Purpose.To determine the impact of biometric characteristics on changes of biomechanical properties of the human cornea due to standard cataract surgery using biomechanical analysis.Patients and Methods.This prospective consecutive cross-sectional study comprised 54 eyes with cataract in stages I or II that underwent phacoemulsification and IOL implantation. CH, CRF, IOPg, and IOPcc intraocular pressure were measured by biomechanical analysis preoperatively and at 1 month postoperatively. Changes (Δ) were calculated as preoperative value versus postoperative value. Biometrical data were extracted from TMS-5 (CSI and SAI), IOLMaster (AL), and EM-3000 (CCT and ECC) preoperatively.Results.The average values of the changes wereΔCH=-0.45±1.27 mmHg,ΔCRF=-0.88±1.1 mmHg,ΔIOPg=-1.58±3.15 mmHg, andΔIOPcc=-1.45±3.93 mmHg. The higher the CSI the smaller the decrease in CH (r=0.302,P=0.028). The higher the CCT the larger the decrease in CRF (r=-0.371,P=0.013). The higher the AL the smaller the decrease in IOPg (r=0.417,P=0.005). The higher the AL, SAI, and EEC the smaller the decrease in IOPcc (r=0.351,P=0.001;r=-0.478,P<0.001;r=0.339,P=0.013).Conclusions.Corneal biomechanical properties were affected by comprehensive factors after cataract surgery, including corneal endothelium properties, biometry, and geometrical characteristics.