Neuroprotective effect of ginger on anti-oxidant enzymes in streptozotocin-induced diabetic rats

2011 ◽  
Vol 49 (4) ◽  
pp. 893-897 ◽  
Author(s):  
Kondeti Ramudu Shanmugam ◽  
Korivi Mallikarjuna ◽  
Nishanth Kesireddy ◽  
Kesireddy Sathyavelu Reddy
Keyword(s):  
Neuroprotective Effect ◽  
Diabetic Rats ◽  
Anti Oxidant

scholarly journals NEUROPROTECTION OF ABELMOSCHUS ESCULENTUS L. AGAINST DIABETIC NEUROPATHY

2018 ◽  
Vol 11 (15) ◽  
pp. 28
Author(s):  
Lee Wei Yang ◽  
Santosh Fattepur ◽  
Kiran Chanabasappa Nilugal ◽  
Fadli Asmani ◽  
Eddy Yusuf ◽  
...  
Keyword(s):  
Body Weight ◽  
Sciatic Nerve ◽  
Diabetic Neuropathy ◽  
Performance Test ◽  
Neuroprotective Effect ◽  
Thermal Hyperalgesia ◽  
Diabetic Rats ◽  
Nerve Fibers ◽  
Abelmoschus Esculentus ◽  
Rotarod Performance

Objective: The present study was designed to determine the neuroprotective effect of Abelmoschus esculentus L. on alloxan-induced diabetic neuropathy in rats.Methods: Diabetes was induced in rats with a single intraperitoneal injection of alloxan monohydrate (130 mg/kg b.w). The ethanol extract of A. esculentus L. at a dose of 100 and 200 mg/kg of body weight was administered at single dose per day to alloxan-induced diabetic rats for 21 days. The fasting blood glucose was screened in the intermittent on day 0, day 14, and day 21. Behavioral tests such as thermal hyperalgesia test and rotarod performance test were performed to assess the thermal sensitivity and muscle grip strength. At the end of the study period, experimental animals were sacrificed and sciatic nerve tissues were obtained for histopathological investigation.Results: Animals treated with A. esculentus L. extarct at a dose of 200 mg/kg of body weight significantly reduced (p<0.05) in hyperglycemia and thermal hyperalgesia and significantly increased (p<0.05) in rotarod performance. The sciatic nerve fiber of diabetic rats receiving 200 mg/kg of body weight of A. esculentus L. extract also shows no swelling of nerve fibers, and lesser demyelination was observed.Conclusion: These findings demonstrate that A. esculentus L. exhibits significant antidiabetic and neuroprotective effect against alloxan-induced diabetic neuropathy in rats.

Correction: In vivo Evaluation of Anti-Hyperglycemic, Anti-hyperlipidemic and Anti-Oxidant Status of Liver and Kidney of Thymol in STZ-Induced Diabetic Rats

Drug Research ◽  
2018 ◽  
Author(s):  
Bijan Oskouei ◽  
Soheil Abbaspour-Ravasjani ◽  
Seyed Jamal Musavinejad ◽  
Seyed Ahmad Salehzadeh ◽  
Alireza Abdolhosseinzadeh ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
In Vivo Evaluation ◽  
Liver And Kidney ◽  
Anti Oxidant ◽  
Oxidant Status

scholarly journals Effect of the ascorbic acid treatment on the NADHd-positive myenteric neurons of diabetic rats proximal colon

2007 ◽  
Vol 50 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Jacqueline Nelisis Zanoni ◽  
Renata Virginia Fernandes Pereira ◽  
Priscila de Freitas
Keyword(s):  
Ascorbic Acid ◽  
Acid Treatment ◽  
Neuroprotective Effect ◽  
Proximal Colon ◽  
Diabetic Rats ◽  
Daily Treatment ◽  
Body Area ◽  
Neuronal Density ◽  
Myenteric Neurons ◽  
Intestinal Segments

The aim of this work was to study the effect of the ascorbic acid on the myenteric neurons of diabetic rats proximal colon. Fifteen rats (90 days old) were divided into three groups: control, untreated diabetic and treated diabetic with ascorbic acid (DA). After 120 days of daily treatment with ascorbic acid, the intestinal segments were submitted to the NADH-diaphorase (NADHd) histochemistry technique to expose the myenteric neurons. The group DA showed a higher neuronal density (33.4 %) when compared to the untreated diabetic animals (p < 0.05). Cellular body area of neurons was significantly larger in group DA (17.3 %) when compared to the untreated diabetics (p < 0.05). It could be concluded that the ascorbic acid promoted a neuroprotective effect on the NADHd myenteric neurons of the proximal colon of diabetic rats.

scholarly journals Tissue Kallikrein Alleviates Cerebral Ischemia-Reperfusion Injury by Activating the B2R-ERK1/2-CREB-Bcl-2 Signaling Pathway in Diabetic Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Ruifeng Shi ◽  
Kunxiong Yuan ◽  
Bin Hu ◽  
Hongfei Sang ◽  
Lizhi Zhou ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Ischemia Reperfusion Injury ◽  
Infarct Volume ◽  
Neuroprotective Effect ◽  
Ischemia Reperfusion ◽  
Camp Response Element Binding ◽  
Diabetic Rats ◽  
Tissue Kallikrein ◽  
Inflammatory Reactions ◽  
Beneficial Effects

Diabetes mellitus (DM) substantially increases the risk of ischemic stroke and reduces the tolerance to ischemic insults. Tissue kallikrein (TK) has been demonstrated to protect neurons from ischemia/reperfusion (I/R) injury in orthoglycemic model by activating the bradykinin B2 receptor (B2R). Considering the differential effects of B2R or bradykinin B1 receptor (B1R) on cardioprotection and neuroprotection in I/R with or without diabetes, this study was designed to investigate the role of TK during cerebral I/R injury in streptozotocin-induced diabetic rats. Intravenous injection of TK inhibited apoptosis in neurons, alleviated edema and inflammatory reactions after focal cerebral I/R, significantly reduced the infarct volume, and improved functional recovery. These beneficial effects were accompanied by activation of the extracellular signal-regulated kinase 1/2 (ERK1/2), cAMP response element-binding (CREB), and Bcl-2 signal proteins. Inhibition of the B2R or ERK1/2 pathway abated the effects of TK, whereas an antagonist of B1R enhanced the effects. These findings reveal that the neuroprotective effect of TK against cerebral I/R injury in streptozotocin-induced diabetic rats mainly involves the enhancement of B2R and ERK1/2-CREB-Bcl-2 signaling pathway activity.

The neuroprotective effect of fish n-3 fatty acids in the hippocampus of diabetic rats

2008 ◽  
Vol 11 (4) ◽  
pp. 161-166 ◽  
Author(s):  
Murat Cosar ◽  
Ahmet Songur ◽  
Onder Sahin ◽  
Efkan Uz ◽  
Ramazan Yilmaz ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Neuroprotective Effect ◽  
Diabetic Rats
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