Blueberry and malvidin inhibit cell cycle progression and induce mitochondrial-mediated apoptosis by abrogating the JAK/STAT-3 signalling pathway

2017 ◽  
Vol 109 ◽  
pp. 534-543 ◽  
Author(s):  
Abdul Basit Baba ◽  
Ramesh Nivetha ◽  
Indranil Chattopadhyay ◽  
Siddavaram Nagini
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Signalling Pathway ◽  
Cycle Progression ◽  
Inhibit Cell Cycle Progression

scholarly journals Cyclin G2, a novel target of sulindac to inhibit cell cycle progression in colorectal cancer

2020 ◽  
Author(s):  
Hongyou Zhao ◽  
Bin Yi ◽  
Zhipin Liang ◽  
Ches’Nique Phillips ◽  
Hui-Yi Lin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Inhibit Cell Cycle Progression ◽  
Cyclin G2 ◽  
Novel Target

Newly identified structurally disparate modulators of osmosensitive taurine efflux inhibit cell cycle progression

2003 ◽  
Vol 474 (2-3) ◽  
pp. 185-193 ◽  
Author(s):  
Mark J. Belsey ◽  
Steven J. Culliford ◽  
Richard M. Morley ◽  
Harry J. Witchel ◽  
Roland Z. Kozlowski
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Inhibit Cell Cycle Progression ◽  
Taurine Efflux

scholarly journals Dominant Alleles of Saccharomyces cerevisiae CDC20 Reveal Its Role in Promoting Anaphase

Genetics ◽  
1998 ◽  
Vol 148 (2) ◽  
pp. 599-610
Author(s):  
Eric J Schott ◽  
M Andrew Hoyt
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Spindle Assembly Checkpoint ◽  
Limiting Factor ◽  
Mutant Form ◽  
Loss Of Function ◽  
Cycle Progression ◽  
Inhibit Cell Cycle Progression ◽  
M Phase

Abstract We identified an allele of Saccharomyces cerevisiae CDC20 that exhibits a spindle-assembly checkpoint defect. Previous studies indicated that loss of CDC20 function caused cell cycle arrest prior to the onset of anaphase. In contrast, CDC20-50 caused inappropriate cell cycle progression through M phase in the absence of mitotic spindle function. This effect of CDC20-50 was dominant over wild type and was eliminated by a second mutation causing loss of function, suggesting that it encodes an overactive form of Cdc20p. Overexpression of CDC20 was found to cause a similar checkpoint defect, causing bypass of the preanaphase arrest produced by either microtubule-depolymerizing compounds or MPS1 overexpression. CDC20 overexpression was also able to overcome the anaphase delay caused by high levels of the anaphase inhibitor Pds1p, but not a mutant form immune to anaphase-promoting complex- (APC-)mediated proteolysis. CDC20 overexpression was unable to promote anaphase in cells deficient in APC function. These findings suggest that Cdc20p is a limiting factor that promotes anaphase entry by antagonizing Pds1p. Cdc20p may promote the APC-dependent proteolytic degradation of Pds1p and other factors that act to inhibit cell cycle progression through mitosis.

Free fatty acids trigger apoptosis and inhibit cell cycle progression in human vascular endothelial cells

2003 ◽  
Vol 18 (1) ◽  
pp. 146-148 ◽  
Author(s):  
Michaela Artwohl ◽  
Michael Roden ◽  
Werner Waldhäusl ◽  
Angelika Freudenthaler ◽  
Sabina M. Baumgartner‐Parzer
Keyword(s):  
Cell Cycle ◽  
Fatty Acids ◽  
Endothelial Cells ◽  
Free Fatty Acids ◽  
Cell Cycle Progression ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Cycle Progression ◽  
Inhibit Cell Cycle Progression

Diarsenic and tetraarsenic oxide inhibit cell cycle progression and bFGF- and VEGF-induced proliferation of human endothelial cells

2005 ◽  
Vol 95 (1) ◽  
pp. 120-130 ◽  
Author(s):  
Sang Hyeok Woo ◽  
Myung-Jin Park ◽  
Sungkwan An ◽  
Hyung-Chahn Lee ◽  
Hyeon-Ok Jin ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Endothelial Cells ◽  
Cell Cycle Progression ◽  
Human Endothelial Cells ◽  
Cycle Progression ◽  
Inhibit Cell Cycle Progression
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