The poorly conducted orchestra of steroid hormones, oxidative stress and inflammation in frailty needs a maestro: Regular physical exercise

2021 ◽  
pp. 111562
Author(s):  
Marcelo Paes de Barros ◽  
André Luís Lacerda Bachi ◽  
Juliana de Melo Batista dos Santos ◽  
Rafael Herling Lambertucci ◽  
Rafael Ishihara ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Physical Exercise ◽  
Steroid Hormones ◽  
Regular Physical Exercise

Does Regular Physical Exercise Preserve Artery Dilation by Lowering Nox2-Related Oxidative Stress?

2018 ◽  
Vol 28 (17) ◽  
pp. 1576-1581 ◽  
Author(s):  
Roberto Cangemi ◽  
Lorenzo Loffredo ◽  
Simona Battaglia ◽  
Ludovica Perri ◽  
Maria Santulli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Physical Exercise ◽  
Regular Physical Exercise

scholarly journals Regular Physical Exercise as a Strategy to Improve Antioxidant and Anti-Inflammatory Status: Benefits in Type 2 Diabetes Mellitus

2012 ◽  
Vol 2012 ◽  
pp. 1-15 ◽  
Author(s):  
Edite Teixeira de Lemos ◽  
Jorge Oliveira ◽  
João Páscoa Pinheiro ◽  
Flávio Reis
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Physical Exercise ◽  
Inflammatory Status ◽  
Anti Inflammatory ◽  
The Impact ◽  
Regular Physical Exercise

Over the last 30 years the combination of both a sedentary lifestyle and excessive food availability has led to a significant increase in the prevalence of obesity and aggravation of rates of metabolic syndrome and type 2 diabetes mellitus (T2DM). Several lines of scientific evidence have been demonstrating that a low level of physical activity and decreased daily energy expenditure leads to the accumulation of visceral fat and, consequently, the activation of the oxidative stress/inflammation cascade, which underlies the development of insulin resistant T2DM and evolution of micro, and macrovascular complications. This paper focuses on the pathophysiological pathways associated with the involvement of oxidative stress and inflammation in the development of T2DM and the impact of regular physical exercise (training) as a natural antioxidant and anti-inflammatory strategy to prevent evolution of T2DM and its serious complications.

scholarly journals Physical Exercise as a Modulator of Oxidative Stress and Inflammation in Atherosclerotic Plaque

2020 ◽  
pp. 36-44
Author(s):  
Matheus Ribeiro Bizuti ◽  
Débora Meneghel ◽  
Eduardo de Camargo Schwede ◽  
Laura Nyland Jost ◽  
Débora Tavares de Resende e Silva
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Diseases ◽  
Physical Exercise ◽  
Inflammatory Diseases ◽  
Inflammatory Cells ◽  
Subendothelial Space ◽  
Inflammatory Processes ◽  
Accumulation Of Lipids ◽  
Regular Physical Exercise

Cardiovascular diseases are the leading cause of death and reduced quality of life worldwide. One of the main risks to the development of cardiovascular diseases is inflammatory diseases, which are related to oxidative stress, among them, atherosclerosis. Atherosclerosis consists of a process of chronic inflammation, in which the accumulation of lipids occurs in the subendothelial space of the tunica intima of large caliber vessels. This is due to the accumulation of fibrous elements and inflammatory cells. Thus, regular physical exercise contributes to improving the body's immune defenses, while modulating inflammatory processes. In addition, physical activity is responsible for increasing the production of antioxidant enzymes, increasing the synthesis of nitric oxide, decreasing oxidative stress and decreasing systemic inflammation. Thus, physical exercise directly changes the genesis of atherosclerosis.

Physical exercise protects dynamic balance and motor coordination of rats treated with vincristine

2020 ◽  
Vol 19 (5) ◽  
pp. 336
Author(s):  
Luiza Minato Sagrillo ◽  
Viviane Nogueira De Zorzi ◽  
Luiz Fernando Freire Royes ◽  
Michele Rechia Fighera ◽  
Beatriz Da Silva Rosa Bonadiman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Locomotor Activity ◽  
Physical Exercise ◽  
Motor Coordination ◽  
Dynamic Balance ◽  
Exercise Group ◽  
Adult Rats ◽  
The Central Nervous System ◽  
Stress Damage ◽  
Training Protocol

Physical exercise has been shown to be an important modulator of the antioxidant system and neuroprotective in several diseases and treatments that affect the central nervous system. In this sense, the present study aimed to evaluate the effect of physical exercise in dynamic balance, motor coordination, exploratory locomotor activity and in the oxidative and immunological balance of rats treated with vincristine (VCR). For that, 40 adult rats were divided into two groups: exercise group (6 weeks of swimming, 1h/day, 5 days/week, with overload of 5% of body weight) and sedentary group. After training, rats were treated with 0.5 mg/kg of vincristine sulfate for two weeks or with the same dose of 0.9% NaCl. The behavioral tests were conducted 1 and 7 days after each dose of VCR. On day 15 we carried out the biochemical analyzes of the cerebellum. The physical exercise was able to protect against the loss of dynamic balance and motor coordination and, had effect per se in the exploratory locomotor activity, and neutralize oxidative stress, damage DNA and immune damage caused by VCR up to 15 days after the end of the training protocol. In conclusion, we observed that previous physical training protects of the damage motor induced by vincristine.Key-words: exercise, oxidative stress, neuroprotection, cerebellum.

The Role of Physical Exercise in Obesity and Diabetes

2018 ◽  
Vol 66 (3) ◽  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Physical Exercise ◽  
Treatment Guidelines ◽  
Treatment Guideline ◽  
Obesity And Diabetes ◽  
Regular Physical Exercise

The prevalence of obesity is increasing world-wide. Obesity is associated with a plethora of metabolic and clinical constraints, which result in a higher risk for the development of cardiovascular complications and metabolic disease, particularly insulin resistance and type 2 diabetes. Obesity is an acknowledged determinant of glycemic control in patients with type 1 diabetes and accounts for the majority of premature death due to cardiovascular events. Physical exercise is generally recommended in patients with diabetes in order to prevent the development of or reduce existing obesity, as adopted by every international treatment guideline so far. Regular physical exercise has a beneficial impact on body composition, cardiovascular integrity, insulin sensitivity and quality of life. However, only a minority of patients participates in regular physical exercise, due to individual or ­disease-related barriers. In type 2 diabetes, there is robust evidence for beneficial effects of physical exercise on glycemic control, cardiovascular health and the development of diabetes-related long-term complications. In type 1 diabetes and patients treated with insulin, a higher risk for exercise-­related hypoglycemia has to be considered, which requires certain prerequisites and adequate adaptions of insulin ­dosing. Current treatment guidelines do only incompletely address the development of exercise-related hypoglycemia. However, every patient with diabetes should participate in regular physical exercise in order to support and enable ­sufficient treatment and optimal glycemic control.

scholarly journals The effect of physical exercise and caloric restriction on the components of metabolic syndrome

2009 ◽  
Vol 45 (3) ◽  
pp. 379-399 ◽  
Author(s):  
Francisco Leonardo Torres-Leal ◽  
Mariana Dutilh de Capitani ◽  
Julio Tirapegui
Keyword(s):  
Metabolic Syndrome ◽  
Physical Exercise ◽  
Caloric Restriction ◽  
Epidemiologic Studies ◽  
Lifestyle Changes ◽  
Moderate Intensity ◽  
Mass Reduction ◽  
Current State ◽  
Regular Physical Exercise

Recent studies of the effects of physical exercise and caloric restriction have found several benefits on the metabolic and cardiovascular risk factors related to metabolic syndrome (MS). This review examines the current state of knowledge of the effects of physical exercise on the main pathologies associated with MS: obesity, insulin resistance, type 2 diabetes mellitus (DM2), dyslipidemias and hypertension. Although there are only a few randomized and controlled studies that evaluated the prevention and treatment of MS, strong evidence from controlled studies indicates that lifestyle changes that include regular physical exercise and caloric restriction are effective in preventing and treating DM2 in overweight individuals with reduced glucose tolerance. Likewise, epidemiologic studies suggest that regular physical exercise prevents the development of DM2 and cardiovascular disease. Based on current recommendations, it is important to increase the level of physical exercise at a moderate intensity to achieve good cardiorespiratory and muscular conditions and to promote fat mass reduction, with consequent reductions of risk of developing metabolic syndrome.

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