Prenatal exposure to a mixture of organochlorines and metals and internalizing symptoms in childhood and adolescence

2022 ◽  
pp. 112701
Author(s):  
Lisa B. Rokoff ◽  
Jessica R. Shoaff ◽  
Brent A. Coull ◽  
Michelle Bosquet Enlow ◽  
David C. Bellinger ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Internalizing Symptoms ◽  
Childhood And Adolescence

scholarly journals Developmental pathways from child maltreatment to adolescent suicide-related behaviors: The internalizing and externalizing comorbidity hypothesis

2019 ◽  
Vol 32 (3) ◽  
pp. 945-959 ◽  
Author(s):  
Erinn Bernstein Duprey ◽  
Assaf Oshri ◽  
Sihong Liu
Keyword(s):  
Suicidal Ideation ◽  
Child Maltreatment ◽  
Childhood Abuse ◽  
Internalizing Symptoms ◽  
Developmental Trajectory ◽  
Developmental Pathways ◽  
Childhood And Adolescence ◽  
Adolescent Risk ◽  
And Behaviors ◽  
Internalizing And Externalizing

AbstractChild maltreatment is a robust risk factor for suicidal ideation and behaviors during adolescence. Elevations in internalizing and externalizing symptomology have been identified as two distinct developmental pathways linking child maltreatment and adolescent risk for suicide. However, recent research suggests that the co-occurrence of internalizing and externalizing symptomology may form a distinct etiological pathway for adolescent risk behaviors. Using the Longitudinal Studies on Child Abuse and Neglect (LONGSCAN) sample (N = 1,314), the present study employed a person-centered approach to identify patterns of concurrent change in internalizing and externalizing psychopathology over five time points from early childhood to adolescence in relation to previous experiences of child maltreatment and subsequent suicidal ideation and behaviors. Results indicated four distinct bivariate externalizing and internalizing growth trajectories. Group membership in a heightened comorbid internalizing and externalizing symptom trajectory mediated the association between childhood abuse and adolescent suicidal ideation and suicidal behaviors. These findings suggest that the concurrent development of externalizing and internalizing symptoms in childhood and adolescence may constitute a unique developmental trajectory that confers risk for suicide-related outcomes.

Externalizing and internalizing symptoms in childhood and adolescence and the risk of alcohol use disorders in young adulthood: A meta-analysis of longitudinal studies

2019 ◽  
Vol 53 (10) ◽  
pp. 965-975 ◽  
Author(s):  
Ivete Meque ◽  
Berihun Assefa Dachew ◽  
Joemer C Maravilla ◽  
Caroline Salom ◽  
Rosa Alati
Keyword(s):  
Alcohol Use ◽  
Young Adulthood ◽  
Odds Ratio ◽  
Internalizing Symptoms ◽  
Meta Analysis ◽  
Alcohol Use Disorders ◽  
Childhood And Adolescence ◽  
Statistical Manual ◽  
Diagnostic And Statistical Manual ◽  
Externalizing And Internalizing Symptoms

Background: Evidence suggests that externalizing and internalizing symptoms are expressed early in life and are associated with problematic drinking in young adulthood. However, few studies have examined their role during childhood and adolescence in predicting alcohol problems later in life. Objectives: To examine the role of childhood and adolescent externalizing and internalizing symptoms in predicting alcohol use disorders in young adulthood. Methods: We searched five electronic databases (PubMed, Scopus, PsycINFO, Web of Sciences and Embase) for studies which diagnosed alcohol use disorders through either the International Classification of Diseases or American Psychiatric Association – Diagnostic and Statistical Manual of Mental Disorders criteria and followed up children or adolescents into the transition to young adulthood. We performed a meta-analysis and obtained pooled odds ratio estimates with 95% confidence intervals using random-effects models. Results: A total of 12 longitudinal studies met eligibility criteria and were included in the meta-analysis. All measured the outcome using Diagnostic and Statistical Manual of Mental Disorders criteria. The majority were of good quality and were conducted in the United States. A total of 19,407 participants (50% female) were included in this meta-analysis. Of these, n = 2337 (12%) had diagnoses of alcohol use disorders/alcohol dependence. Participant ages ranged from birth to 36 years. Internalizing symptoms increased the risk of young adult alcohol use disorders by 21% (odds ratio = 1.21; 95% confidence interval = [1.05, 1.39]), with no strong evidence of publication bias. Subgroup analysis suggested significantly lower heterogeneity than for externalizing studies. Externalizing symptoms increased the risk of alcohol use disorders by 62% (odds ratio = 1.62, 95% confidence interval = [1.39, 1.90]). We found some evidence of publication bias and significant heterogeneity in the studies. Conclusion: Our findings highlight the contribution of early behavioural problems to the development of alcohol use disorders in young adulthood and the need for timely scrutiny of and intervention on early behavioural problems.

scholarly journals The codevelopment of internalizing symptoms, externalizing symptoms, and cognitive ability across childhood and adolescence

2019 ◽  
Vol 32 (4) ◽  
pp. 1375-1389 ◽  
Author(s):  
Efstathios Papachristou ◽  
Eirini Flouri
Keyword(s):  
Cognitive Ability ◽  
Cognitive Skills ◽  
Internalizing Symptoms ◽  
Maternal Education ◽  
Growth Parameters ◽  
Externalizing Symptoms ◽  
Childhood And Adolescence ◽  
Growth Curve Models ◽  
Uk Millennium Cohort Study ◽  
Time Varying Covariates

AbstractCognitive ability, externalizing symptoms, and internalizing symptoms are correlated in children. However, it is not known why they combine in the general child population over time. To address this, we used data on 17,318 children participating in the UK Millennium Cohort Study and followed-up five times between ages 3 and 14 years. We fitted three parallel-process latent growth curve models to identify the parallel unfolding of children's trajectories of internalizing symptoms, externalizing symptoms, and cognitive ability across this period. We also examined the effects of time-invariant (ethnicity, birth weight, maternal education and age at birth, and breastfeeding status) and time-varying covariates (maternal psychological distress and socioeconomic disadvantage) on the growth parameters of the trajectories. The results showed that the intercepts of the trajectories of cognitive ability and, particularly, externalizing symptoms were inversely correlated. Their linear slopes were also inversely correlated, suggesting parallel development. Internalizing symptoms were correlated positively with externalizing symptoms and inversely (and more modestly) with cognitive ability at baseline, but the slope of internalizing symptoms correlated (positively) only with the slope of externalizing symptoms. The covariates predicted 9% to 41% of the variance in the intercepts and slopes of all domains, suggesting they are important common risk factors. Overall, it appears that externalizing symptoms develop in parallel with both cognitive ability and internalizing symptoms from early childhood through to middle adolescence. Children on an increasing trajectory of externalizing symptoms are likely both increasing in internalizing symptoms and decreasing in cognitive skills as well, and are thus an important group to target for intervention.

scholarly journals Prenatal exposure to organophosphate pesticides and risk-taking behaviors in early adulthood

2022 ◽  
Vol 21 (1) ◽  
Author(s):  
Sharon K. Sagiv ◽  
Stephen Rauch ◽  
Katherine R. Kogut ◽  
Carly Hyland ◽  
Robert B. Gunier ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Risk Taking ◽  
Small Sample Size ◽  
Geometric Mean ◽  
Early Adulthood ◽  
Health Assessment ◽  
Fold Increase ◽  
Small Sample ◽  
Childhood And Adolescence ◽  
Risk Taking Behaviors

Abstract Introduction Previous studies show evidence for associations of prenatal exposure to organophosphate (OP) pesticides with poorer childhood neurodevelopment. As children grow older, poorer cognition, executive function, and school performance can give rise to risk-taking behaviors, including substance abuse, delinquency, and violent acts. We investigated whether prenatal OP exposure was associated with these risk-taking behaviors in adolescence and young adulthood in a Mexican American cohort. Methods We measured urinary dialkyl phosphates (DAPs), non-specific metabolites of OPs, twice (13 and 26 weeks gestation) in pregnant women recruited in 1999–2000 in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study, a birth cohort set in a primarily Latino agricultural community in the Salinas Valley, California. We followed up children throughout their childhood and adolescence; at the 18-year visit, adolescent youth (n = 315) completed a computer-based questionnaire which included questions about substance use, risky sexual activity, risky driving, and delinquency and police encounters. We used multivariable models to estimate associations of prenatal total DAPs with these risk-taking behaviors. Results The prevalence of risk-taking behaviors in CHAMACOS youth ranged from 8.9% for smoking or vaping nicotine to 70.2% for committing a delinquent act. Associations of total prenatal DAPs (geometric mean = 132.4 nmol/L) with risk-taking behavior were generally null and imprecise. Isolated findings included a higher risk for smoking or vaping nicotine within the past 30 days (relative risk [RR] per 10-fold increase in prenatal DAPs = 1.89, 95% CI: 1.00, 3.56) and driving without a license (RR = 1.74, 95% CI: 1.25, 2.42). There were no consistent differences by sex or childhood adversity. Discussion We did not find clear or consistent evidence for associations of prenatal OP exposure with risk-taking behaviors in adolescence/early adulthood in the CHAMACOS population. Our small sample size may have prevented us from detecting potentially subtle associations of early life OP exposure with these risk-taking behaviors.

scholarly journals It gets better or does it? Peer victimization and internalizing problems in the transition to young adulthood

2014 ◽  
Vol 26 (3) ◽  
pp. 675-688 ◽  
Author(s):  
Bonnie J. Leadbeater ◽  
Kara Thompson ◽  
Paweena Sukhawathanakul
Keyword(s):  
High School ◽  
Peer Victimization ◽  
Young Adulthood ◽  
Internalizing Problems ◽  
Internalizing Symptoms ◽  
Relational Victimization ◽  
Childhood And Adolescence ◽  
Youth Survey ◽  
Harmful Effects ◽  
Over Time

AbstractConsistent research shows that peer victimization predicts internalizing symptoms in childhood and adolescence, but the extent to which peer victimization and its harmful effects on mental health persists into young adulthood is unclear. The current study describes patterns of physical and relational victimization during and after high school, and examines concurrent and prospective associations between internalizing symptoms (depressive and anxious symptoms) and peer victimization (physical and relational) from adolescence to young adulthood (ages 12–27). Data were collected from the Victoria Healthy Youth Survey, a five-wave multicohort study conducted biennially between 2003 and 2011 (N = 662). Physical victimization was consistently low and stable over time. Relational victimization increased for males after high school. Both types of victimization were associated concurrently with internalizing symptoms across young adulthood for males and for females. Although sex differences were important, victimization in high school also predicted increases in internalizing problems over time.

Parent–child attachment and internalizing symptoms in childhood and adolescence: A review of empirical findings and future directions

2010 ◽  
Vol 22 (1) ◽  
pp. 177-203 ◽  
Author(s):  
Laura E. Brumariu ◽  
Kathryn A. Kerns
Keyword(s):  
Internalizing Problems ◽  
Internalizing Symptoms ◽  
Attachment Security ◽  
Insecure Attachment ◽  
Anxiety And Depression ◽  
Childhood And Adolescence ◽  
Future Directions ◽  
Child Attachment ◽  
Key Questions ◽  
Parent Child

AbstractThe purpose of this paper is to evaluate the theory and evidence for the links of parent–child attachment with internalizing problems in childhood and adolescence. We address three key questions: (a) how consistent is the evidence that attachment security or insecurity is linked to internalizing symptoms, anxiety, and depression? (b) How consistent is the evidence that specific forms of insecurity are more strongly related to internalizing symptoms, anxiety, and depression than are other forms of insecurity? (c) Are associations with internalizing symptoms, anxiety, and depression consistent for mother–child and father–child attachment? The current findings are consistent with the hypothesis that insecure attachment is associated with the development of internalizing problems. The links between specific insecure attachment patterns and internalizing problems are difficult to evaluate. Father–child and mother–child attachments have a comparable impact, although there are relatively few studies of father–child attachment. No moderators consistently affect these relations. We also propose two models of how attachment insecurity may combine with other factors to lead to anxiety or depression.

scholarly journals Longitudinal changes in amygdala, hippocampus and cortisol development following early caregiving adversity

2019 ◽  
Author(s):  
Michelle VanTieghem ◽  
Marta Korom ◽  
Jessica Flannery ◽  
Tricia Choy ◽  
Christina Caldera ◽  
...  
Keyword(s):  
Internalizing Symptoms ◽  
Longitudinal Design ◽  
Early Adulthood ◽  
Institutional Care ◽  
Structural Mri ◽  
Hippocampal Volume ◽  
Stress Physiology ◽  
Childhood And Adolescence ◽  
Long Term Effects ◽  
Morning Cortisol

Decades of research have shown long-term effects of early caregiving adversity (ECA) on stress physiology and limbic brain volume (e.g. amygdala, hippocampus). Although these systems undergo significant maturational change during childhood and adolescence, and reciprocally influence each other, the effects of ECA on these developmental processes is not well understood. In the current study, we used an accelerated longitudinal design to assess the development of stress physiology, amygdala, and hippocampal volume following early institutional care. Previously Institutionalized (PI; N = 93) and comparison (COMP; N = 161) youth (ages 4-20 years old) completed 1-3 waves of data collection, each spaced approximately 2 years apart, for diurnal cortisol (N = 239, providing a total of 380 diurnal datasets), structural MRI (N = 156, providing a total of 306 scans) and parent-reported internalizing symptoms (N = 133, providing a total of 227 time points). We observed a developmental shift in morning cortisol in the PI group, with blunted levels in childhood and heightened levels in late adolescence. PI history was associated with reduced hippocampal volume and reduced growth rate of the amygdala, resulting in smaller volumes by adolescence. Results also suggested feed-forward brain-to-hormone mechanisms; amygdala and hippocampal volumes were prospectively associated with morning cortisol levels two years later. Finally, amygdala and hippocampal volumes were independently associated with internalizing scores. These results indicate that adversity-related physiological and neural phenotypes are not stationary during development but instead exhibit dynamic and interdependent changes from early childhood to early adulthood.

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