High negative predictive value of RT-PCR in patients with high likelihood of SARS-CoV-2 infection

SummaryThe high negative predictive value of FDG-PET in therapy control of Hodgkin lymphoma is proven by the data acquired up to now. Thus, the analysis of the HD15 trial has shown that consolidation radiotherapy might be omitted in PET negative patients after effective chemotherapy. Further response adapted therapy guided by PET seems to be a promising approach in reducing the toxicity for patients undergoing chemotherapy. The criteria used for the PET interpretation have been standardized by the German study groups for Hodgkin lymphoma patients and will be reevaluated in the current studies.

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Su1188 Transabdominal Ultrasound Has High Negative Predictive Value for Short-Term Complications of Inflammatory Bowel Disease

Gastroenterology ◽

10.1016/s0016-5085(15)31459-1 ◽

2015 ◽

Vol 148 (4) ◽

pp. S-432

Author(s):

Zuzana Zelinkova ◽

Barbora Kadleckova ◽

Beata Repakova

Keyword(s):

Inflammatory Bowel Disease ◽

Negative Predictive Value ◽

Bowel Disease ◽

Predictive Value ◽

Transabdominal Ultrasound ◽

Short Term ◽

High Negative Predictive Value ◽

Inflammatory Bowel

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Association between clinical risk scores and mortality in atrial fibrillation: Systematic review and network meta-regression of 669,000 patients

European Journal of Preventive Cardiology ◽

10.1177/2047487318817662 ◽

2018 ◽

Vol 27 (6) ◽

pp. 633-644 ◽

Cited By ~ 3

Author(s):

Marco Proietti ◽

Alessio Farcomeni ◽

Giulio Francesco Romiti ◽

Arianna Di Rocco ◽

Filippo Placentino ◽

...

Keyword(s):

Atrial Fibrillation ◽

Negative Predictive Value ◽

Predictive Value ◽

Predictive Ability ◽

Risk Scores ◽

Clinical Risk ◽

Increased Risk ◽

High Negative Predictive Value ◽

Meta Regression

Aims Many clinical scores for risk stratification in patients with atrial fibrillation have been proposed, and some have been useful in predicting all-cause mortality. We aim to analyse the relationship between clinical risk score and all-cause death occurrence in atrial fibrillation patients. Methods We performed a systematic search in PubMed and Scopus from inception to 22 July 2017. We considered the following scores: ATRIA-Stroke, ATRIA-Bleeding, CHADS2, CHA2DS2-VASc, HAS-BLED, HATCH and ORBIT. Papers reporting data about scores and all-cause death rates were considered. Results Fifty studies and 71 scores groups were included in the analysis, with 669,217 patients. Data on ATRIA-Bleeding, CHADS2, CHA2DS2-VASc and HAS-BLED were available. All the scores were significantly associated with an increased risk for all-cause death. All the scores showed modest predictive ability at five years (c-indexes (95% confidence interval) CHADS2: 0.64 (0.63–0.65), CHA2DS2-VASc: 0.62 (0.61–0.64), HAS-BLED: 0.62 (0.58–0.66)). Network meta-regression found no significant differences in predictive ability. CHA2DS2-VASc score had consistently high negative predictive value (≥94%) at one, three and five years of follow-up; conversely it showed the highest probability of being the best performing score (63% at one year, 60% at three years, 68% at five years). Conclusion In atrial fibrillation patients, contemporary clinical risk scores are associated with an increased risk of all-cause death. Use of these scores for death prediction in atrial fibrillation patients could be considered as part of holistic clinical assessment. The CHA2DS2-VASc score had consistently high negative predictive value during follow-up and the highest probability of being the best performing clinical score.

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Rectal screening displays high negative predictive value for bloodstream infection with (ESBL-producing) Gram-negative bacteria in neonates with suspected sepsis in a low-resource setting neonatal care unit

Journal of Global Antimicrobial Resistance ◽

10.1016/j.jgar.2020.08.017 ◽

2020 ◽

Vol 23 ◽

pp. 102-107

Author(s):

Annick Lenglet ◽

Jorien Schuurmans ◽

Cono Ariti ◽

Emily Borgundvaag ◽

Kessiane Charles ◽

...

Keyword(s):

Negative Predictive Value ◽

Bloodstream Infection ◽

Predictive Value ◽

Gram Negative Bacteria ◽

Suspected Sepsis ◽

Gram Negative ◽

Resource Setting ◽

Low Resource Setting ◽

High Negative Predictive Value ◽

Neonatal Care Unit

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Serum Angiotensin-Converting Enzyme Has a High Negative Predictive Value in the Investigation for Systemic Sarcoidosis

American Journal of Ophthalmology ◽

10.1016/j.ajo.2018.07.010 ◽

2018 ◽

Vol 194 ◽

pp. 82-87 ◽

Cited By ~ 13

Author(s):

Rachael L. Niederer ◽

Ahmed Al-Janabi ◽

Sue L. Lightman ◽

Oren Tomkins-Netzer

Keyword(s):

Angiotensin Converting Enzyme ◽

Negative Predictive Value ◽

Predictive Value ◽

Converting Enzyme ◽

Serum Angiotensin Converting Enzyme ◽

High Negative Predictive Value ◽

Systemic Sarcoidosis

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Role of Covid Antigen in the Diagnosis of Covid Positive in Obstetric Patients

10.53350/pjmhs2115103356 ◽

2021 ◽

Vol 15 (10) ◽

pp. 3356-3358

Author(s):

Ambreen Fatima ◽

Nidda Yaseen ◽

Amna Fareed ◽

Kashif Ali Samin ◽

Shumaela Kanwal ◽

...

Keyword(s):

Nucleic Acid ◽

Early Detection ◽

Negative Predictive Value ◽

Predictive Value ◽

False Negative ◽

Nucleic Acid Amplification ◽

Antigen Test ◽

Rt Pcr ◽

Cross Sectional ◽

Specificity And Sensitivity

Background and Aim: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapid emergence postured significant challenges on the health system in recent years. The early detection of cases is thought to be critical in preventing this pandemic by coronavirus disease (COVID-19), especially important in the obstetrical population due to theirs numerous interactions with another parturient when hospitalized for delivery. Therefore, the present study aimed to assess the COVID antigen test performance in COVID-positive obstetrics patients. Materials and Methods: This cross-sectional study was conducted on 1296 Covid-19 asymptomatic women admitted to the Obstetrics and Gynaecology Department of Muhammad Teaching Hospital & Medical College, Peshawar and Fauji Foundation Hospital, Rawalpindi for the duration of six months from February 2021 to July 2021. Antigen-based test rapid diagnostic test (RDT) was used for screening out COVID-19 positive obstetrics patients or women through nasopharyngeal swabs. Women with negative rapid antigen test results were confirmed with RT-polymers chain reaction test of nucleic acid amplification tests (NAAT). Ethical approval and informed consent were taken from the hospital ethical committee and each individual respectively. All the known positive COVID-19 patients during admission were excluded. SPSS version 24 was used for data analysis. Results: The overall prevalence of rapid antigen-positive tested patients was 13.2% (171/1296). The prevalence of positive tested women through rapid antigen test, Nucleic Acid Amplification Test (NAAT), and RT-PCR were 27 (2.1%), 51 (3.9%), and 93 (7.2%) respectively. Of the total 1296 rapid antigen tests, 27 were positive, and the false-negative confirmed positive by NAAT was 144.Thus the sensitivity of the rapid antigen test was 15.8% and the negative predictive value was 93.7%. Of the total 298 Nucleic Acid Amplification Tested had sensitivity and negative predictive value of 89.6% and 99.06% respectively. RT-PCR was carried out on 972 patients, positive diagnosed cases were 36 while 15 were initially negative and were positive with the test was repeated. The sensitivity and negative predictive value was 71.45% and 95.8% respectively. Conclusion: Our study found that Ag-RDT plays a significant role in SARS-CoV-2 early detection in infected individuals, with high specificity and sensitivity to disease infectious stage, whether symptomatic or asymptomatic, and can be used as a decision supported tool. Early detection of COVID-19 status in women admitted for delivery could benefit neonatal protection care. Keywords: Covid-19; Rapid antigen test; RT-PCR test

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Incidence of Heparin-Induced Thrombocytopenia in Patients With Newly Implanted Mechanical Circulatory Support Devices

Annals of Pharmacotherapy ◽

10.1177/10600280211038705 ◽

2021 ◽

pp. 106002802110387

Author(s):

Long To ◽

Dana Attar ◽

Brittany Lines ◽

Melissa McCarty ◽

Hassan Nemeh ◽

...

Keyword(s):

Negative Predictive Value ◽

Predictive Value ◽

Mechanical Circulatory Support ◽

Serotonin Release ◽

Circulatory Support ◽

Anticoagulation Management ◽

Heparin Induced Thrombocytopenia ◽

Mechanical Circulatory Support Devices ◽

High Negative Predictive Value ◽

Release Assay

Background: Heparin exposure and device-related thrombocytopenia complicate the diagnosis of heparin-induced thrombocytopenia (HIT) in patients receiving mechanical circulatory support (MCS). To improve anticoagulation management for patients with newly implanted MCS devices, incidence of confirmed HIT needs to be further characterized. Objectives: The purpose of this study is to describe the incidence of HIT and clinical utility of the 4Ts score in patients with newly implanted MCS devices. Methods: This is a retrospective analysis of MCS patients receiving unfractionated heparin from 2014 to 2017. The primary end point was incidence of laboratory-confirmed HIT. Strong positive, likely positive, low probability, and negative HIT categories were established based on heparin-induced platelet antibody (HIPA) and serotonin release assay (SRA). Secondary end points include characterization of platelet trends, argatroban use, incidence of HIT among each of the MCS devices, and utility of 4Ts score. Results: A total of 342 patient encounters met inclusion criteria, of which 68 HIPA tests and 25 SRAs were ordered. The incidence of HIT was 0.88% (3/342) and 4.4% (3/68) in patients with suspected HIT. Of the 68 HIPA tests, 3 (4.4%) were considered strong positive and 3 of the 25 SRAs were positive. Median 4Ts score was 4 [2.5-4] and optical density 0.19 [0.11-0.54]. The positive predictive value for the 4Ts score was 0.15 (CI = 0.03-0.46) and negative predictive value, 0.93 (CI = 0.82-0.98). Conclusion and Relevance: HIT occurs infrequently with newly implanted MCS devices. The 4Ts score appears to have a high negative predictive value for ruling out HIT.

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Evaluation of broad-range 16S rRNA PCR for the diagnosis of bloodstream infections: two years of experience

The Journal of Infection in Developing Countries ◽

10.3855/jidc.4867 ◽

2014 ◽

Vol 8 (10) ◽

pp. 1252-1258 ◽

Cited By ~ 7

Author(s):

Reem Mostafa Hassan ◽

Mervat G El Enany ◽

Hussien H Rizk

Keyword(s):

Blood Culture ◽

16S Rrna ◽

Negative Predictive Value ◽

Predictive Value ◽

Bloodstream Infections ◽

Molecular Techniques ◽

Molecular Technique ◽

High Negative Predictive Value ◽

Patient Groups ◽

Low Sensitivity

Introduction: Diagnosis of bloodstream infections using bacteriological cultures suffers from low sensitivity and reporting delay. Advanced molecular techniques introduced in many laboratories provide rapid results and may show improvements in patient outcomes. This study aimed to evaluate the usefulness of a molecular technique, broad-range 16S rRNA PCR followed by sequencing for the diagnosis of bloodstream infections, compared to blood culture in different patient groups. Methodology: Conventional PCR was performed, using broad-range 16S rRNA primers, on blood cultures collected from different patients with suspected bloodstream infections; results were compared with those of blood culture. Results: Though blood culture is regarded as the gold standard, PCR evaluation showed sensitivity of 86.25%, specificity of 91.25%, positive predictive value of 76.67%, negative predictive value of 95.22%, and accuracy of 88.8%. Conclusions: Molecular assays seem not to be sufficient to replace microbial cultures in the diagnosis of bloodstream infections, but they can offer a rapid, good negative test to rule out infection due to their high negative predictive value.

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