Influence of insulin sensitivity and secretion on glycated albumin and hemoglobin A1c in pregnant women with gestational diabetes mellitus

Background: Gestational Diabetes Mellitus (GDM) is a public health problem in India with implications well pronounced in pregnancy and beyond. Biomarkers like Glycated Albumin (G.A.) can well monitor the glycaemic status and evaluate the transient hyperglycaemic spikes, which account for the diabetic complications. Aims and Objectives: In this study, we intend to study urinary G.A. excretion with respect to urinary albumin excretion expressed as UGA% in gestational diabetes mellitus. Materials and Methods: A prospective observational study was conducted for a period of 16 months on 177 pregnant women who attended antenatal clinics for the first time at a single centre.Among the surveyed population, 26 pregnant women subsequently developed GDM, and 31 healthy pregnant women who did not develop GDM were included in the study. Results: The UGA% between GDM and healthy mothers showed an increase in GDM with a p value <0.05 during the first and second trimesters. Pearson’s correlation coefficient at 5% interval showed moderate to strong correlation for fasting plasma glucose (FBS) vs UGA% in 1st trimester(r= 0.61) and 3rd trimester(r=0.54). Conclusion: The higher UGA% in GDM mothers in the early trimester may help monitor glycaemic status efficiently and timely. Long term follows up would be worthwhile to predict future progression to nephropathy, retinopathy, and neuropathy. Henceforth, UGA being a non-invasive marker may emerge as a more patient-friendly marker reducing the hassles of innumerable invasive tests to monitor the well-being of a mother aswell as a foetus during pregnancy.

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Differences in insulin sensitivity in pregnant women with overweight and gestational diabetes mellitus

Gynecological Endocrinology ◽

10.1080/09513590600724836 ◽

2006 ◽

Vol 22 (6) ◽

pp. 343-349 ◽

Cited By ~ 39

Author(s):

Satoko Endo ◽

Kazuhisa Maeda ◽

Masanori Suto ◽

Takashi Kaji ◽

Mikio Morine ◽

...

Keyword(s):

Diabetes Mellitus ◽

Insulin Sensitivity ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women

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Myoinositol in the Prevention of Gestational Diabetes Mellitus: Is It Sensible?

Journal of Diabetes Research ◽

10.1155/2019/3915253 ◽

2019 ◽

Vol 2019 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Angelika Sobota-Grzeszyk ◽

Mariusz Kuźmicki ◽

Jacek Szamatowicz

Keyword(s):

Diabetes Mellitus ◽

Insulin Sensitivity ◽

Side Effects ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Adverse Outcomes ◽

Diagnosis And Treatment

Gestational diabetes mellitus (GDM) is a complication that increasingly affects pregnant women. Due to the risk of adverse outcomes in the mother as well as in the fetus which is caused by GDM, appropriate diagnosis and treatment is very essential. Nevertheless, it is important to find new, effective ways of prevention of GDM to avoid side effects. A promising example of such an action may be supplementation of myoinositol. As shown in studies, myoinositol may reduce the risk of developing gestational diabetes mellitus by improving insulin sensitivity.

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Insulin sensitivity and plasma glucose response to aerobic exercise in pregnant women at risk for gestational diabetes mellitus

Ethiopian Journal of Health Sciences ◽

10.4314/ejhs.v26i5.2 ◽

2016 ◽

Vol 26 (5) ◽

pp. 409 ◽

Cited By ~ 10

Author(s):

Heba Embaby ◽

Enas Elsayed ◽

Mohamed Fawzy

Keyword(s):

Diabetes Mellitus ◽

At Risk ◽

Insulin Sensitivity ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Aerobic Exercise ◽

Pregnant Women ◽

Plasma Glucose ◽

Glucose Response

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Diagnostic value of glycemic markers HbA1c, 1,5-anhydroglucitol and glycated albumin in evaluating gestational diabetes mellitus

Therapeutic Advances in Endocrinology and Metabolism ◽

10.1177/2042018817742580 ◽

2017 ◽

Vol 8 (12) ◽

pp. 161-167 ◽

Cited By ~ 6

Author(s):

Baris Saglam ◽

Sezer Uysal ◽

Sadik Sozdinler ◽

Omer Erbil Dogan ◽

Banu Onvural

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Glucose Tolerance ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Glycated Albumin ◽

Tolerance Test ◽

Oral Glucose ◽

Significant Difference ◽

Glycemic Markers

Background: The oral glucose tolerance test (OGTT) is the current established method performed worldwide to diagnose gestational diabetes mellitus (GDM). The purpose of this study was to assess the utility of the use of long- and short-term markers of glycemic status. Methods: The study group was composed of 80 pregnant women, 40 with GDM and 40 with normal glucose tolerance. GDM was diagnosed with the American Diabetes Association criteria. Glycemic markers were measured in the OGTT blood samples of women at 24–28 weeks of gestation. Results: HbA1c was significantly higher in the GDM group when compared with the controls, whereas 1,5-anhydroglucitol (1,5-AG) levels were significantly lower. There was not a significant difference between the groups for glycated albumin. Whereas HbA1c levels were correlated with fasting and 1 h glucose and negatively correlated with mean corpuscular volume, 1,5-AG was only negatively correlated with the first hour glucose. No difference was found for the diagnostic performances of HbA1c and 1,5-AG (receiver operating characteristic of the area under the concentration curve values were 0.756 and 0.722, respectively). Conclusion: HbA1c and 1,5-AG alone does not have sufficient diagnostic accuracy to diagnose GDM. 1,5-AG values were correlated with post-load glucose values in pregnant women so will improve the GDM management and be useful to predict complications.

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Changes of Serum Adiponectin and Glycated Albumin Levels in Gestational Diabetes Mellitus Patients and Their Relationship with Insulin Resistance

Iranian Journal of Public Health ◽

10.18502/ijph.v49i7.3578 ◽

2020 ◽

Author(s):

Qingju WANG ◽

Juan DU ◽

Fenglian LIU

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Glycated Albumin ◽

Serum Adiponectin ◽

Control Group ◽

Childbearing Age ◽

And Control

Background: We aimed to investigate the changes of serum adiponectin and glycated albumin (GA) levels in gestational diabetes mellitus patients and their relationship with insulin resistance. Methods: Overall, 137 pregnant women were enrolled from Jinan City People's Hospital, Laiwu District, China from Jan 2015 to Jun 2018. Among them, 71 pregnant women with gestational diabetes mellitus were examined as diabetes group, and 66 normal pregnant women as normal pregnant women group. In addition, 58 normal non-pregnant women of childbearing age who were examined in our hospital during the same period were selected as a control group. The serum adiponectin and GA levels of the three groups were compared, and the relationship between serum adiponectin, GA levels and insulin resistance was analyzed. Results: The serum adiponectin level of pregnant women in gestational diabetes mellitus (GDM) group was significantly lower than that of normal pregnant women and control group (P=0.031, P=0.027). The serum GA level of pregnant women in GDM group was significantly higher than that of normal pregnant women and control group (P<0.001). Pearson correlation analysis showed that GA was positively correlated with Fasting plasma glucose (FPG), Fasting insulin (FINS) and Insulin resistance index(HOMA-IR) levels (P<0.001), while adiponectin was negatively correlated with FPG FINS and HOMA-IR levels (P<0.001). Conclusion: Abnormal levels of serum GA and adiponectin are closely related to insulin resistance in patients with gestational diabetes mellitus. Detection of serum GA and adiponectin levels can diagnose gestational diabetes mellitus quickly and effectively.

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Thyroid function in pregnant women; relation to Gestational Diabetes Mellitus (GDM) and Body Mass Index (BMI)

Endocrine Abstracts ◽

10.1530/endoabs.56.gp264 ◽

2018 ◽

Author(s):

George Simeakis ◽

Evangelia Vogiatzi ◽

Panagiota Konstantakou ◽

Evangelia Zapanti ◽

Katerina Saltiki ◽

...

Keyword(s):

Diabetes Mellitus ◽

Body Mass Index ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Body Mass ◽

Thyroid Function

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86-LB: Elevated First-Trimester Neutrophil Count Is Associated with the Development of Gestational Diabetes Mellitus in Pregnant Women

Diabetes ◽

10.2337/db19-86-lb ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 86-LB

Author(s):

TIANGE SUN ◽

FANHUA MENG ◽

RUI ZHANG ◽

ZHIYAN YU ◽

SHUFEI ZANG ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Neutrophil Count ◽

First Trimester

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Thyroid Dysfunction in Pregnant Women with Gestational Diabetes Mellitus

Current Diabetes Reviews ◽

10.2174/1573399816666191223111833 ◽

2020 ◽

Vol 16 (8) ◽

pp. 895-899 ◽

Cited By ~ 1

Author(s):

Shahin Safian ◽

Farzaneh Esna-Ashari ◽

Shiva Borzouei

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Thyroid Dysfunction ◽

Control Group ◽

Thyroid Peroxidase ◽

Free T4 ◽

Significant Difference ◽

Experimental Group

Aims: Investigation thyroid dysfunction and autoimmunity in pregnant women with gestational diabetes mellitus. Background: This article was written to evaluate the thyroid function and anti-thyroid peroxidase (anti- TPO) antibodies in pregnant women with gestational diabetes mellitus (GDM). Method: A total of 252 women with GDM and 252 healthy pregnant women were enrolled. Thyroid tests, including TSH, FreeT3, Free T4, and anti-TPO were performed for all women at 24–28 weeks of gestation. Data analysis was then carried out using SPSS ver. 22. Result: There was a significant difference between the experimental group (38.4%) and the control group (14.06%) in terms of the prevalence of subclinical hypothyroidism (p= 0.016). The frequency of anti-TPO was higher in the experimental group than the control group and positive anti-TPO was observed in 18.6% of women with GDM and 10.3% of healthy pregnant women (P= 0.008). Conclusion: Thyroid disorders are observed in pregnant women with GDM more frequently than healthy individuals and it may be thus reasonable to perform thyroid tests routinely.

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