Analyzing Intraductal Papillary Mucinous Neoplasms Using Artificial Neural Network Methodologic Triangulation

Author(s):  
Steven Walczak ◽  
Jennifer B. Permuth ◽  
Vic Velanovich

Intraductal papillary mucinous neoplasms (IPMN) are a type of mucinous pancreatic cyst. IPMN have been shown to be pre-malignant precursors to pancreatic cancer, which has an extremely high mortality rate with average survival less than 1 year. The purpose of this analysis is to utilize methodological triangulation using artificial neural networks and regression to examine the impact and effectiveness of a collection of variables believed to be predictive of malignant IPMN pathology. Results indicate that the triangulation is effective in both finding a new predictive variable and possibly reducing the number of variables needed for predicting if an IPMN is malignant or benign.

2022 ◽  
pp. 867-880
Author(s):  
Steven Walczak ◽  
Jennifer B. Permuth ◽  
Vic Velanovich

Intraductal papillary mucinous neoplasms (IPMN) are a type of mucinous pancreatic cyst. IPMN have been shown to be pre-malignant precursors to pancreatic cancer, which has an extremely high mortality rate with average survival less than 1 year. The purpose of this analysis is to utilize methodological triangulation using artificial neural networks and regression to examine the impact and effectiveness of a collection of variables believed to be predictive of malignant IPMN pathology. Results indicate that the triangulation is effective in both finding a new predictive variable and possibly reducing the number of variables needed for predicting if an IPMN is malignant or benign.


2021 ◽  
Vol 11 (9) ◽  
pp. 67-73
Author(s):  
Przemysław Raczkiewicz ◽  
Maria Kalicka ◽  
Tomasz Korzec ◽  
Konrad Kania ◽  
Katarzyna Cyboran

Introduction: The pancreatic cancer arises from non-invasive precursor lesions and develops through the accumulation of characteristic gene mutations. The recent scientific reports based on genetic tests state that the approximate time between cancerous initiation and the development of cancer with metastasisis15 years. We candistinguish three main precancerous lesions leading to the pancreatic cancer: pancreatic intraepithelial neoplasia (PanIN), mucinous cystic neoplasms (MCN), and intraductal papillary mucinous neoplasms (IPMN). The imaging tests used for the diagnostics and observation of precancerous pancreas lesions are MR, MRC, CT and EUS. Method: review of the recent literature based on PubMEd, Google scholar research based onthe following key words: pancreatic cancer, precancer of the pancreas, pancreatic cyst, tuber of the pancreas, medical imaging of the pancreasPurpose of the work: systematizing information about precancers of the pancreatic cancer based on the latest research and findings


2020 ◽  
Vol 14 (11) ◽  
pp. 1009-1020
Author(s):  
Ryota Nakano ◽  
Shin Nishiumi ◽  
Takashi Kobayashi ◽  
Takuya Ikegawa ◽  
Yuzo Kodama ◽  
...  

Aim: The aim of this study was to identify whether metabolite biomarker candidates for pancreatic cancer (PC) could aid detection of intraductal papillary mucinous neoplasms (IPMN), recognized as high-risk factors for PC. Materials & methods: The 12 metabolite biomarker candidates, which were found to be useful to detect PC in our previous study, were evaluated for plasma samples from patients with PC (n = 44) or IPMN (n = 24) or healthy volunteers (n = 46). Results: Regarding the performance of individual biomarkers of PC and PC high-risk IPMN, lysine exhibited the best performance (sensitivity: 67.8%; specificity: 86.9%). The multiple logistic regression analysis-based detection model displayed high sensitivity and specificity values of 92.5 and 90.6%, respectively. Conclusion: Metabolite biomarker candidates for PC are useful for detecting high-risk IPMN, which can progress to PC.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhonghui Thong ◽  
Jolena Ying Ying Tan ◽  
Eileen Shuzhen Loo ◽  
Yu Wei Phua ◽  
Xavier Liang Shun Chan ◽  
...  

AbstractRegression models are often used to predict age of an individual based on methylation patterns. Artificial neural network (ANN) however was recently shown to be more accurate for age prediction. Additionally, the impact of ethnicity and sex on our previous regression model have not been studied. Furthermore, there is currently no age prediction study investigating the lower limit of input DNA at the bisulfite treatment stage prior to pyrosequencing. Herein, we evaluated both regression and ANN models, and the impact of ethnicity and sex on age prediction for 333 local blood samples using three loci on the pyrosequencing platform. Subsequently, we trained a one locus-based ANN model to reduce the amount of DNA used. We demonstrated that the ANN model has a higher accuracy of age prediction than the regression model. Additionally, we showed that ethnicity did not affect age prediction among local Chinese, Malays and Indians. Although the predicted age of males were marginally overestimated, sex did not impact the accuracy of age prediction. Lastly, we present a one locus, dual CpG model using 25 ng of input DNA that is sufficient for forensic age prediction. In conclusion, the two ANN models validated would be useful for age prediction to provide forensic intelligence leads.


2021 ◽  
Author(s):  
Sascha Flaig ◽  
Timothy Praditia ◽  
Alexander Kissinger ◽  
Ulrich Lang ◽  
Sergey Oladyshkin ◽  
...  

<p>In order to prevent possible negative impacts of water abstraction in an ecologically sensitive moor south of Munich (Germany), a “predictive control” scheme is in place. We design an artificial neural network (ANN) to provide predictions of moor water levels and to separate hydrological from anthropogenic effects. As the moor is a dynamic system, we adopt the „Long short-term memory“ architecture.</p><p>To find the best LSTM setup, we train, test and compare LSTMs with two different structures: (1) the non-recurrent one-to-one structure, where the series of inputs are accumulated and fed into the LSTM; and (2) the recurrent many-to-many structure, where inputs gradually enter the LSTM (including LSTM forecasts from previous forecast time steps). The outputs of our LSTMs then feed into a readout layer that converts the hidden states into water level predictions. We hypothesize that the recurrent structure is the better structure because it better resembles the typical structure of differential equations for dynamic systems, as they would usually be used for hydro(geo)logical systems. We evaluate the comparison with the mean squared error as test metric, and conclude that the recurrent many-to-many LSTM performs better for the analyzed complex situations. It also produces plausible predictions with reasonable accuracy for seven days prediction horizon.</p><p>Furthermore, we analyze the impact of preprocessing meteorological data to evapotranspiration data using typical ETA models. Inserting knowledge into the LSTM in the form of ETA models (rather than implicitly having the LSTM learn the ETA relations) leads to superior prediction results. This finding aligns well with current ideas on physically-inspired machine learning.</p><p>As an additional validation step, we investigate whether our ANN is able to correctly identify both anthropogenic and natural influences and their interaction. To this end, we investigate two comparable pumping events under different meteorological conditions. Results indicate that all individual and combined influences of input parameters on water levels can be represented well. The neural networks recognize correctly that the predominant precipitation and lower evapotranspiration during one pumping event leads to a lower decrease of the hydrograph.</p><p>To further demonstrate the capability of the trained neural network, scenarios of pumping events are created and simulated.</p><p>In conclusion, we show that more robust and accurate predictions of moor water levels can be obtained if available physical knowledge of the modeled system is used to design and train the neural network. The artificial neural network can be a useful instrument to assess the impact of water abstraction by quantifying the anthropogenic influence.</p>


2017 ◽  
Vol 3 ◽  
pp. e137 ◽  
Author(s):  
Mona Alshahrani ◽  
Othman Soufan ◽  
Arturo Magana-Mora ◽  
Vladimir B. Bajic

Background Artificial neural networks (ANNs) are a robust class of machine learning models and are a frequent choice for solving classification problems. However, determining the structure of the ANNs is not trivial as a large number of weights (connection links) may lead to overfitting the training data. Although several ANN pruning algorithms have been proposed for the simplification of ANNs, these algorithms are not able to efficiently cope with intricate ANN structures required for complex classification problems. Methods We developed DANNP, a web-based tool, that implements parallelized versions of several ANN pruning algorithms. The DANNP tool uses a modified version of the Fast Compressed Neural Network software implemented in C++ to considerably enhance the running time of the ANN pruning algorithms we implemented. In addition to the performance evaluation of the pruned ANNs, we systematically compared the set of features that remained in the pruned ANN with those obtained by different state-of-the-art feature selection (FS) methods. Results Although the ANN pruning algorithms are not entirely parallelizable, DANNP was able to speed up the ANN pruning up to eight times on a 32-core machine, compared to the serial implementations. To assess the impact of the ANN pruning by DANNP tool, we used 16 datasets from different domains. In eight out of the 16 datasets, DANNP significantly reduced the number of weights by 70%–99%, while maintaining a competitive or better model performance compared to the unpruned ANN. Finally, we used a naïve Bayes classifier derived with the features selected as a byproduct of the ANN pruning and demonstrated that its accuracy is comparable to those obtained by the classifiers trained with the features selected by several state-of-the-art FS methods. The FS ranking methodology proposed in this study allows the users to identify the most discriminant features of the problem at hand. To the best of our knowledge, DANNP (publicly available at www.cbrc.kaust.edu.sa/dannp) is the only available and on-line accessible tool that provides multiple parallelized ANN pruning options. Datasets and DANNP code can be obtained at www.cbrc.kaust.edu.sa/dannp/data.php and https://doi.org/10.5281/zenodo.1001086.


2015 ◽  
Vol 60 (9) ◽  
pp. 2800-2806 ◽  
Author(s):  
Wilson T. Kwong ◽  
Robert D. Lawson ◽  
Gordon Hunt ◽  
Syed M. Fehmi ◽  
James A. Proudfoot ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document