Su1348 The Impact of Endoscopic Ultrasound on Diagnosis and Management of Presumed Mucinous Neoplasms When Done for Pancreatic Cyst Morphology Change on Non-Invasive Surveillance Imaging

Abstract Background and study aims Guidelines for management of presumed neoplastic pancreatic cysts have encouraged noninvasive imaging for low-risk surveillance, while reserving endoscopic ultrasound for worrisome features including morphologic change. We aim to study the impact of endoscopic ultrasound on diagnosis and management compared with non-invasive imaging. Patients and methods A single-institution pancreatic cyst database was retrospectively queried for patients who underwent endoscopic ultrasound for the indication of change in cyst morphology. Diagnoses were classified as presumed mucinous neoplasm with or without worrisome features or high-risk stigmata and non-mucinous lesions. Management decisions were defined a priori as surgical evaluation for patients with high-risk stigmata, positive cytology or mural nodule, or continued surveillance for all others. Results Between January 2013 and October 2016, 709 pancreas cyst endoscopic ultrasounds were performed of which 89 were for cyst morphology change seen on noninvasive imaging including 10 presumed pseudocysts, nine presumed serous cystadenomas, and 70 presumed mucinous cystic neoplasms. Cyst morphologic changes included increase in caliber of the main pancreatic duct (7 cases), increase in cyst size (68 cases), cyst ≥ 30 mm (10 cases), and presence of a solid nodule (1 case). Median cyst size increase was 5 mm with interquartile range of 4 mm over 2.1 ± 1.9 years. Endoscopic ultrasound done for morphologic change resulted in a change in diagnosis and management in 16 % and 13 % of cases, respectively. Conclusion Endoscopic ultrasound has a modest but clinically significant role in impacting diagnosis and management for presumed mucinous cystic neoplasms when performed for the indication of cyst morphology change.

Download Full-text

Analyzing Intraductal Papillary Mucinous Neoplasms Using Artificial Neural Network Methodologic Triangulation

International Journal of Healthcare Information Systems and Informatics ◽

10.4018/ijhisi.2019100102 ◽

2019 ◽

Vol 14 (4) ◽

pp. 21-32 ◽

Cited By ~ 1

Author(s):

Steven Walczak ◽

Jennifer B. Permuth ◽

Vic Velanovich

Keyword(s):

Neural Network ◽

Pancreatic Cancer ◽

Pancreatic Cyst ◽

Intraductal Papillary Mucinous Neoplasms ◽

Methodological Triangulation ◽

Average Survival ◽

Mucinous Neoplasms ◽

Artificial Neural ◽

The Impact ◽

Malignant Ipmn

Intraductal papillary mucinous neoplasms (IPMN) are a type of mucinous pancreatic cyst. IPMN have been shown to be pre-malignant precursors to pancreatic cancer, which has an extremely high mortality rate with average survival less than 1 year. The purpose of this analysis is to utilize methodological triangulation using artificial neural networks and regression to examine the impact and effectiveness of a collection of variables believed to be predictive of malignant IPMN pathology. Results indicate that the triangulation is effective in both finding a new predictive variable and possibly reducing the number of variables needed for predicting if an IPMN is malignant or benign.

Download Full-text

Diagnosis of the pancreatic cancer

Journal of Education, Health and Sport ◽

10.12775/jehs.2021.11.09.009 ◽

2021 ◽

Vol 11 (9) ◽

pp. 67-73

Author(s):

Przemysław Raczkiewicz ◽

Maria Kalicka ◽

Tomasz Korzec ◽

Konrad Kania ◽

Katarzyna Cyboran

Keyword(s):

Pancreatic Cancer ◽

Pancreatic Cyst ◽

Precancerous Lesions ◽

Gene Mutations ◽

Intraepithelial Neoplasia ◽

Key Words Pancreatic Cancer ◽

Intraductal Papillary Mucinous Neoplasms ◽

Cystic Neoplasms ◽

Non Invasive ◽

Mucinous Neoplasms

Introduction: The pancreatic cancer arises from non-invasive precursor lesions and develops through the accumulation of characteristic gene mutations. The recent scientific reports based on genetic tests state that the approximate time between cancerous initiation and the development of cancer with metastasisis15 years. We candistinguish three main precancerous lesions leading to the pancreatic cancer: pancreatic intraepithelial neoplasia (PanIN), mucinous cystic neoplasms (MCN), and intraductal papillary mucinous neoplasms (IPMN). The imaging tests used for the diagnostics and observation of precancerous pancreas lesions are MR, MRC, CT and EUS. Method: review of the recent literature based on PubMEd, Google scholar research based onthe following key words: pancreatic cancer, precancer of the pancreas, pancreatic cyst, tuber of the pancreas, medical imaging of the pancreasPurpose of the work: systematizing information about precancers of the pancreatic cancer based on the latest research and findings

Download Full-text

ENDOSCOPIC ULTRASOUND WITH ‘BITE’ FINE NEEDLE BIOPSY IN A PATIENT WITH PANCREATIC CYST

10.1055/s-0040-1705026 ◽

2020 ◽

Author(s):

E Rinja ◽

O Plotogea ◽

V Sandru ◽

C Vladut ◽

M Ilie

Keyword(s):

Endoscopic Ultrasound ◽

Needle Biopsy ◽

Pancreatic Cyst ◽

Fine Needle Biopsy ◽

Fine Needle

Download Full-text

Flexible Potentiometric Sensor System for Non-Invasive Determination of Antioxidant Activity of Human Skin: Application for Evaluating the Effectiveness of Phytocosmetic Products

Chemosensors ◽

10.3390/chemosensors9040076 ◽

2021 ◽

Vol 9 (4) ◽

pp. 76

Author(s):

Aleksey V. Tarasov ◽

Ekaterina I. Khamzina ◽

Maria A. Bukharinova ◽

Natalia Yu. Stozhko

Keyword(s):

Antioxidant Activity ◽

Human Skin ◽

Skin Diseases ◽

Silver Chloride ◽

Potentiometric Sensor ◽

Sensor System ◽

Non Invasive ◽

Pet Film ◽

The Impact

In contemporary bioanalysis, monitoring the antioxidant activity (AOA) of the human skin is used to assess stresses, nutrition, cosmetics, and certain skin diseases. Non-invasive methods for skin AOA monitoring have certain advantages over invasive methods, namely cost-effectiveness, lower labor intensity, reduced risk of infection, and obtaining results in the real-time mode. This study presents a new flexible potentiometric sensor system (FPSS) for non-invasive determination of the human skin AOA, which is based on flexible film electrodes (FFEs) and membrane containing a mediator ([Fe(CN)6]3–/4–). Low-cost available materials and scalable technologies were used for FFEs manufacturing. The indicator FFE was fabricated based on polyethylene terephthalate (PET) film and carbon veil (CV) by single-sided hot lamination. The reference FFE was fabricated based on PET film and silver paint by using screen printing, which was followed by the electrodeposition of precipitate containing a mixture of silver chloride and silver ferricyanide (SCSF). The three-electrode configuration of the FPSS, including two indicator FFEs (CV/PET) and one reference FFE (SCSF/Ag/PET), has been successfully used for measuring the skin AOA and evaluating the impact of phytocosmetic products. FPSS provides reproducible (RSD ≤ 7%) and accurate (recovery of antioxidants is almost 100%) results, which allows forecasting its broad applicability in human skin AOA monitoring as well as for evaluating the effectiveness of topically and orally applied antioxidants.

Download Full-text

Transcranial Magnetic Stimulation as a Tool to Investigate Motor Cortex Excitability in Sport

Brain Sciences ◽

10.3390/brainsci11040432 ◽

2021 ◽

Vol 11 (4) ◽

pp. 432

Author(s):

Fiorenzo Moscatelli ◽

Antonietta Messina ◽

Anna Valenzano ◽

Vincenzo Monda ◽

Monica Salerno ◽

...

Keyword(s):

Transcranial Magnetic Stimulation ◽

Motor Cortex ◽

Magnetic Stimulation ◽

Motor Coordination ◽

Cortical Excitability ◽

Non Invasive ◽

Motor Cortex Excitability ◽

Invasive Method ◽

And Control ◽

The Impact

Transcranial magnetic stimulation, since its introduction in 1985, has brought important innovations to the study of cortical excitability as it is a non-invasive method and, therefore, can be used both in healthy and sick subjects. Since the introduction of this cortical stimulation technique, it has been possible to deepen the neurophysiological aspects of motor activation and control. In this narrative review, we want to provide a brief overview regarding TMS as a tool to investigate changes in cortex excitability in athletes and highlight how this tool can be used to investigate the acute and chronic responses of the motor cortex in sport science. The parameters that could be used for the evaluation of cortical excitability and the relative relationship with motor coordination and muscle fatigue, will be also analyzed. Repetitive physical training is generally considered as a principal strategy for acquiring a motor skill, and this process can elicit cortical motor representational changes referred to as use-dependent plasticity. In training settings, physical practice combined with the observation of target movements can enhance cortical excitability and facilitate the process of learning. The data to date suggest that TMS is a valid technique to investigate the changes in motor cortex excitability in trained and untrained subjects. Recently, interest in the possible ergogenic effect of non-invasive brain stimulation in sport is growing and therefore in the future it could be useful to conduct new experiments to evaluate the impact on learning and motor performance of these techniques.

Download Full-text

Thermal Liquid Biopsy (TLB) Focused on Benign and Premalignant Pancreatic Cyst Diagnosis

Journal of Personalized Medicine ◽

10.3390/jpm11010025 ◽

2020 ◽

Vol 11 (1) ◽

pp. 25

Author(s):

Sonia Hermoso-Durán ◽

Guillermo García-Rayado ◽

Laura Ceballos-Laita ◽

Carlos Sostres ◽

Sonia Vega ◽

...

Keyword(s):

Liquid Biopsy ◽

Pancreatic Cyst ◽

Point Of View ◽

Invasive Technique ◽

Background Current ◽

Interesting Point ◽

Pancreatic Lesion ◽

Non Invasive ◽

Patient Diagnosis ◽

New Biomarkers

Background: Current efforts in the identification of new biomarkers are directed towards an accurate differentiation between benign and premalignant cysts. Thermal Liquid Biopsy (TLB) has been previously applied to inflammatory and tumor diseases and could offer an interesting point of view in this type of pathology. Methods: In this work, twenty patients (12 males and 8 females, average ages 62) diagnosed with a pancreatic cyst benign (10) and premalignant (10) cyst lesions were recruited, and biological samples were obtained during the endoscopic ultrasonography procedure. Results: Proteomic content of cyst liquid samples was studied and several common proteins in the different groups were identified. TLB cyst liquid profiles reflected protein content. Also, TLB serum score was able to discriminate between healthy and cysts patients (71% sensitivity and 98% specificity) and between benign and premalignant cysts (75% sensitivity and 67% specificity). Conclusions: TLB analysis of plasmatic serum sample, a quick, simple and non-invasive technique that can be easily implemented, reports valuable information on the observed pancreatic lesion. These preliminary results set the basis for a larger study to refine TLB serum score and move closer to the clinical application of TLB providing useful information to the gastroenterologist during patient diagnosis.

Download Full-text