Objective. To test the biomechanical properties of 3D printed tantalum and titanium porous scaffolds. Methods. Four types of tantalum and titanium scaffolds with four alternative pore diameters, #1 (1000-700 μm), #2 (700-1000 μm), #3 (500-800 μm), and #4 (800-500 μm), were molded by selective laser melting technique, and the scaffolds were tested by scanning electronic microscope, uniaxial-compression tests, and Young’s modulus tests; they were compared with same size pig femoral bone scaffolds. Results. Under uniaxial-compression tests, equivalent stress of tantalum scaffold was
411
±
1.43
MPa, which was significantly larger than the titanium scaffolds (
P
<
0.05
). Young’s modulus of tantalum scaffold was
2.61
±
0.02
GPa, which was only half of that of titanium scaffold. The stress-strain curves of tantalum scaffolds were more similar to pig bone scaffolds than titanium scaffolds. Conclusion. 3D printed tantalum scaffolds with varying pore diameters are more similar to actual bone scaffolds compared with titanium scaffolds in biomechanical properties.