The synergistic effects of cinnamon essential oil and nano TiO2 on antimicrobial and functional properties of sago starch films

AbstractCombination of various compounds and essential oils for pharmaceutical formulations withdraw attention. In this present study, it was aimed to evaluate the in vitro potential synergistic antibacterial effect of Lavandula latifolia (spike lavender) essential oil with camphor by using the checkerboard method against the human pathogens; Staphylococcus aureus and Listeria monocytogenes. Pharmacopoeia quality L. latifolia essential oil and racemic camphor were analyzed and verified by GC-FID and GC/MS, simultaneously. In vitro antibacterial activity of essential oil and camphor (MIC range: 0.16–20 mg/mL) and standard antimicrobial clarithromycin (MIC range: 0.125–16 μg/mL) were carried out by broth microdilution against S. aureus and L. monocytogenes standard strains, respectively. Resulting antibacterial effects were evaluated for their fractional inhibitory concentrations (FICs) as antagonistic, additive and synergistic effects. The analytical results showed that the major component of essential oil was linalool (45.2%) and 1,8-cineole (25.6%). Antibacterial effects of essential oil were determined as MIC 1.25–5 mg/mL. As a result of the experiments, L. latifolia essential oil–camphor combinations were identified as “synergistic (FIC ≤ 0.5), and additive (0.5 < FIC ≤ 1)” in the respective combinations, suggesting further evaluation for formulations for potential antimicrobial applications in food and pharmaceuticals.

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Antimicrobial activity, physical, mechanical and barrier properties of sugar palm based nanocellulose/starch biocomposite films incorporated with cinnamon essential oil

Journal of Materials Research and Technology ◽

10.1016/j.jmrt.2020.12.091 ◽

2020 ◽

Author(s):

R. Syafiq ◽

S.M. Sapuan ◽

M.R.M. Zuhri

Keyword(s):

Antimicrobial Activity ◽

Essential Oil ◽

Barrier Properties ◽

Biocomposite Films ◽

Cinnamon Essential Oil

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Antibacterial and antibiofilm activities of cinnamon essential oil nanoemulsion against multi-species oral biofilms

Scientific Reports ◽

10.1038/s41598-021-85375-3 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Yeo-Jin Jeong ◽

Hee-Eun Kim ◽

Su-Jin Han ◽

Jun-Seon Choi

Keyword(s):

Essential Oil ◽

Repeated Measures ◽

Antibacterial Properties ◽

Three Solutions ◽

Bacterial Colony ◽

Biofilm Model ◽

Oral Biofilms ◽

Cinnamon Essential Oil ◽

Cocamidopropyl Betaine ◽

Bovine Enamel

AbstractCinnamon essential oil (CEO) has antibacterial properties, but its ability to suppress the formation of multi-species oral biofilms has not been fully elucidated. This study evaluated the antibacterial and antibiofilm activities of cinnamon essential oil nanoemulsion (CEON) against oral biofilms formed using a microcosm biofilm model. The biofilms were formed on bovine enamel specimens over a 7-day period, during which all specimens were treated with one of three solutions: 5% CEON (n = 35), 0.5% cocamidopropyl betaine (n = 35), or 0.12% chlorhexidine gluconate (CHX; n = 35). Antibacterial and antibiofilm activities were determined by the red/green ratios (R/G values) of 7-day-old mature biofilms photographed with quantitative light-induced fluorescence-digital, the number of aciduric bacterial colony-forming units (CFUs) within each biofilm, and the absorbance of bacterial suspensions. One-way and repeated-measures analysis of variance were performed to compare differences among the three solutions. R/G values were lowest in the 0.12% CHX group, but not significantly differ from the 5% CEON group. The number of CFUs and absorbance were lowest in the 5% CEON group. This study showed that nanoemulsified CEO inhibited the maturation of multi-species oral biofilms and the growth of oral microorganisms in biofilms, including aciduric bacteria that cause dental caries.

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Fabrication of kappa–carrageenan hydrogels with cinnamon essential oil/hydroxypropyl–β–cyclodextrin composite: Evaluation of physicochemical properties, release kinetics and antimicrobial activity

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2020.12.176 ◽

2021 ◽

Vol 170 ◽

pp. 593-601

Author(s):

Yanli Wang ◽

Chao Yuan ◽

Yawei Liu ◽

Bo Cui

Keyword(s):

Antimicrobial Activity ◽

Essential Oil ◽

Physicochemical Properties ◽

Release Kinetics ◽

Cinnamon Essential Oil ◽

Kappa Carrageenan

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Development of New Generation Bone Graft Material: Silver, Silicon Co-Substituted Apatite with Bi-Functional Properties

MRS Proceedings ◽

10.1557/opl.2014.44 ◽

2014 ◽

Vol 1626 ◽

Cited By ~ 2

Author(s):

Poon Nian Lim ◽

Lei Chang ◽

Bow Ho ◽

Bee Yen Tay ◽

Choong Cleo ◽

...

Keyword(s):

Bone Graft ◽

Functional Properties ◽

Bone Mineral ◽

Antibacterial Property ◽

Synergistic Effects ◽

Precipitation Method ◽

Type I ◽

Ageing Population ◽

Graft Material ◽

Medical Needs

ABSTRACTWith the rise of ageing population, the need to restore the function of degenerative bone greatly drives the market for bone grafts. Hydroxyapatite (HA) is chemically similar to natural bone mineral and has been widely used in bone graft applications. However, its slow osseointegration process and lack of antibacterial property could lead to implant-related infection, resulting in implant failure. Studies on ionic substitution of apatite have gained attention in recent years with greater understanding of the composition of bone mineral being a multi-substituted apatite. An integrated approach is proposed by co-substituting silver (Ag) and silicon (Si) into HA (Ag,Si-HA) to modify its surface for bi-functional properties. Incorporation of Si can enhance the biomineralization of HA and introduction of Ag can create antibacterial property. Ag,Si-HA containing 0.5 wt.% of Ag and 0.8 wt.% of Si was prepared by a wet precipitation method. A phase-pure apatite with a nanorod morphology of dimensions 60 nm in length and 10 nm in width was synthesized. Surface Ag+ ions of Ag,Si-HA were demonstrated to prevent the replication of adherent Staphylococcus aureus bacteria for up to 120 h. Biocompatibility tests revealed that human adipose-derived mesenchymal stem cells (hMSCs) proliferated well on Ag,Si-HA with culturing time. Enhanced cell attachment in turn permitted greater bone differentiation as evidenced in the increase of collagen type I and osteocalcin expressions of hMSCs cultured on Ag,Si-HA as compared to HA from day 14 onwards. Overall, co-substitution of Ag and Si could complement the benefits of each substituent by endowing HA with antibacterial property, and concurrently promoting its biological performance. Their synergistic effects can serve unmet medical needs and solve the problem of implant-related infection. This work also enhances the understanding of substituted apatite with multiple ions for bi-functional properties.

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