scholarly journals Inhalation and ingestion of Synthetic musks in pregnant women: In silico spontaneous abortion risk evaluation and control

2022 ◽  
Vol 158 ◽  
pp. 106911
Author(s):  
Xixi Li ◽  
Yuanyuan Zhao ◽  
Bing Chen ◽  
Zhiwen Zhu ◽  
Qiao Kang ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Spontaneous Abortion ◽  
In Silico ◽  
Risk Evaluation ◽  
Synthetic Musks ◽  
And Control

Reducing Anxiety of Pregnant Women with a History of Pregnancy Loss-A Randomize Clinical Trial

2020 ◽  
Vol 16 (2) ◽  
pp. 160-166
Author(s):  
Hoda Zaraj ◽  
Katayon Vakilian ◽  
Fatemeh Mehrabi Rezveh
Keyword(s):  
Clinical Trial ◽  
Cognitive Behavioral Therapy ◽  
Pregnant Women ◽  
Spontaneous Abortion ◽  
Behavioral Therapy ◽  
T Test ◽  
Cognitive Behavioral ◽  
Significant Difference ◽  
History Of ◽  
And Control

Background: Spontaneous abortion is the most common complication of pregnancy which is considered an unfavorable experience both physically and psychologically. Objective: This study was conducted to investigate the effect of group counseling through cognitive behavioral therapy (CBT) on the anxiety of pregnant women with a history of spontaneous abortion. Methods: This study was randomized clinical trial type, in which convenient sampling was performed to select 64 subjects from healthcare centers in Arak province. After receiving written consent from the participants, the sampling was performed and the subjects were categorized randomly into two 32-subject groups as intervention and control. The intervention was performed as six 60- min sessions through cognitive behavioral therapy (CBT). Control group, however, only routine cares of pregnancy were provided. For data collection, The Spielberger State-Trait Anxiety Inventory was utilized at the beginning and end of the study. Then, the collected information was analyzed by SPSS 21 through paired t-test, independent t-test. Results: The mean anxiety after the intervention in the intervention and control groups was 65.13±8.11 and 75.91±5.56, respectively, whereby a significant difference was observed between the two groups (p≤0.05). Conclusion: It seems that women with a previous history of abortion require psychological support during pregnancy. It is recommended that the skills of midwives also be improved to psychologically support these women.

Recurrent miscarriage is associated with increased numbers of CD5/20 positive lymphocytes and an increased incidence of thyroid antibodies

1996 ◽  
Vol 134 (1) ◽  
pp. 84-86 ◽  
Author(s):  
Judith Roberts ◽  
Carol Jenkins ◽  
Rhoda Wilson ◽  
Charles Pearson ◽  
Ian A Franklin ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Spontaneous Abortion ◽  
Recurrent Miscarriage ◽  
Previous History ◽  
Cell Subset ◽  
First Trimester ◽  
Normal Pregnancy ◽  
Anticardiolipin Antibodies ◽  
Royal Infirmary ◽  
Thyroid Antibodies

Roberts J. Jenkins C, Wilson R, Pearson C, Franklin IA, MacLean MA, McKillop JH, Walker JJ. Recurrent miscarriage is associated with increased numbers of CD5/20 positive lymphocytes and an increased incidence of thyroid antibodies. Eur J Endocrinol 1996;134:84–6. ISSN 0804–4643 The aim of this study was to determine whether recurrent miscarriage (three or more miscarriages, no live children) was associated with an increased incidence of autoantibodies. Five groups were enrolled into the study; healthy non-pregnant women, healthy first-trimester pregnant women, women suffering spontaneous abortion, those undergoing termination of pregnancy and those with a previous history of miscarriage. The number of total B cells and the numbers of the antibody producing B cell subset CD5+/CD20+ were determined for each group. Samples were tested for anticardiolipin antibodies, antinuclear antibodies and thyroid microsomal and thyroglobulin antibodies. The results showed that compared to normal pregnancy or spontaneous abortion, recurrent miscarriage was associated with a significant increase in the number of CD5+/20+ positive cells (0.8 ± 0.3 vs 0.5 ± 0.1 vs 1.1 ± 0.3 × 108/l: p < 0.001). These women were also found to have a higher incidence of thyroid antibodies, with four out of the 11 patients being positive for thyroid microsomal antibodies. These results suggest that there may be an association between autoimmunity and recurrent miscarriage. R Wilson, Department of Medicine, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK

TSH/miR‐17‐5p/ZNF367 axis is related to spontaneous abortion in patients with TSH above 2.5 mIU/L

2021 ◽  
Author(s):  
Yang Yang ◽  
Jiashu Li ◽  
Yingying Zhou ◽  
Wen Dai ◽  
Weiping Teng ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Spontaneous Abortion ◽  
Biological Function ◽  
Zinc Finger Protein ◽  
First Trimester ◽  
Cell Counting ◽  
Luciferase Reporter ◽  
Migration And Invasion ◽  
Chorionic Villi ◽  
Increased Risk

Elevated thyroid stimulating hormone (TSH) is associated with an increased risk of spontaneous abortion (SA); however, the associated mechanism remains unclear. This study aimed to investigate the expression of microRNAs (miRNAs) and pathogenesis in the chorionic villi of TSH > 2.5 mIU/L-related SA patients. The chorionic villi were collected from pregnant women in the first trimester with TSH > 2.5 mIU/L with or without SA, as well as TSH < 2.5 mIU/L with or without SA to determine the level of miRNA expression. Differentially expressed miRNAs were confirmed by qRT-PCR in a total of 92 subjects. Cell counting kit-8 (CCK8), wound healing, transwell assays, and Western blotting were used to measure cellular biological functions and related protein in HTR-8/SVneo cells. The potential mechanisms were determined using a Luciferase reporter assay and rescue experiment. Compared with normal pregnant women, miR-17-5p was decreased and zinc finger protein 367 (ZNF367) was upregulated in the chorionic villi of TSH > 2.5 mIU/L-related SA patients. Using HTR-8/SVneo cells, we demonstrated that elevated TSH inhibited miR-17-5p expression, as well as trophoblast migration and invasion. The overexpression of miR-17-5p targeted and inhibited ZNF367 expression promoting the biological function of trophoblasts. Further studies confirmed that ZNF367 interference partially reversed the biological function of the miR-17-5p inhibitor on HTR-8/SVneo cells. Taken together, our results showed that miR-17-5p promoted biological function of trophoblasts by suppressing ZNF367.

High Rates of Streptococcus Agalactiae Clindamycin and Erythromycin Resistance in Vietnamese Pregnant Women

2021 ◽  
Author(s):  
Vu Du ◽  
Pham Thai Dung ◽  
Nguyen Linh Toan ◽  
Can Mao ◽  
Nguyen Thanh Bac ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Antimicrobial Susceptibility ◽  
Prevention And Control ◽  
Control Strategies ◽  
Geographic Area ◽  
Resistance Rate ◽  
Antibiotics Resistance ◽  
Erythromycin Resistance ◽  
Antimicrobial Susceptibility Pattern ◽  
And Control

Abstract Background Group B streptococcus (GBS) is a leading cause of morbidity and mortality in newborns. Maternal GBS colonization rates vary depending on geographic area, ethnic and social conditions worldwide. Many studies suggested the continuous surveillance of GBS to provide data to guide decision-making and planning prevention and control strategies. Here, we report the rate and the antimicrobial susceptibility pattern of GBS from Vietnamese pregnant women over 5 year period. Methods We worked with 3863 Vietnamese pregnant women at < 37 weeks of gestation at the National Hospital of Obstetrics and Gynecology, Hanoi, Vietnam from Jan 2016 to Dec 2020. The data were recorded and retrieved from the computerized laboratory database. GBS was identified according to the American Society for Microbiology’s guidelines. Antimicrobial susceptibility was tested by the VITEK 2 system or E-test strips. The results were calculated according to the MIC breakpoints recommended by the Clinical and Laboratory Standards Institute. Results The positivity for GBS was 8.02% (310/3863) and the highest resistance rate was to tetracycline 89.66% (234/261), followed by 76.23% (202/265) for erythromycin, 58.21% (156/268) for clindamycin. The multidrug-resistance rate was 59.19% (161/272), and 8.46% (23/272) of isolates were resistant to 6 to 7 of the 12 antibiotics. Resistance to clindamycin in the absence of erythromycin resistance was found in 6/272 (2.2%) samples. The resistance rate to clindamycin was significantly increased (p < 0.01) over the time study period. Nevertheless, all isolates were sensitive to penicillin, ampicillin, ceftriaxone, cefotaxime, quinupristin/dalfopristin, and vancomycin. Conclusion Our results indicate that penicillin and ampicillin are currently the drugs of choice for the prevention and treatment of GBS-related diseases for Vietnamese pregnant women. However, antibiotic resistance to erythromycin and clindamycin was high. Thus, it reinforces the need for continuous surveillance of GBS to provide data to guide planning prevention and control strategies.

The Influence of Antiphospholipid Antibodies on the Pregnancy Outcome of Patients With Recurrent Spontaneous Abortion

2001 ◽  
Vol 7 (4) ◽  
pp. 281-285 ◽  
Author(s):  
L. Heilmann ◽  
G.-F. v. Tempelhoff ◽  
S. Kuse
Keyword(s):  
Pregnant Women ◽  
Intravenous Immunoglobulin ◽  
Spontaneous Abortion ◽  
Antiphospholipid Antibodies ◽  
Lupus Anticoagulant ◽  
Standard Therapy ◽  
Loss Rate ◽  
Fetal Loss ◽  
Negative Group ◽  
History Of

Several therapeutic regimens have been proposed for women with recurrent spontaneous abortion (RSA) and antiphospholipid antibodies (APA). Conflicting results have been reported about women with history of RSA, positive APA, and failure of standard therapy. To evaluate the use of intravenous immunoglobulin in RSA patients with APA and history of treatment failure, we initiated a study with standard therapy (aspirin and low-molecular- weight heparin) and intravenous immunoglobulin. We used an enzyme-linked immunosorbent assay (ELISA)test to screen IgG and IgM anticardiolipin antibodies, and a diluted Russel viper venom time assay for the lupus anticoagulant activity. Altogether. 66 pregnant women with positive APAs at the first visit could be included. Patients with hereditable thrainbaghilic factors were excluded. After confirmation of the pregnancy, women received a basis immunization of 0.3 g/kg immunoglobulin in a 4-week cycle until the 28th to 32nd week of gestation. All patients received 100 mg/d aspirin and 3,000 anti-Xa U/d certoparin. Among the 66 pregnant women, 17 were persistently autoantibody positive (25.8%), of whom 11 (16.7%) were ACA positive alone, 2 (3%) were lupus anticoagulant positive, and 4 (6.4%) had both antibody types. A total of 49 patients had positive APAs at the initial test, but were negative for ACA and lupus anticoagulant at the second test administered approximately 5 weeks after the start of therapy. We described this group in our following observation as "antibody negative." Sixteen of the 17 autoantibody-positive patients (94.1 %) were delivered of live infants compared with 40 patients (81.6%) in the antibody-negative group (odds ratio [OR]: 1.2; 95% CI: 0.98 to 1.4). The overall miscarriage rate was 12.1% and the fetal loss rate was 15.2%. Four patients (25%) in the antibody-positive group developed symptoms of preeclampsia and fetal growth retardation compared with four patients (9.8%) in the antibody-negative group. In conclusion. we see a reduction of the fetal loss rate in patients with RSA and positive APA (5.8%) compared with APAnegative (18.4%) women with the same therapy (OR: 0.3; 95% CI: 0.04 to 2.3).

scholarly journals Effect of Serum Copper on Circulating Angiogenesis-Related Factors in Women with Preeclampsia

2019 ◽  
Author(s):  
Khalid Najm Nadheer ◽  
Zohreh Zahraei ◽  
Hussein Al-Hakeim
Keyword(s):  
Pregnant Women ◽  
Serum Copper ◽  
Control Group ◽  
Vascular Endothelial ◽  
Related Factors ◽  
Soluble Endoglin ◽  
Iraqi Women ◽  
Endothelial Integrity ◽  
And Control ◽  
Endothelial Growth Factor

Preeclampsia (PE) is characterized by a series of clinical features such as hypertension and proteinuria associated with endothelial dysfunction and the impairment of placenta vascular endothelial integrity. This study aimed to investigate the effect of serum copper (Cu) level on some angiogenesis-related factors including vascular endothelial growth factor-A (VEGF-A), soluble Fms-like tyrosine kinase-1 (sVEGF-R1), soluble endoglin (sEng) and cerruloplasmin (Cp) in Iraqi women with preeclampsia (PE) and control pregnant women. Therefore, 60 women with PE in addition to 30 healthy pregnant women were enrolled in the study. Serum concentration of sEng, VEGF-A, sVEGF-R1, and Cu in PE group significantly increased (p&lt;0.05) in the PE group compared with that in the control group. Increased production of antiangiogenic factors, soluble VEGF-A and sEng contribute to the pathophysiology of PE, indicating the involvement of these parameters in the angiogenic balance in patients with PE. Tests for between-subject effects showed that the circulating angiogenesis factors and Cu were significantly associated with the presence of PE. Serum Cu level was significantly correlated with VEGF- A and VEGF-R1 levels but not with sEng. Multiple regression analysis revealed that only Cp and BP can significantly predict the complications in women with PE. In conclusion, serum Cu has a role in the angiogenesis in women with PE and may be a new drug target in the prevention or treatment of PE.

scholarly journals Effect of Educational Counseling on Knowledge and Attitude of Pregnant Women Towards Sex During Pregnancy

2020 ◽  
Vol 9 (2) ◽  
pp. 52-58
Author(s):  
Atefeh Pakray ◽  
Atefeh Ahmadi ◽  
Younes Jahani ◽  
Masoumeh Ghazanfarpour
Keyword(s):  
Pregnant Women ◽  
Intervention Group ◽  
Sexual Relationships ◽  
Fisher Exact Test ◽  
Random Allocation ◽  
Sexual Knowledge ◽  
Significant Difference ◽  
The Mean ◽  
Knowledge And Attitude ◽  
And Control

Background: Insufficient information about sex during pregnancy as well as negative attitude towards it may lead to serious problems in the couple’s communication and sexual relationship. Therefore, this study was conducted to determine the effect of educational counselling on sexual knowledge and attitude of pregnant women during 2014-2015. Materials and Methods: This study was performed on 200 pregnant women referred to 5 health care centers in Kerman. The random allocation method was used to assign mothers to intervention (n=100) and control (n=100) groups. Data were collected by demographic information, sexual knowledge, and attitude questionnaires. Data were analyzed by paired and independent t test, Fisher exact test, chi-square test, Mann-Whitney, Wilcoxon, ANOVA, Kruskal-Wallis, and Pearson’s and Spearman’s correlation tests in SPSS software version 22.0. Results: The mean scores of sexual knowledge and attitude before educational counselling in intervention group were 33.7±15.44 and 50.09±10.88, respectively. Before the intervention, no significant differences were observed between the two groups in knowledge and attitude. One month after the counselling, the mean scores of knowledge and attitude in the intervention and control groups were respectively 79.03±8.71 and 67.88±8.62, indicating a significant difference (P<0.0001). Conclusion: The results of this study confirmed the positive role of counseling and education in increasing knowledge and creating positive attitude towards sexual relationships in pregnant women.

scholarly journals Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions

2021 ◽  
Author(s):  
Ümit Görkem ◽  
Özgür Kan ◽  
Mehmet Ömer Bostancı ◽  
Deniz Taşkıran ◽  
Hasan Ali İnal
Keyword(s):  
Pregnant Women ◽  
Spontaneous Abortion ◽  
Pregnancy Outcomes ◽  
Significant Relationship ◽  
Blood Count ◽  
Complete Blood Count ◽  
First Trimester ◽  
Study Groups ◽  
Control Group ◽  
Gestational Stage

Objective: Spontaneous abortion is the most common complication of early pregnancy, affecting up to 20% of recognized pregnancies. Kisspeptin is predominantly released by placental syncytiotrophoblasts, and regulates their placental invasion into the uterine matrices. We aimed to establish an association of serum kisspeptin levels with pregnancy outcomes during the early gestational stage of the first trimester. Method: In this prospective study, 90 pregnant women in their 7 to 8 6/7 gestational weeks were classified into three groups: (i) The control group, consisting of healthy pregnant women (n=30), (ii) the threatened abortion group (n=30), and (iii) the spontaneous abortion group (n=30). The maternal serum samples were analyzed for complete blood count parameters and kisspeptin levels. Results: There was no statistical difference regarding body mass index (BMI) and gestational age (p=0.370). Regarding detailed obstetric notations, including gravida, parity, abortion, and living children, socioeconomic levels, and employment rates, all study groups were comparable (p>0.05, for all). No significant association was found regarding the biochemical parameters of complete blood count, including neutrophil, lymphocyte, and platelet concentrations, as well as neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratios (PLR) (p>0.05, for all). The median serum kisspeptin levels of the study groups did not differ between the groups (p=0.153). Correlation analysis revealed no significant relationship between serum kisspeptin levels and other study parameters in any study groups (p>0.05, for all) Conclusions: We found no statistically significant relationship between serum kisspeptin concentrations and pregnancy outcomes in the early gestational stage of the first trimester, and serum kisspeptin concentrations did not seem to be a reliable marker to distinguish abortion status from viable pregnancy

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