Long non-coding RNA VIM-AS1 is upregulated in high-grade invasive ductal breast tumors and promotes breast cancer metastasis via inducing EMT

Gene Reports ◽  
2022 ◽  
pp. 101501
Author(s):  
Hajar Rezanejad ◽  
Malek Hossein Asadi
Keyword(s):  
Breast Cancer ◽  
Cancer Metastasis ◽  
Breast Tumors ◽  
Breast Cancer Metastasis ◽  
High Grade ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Retraction Note to: Long non-coding RNA SATB2-AS1 inhibits microRNA-155-3p to suppress breast cancer cell growth by promoting breast cancer metastasis suppressor 1-like

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shaoqiang Cheng ◽  
Bingshu Xia ◽  
Hongbin Li ◽  
Yuying Li ◽  
Xinxin Lv ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Metastasis Suppressor ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Non Coding Rna ◽  
Metastasis Suppressor 1 ◽  
Retraction Notice ◽  
Long Non Coding Rna

This article has been retracted. Please see the Retraction Notice for more detail: 10.1186/s12935-021-01798-y

scholarly journals Long Non-Coding RNA: Dual Effects on Breast Cancer Metastasis and Clinical Applications

Cancers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1802 ◽  
Author(s):  
Qi-Yuan Huang ◽  
Guo-Feng Liu ◽  
Xian-Ling Qian ◽  
Li-Bo Tang ◽  
Qing-Yun Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Distant Metastasis ◽  
Cancer Metastasis ◽  
Epithelial To Mesenchymal Transition ◽  
Therapy Resistance ◽  
Breast Cancer Metastasis ◽  
Mesenchymal Transition ◽  
Non Coding Rna ◽  
Regulatory Effects ◽  
Long Non Coding Rna

As a highly heterogeneous malignancy, breast cancer (BC) has become the most significant threat to female health. Distant metastasis and therapy resistance of BC are responsible for most of the cases of mortality and recurrence. Distant metastasis relies on an array of processes, such as cell proliferation, epithelial-to-mesenchymal transition (EMT), mesenchymal-to-epithelial transition (MET), and angiogenesis. Long non-coding RNA (lncRNA) refers to a class of non-coding RNA with a length of over 200 nucleotides. Currently, a rising number of studies have managed to investigate the association between BC and lncRNA. In this study, we summarized how lncRNA has dual effects in BC metastasis by regulating invasion, migration, and distant metastasis of BC cells. We also emphasize that lncRNA has crucial regulatory effects in the stemness and angiogenesis of BC. Clinically, some lncRNAs can regulate chemotherapy sensitivity in BC patients and may function as novel biomarkers to diagnose or predict prognosis for BC patients. The exact impact on clinical relevance deserves further study. This review can be an approach to understanding the dual effects of lncRNAs in BC, thereby linking lncRNAs to quasi-personalized treatment in the future.

scholarly journals Long non-coding RNA-CTD-2108O9.1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor

2018 ◽  
Vol 109 (6) ◽  
pp. 1764-1774 ◽  
Author(s):  
Mozhi Wang ◽  
Mengshen Wang ◽  
Zhenning Wang ◽  
Xueting Yu ◽  
Yongxi Song ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Leukemia Inhibitory Factor ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Inhibitory Factor ◽  
Leukemia Inhibitory Factor Receptor ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals The role of EMT-related lncRNA in the process of triple-negative breast cancer metastasis

2021 ◽  
Vol 41 (2) ◽  
Author(s):  
Haomeng Zhang ◽  
Jiao Wang ◽  
Yulong Yin ◽  
Qingjie Meng ◽  
Yonggang Lyu
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Cancer Metastasis ◽  
Triple Negative ◽  
Epithelial Mesenchymal Transition ◽  
Breast Cancer Metastasis ◽  
Signal Pathways ◽  
Mesenchymal Transition ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Abstract Triple-negative breast cancer (TNBC) is the most malignant and fatal subtype of breast cancer, which has characterized by negativity expression of ER, PR, and HER2. Metastasis is the main factor affecting the prognosis of TNBC, and the process of metastasis is related to abnormal activation of epithelial–mesenchymal transition (EMT). Recent studies have shown that long non-coding RNA (LncRNA) plays an important role in regulating the metastasis and invasion of TNBC. Therefore, based on the metastasis-related EMT signaling pathway, great efforts have confirmed that LncRNA is involved in the molecular mechanism of TNBC metastasis, which will provide new strategies to improve the treatment and prognosis of TNBC. In this review, we summarized many signal pathways related to EMT involved in the transfer process. The advances from the most recent studies of lncRNAs in the EMT-related signal pathways of TNBC metastasis. We also discussed the clinical research, application, and challenges of LncRNA in TNBC.

scholarly journals Differential MicroRNA Landscape Triggered by Estrogens in Cancer Associated Fibroblasts (CAFs) of Primary and Metastatic Breast Tumors

Cancers ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 412 ◽  
Author(s):  
Adele Vivacqua ◽  
Maria Muoio ◽  
Anna Miglietta ◽  
Marcello Maggiolini
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Cancer Metastasis ◽  
Metastatic Breast ◽  
Breast Tumors ◽  
Breast Cancer Metastasis ◽  
Cutaneous Metastasis ◽  
Breast Cancer Progression ◽  
Main Role ◽  
Cancer Associated Fibroblasts

Cancer associated fibroblasts (CAFs) play a main role in breast cancer progression and metastasis. Estrogens modulate in breast CAFs the expression of microRNAs (miRNAs) that are involved in the development of many tumors. In order to provide novel insights on the regulation of miRNAs by estrogens in breast cancer, we analyzed the expression of 754 miRNAs in CAFs obtained from primary mammary tumors and CAFs derived from a cutaneous breast cancer metastasis. Using the TaqMan™ Human MicroRNA Array, we found that 17β-estradiol (E2) modulates numerous peculiar and common miRNAs in CAFs derived from primary and the metastatic malignancies. In particular, we assessed that E2 modulates 133 miRNAs (41 up and 92 downregulated) in CAFs derived from primary breast tumors, whereas E2 modulates 415 miRNAs (399 up and 16 downregulated) in CAFs derived from a cutaneous metastasis of breast carcinoma. Therefore, a number of miRNAs three times higher in metastatic CAFs with respect to primary breast CAFs was found modulated by E2. Our findings shed new light on the cumulative regulation of miRNAs by E2 in the main players of the tumor microenvironment as CAFs. Moreover, our data may be taken into consideration that is useful toward innovative prognostic and therapeutic approaches in breast cancer progression.

scholarly journals Lipoma HMGIC fusion partner expression differs in primary tumors and lymph node metastases in malignancy.

2021 ◽  
Author(s):  
Vijay S
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Lymph Node Metastases ◽  
Cancer Metastasis ◽  
Breast Tumors ◽  
Breast Cancer Metastasis ◽  
Axillary Lymph ◽  
Node Metastasis ◽  
Node Metastases

Abstract Breast cancer is the most common cancer found in women. 1. Metastasis is the leading cause of mortality among cancer patients. 2. As the number of axillary lymph nodes with metastases grows the prognosis for patients with breast cancer worsens3. We used a published microarray dataset4 to find genes linked to lymph node metastasis, which is an early stage of breast cancer metastasis. When comparing original breast tumors to lymph node metastases from patients diagnosed with breast cancer, we discovered substantial differences in LHFP gene expression. When comparing primary breast tumors to neighboring normal breast tissue, LHFP was shown to be one of the most differentially expressed genes in a separate microarray dataset5. In individuals with breast cancer, LHFP expression was shown to be substantially linked with median overall survival. LHFP may be involved in the mechanisms that lead to the transformation or progression of the original tumor in human breast cancer, as well as lymph node metastasis. Breast cancer, breast cancer metastasis, lymph node metastasis, LHFP, breast cancer systems biology, and breast cancer targeted treatments.

scholarly journals Latent Cytomegalovirus Infection in Female Mice Increases Breast Cancer Metastasis

Cancers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 447 ◽  
Author(s):  
Zelei Yang ◽  
Xiaoyun Tang ◽  
Guanmin Meng ◽  
Matthew Benesch ◽  
Martina Mackova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Cancer Metastasis ◽  
Lung Metastases ◽  
Breast Tumors ◽  
Breast Cancer Metastasis ◽  
Negative Control ◽  
Breast Cancer Patients ◽  
Mcmv Infection ◽  
Latently Infected

Cytomegalovirus (CMV) infects 40–70% of women, but infection has been reported in >95% of breast cancer patients. We investigated the consequences of these observations by infecting mice with mCMV or a negative control medium for 4 days, 11 days or 10 weeks to establish active, intermediate or latent infections, respectively. Syngeneic 4T1 or E0771 breast cancer cells were then injected into a mammary fat pad of BALB/c or C57BL/6 mice, respectively. Infection did not affect tumor growth in these conditions, but latently infected BALB/c mice developed more lung metastases. The latent mCMV infection of MMTV-PyVT mice, which develop spontaneous breast tumors, also did not affect the number or sizes of breast tumors. However, there were more tumors that were multilobed with greater blood content, which had enhanced vasculature and decreased collagen content. Most significantly, mCMV infection also increased the number and size of lung metastases, which showed a higher cell proliferation. Viral DNA was detected in breast tumors and lung nodules although viral mRNA was not. These novel results have important clinical implications since an increased metastasis is prognostic of decreased survival. This work provides evidence that treating or preventing HCMV infections may increase the life expectancy of breast cancer patients by decreasing metastasis.

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