Spray-drying of oil-in-water emulsions for encapsulation of retinoic acid: polysaccharide- and protein-based microparticles characterization and controlled release studies

The purpose of the current investigation was to develop chondroitin sulfate/carbopol-co-poly(acrylic acid) (CS/CBP-co-PAA) hydrogels for controlled delivery of diclofenac sodium (DS). Different concentrations of polymers chondroitin sulfate (CS), carbopol 934 (CBP), and monomer acrylic acid (AA) were cross-linked by ethylene glycol dimethylacrylate (EGDMA) in the presence of ammonium peroxodisulfate (APS) (initiator). The fabricated hydrogels were characterized for further experiments. Characterizations such as Scanning electron microscopy (SEM), Thermogravimetric analysis (TGA), Differential scanning calorimetry (DSC), Powder X-ray diffractometry (PXRD), and Fourier transform infrared spectroscopy (FTIR) were conducted to understand the surface morphology, thermodynamic stability, crystallinity of the drug, ingredients, and developed hydrogels. The swelling and drug release studies were conducted at two different pH mediums (pH 1.2 and 7.4), and pH-dependent swelling and drug release was shown due to the presence of functional groups of both polymers and monomers; hence, greater swelling and drug release was observed at the higher pH (pH 7.4). The percent drug release of the developed system and commercially available product cataflam was compared and high controlled release of the drug from the developed system was observed at both low and high pH. The mechanism of drug release from the hydrogels followed Korsmeyer–Peppas model. Conclusively, the current research work demonstrated that the prepared hydrogel could be considered as a suitable candidate for controlled delivery of diclofenac sodium.

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Synthesis, characterization and drug release studies of poly(2-hydroxyethyl methacrylate)/KIT-5 nanocomposite as an innovative organic–inorganic hybrid carrier system

RSC Advances ◽

10.1039/c4ra13930e ◽

2015 ◽

Vol 5 (16) ◽

pp. 12463-12471 ◽

Cited By ~ 8

Author(s):

Roozbeh Javad Kalbasi ◽

Ali Zirakbash

Keyword(s):

Controlled Release ◽

Drug Release ◽

Hybrid Material ◽

Great Promise ◽

Hydroxyethyl Methacrylate ◽

Carrier System ◽

Inorganic Hybrid ◽

Drug Molecules ◽

System P ◽

Release Studies

PHEMA/KIT-5 with various pore sizes was prepared. Efficient encapsulation of drug molecules inside the pores of the hybrid material and controlled release of them in an aqueous medium, suggest the great promise of the composite as a carrier system.

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Production of a rich-carotenoid colorant from pumpkin peels using oil-in-water emulsion followed by spray drying

Food Research International ◽

10.1016/j.foodres.2021.110627 ◽

2021 ◽

pp. 110627

Author(s):

Priscilla M. Lima ◽

Gustavo C. Dacanal ◽

Lorena Silva Pinho ◽

Luis Jaime Pérez-Córdoba ◽

Marcelo Thomazini ◽

...

Keyword(s):

Spray Drying ◽

Water Emulsion ◽

Oil In Water ◽

Oil In Water Emulsion

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Controlled release of all-trans-retinoic acid from PEGylated gelatin nanopaticles by enzymatic degradation

Biotechnology and Bioprocess Engineering ◽

10.1007/bf02931932 ◽

1999 ◽

Vol 4 (3) ◽

pp. 215-218 ◽

Cited By ~ 4

Author(s):

Kyung Jin Kim ◽

Youngro Byun

Keyword(s):

Retinoic Acid ◽

Controlled Release ◽

Enzymatic Degradation ◽

Trans Retinoic Acid ◽

All Trans Retinoic Acid

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Microencapsulation of Purple Cactus Pear Fruit (Opuntia ficus indica) Extract by the Combined Method W/O/W Double Emulsion-Spray Drying and Conventional Spray Drying: A Comparative Study

Processes ◽

10.3390/pr6100189 ◽

2018 ◽

Vol 6 (10) ◽

pp. 189 ◽

Cited By ~ 3

Author(s):

Keren Toledo-Madrid ◽

Tzayhrí Gallardo-Velázquez ◽

Guillermo Osorio-Revilla

Keyword(s):

Spray Drying ◽

Desirability Function ◽

Double Emulsion ◽

Dry Weight ◽

Antioxidant Compounds ◽

Pear Fruit ◽

Cactus Pear ◽

Opuntia Ficus Indica ◽

Globule Size ◽

Oil In Water

The aim of this study was to microencapsulate an optimized extract of purple cactus pear fruit (Opuntia ficus indica), rich in phenolic compounds (PC), betacyanins (BC), and betaxanthins (BX), with antioxidant capacity (AC), by two methodologies: combined water-in-oil-in water double emulsions-spray drying (W/O/W-SP) and conventional spray drying, studying the effect of spray drying (SP) on PC and AC. Optimal extraction conditions for bioactive compounds were: 52 °C, for 30 min, using aqueous ethanol (40%) as the solvent, with a 0.85 desirability function, obtaining 17.39 ± 0.11 mg GAE/gdw (gallic acid equivalents per gram of dry weight) for PC, 0.35 mg BE/gdw (betanin equivalents per gram of dry weight) for BC, and 0.26 mg IE/gdw (indicaxanthin equivalents per gram of dry weight) for BX. The best combination of temperatures for conventional SP and W/O/W-SP was 160–80 °C obtaining the highest retention and encapsulation efficiencies for PC. For conventional SP, results were: 107% and 100% PC and AC retention efficiencies (RE-PC and RE-AC), respectively, with 97% of PC encapsulation efficiency (EE-PC), meanwhile for the W/O/W-SP results were: 78% and 103% RE-PC and RE-AC, respectively, with 70% of EE-PC. Microcapsules obtained with W/O/W-SP maintained their structure and integrity and showed a considerable reduction in globule size in the reconstituted W/O/W emulsions due to the spray drying stress. Despite having lower EE-PC than conventional SP, spray dried W/O/W emulsions seems to be a promising controlled-delivery vehicle for antioxidant compounds.

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