A Study on Urinary Glycated Albumin to urinary albumin excretion in gestational diabetes mellitus

Background: Gestational Diabetes Mellitus (GDM) is a public health problem in India with implications well pronounced in pregnancy and beyond. Biomarkers like Glycated Albumin (G.A.) can well monitor the glycaemic status and evaluate the transient hyperglycaemic spikes, which account for the diabetic complications. Aims and Objectives: In this study, we intend to study urinary G.A. excretion with respect to urinary albumin excretion expressed as UGA% in gestational diabetes mellitus. Materials and Methods: A prospective observational study was conducted for a period of 16 months on 177 pregnant women who attended antenatal clinics for the first time at a single centre.Among the surveyed population, 26 pregnant women subsequently developed GDM, and 31 healthy pregnant women who did not develop GDM were included in the study. Results: The UGA% between GDM and healthy mothers showed an increase in GDM with a p value <0.05 during the first and second trimesters. Pearson’s correlation coefficient at 5% interval showed moderate to strong correlation for fasting plasma glucose (FBS) vs UGA% in 1st trimester(r= 0.61) and 3rd trimester(r=0.54). Conclusion: The higher UGA% in GDM mothers in the early trimester may help monitor glycaemic status efficiently and timely. Long term follows up would be worthwhile to predict future progression to nephropathy, retinopathy, and neuropathy. Henceforth, UGA being a non-invasive marker may emerge as a more patient-friendly marker reducing the hassles of innumerable invasive tests to monitor the well-being of a mother aswell as a foetus during pregnancy.

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Influence of insulin sensitivity and secretion on glycated albumin and hemoglobin A1c in pregnant women with gestational diabetes mellitus

International Journal of Gynecology & Obstetrics ◽

10.1016/j.ijgo.2013.01.017 ◽

2013 ◽

Vol 121 (3) ◽

pp. 252-256 ◽

Cited By ~ 15

Author(s):

Jiemin Pan ◽

Feng Zhang ◽

Lei Zhang ◽

Yuqian Bao ◽

Minfang Tao ◽

...

Keyword(s):

Diabetes Mellitus ◽

Insulin Sensitivity ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Hemoglobin A1c ◽

Glycated Albumin

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Metagenomic Diversity of Gut Microbiota of Gestational Diabetes Mellitus of Pregnant Women

Biomedika ◽

10.31001/biomedika.v13i1.747 ◽

2020 ◽

Vol 13 (1) ◽

pp. 1-8

Author(s):

Minarti Minarti ◽

Nurhidayat Triananinsi ◽

Nurqalbi Nurqalbi ◽

Sumarni Sumarni ◽

Mudyawati Kamaruddin

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gut Microbiota ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Public Health Problem ◽

Genus Level ◽

Significant Public Health Problem ◽

Significant Public Health ◽

Varied Composition

Gestational Diabetes Mellitus (GDM) is defined as a condition in which a woman without diabetes develops abnormal glucose tolerance that is first recognized during pregnancy. GDM is a significant public health problem with an incidence of 1.9 – 3.6% of all pregnancies in Indonesia. Additionally, women with GDM during pregnancy have a high risk of developing diabetes when they are not pregnant, such as type 2 diabetes (T2D). One alternative variable in the management of T2D globally is gut microbiota. Here, to find out the role of gut microbiota in pregnancy, we characterized the stools of 30 pregnant women, each consisting of fifteen GDM-detected pregnant women, and healthy pregnant women using metagenomic approach with genome analysis by directly isolating genomic DNA from the microbiota ecosystem that occupies the digestive tract. DNA sequencing results were analyzed by MEGA 6 software with the BLASTn algorithm in NCBI. Thus fifteen GDM-detected showed high nucleotide sequence homology with the Proteobacteria at phylum level, and Escherichia, Orchobacterium, Cronobacter, Shigella, Salmonella, Enterobacter, Klebsiella, Kosakonia, Vibrio dan Gamma-Proteobacterium at genus level compared to the healthy pregnant women which found by Firmicutes at phylum level and Ruminococcus, Clostridium, Clostridiales, Lachnospiraceae, Roseburia, Weisella, Eubacterium at genus level had a higher abundance in healthy pregnant women. In this result, we found also one of the fifteen healthy pregnant women showed differential abundance with enrichment of Prevotella species. Gut microbiota of GDM-diagnosed pregnant women has more varied composition, and dominated by the phylum Proteobacteria than in normal pregnant women.

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Diagnostic value of glycemic markers HbA1c, 1,5-anhydroglucitol and glycated albumin in evaluating gestational diabetes mellitus

Therapeutic Advances in Endocrinology and Metabolism ◽

10.1177/2042018817742580 ◽

2017 ◽

Vol 8 (12) ◽

pp. 161-167 ◽

Cited By ~ 6

Author(s):

Baris Saglam ◽

Sezer Uysal ◽

Sadik Sozdinler ◽

Omer Erbil Dogan ◽

Banu Onvural

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Glucose Tolerance ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Glycated Albumin ◽

Tolerance Test ◽

Oral Glucose ◽

Significant Difference ◽

Glycemic Markers

Background: The oral glucose tolerance test (OGTT) is the current established method performed worldwide to diagnose gestational diabetes mellitus (GDM). The purpose of this study was to assess the utility of the use of long- and short-term markers of glycemic status. Methods: The study group was composed of 80 pregnant women, 40 with GDM and 40 with normal glucose tolerance. GDM was diagnosed with the American Diabetes Association criteria. Glycemic markers were measured in the OGTT blood samples of women at 24–28 weeks of gestation. Results: HbA1c was significantly higher in the GDM group when compared with the controls, whereas 1,5-anhydroglucitol (1,5-AG) levels were significantly lower. There was not a significant difference between the groups for glycated albumin. Whereas HbA1c levels were correlated with fasting and 1 h glucose and negatively correlated with mean corpuscular volume, 1,5-AG was only negatively correlated with the first hour glucose. No difference was found for the diagnostic performances of HbA1c and 1,5-AG (receiver operating characteristic of the area under the concentration curve values were 0.756 and 0.722, respectively). Conclusion: HbA1c and 1,5-AG alone does not have sufficient diagnostic accuracy to diagnose GDM. 1,5-AG values were correlated with post-load glucose values in pregnant women so will improve the GDM management and be useful to predict complications.

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Diabetes Mellitus Gestacional com ênfase nas Gestantes de Alto Risco / Gestational Diabetes Mellitus with an emphasis on High-Risk Pregnant Women

ID on line REVISTA DE PSICOLOGIA ◽

10.14295/idonline.v15i58.3328 ◽

2021 ◽

Vol 15 (58) ◽

pp. 278-291

Author(s):

Ana Luiza Almeida da Silva ◽

Ana Paula Silveira Santos ◽

Simei Gleide Silva Matos ◽

Matheus Santos Marques

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

High Risk ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Public Health Problem ◽

High Risk Pregnancy ◽

Mortality Factors ◽

Risk Pregnancy

Resumo: Considerando o Diabetes Mellitus um problema de saúde pública e sendo um dos principais fatores de morbimortalidade no Brasil, torna-se relevante destacar o aumento de casos ocorridos do DMG em gestantes de alto risco. Esta pesquisa teve por objetivo: investigar o perfil clínico do diabetes mellitus gestacional (DMG) e como o mesmo pode levar a uma gravidez de alto risco, sua associação aos fatores de riscos e suas principais complicações. Quanto à metodologia é exclusivamente de caráter bibliográfico. Foi feita uma pesquisa de revisão bibliográfica, a qual utilizou fontes de internet, onde foram aplicados critérios de inclusão e exclusão, chegando a um total de 12 artigos selecionados. A partir desses artigos, a pesquisa verificou que os fatores de riscos associados ao DMG e suas complicações, fazem correlação com a gravidez de alto risco. Assim, se faz necessário o rastreamento e monitoramento, a prevenção, o diagnóstico e tratamento do DMG tanto para a mãe quanto para o feto. Logo é fundamental a atuação do farmacêutico na equipe multidisciplinar, pois contribui desde a gestão, aquisição até a dispensação eficiente dos medicamentos auxiliando de forma a reduzir os riscos, promovendo atenção, cuidado e uma saúde de qualidade às gestantes. Palavras Chave: Diabetes Mellitus. Diabetes Mellitus Gestacional. Gravidez de Alto Risco. Abstract: Considering Diabetes Mellitus a public health problem and one of the main morbidity and mortality factors in Brazil, it is relevant to highlight the increase in cases of GDM in high-risk pregnant women. This research aimed to: investigate the clinical profile of gestacional diabetes mellitus (GDM) and how it can lead to a high-risk pregnancy, its association with risk factors and its main complications. As for the methodology, it is exclusively bibliographic in nature. A bibliographic review research was carried out, using internet sources, where inclusion and exclusion criteria were applied, reaching a total of 12 selected articles. From these articles, the research found that the risk factors associated with GDM and its complications are correlated with high-risk pregnancy. Thus, it is necessary the tracking and monitoring, prevention, diagnosis and treatment of GDM for both mother and fetus. Therefore, the role of the pharmacist in the multidisciplinary team is essential, as he contributes from the management, acquisition to the efficient dispensing of medicines, helping to reduce risks, promoting attention, care and quality health for pregnant women. Keywords: Diabetes Mellitus. Gestational Diabetes Mellitus. High-risk Pregnancy.

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Changes of Serum Adiponectin and Glycated Albumin Levels in Gestational Diabetes Mellitus Patients and Their Relationship with Insulin Resistance

Iranian Journal of Public Health ◽

10.18502/ijph.v49i7.3578 ◽

2020 ◽

Author(s):

Qingju WANG ◽

Juan DU ◽

Fenglian LIU

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Glycated Albumin ◽

Serum Adiponectin ◽

Control Group ◽

Childbearing Age ◽

And Control

Background: We aimed to investigate the changes of serum adiponectin and glycated albumin (GA) levels in gestational diabetes mellitus patients and their relationship with insulin resistance. Methods: Overall, 137 pregnant women were enrolled from Jinan City People's Hospital, Laiwu District, China from Jan 2015 to Jun 2018. Among them, 71 pregnant women with gestational diabetes mellitus were examined as diabetes group, and 66 normal pregnant women as normal pregnant women group. In addition, 58 normal non-pregnant women of childbearing age who were examined in our hospital during the same period were selected as a control group. The serum adiponectin and GA levels of the three groups were compared, and the relationship between serum adiponectin, GA levels and insulin resistance was analyzed. Results: The serum adiponectin level of pregnant women in gestational diabetes mellitus (GDM) group was significantly lower than that of normal pregnant women and control group (P=0.031, P=0.027). The serum GA level of pregnant women in GDM group was significantly higher than that of normal pregnant women and control group (P<0.001). Pearson correlation analysis showed that GA was positively correlated with Fasting plasma glucose (FPG), Fasting insulin (FINS) and Insulin resistance index(HOMA-IR) levels (P<0.001), while adiponectin was negatively correlated with FPG FINS and HOMA-IR levels (P<0.001). Conclusion: Abnormal levels of serum GA and adiponectin are closely related to insulin resistance in patients with gestational diabetes mellitus. Detection of serum GA and adiponectin levels can diagnose gestational diabetes mellitus quickly and effectively.

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Factors Associated With Gestational Diabetes Mellitus in Rural Areas of Limpopo Province: A Descriptive Analysis

10.21203/rs.3.rs-110121/v1 ◽

2020 ◽

Author(s):

Elelwani Thelma Ntshauba ◽

Eric Maimela ◽

Thembelihle Sam Ntuli

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Antenatal Care ◽

Pregnant Women ◽

Well Being ◽

Care Clinic ◽

Healthcare Centre ◽

Clinic Visits

Abstract Background: Sustainable Developmental Goal (SDG) no 3 of the United Nations Organisation places emphasise on ensuring healthy lives and promoting the well-being of all people of all age groups. Yet the prevalence of Gestational Diabetes Mellitus (GDM) is increasing and this can have an adverse impact on maternal and infant health and well-being. Currently, more studies have been conducted in International countries on prevalence and risk factors of GDM and few in South African Context. The current study sought to investigate the prevalence, risk factors, maternal and infant outcomes of women with gestational diabetes mellitus in Mopani District. Methods: A cross-sectional descriptive study was conducted amongst pregnant women during Antenatal Care Clinic Visits at Nkhensani Hospital, Nkhensani Gateway clinic and Giyani Healthcare Centre. Information from participants was collected using adapted questionnaire from Michigan Diabetes Research and Training Centre DCP 2.0 and data entry form, captured on Microsoft excel spread sheet and analysed using Statistical Package for Social Sciences (SPSS) and p-value of <0.05 was considered statistically significant.Results: One hundred and one (101) pregnant women (74%) who were attending antenatal care clinic visits at Nkhensani Hospital, Nkhensani Gateway Clinic and Giyani Healthcare Centre completed the questionnaire. Prevalence of Gestational Diabetes Mellitus (GDM) in Mopani District was 1.9% (2 women). Pregnant women above 30 years with secondary education, employed, obese and at gestational age of 31-35 weeks were more likely to present with GDM. A family history of diabetes was significantly associated with development of GDM. Conclusions: The use of various GDM screening strategies across population and countries resulted in discrepancies in the prevalence rate. Universal GDM screening strategy which will benefit our socioeconomic and clinical context to ensure that the true burden of GDM is determined needs to be adopted.

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Thyroid function in pregnant women; relation to Gestational Diabetes Mellitus (GDM) and Body Mass Index (BMI)

Endocrine Abstracts ◽

10.1530/endoabs.56.gp264 ◽

2018 ◽

Author(s):

George Simeakis ◽

Evangelia Vogiatzi ◽

Panagiota Konstantakou ◽

Evangelia Zapanti ◽

Katerina Saltiki ◽

...

Keyword(s):

Diabetes Mellitus ◽

Body Mass Index ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Body Mass ◽

Thyroid Function

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86-LB: Elevated First-Trimester Neutrophil Count Is Associated with the Development of Gestational Diabetes Mellitus in Pregnant Women

Diabetes ◽

10.2337/db19-86-lb ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 86-LB

Author(s):

TIANGE SUN ◽

FANHUA MENG ◽

RUI ZHANG ◽

ZHIYAN YU ◽

SHUFEI ZANG ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Neutrophil Count ◽

First Trimester

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Thyroid Dysfunction in Pregnant Women with Gestational Diabetes Mellitus

Current Diabetes Reviews ◽

10.2174/1573399816666191223111833 ◽

2020 ◽

Vol 16 (8) ◽

pp. 895-899 ◽

Cited By ~ 1

Author(s):

Shahin Safian ◽

Farzaneh Esna-Ashari ◽

Shiva Borzouei

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Thyroid Dysfunction ◽

Control Group ◽

Thyroid Peroxidase ◽

Free T4 ◽

Significant Difference ◽

Experimental Group

Aims: Investigation thyroid dysfunction and autoimmunity in pregnant women with gestational diabetes mellitus. Background: This article was written to evaluate the thyroid function and anti-thyroid peroxidase (anti- TPO) antibodies in pregnant women with gestational diabetes mellitus (GDM). Method: A total of 252 women with GDM and 252 healthy pregnant women were enrolled. Thyroid tests, including TSH, FreeT3, Free T4, and anti-TPO were performed for all women at 24–28 weeks of gestation. Data analysis was then carried out using SPSS ver. 22. Result: There was a significant difference between the experimental group (38.4%) and the control group (14.06%) in terms of the prevalence of subclinical hypothyroidism (p= 0.016). The frequency of anti-TPO was higher in the experimental group than the control group and positive anti-TPO was observed in 18.6% of women with GDM and 10.3% of healthy pregnant women (P= 0.008). Conclusion: Thyroid disorders are observed in pregnant women with GDM more frequently than healthy individuals and it may be thus reasonable to perform thyroid tests routinely.

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