Augmented control of drug-resistant Candida spp. via fluconazole loading into fungal chitosan nanoparticles

2019 ◽  
Vol 141 ◽  
pp. 511-516 ◽  
Author(s):  
Haddad A. El Rabey ◽  
Fahad M. Almutairi ◽  
Adel I. Alalawy ◽  
Mohammed A. Al-Duais ◽  
Mohamed I. Sakran ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Drug Resistant ◽  
Candida Spp ◽  
Fungal Chitosan

Effects of fungal chitosan nanoparticles as eco-friendly edible coatings on the quality of postharvest table grapes

2018 ◽  
Vol 139 ◽  
pp. 56-66 ◽  
Author(s):  
Natália Ferrão Castelo Branco Melo ◽  
Bruna Lúcia de MendonçaSoares ◽  
Katharina Marques Diniz ◽  
Camila Ferreira Leal ◽  
Darllety Canto ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Edible Coatings ◽  
Table Grapes ◽  
Fungal Chitosan

scholarly journals Antifungal Carvacrol Loaded Chitosan Nanoparticles

Antibiotics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 11
Author(s):  
Alberto Vitali ◽  
Annarita Stringaro ◽  
Marisa Colone ◽  
Alexandra Muntiu ◽  
Letizia Angiolella
Keyword(s):  
Fungal Infections ◽  
Release Kinetics ◽  
Chitosan Nanoparticles ◽  
Antibiofilm Activity ◽  
Loading Capacity ◽  
Candida Spp ◽  
Life Threatening ◽  
Functional Features ◽  
Nanoparticle Formulation ◽  
Microscopy Techniques

The increased prevalence and incidence of fungal infections, of which Candida albicans represents one of the most life-threatening organisms, is prompting the scientific community to develop novel antifungal molecules. Many essential oils components are attracting attention for their interesting antifungal activities. Given the chemical and physical characteristics of these compounds, the use of appropriate nanodelivery systems is becoming increasingly widespread. In this study, chitosan nanoparticles were prepared using an ionic gelation procedure and loaded with the phenolic monoterpene carvacrol. After a bioassay guided optimization, the best nanoparticle formulation was structurally characterized by means of different spectroscopic (UV, FTIR and DLS) and microscopy techniques (SEM) and described for their functional features (encapsulation efficiency, loading capacity and release kinetics). The antifungal activity of this formulation was assayed with different Candida spp., both in planktonic and biofilm forms. From these studies, it emerged that the carvacrol loaded nanoparticles were particularly active against planktonic forms and that the antibiofilm activity was highly dependent on the species tested, with the C. tropicalis and C. krusei strains resulting as the most susceptible.

Cefazolin loaded chitosan nanoparticles to cure multi drug resistant Gram-negative pathogens

2016 ◽  
Vol 136 ◽  
pp. 682-691 ◽  
Author(s):  
Bushra Jamil ◽  
Huma Habib ◽  
Shahid Abbasi ◽  
Habib Nasir ◽  
Abdur Rahman ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Drug Resistant ◽  
Gram Negative

Augmented anticancer activity of curcumin loaded fungal chitosan nanoparticles

2020 ◽  
Vol 155 ◽  
pp. 861-867 ◽  
Author(s):  
Fahad M. Almutairi ◽  
Haddad A. El Rabey ◽  
Ahmed A. Tayel ◽  
Adel I. Alalawy ◽  
Mohammed A. Al-Duais ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Chitosan Nanoparticles ◽  
Fungal Chitosan

scholarly journals SUSCEPTIBILITY OF Candida spp. ISOLATED FROM BLOOD CULTURES AS EVALUATED USING THE M27-A3 AND NEW M27-S4 APPROVED BREAKPOINTS

2014 ◽  
Vol 56 (6) ◽  
pp. 477-482 ◽  
Author(s):  
Edileusa Rosa dos Santos ◽  
Camila F. Dal Forno ◽  
Mari Glei Hernandez ◽  
Thaís Felli Kubiça ◽  
Tarcieli P. Venturini ◽  
...  
Keyword(s):  
Antifungal Agents ◽  
Mortality Rates ◽  
Blood Cultures ◽  
Drug Resistant ◽  
Candida Spp ◽  
Fungal Isolates ◽  
Clinical Breakpoints ◽  
Susceptibility Tests ◽  
Species Specific ◽  
Emergence Of Resistance

The high mortality rates associated with candidemia episodes and the emergence of resistance to antifungal agents necessitate the monitoring of the susceptibility of fungal isolates to antifungal treatments. The new, recently approved, species-specific clinical breakpoints (SS-CBPs)(M27-S4) for evaluating susceptibility require careful interpretation and comparison with the former proposals made using the M27-A3 breakpoints, both from CLSI. This study evaluated the susceptibility of the different species of Candida that were isolated from candidemias based on these two clinical breakpoints. Four hundred and twenty-two isolates were identified and, among them, C. parapsilosis comprised 46.68%, followed by C. albicans (35.78%), C. tropicalis (9.71%), C. glabrata (3.55%), C. lusitaniae (1.65%), C. guilliermondii (1.65%) and C. krusei (0.94%). In accordance with the M27-A3 criteria, 33 (7.81%) non-susceptible isolates were identified, of which 16 (3.79%) were resistant to antifungal agents. According to SS-CBPs, 80 (18.95%) isolates were non-susceptible, and 10 (2.36%) of these were drug resistant. When the total number of non-susceptible isolates was considered, the new SS-CBPs detected 2.4 times the number of isolates that were detected using the M27-A3 interpretative criteria. In conclusion, the detection of an elevated number of non-susceptible species has highlighted the relevance of evaluating susceptibility tests using new, species-specific clinical breakpoints (SS-CBPs), which could impact the profile of non-susceptible Candida spp. to antifungal agents that require continuous susceptibility monitoring.

Effect of chitosan nanoparticles on the inhibition of Candida spp. biofilm on denture base surface

2018 ◽  
Vol 94 ◽  
pp. 99-107 ◽  
Author(s):  
Brenna Louise Cavalcanti Gondim ◽  
Lúcio Roberto Cançado Castellano ◽  
Ricardo Dias de Castro ◽  
Giovanna Machado ◽  
Hugo Lemes Carlo ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Candida Spp ◽  
Base Surface ◽  
Denture Base

scholarly journals Fecal microbiota transplantation in the treatment of intestinal steroid-resistant graft-versus-host disease: two case reports and a review of the literature

2020 ◽  
Vol 48 (6) ◽  
pp. 030006052092569 ◽  
Author(s):  
Monika Maria Biernat ◽  
Donata Urbaniak-Kujda ◽  
Jarosław Dybko ◽  
Katarzyna Kapelko-Słowik ◽  
Iwona Prajs ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Fecal Microbiota Transplantation ◽  
Case Reports ◽  
Fecal Microbiota ◽  
Drug Resistant ◽  
Candida Spp ◽  
Hematopoietic Stem ◽  
Steroid Resistant ◽  
Host Disease ◽  
Graft Versus Host

Acute graft-versus-host disease (aGvHD) reduces the efficiency and safety of allogeneic hematopoietic stem cell transplantation (allo-HSCT). In recent years, attempts have been made to transplant fecal microbiota from healthy donors to treat intestinal GvHD. This study presented two cases of patients undergoing allo-HSCT who were later selected for fecal microbiota transplantation (FMT). In the first patient, FMT resulted in the complete resolution of symptoms, whereas therapeutic efficacy was not achieved in the second patient. FMT eliminated drug-resistant pathogens, namely very drug-resistant Enterococcus spp., but not multidrug-resistant Acinetobacter baumannii or Candida spp. Further research is needed, particularly on the safety of FMT in patients with intestinal steroid-resistant GvHD and on the distant impact of transplanted microflora on the outcomes of allo-HSCT. FMT appears promising for the treatment of patients with steroid-resistant GvHD.

scholarly journals Micafungin Is an Efficient Treatment of Multi Drug-Resistant Candida glabrata Urosepsis: A Case Report

2021 ◽  
Vol 7 (10) ◽  
pp. 800
Author(s):  
Zuzana Javorova Rihova ◽  
Lubica Slobodova ◽  
Anna Hrabovska
Keyword(s):  
Drug Resistance ◽  
Urinary Tract ◽  
Candida Glabrata ◽  
Multi Drug Resistance ◽  
Drug Resistant ◽  
Candida Spp ◽  
Efficient Treatment ◽  
Pharmacokinetic Properties ◽  
Life Threatening ◽  
Low Levels

Candiduria is a common nosocomial infection in hospitalized patients, which may progress into life-threatening candidemia. Successful treatment of urosepsis requires early and effective antifungal therapy, while the available agents within three pharmacological classes each have characteristic pharmacokinetics and side effect profiles. Moreover, treatment of Candida spp. infections is becoming challenging due to increasing multi drug-resistance. Here, we present a case of candidemia resulting from a multi drug-resistant C. glabrata infection of the urinary tract. Due to resistance to fluconazole and a contraindication for amphotericin B, micafungin was used in the treatment, regardless of its unfavorable pharmacokinetic properties. Our study showed that despite the expected low levels in the urinary tract, micafungin was successful in the eradication of C. glabrata allowing full recovery of the patient. Thus, micafungin should be considered in the management of urosepsis caused by sensitive Candida spp.

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