Antioxidative and anticancer activities of various ethanolic extract fractions from crown-of-thorns starfish (Acanthaster planci)

Three new steroid biglycosides, plancisides A-C (1-3), were isolated from the ethanolic extract of the starfish Acanthaster planci. The structures of 1-3 were determined by extensive NMR and ESI-MS techniques, as (24 S)-28- O-[β-D-galactofuranosyl-(1→5)-α-L-arabinofuranosyl]-24-methyl-5α-cholestane-3β,4β,6α,8,15β,16β,28-heptol (1), (24 S)-28- O-[α-L-fucopyranosyl-(1→2)-3- O-methyl-β-D-xylopyranosyl]–24-methyl-5α-cholestane-3β,4β,6α,8,15β,16β,28-heptol (2) and (24 S)-28- O-[2,4-di- O-methyl-β-D-xylopyranosyl-(1→2)-α-L-arabinofuranosyl]-24-methyl-5α-cholestane-3β,4β,6α,8,15β,16β,28-heptol 6- O-sulfate (3), respectively. Compound 2 is the first steroid glycoside containing an α-fucopyranose unit found from starfish. Compound 1 slightly inhibits cell proliferation of HCT-116, T-47D, and RPMI-7951 cancer cell lines, but has no effect on colony formation of these cells in a soft agar clonogenic assay.

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Maydis Stigma Elicits Analgesia and Blocks Edema in Mice and Inhibits Inflammation in Macrophages

The American Journal of Chinese Medicine ◽

10.1142/s0192415x1750080x ◽

2017 ◽

Vol 45 (07) ◽

pp. 1477-1496 ◽

Cited By ~ 4

Author(s):

Yun Hee Jeong ◽

You-Chang Oh ◽

Won-Kyung Cho ◽

Hye Jin Yang ◽

Jin Yeul Ma

Keyword(s):

Acetic Acid ◽

Target Genes ◽

Biological Activities ◽

Scientific Evidence ◽

Ethanolic Extract ◽

Anticancer Activities ◽

Ear Edema ◽

Anti Inflammatory

Maydis Stigma (MS) is an herb traditionally used in many parts of the world. Previous studies have reported that MS plays a role in several biological activities, including antidiabetic and anticancer activities. However, the effects of a MS ethanolic extract (MSE) on the anti-inflammatory cellular mechanism remain unclear. Here, we investigated the anti-inflammatory properties of MSE and its molecular mechanism both in vitro and in vivo. The effects of MSE on the production of inflammatory mediators, cytokines, and related proteins and the identification of target genes were determined using LPS-stimulated macrophages. We also determined the analgesic and anti-inflammatory effects of MSE by examining acetic acid-induced writhing responses and xylene-induced ear edema in mice. Our results indicated that MSE markedly decreased iNOS and COX-2 levels without causing cytotoxicity and suppressed the secretion of NO in LPS-stimulated macrophages. MSE also inhibited the production of proinflammatory cytokines, such as TNF-[Formula: see text], IL-6, and IL-1[Formula: see text], and induced the expression of HO-1. Moreover, MSE treatment significantly reduced the LPS-stimulated activation of MAPK, NF-[Formula: see text]B, and AP-1. Furthermore, MSE exerted an analgesic effect on the acetic acid-induced abdominal writhing response test and an anti-inflammatory effect on xylene-induced ear edema in ICR mice. Finally, we investigated the components of MSE using UPLC-ESI-MS and found that it contains the maysin as a marker component. Overall, these observations demonstrate that MSE has anti-inflammatory and antinociceptive effects both in vitro and in vivo, which may provide new scientific evidence for its use as a potential therapeutic agent for the treatment of inflammation.

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In vitro antimicrobial, antioxidant and anticancer activities of globe artichoke (Cynara cardunculus var. scolymus L.) bracts and receptacles ethanolic extract

Biocatalysis and Agricultural Biotechnology ◽

10.1016/j.bcab.2020.101774 ◽

2020 ◽

Vol 29 ◽

pp. 101774

Author(s):

Magdy A. Shallan ◽

Mohamed A. Ali ◽

Walaa A. Meshrf ◽

Diaa A. Marrez

Keyword(s):

Ethanolic Extract ◽

Globe Artichoke ◽

Cynara Cardunculus ◽

Anticancer Activities

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Formation and Biopharmaceutical Characterization of Electrospun PVP Mats with Propolis and Silver Nanoparticles for Fast Releasing Wound Dressing

BioMed Research International ◽

10.1155/2016/4648287 ◽

2016 ◽

Vol 2016 ◽

pp. 1-11 ◽

Cited By ~ 11

Author(s):

Erika Adomavičiūtė ◽

Sigitas Stanys ◽

Modestas Žilius ◽

Vaida Juškaitė ◽

Alvydas Pavilonis ◽

...

Keyword(s):

Antimicrobial Activity ◽

Wound Healing ◽

Silver Nanoparticles ◽

Phenolic Compounds ◽

Wound Dressing ◽

Ethanolic Extract ◽

Anticancer Activities ◽

Dressing Materials ◽

Fast Release

Antibacterial, antiviral, antifungal, antioxidant, anti-inflammatory, and anticancer activities of propolis and its ability to stimulate the immune system and promote wound healing make it a proper component for wound dressing materials. Silver nanoparticles are recognized to demonstrate strong antiseptic and antimicrobial activity; thus, it also could be considered in the development of products for wound healing. Combining propolis and silver nanoparticles can result in improved characteristics of products designed for wound healing and care. The aim of this study was to formulate electrospun fast dissolving mats for wound dressing containing propolis ethanolic extract and silver nanoparticles. Produced electrospun nano/microfiber mats were evaluated studying their structure, dissolution rate, release of propolis phenolic compounds and silver nanoparticles, and antimicrobial activity. Biopharmaceutical characterization of electrospun mats demonstrated fast release of propolis phenolic compounds and silver nanoparticles. Evaluation of antimicrobial activity onStaphylococcus aureus,Staphylococcus epidermidis,Enterococcus faecalis,Escherichia coli,Pseudomonas aeruginosa,Proteus vulgaris,Bacillus subtilis,Bacillus cereus, andCandida albicansstrains confirmed the ability of electrospun mats to inhibit the growth of the tested microorganisms.

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In vitro antioxidant and anticancer activities of ethanolic extract of selenium-enriched green tea

Food Chemistry ◽

10.1016/j.foodchem.2008.03.057 ◽

2008 ◽

Vol 111 (1) ◽

pp. 165-170 ◽

Cited By ~ 33

Author(s):

Feng Li ◽

Feifei Wang ◽

Fang Yu ◽

Yong Fang ◽

Zhihong Xin ◽

...

Keyword(s):

Green Tea ◽

Ethanolic Extract ◽

Anticancer Activities

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Evaluation of the Antioxidant, Anti-Inflammatory, and Anticancer Activities of Euphorbia hirta Ethanolic Extract

Molecules ◽

10.3390/molecules190914567 ◽

2014 ◽

Vol 19 (9) ◽

pp. 14567-14581 ◽

Cited By ~ 16

Author(s):

Neelesh Sharma ◽

Kalpa Samarakoon ◽

Rajendra Gyawali ◽

Yang-Ho Park ◽

Sung-Jin Lee ◽

...

Keyword(s):

Ethanolic Extract ◽

Anticancer Activities ◽

Euphorbia Hirta ◽

Anti Inflammatory

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Inhibition of Human Cervical Cancer Cell Growth by Ethanolic Extract ofBoerhaavia diffusaLinn. (Punarnava) Root

Evidence-based Complementary and Alternative Medicine ◽

10.1093/ecam/nep223 ◽

2011 ◽

Vol 2011 ◽

pp. 1-13 ◽

Cited By ~ 9

Author(s):

Rakhi Srivastava ◽

Daman Saluja ◽

Bilikere S. Dwarakanath ◽

Madhu Chopra

Keyword(s):

Cell Cycle ◽

Hela Cells ◽

Morphological Changes ◽

Ethanolic Extract ◽

Antiproliferative Effect ◽

Chloroform Fraction ◽

Anticancer Activities ◽

Cancer Cell Growth ◽

Human Cervical Cancer Cell ◽

Inhibition Of Dna Synthesis

In Indian traditional medicine,Boerhaavia diffusa(punarnava) roots have been widely used for the treatment of dyspepsia, jaundice, enlargement of spleen, abdominal pain and as an anti-stress agent. Pharmacological evaluation of the crude ethanolic extract ofB. diffusaroots has been shown to possess antiproliferative and immunomodulatory properties. The extract ofB. diffusawas studied for anti-proliferative effects on the growth of HeLa cells and for its effect on cell cycle. Bio-assays of extracts fromB. diffusaroot showed that a methanol : chloroform fraction (BDF 5) had an antiproliferative effect on HeLa cells. After 48 h of exposure, this fraction at a concentration of 200 μg mL−1significantly reduced cell proliferation with visible morphological changes in HeLa cells. Cell cycle analysis suggests that antiproliferative effect of BDF 5 could be due to inhibition of DNA synthesis in S-phase of cell cycle in HeLa cells, whereas no significant change in cell cycle was detected in control cells. The fraction BDF 5 caused cell death via apoptosis as evident from DNA fragmentation and caspase-9 activation. Thus the extract has potential to be evaluated in detail to assess the molecular mechanism-mediated anticancer activities of this plant.

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Evaluation of antioxidant and chemopreventive effect of Cocos nucifera L.

Jahangirnagar University Journal of Biological Sciences ◽

10.3329/jujbs.v6i2.36590 ◽

2018 ◽

Vol 6 (2) ◽

pp. 47-58

Author(s):

Shrabanti Dev ◽

Anha Afrin Shefa ◽

Archana Mandal ◽

Projit Roy Gayen ◽

Kaniz Asma ◽

...

Keyword(s):

Cocos Nucifera ◽

Ethanolic Extract ◽

Natural Antioxidants ◽

Anticancer Activities ◽

Initiation And Propagation ◽

Ic50 Value ◽

Activity Marker ◽

Cocos Nucifera L ◽

Preventive Role ◽

Different Doses

This study revealed the antioxidant and anticancer activities of the ethanolic extract of the tender fruits of Cocos nucifera. In antioxidant screening, IC50 value was found to be 7.71μg/mlfor ascorbic acid and44.67 μg/ml for C. nucifera fruits. The phenolic content, total flavonoid and total tannin content were 537.89 mg GAE/100 gm, 40.69mg of QE/100 gm and 44.61 mg of GAE/100 gm of dry powder of C. nucifera respectively. In DMBA and croton oil-induced skin cancer in model mice,the extract significantly decreased the number, size, yield and burden of tumor when compared with carcinogenic control. The extract increased the level of natural antioxidants like GSH, SOD and Catalase. Moreover, substantial decrease in SGPT, SGOT (liver activity marker) was observed at different doses ofthe crude extract. Lipid profile of mice treated with C. nucifera was brought back to normal level to some extent when compared to carcinogenic control. In conclusion,C. nucifera fruits have antioxidant activity as well as preventive role on cancer initiation and propagation without major toxicity.Jahangirnagar University J. Biol. Sci. 6(2): 47-58, 2017 (December)

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