scholarly journals A reduced susceptibility to chemoconvulsant stimulation in adenylyl cyclase 8 knockout mice

2016 ◽  
Vol 119 ◽  
pp. 24-29 ◽  
Author(s):  
Xia Chen ◽  
Guoying Dong ◽  
Changhong Zheng ◽  
Hongbing Wang ◽  
Wenwei Yun ◽  
...  
Keyword(s):  
Adenylyl Cyclase ◽  
Knockout Mice ◽  
Adenylyl Cyclase 8

scholarly journals Identification of FDA-Approved Small Molecules Capable of Disrupting the Calmodulin–Adenylyl Cyclase 8 Interaction through Direct Binding to Calmodulin

2017 ◽  
Vol 9 (2) ◽  
pp. 346-357 ◽  
Author(s):  
Michael P. Hayes ◽  
Monica Soto-Velasquez ◽  
C. Andrew Fowler ◽  
Val J. Watts ◽  
David L. Roman
Keyword(s):  
Small Molecules ◽  
Adenylyl Cyclase ◽  
Direct Binding ◽  
Adenylyl Cyclase 8

scholarly journals Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells

Diabetologia ◽  
2014 ◽  
Vol 58 (2) ◽  
pp. 324-333 ◽  
Author(s):  
Haiqiang Dou ◽  
Changhe Wang ◽  
Xi Wu ◽  
Lijun Yao ◽  
Xiaoyu Zhang ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Adenylyl Cyclase ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Calcium Influx ◽  
Adenylyl Cyclase 8

scholarly journals Gene Expression Profiles of Main Olfactory Epithelium in Adenylyl Cyclase 3 Knockout Mice

2015 ◽  
Vol 16 (12) ◽  
pp. 28320-28333 ◽  
Author(s):  
Zhenshan Wang ◽  
Yanfen Zhou ◽  
Yingtao Luo ◽  
Jing Zhang ◽  
Yunpeng Zhai ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adenylyl Cyclase ◽  
Olfactory Epithelium ◽  
Knockout Mice ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Main Olfactory Epithelium

Implication of adenylyl cyclase 8 in pathological smooth muscle cell migration occurring in rat and human vascular remodelling

2010 ◽  
Vol 221 (3) ◽  
pp. 331-342 ◽  
Author(s):  
Marie Gueguen ◽  
Zela Keuylian ◽  
Véronique Mateo ◽  
Nathalie Mougenot ◽  
Anne-Marie Lompré ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Cell Migration ◽  
Smooth Muscle Cell ◽  
Adenylyl Cyclase ◽  
Muscle Cell ◽  
Vascular Remodelling ◽  
Smooth Muscle Cell Migration ◽  
Adenylyl Cyclase 8

scholarly journals Characterization of lpa2 (Edg4) and lpa1/lpa2 (Edg2/Edg4) Lysophosphatidic Acid Receptor Knockout Mice: Signaling Deficits without Obvious Phenotypic Abnormality Attributable to lpa2

2002 ◽  
Vol 22 (19) ◽  
pp. 6921-6929 ◽  
Author(s):  
James J. A. Contos ◽  
Isao Ishii ◽  
Nobuyuki Fukushima ◽  
Marcy A. Kingsbury ◽  
Xiaoqin Ye ◽  
...  
Keyword(s):  
Adenylyl Cyclase ◽  
Lysophosphatidic Acid ◽  
Knockout Mice ◽  
Cell Types ◽  
Fiber Formation ◽  
Mouse Development ◽  
Double Knockout ◽  
Cellular Effects ◽  
Cyclase Activation ◽  
Craniofacial Dysmorphism

ABSTRACT Lysophosphatidic acid (LPA), a bioactive lipid produced by several cell types including postmitotic neurons and activated platelets, is thought to be involved in various biological processes, including brain development. Three cognate G protein-coupled receptors encoded by lpa1 /lp A1/Edg-2/Gpcr26, lpa2 /lp A2/Edg-4, and lpa3 /lp A3/Edg-7 mediate the cellular effects of LPA. We have previously shown that deletion of lpa1 in mice results in craniofacial dysmorphism, semilethality due to defective suckling behavior, and generation of a small fraction of pups with frontal hematoma. To further investigate the role of these receptors and LPA signaling in the organism, we deleted lpa2 in mice. Homozygous knockout (lpa2 (−/−)) mice were born at the expected frequency and displayed no obvious phenotypic abnormalities. Intercrosses allowed generation of lpa1 (−/−) lpa2 (−/−) double knockout mice, which displayed no additional phenotypic abnormalities relative to lpa1 (−/−) mice except for an increased incidence of perinatal frontal hematoma. Histological analyses of lpa1 (−/−) lpa2 (−/−) embryonic cerebral cortices did not reveal obvious differences in the proliferating cell population. However, many LPA-induced responses, including phospholipase C activation, Ca2+ mobilization, adenylyl cyclase activation, proliferation, JNK activation, Akt activation, and stress fiber formation, were absent or severely reduced in embryonic fibroblasts derived from lpa1 (−/−) lpa2 (−/−) mice. Except for adenylyl cyclase activation [which was nearly abolished in lpa1 (−/−) fibroblasts], these responses were only partially affected in lpa1 (−/−) and lpa2 (−/−) fibroblasts. Thus, although LPA2 is not essential for normal mouse development, it does act redundantly with LPA1 to mediate most LPA responses in fibroblasts.

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