High Mortality and Morbidity in Acute Coronary Syndrome Patients who Received Medical (Non-Revascularisation) Management

2010 ◽  
Vol 19 ◽  
pp. S21-S22
Author(s):  
JL Looi ◽  
KL Looi ◽  
KL Chow ◽  
S Haliday ◽  
M Lee ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
High Mortality ◽  
Mortality And Morbidity ◽  
Coronary Syndrome

Assessment Framework for Recognizing Clinical Deterioration in Patients With ACS Undergoing PCI

2021 ◽  
Vol 41 (4) ◽  
pp. 18-28
Author(s):  
Kevin White ◽  
Judy Currey ◽  
Julie Considine
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Acute Coronary Syndrome ◽  
Signs And Symptoms ◽  
Coronary Artery Occlusion ◽  
Coronary Intervention ◽  
Clinical Deterioration ◽  
Access Site ◽  
Mortality And Morbidity ◽  
Coronary Syndrome ◽  
Percutaneous Coronary

Topic Patients with acute coronary syndrome undergoing primary percutaneous coronary intervention are at risk of clinical deterioration that results in similar general signs and symptoms regardless of its cause. However, specific causes and forms of clinical deterioration are associated with key differences in assessment findings. Focused clinical assessments using a modified primary survey enable nurses to rapidly identify the cause and form of clinical deterioration, facilitating targeted treatment. Clinical Relevance Clinical deterioration during percutaneous coronary intervention is associated with increased mortality and morbidity. Previous studies identified nursing inconsistencies when recognizing clinical deterioration, with inconsistent collection of cues and prioritization of cues related to cardiac performance over more sensitive indicators of clinical deterioration. Purpose of Paper To describe a framework to help nurses optimize physiological cue collection to improve recognition of clinical deterioration during periprocedural care of patients undergoing percutaneous coronary intervention for unstable acute coronary syndrome. Content Covered Literature analysis revealed 7 forms of clinical deterioration in patients undergoing percutaneous coronary intervention: coronary artery occlusion, stroke, ventricular rupture, valvular insufficiency, lethal cardiac arrhythmias, access-site and non–access-site bleeding, and anaphylaxis. Evidence for the pathophysiology, incidence, severity, and clinical features of each form of clinical deterioration is identified. A framework is proposed to help nurses conduct highly focused patient assessments, enabling prompt recognition of and response to the specific forms of clinical deterioration that occur in patients undergoing percutaneous coronary intervention.

scholarly journals Acute Coronary Syndrome after 17 Years of Bare Metal Stent Implantation: “Very” Very Late Stent Thrombosis

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Raghavendra Rao K ◽  
S. Reddy ◽  
J. R. Kashyap ◽  
K. Vikas ◽  
Hithesh Reddy ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Stent Thrombosis ◽  
Plaque Rupture ◽  
Bare Metal Stents ◽  
Metal Stents ◽  
Bare Metal ◽  
Late Stent Thrombosis ◽  
Very Late Stent Thrombosis ◽  
Mortality And Morbidity ◽  
Coronary Syndrome

Very late stent thrombosis (VLST) is a catastrophic and life-threatening complication after percutaneous coronary intervention which presents as an acute coronary syndrome with significantly high mortality and morbidity. VLST is a rare entity with drug-eluting stents and even rarer with bare metal stents. The exact pathophysiologic mechanism of VLST after BMS implantation is not known although various mechanisms have been proposed. Recently, in-stent neoatherosclerosis with intimal plaque rupture has been proposed as a potential mechanism of VLST after BMS. We report a rare case of VLST occurring 17 years after BMS implantation with angiographic and intravascular imaging evidence which provides insight into the mechanisms of VLST.

scholarly journals High mortality rates in conservatively managed patients with acute coronary syndrome

2006 ◽  
Vol 40 (3) ◽  
pp. 137-144 ◽  
Author(s):  
Erlend Aune ◽  
Jøran Hjelmesæth ◽  
Keith A. A. Fox ◽  
Knut Endresen ◽  
Jan Erik Otterstad
Keyword(s):  
Acute Coronary Syndrome ◽  
High Mortality ◽  
Mortality Rates ◽  
Coronary Syndrome

scholarly journals Prevalence of Modifiable Risk Factors among Acute Coronary Syndrome Patients in a Tertiary Care Hospital

2021 ◽  
pp. 765-772
Author(s):  
I. Mariraj ◽  
M. Naveen Kumar ◽  
N. S. Ani Rubitha ◽  
R. Rameshwar
Keyword(s):  
Risk Factors ◽  
Acute Coronary Syndrome ◽  
Cardiovascular Diseases ◽  
Great Reduction ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Modifiable Risk Factors ◽  
Care Hospital ◽  
Mortality And Morbidity ◽  
Coronary Syndrome

Background and Objectives: Acute Coronary Syndrome (ACS) is one of the major causes for mortality and morbidity among the cardiovascular diseases in India. In this study the modifiable risk factors leading to ACS are considered and its prevalence in a Tertiary care hospital is studied. Materials and Methods: This is a prospective type of study conducted in a tertiary care hospital. A total of 100 patients diagnosed with ACS were taken in this study. Their data was taken, and results were formulated in excel data sheet. Results: Among the UA patients, 65% were found to be dyslipidaemic, 60% as obese, 45% as diabetics, 47.5% as hypertensive and 40% as smokers. Among the NSTEMI patients, 66.67% were found to be dyslipidaemic, 52.78% as hypertensive, 44.44% as smokers, 30.56% as diabetics and 27.78% as obese. Among the STEMI patients, 37.50% were found to be dyslipidemic, 25% as both diabetic and obese, 20.83% as hypertensive,12.5% as smokers. Hypertension, dyslipidemia, smoking and obesity showed significance. Conclusion: The prevalence of modifiable risk factors is a major concern for developing ACS and when they are modified there will be a great reduction in the incidence of ACS.

Explicating Links between Acute Coronary Syndrome and Depression: Study Design and Methods

2006 ◽  
Vol 40 (3) ◽  
pp. 245-252 ◽  
Author(s):  
Gordon Parker ◽  
Gabriella Heruc ◽  
Therese Hilton ◽  
Amanda Olley ◽  
Heather Brotchie ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
International Studies ◽  
Depression And Anxiety ◽  
Regional Study ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Mortality And Morbidity ◽  
Cardiac Morbidity ◽  
Coronary Syndrome ◽  
Design And Methods

Objective: To describe a regional study seeking to replicate the suggested strong links whereby lifetime and post-coronary infarction depression are associated with a significant increase in mortality and cardiac morbidity, and consider the comparative influence of both depression and anxiety. Method: We detail relevant international studies and describe both the methodology as well as baseline and 1-month data from our study. Results: Over a 3-year period we recruited 489 subjects admitted to a Sydney cardiac unit with an Acute Coronary Syndrome (ACS), and assessed by a range of cardiac variables and measures of current and lifetime depression. Ninety-eight per cent of the sample were assessed one month after baseline recruitment to establish depression rates. Long-term outcome reviews of mortality and morbidity and hospitalization rates are proceeding. For those subjects who were depressed in the post-ACS period and, even more so for those who had experienced lifetime depression, distinctly higher scores on anxiety variables (and lifetime caseness for anxiety disorders) were established. Conclusions: The strong interdependence between anxiety and depression in this sample of patients admitted with an ACS will allow examination of the comparative extent to which expressions of ‘depression’ and ‘anxiety’ contribute to post-ACS morbidity.

scholarly journals Akut coronariaszindróma ellátása – 2016

2016 ◽  
Vol 157 (38) ◽  
pp. 1500-1506
Author(s):  
Dávid Becker ◽  
Béla Merkely
Keyword(s):  
Acute Coronary Syndrome ◽  
Mortality Rate ◽  
High Mortality ◽  
Coronary Intervention ◽  
Continuous Development ◽  
Coronary Syndrome ◽  
Optimal Therapy ◽  
European Guidelines ◽  
Life Threatening ◽  
Care System

Acute coronary syndrome is a life threatening disease with high mortality rate without optimal therapy. Due to the continuous development in the treatment of the disease, the prognosis has dramatically improved over the last 30 years. Apart from the improvement of the medication, the most important factor is the availability of an immediate coronary intervention for everyone, at any time. Currently, nineteen interventional centers provide this care in Hungary, 24 hours a day. Thanks to the European guidelines, the care system is now more efficient in determining who and when needs the treatment. This article summarises the principles of the treatment currently in use. Orv. Hetil., 2016, 157(38), 1500–1506.

scholarly journals Massive pulmonary haemorrhage complicating the treatment of acute coronary syndrome

Heart ◽  
2004 ◽  
Vol 90 (3) ◽  
pp. e15-e15 ◽  
Author(s):  
D S Gill ◽  
K Ng ◽  
K-S Ng
Keyword(s):  
Acute Coronary Syndrome ◽  
Acute Coronary Syndromes ◽  
Patient Survival ◽  
Rare Complication ◽  
Pulmonary Haemorrhage ◽  
Acute Pulmonary Oedema ◽  
Diagnostic Dilemma ◽  
Mortality And Morbidity ◽  
Coronary Syndrome ◽  
Coronary Syndromes

Antiplatelet medications such as clopidogrel and tirofiban (glycoprotien IIb/IIIa inhibitors) are associated with a reduction in mortality and morbidity and are therefore recommended in the treatment of acute coronary syndromes. Massive pulmonary haemorrhage is a rare complication of both clopidogrel and tirofiban. Pulmonary haemorrhage may easily be mistaken for acute pulmonary oedema, a condition commonly seen in patients with acute coronary syndrome. Physicians need to be aware of this diagnostic dilemma because early treatment increases the chances of patient survival.

scholarly journals Particulate Matter-Induced Acute Coronary Syndrome: MicroRNAs as Microregulators for Inflammatory Factors

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Nur Izah Ab Razak ◽  
Nor Eliani Ezani ◽  
Norzian Ismail
Keyword(s):  
Gene Expression ◽  
Air Pollution ◽  
Acute Coronary Syndrome ◽  
Particulate Matter ◽  
Ultrafine Particles ◽  
Inflammatory Factors ◽  
Potential Contribution ◽  
Mortality And Morbidity ◽  
Coronary Syndrome ◽  
Polycyclic Aromatic

The most prevalent cause of mortality and morbidity worldwide is acute coronary syndrome (ACS) and its consequences. Exposure to particulate matter (PM) from air pollution has been shown to impair both. Various plausible pathogenic mechanisms have been identified, including microRNAs (miRNAs), an epigenetic regulator for gene expression. Endogenous miRNAs, average 22-nucleotide RNAs (ribonucleic acid), regulate gene expression through mRNA cleavage or translation repression and can influence proinflammatory gene expression posttranscriptionally. However, little is known about miRNA responses to fine PM (PM2.5, PM10, ultrafine particles, black carbon, and polycyclic aromatic hydrocarbon) from air pollution and their potential contribution to cardiovascular consequences, including systemic inflammation regulation. For the past decades, microRNAs (miRNAs) have emerged as novel, prospective diagnostic and prognostic biomarkers in various illnesses, including ACS. We wanted to outline some of the most important studies in the field and address the possible utility of miRNAs in regulating particulate matter-induced ACS (PMIA) on inflammatory factors in this review.

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