediate in 37 (30.1%) women. In addition, pre-menopausal women with obesity showed a significantly higher chance to have an intermediate chronotype (OR = 2.21, 95% CI 1.28–3.83; p = 0.004), whereas post-menopausal women with obesity showed a trend to have a higher morning chronotype (OR = 1.42, 95% CI 0.98–2.06; p = 0.051), although this did not reach statistical significance. No significant differences were detected in terms of prevalence of evening chronotype between the two groups. However, the evening chronotype had a significantly higher risk to have T2DM compared to the morning (OR = 17.29, 95% CI 2.40–124.27; p = 0.005) and intermediate chronotypes (OR = 30.86, 95% CI 2.05–464.32; p = 0.013) in both pre- and post-menopausal women with obesity. In conclusion, the intermediate chronotype was significantly more prevalent in pre-menopausal women with obesity compared to post-menopausal women. Evening chronotype was associated to T2DM in both pre- and post-menopause. These results support the importance of including the assessment of chronotype in the management of women with obesity in post-menopause.

scholarly journals How do women living with HIV experience menopause? Menopausal symptoms, anxiety and depression according to reproductive age in a multicenter cohort

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ines Suarez-García ◽  
◽  
Belén Alejos ◽  
Maria-Jesús Pérez-Elías ◽  
Jose-Antonio Iribarren ◽  
...  
Keyword(s):  
Menopausal Status ◽  
Somatic Symptoms ◽  
Menopausal Symptoms ◽  
Women Living With Hiv ◽  
Menopausal Women ◽  
Post Menopause ◽  
Post Menopausal ◽  
Living With Hiv ◽  
Anxiety Depression ◽  
Urogenital Symptoms

Abstract Background To estimate the prevalence and severity of menopausal symptoms and anxiety/depression and to assess the differences according to menopausal status among women living with HIV aged 45–60 years from the cohort of Spanish HIV/AIDS Research Network (CoRIS). Methods Women were interviewed by phone between September 2017 and December 2018 to determine whether they had experienced menopausal symptoms and anxiety/depression. The Menopause Rating Scale was used to evaluate the prevalence and severity of symptoms related to menopause in three subscales: somatic, psychologic and urogenital; and the 4-item Patient Health Questionnaire was used for anxiety/depression. Logistic regression models were used to estimate odds ratios (ORs) of association between menopausal status, and other potential risk factors, the presence and severity of somatic, psychological and urogenital symptoms and of anxiety/depression. Results Of 251 women included, 137 (54.6%) were post-, 70 (27.9%) peri- and 44 (17.5%) pre-menopausal, respectively. Median age of onset menopause was 48 years (IQR 45–50). The proportions of pre-, peri- and post-menopausal women who had experienced any menopausal symptoms were 45.5%, 60.0% and 66.4%, respectively. Both peri- and post-menopause were associated with a higher likelihood of having somatic symptoms (aOR 3.01; 95% CI 1.38–6.55 and 2.63; 1.44–4.81, respectively), while post-menopause increased the likelihood of having psychological (2.16; 1.13–4.14) and urogenital symptoms (2.54; 1.42–4.85). By other hand, post-menopausal women had a statistically significant five-fold increase in the likelihood of presenting severe urogenital symptoms than pre-menopausal women (4.90; 1.74–13.84). No significant differences by menopausal status were found for anxiety/depression. Joint/muscle problems, exhaustion and sleeping disorders were the most commonly reported symptoms among all women. Differences in the prevalences of vaginal dryness (p = 0.002), joint/muscle complaints (p = 0.032), and sweating/flush (p = 0.032) were found among the three groups. Conclusions Women living with HIV experienced a wide variety of menopausal symptoms, some of them initiated before women had any menstrual irregularity. We found a higher likelihood of somatic symptoms in peri- and post-menopausal women, while a higher likelihood of psychological and urogenital symptoms was found in post-menopausal women. Most somatic symptoms were of low or moderate severity, probably due to the good clinical and immunological situation of these women.

scholarly journals Oral hygiene status in relation to salivary estradiol hormone level among pre-menopausal and post-menopausal Iraqi women

2019 ◽  
Vol 31 (2) ◽  
pp. 70-74
Author(s):  
Najlaa S Al-Obaidi ◽  
Alhan A Qasim
Keyword(s):  
Oral Hygiene ◽  
Ovarian Function ◽  
Hormone Level ◽  
Plaque Index ◽  
Control Group ◽  
Gingival Index ◽  
Increased Risk ◽  
Menopausal Women ◽  
Post Menopause ◽  
Post Menopausal

Background: The menopause is physiological changes in women that give rise to adaptive changes at both systemic and oral level. During menopause, ovarian function declines and the production of sex steroid hormones reduces significantly affecting the oral tissues and periodontal structures leading to chronic inflammation of the gingiva, increased risk of tooth loss. Aim of study: The present study was designed to estimate the oral hygiene status in relation to salivary estradiol level among pre and post-menopausal women. Materials and Methods: Ninety women aged 48-52 years old, the control group consisted of 45 pre-menopausal women and the study group consisted of 45 post-menopause were examined for gingival index, plaque index and calculus index. Unstimulated saliva was collected from all women to analyze estradiol hormone level. Results: the mean rank of the gingival index, plaque index and calculus index were higher in post-menopause than that of pre-menopause group with lower level of salivary estradiol hormone (E2).These oral hygiene indices have a negative relation with estradiol (E2) hormone level in both test groups. Conclusion: Oral hygiene status affected by salivary estradiol hormone level in women. Oral hygiene status was worse among post-menopausal women and correlated negatively with salivary Estradiol hormone level.

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