Ralstonia pickettii bacteremia: An emerging infection in a Tertiary care hospital setting

Objective: Denguefeveris one of the important tropical disease of public health significance caused by flavivirus. It is a major cause of morbidity and mortality worldwide. Identification of factors associated with severity of dengue can improve the prognosis of the disease.This study tried toassess the factors associated with severity of dengue.Methods: A record based study was conducted in a tertiary care hospital setting in southern India. A total of 550 case files were reviewed to ascertain demographic, clinical and laboratory parameters among confirmed cases of dengue. The severity of dengue was categorized using WHO 2009 classification.Results: Of 550 records reviewed, 449 (81.6%) were classified as non-severe dengue and 101 (18.4%) as severe dengue. Factors associated with severe dengue on univariate analysis were: gender, backache, skin rash, nausea and vomiting, abdominal distension, haemorrhage, breathlessness, oliguria, hepatomegaly, splenomegaly, ascites, leukopenia, hypoproteinemia, and elevated serum alanine transaminase (ALT) >63 IU/L.On multivariate analysis,haemorrhage (OR=11.75, 95%; CI=6.38-21.62), oliguria (OR=4.01, 95%; CI=1.32-12.15), ascites (OR=2.68, 95%; CI=1.19-6.01), ALT>63 IU/L (OR=1.77, 95%; CI=1.01-3.1) and hypoproteinemia (OR=5.57, 95%; CI=2.82-10.98) were found to have significant association with the development of severe dengue.Conclusion: This study indicates thatwhen dengue patients present with bleeding episodes, ascites, oliguria,raised ALT and low serum protein levels, clinicians should be alert to the appearance of severe complications. Early identification of these factors will help clinicians to recognise the severity of dengue illness and enable them to implement appropriate interventions.

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High-Quality Draft Genome Sequences of Rare Nontuberculous Mycobacteria Isolated from Surfaces of a Hospital

Microbiology Resource Announcements ◽

10.1128/mra.00496-19 ◽

2019 ◽

Vol 8 (21) ◽

Cited By ~ 1

Author(s):

Igor Tiago ◽

Susana Alarico ◽

Ana Maranha ◽

Catarina Coelho ◽

Sónia Gonçalves Pereira ◽

...

Keyword(s):

Tertiary Care Hospital ◽

Nontuberculous Mycobacteria ◽

Tertiary Care ◽

Draft Genome ◽

Hospital Setting ◽

Multidrug Resistant ◽

Care Hospital ◽

Opportunistic Pathogens ◽

Genome Sequences ◽

High Quality

Nontuberculous mycobacteria (NTM), some of which had multidrug-resistant profiles, were isolated from a tertiary care hospital setting. Although most NTM are nonpathogenic, contamination of hospital surfaces by these opportunistic pathogens poses a health risk to vulnerable inpatients.

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Antihistamines prescribed off-label among paediatric patients at a tertiary care hospital setting in Malaysia

International Journal of Clinical Pharmacy ◽

10.1007/s11096-016-0364-8 ◽

2016 ◽

Vol 38 (5) ◽

pp. 1277-1285 ◽

Cited By ~ 1

Author(s):

Rou Wei Tan ◽

Noraida Mohamed Shah

Keyword(s):

Tertiary Care Hospital ◽

Tertiary Care ◽

Hospital Setting ◽

Care Hospital ◽

Off Label ◽

Paediatric Patients

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Assessment of Perinatal Mortality in a Tertiary Care Hospital by Using Wigglesworth Classification

Bangladesh Journal of Child Health ◽

10.3329/bjch.v31i1.6072 ◽

1970 ◽

pp. 32-39

Author(s):

Lutfun Nahar Begum ◽

Kishwar Azad ◽

Shahida Akhter ◽

Nazmun Nahar ◽

Abu Hasan Md Abdullah

Keyword(s):

Child Health ◽

Key Words ◽

Causes Of Death ◽

Tertiary Care Hospital ◽

Perinatal Death ◽

Perinatal Asphyxia ◽

Tertiary Care ◽

Hospital Setting ◽

Care Hospital ◽

Perinatal Deaths

Objective: To determine the causes of perinatal death using Wigglesworth classification and to assess the feasibility of using Wigglesworth classification in a tertiary care hospital setting. Methods: All live and stillborn babies delivered at BIRDEM over a 5 yr period(from January 2000 to December 2004) were recorded. Perinatal deaths of that period were analysed according to Wigglesworth classification Results: According to Wigglesworth classification, majority of deaths were in the group "macerated stillbirths" (63.5%). Perinatal asphyxia was responsible for 13.6% of deaths, lethal congenital malformation was found in 11.2% and immaturity and "others" each accounted for 6.1%. Conclusion: Macerated stillbirth and asphyxia were the two leading causes of death at BIRDEM and Wigglesworth classification has been found to be feasible in BIRDEM for categorising perinatal deaths retrospectively. Key words: Perinatal death; Wigglesworth classification DOI: 10.3329/bjch.v31i1.6072 Bangladesh Journal of Child Health 2007; Vol.31(1-3): 32-39

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Study of prescription pattern of antimicrobials used in post-operative surgical patients in tertiary care hospital

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20212068 ◽

2021 ◽

Vol 10 (6) ◽

pp. 627

Author(s):

Jitendra H. Hotwani ◽

Nishikant H. Madkholkar

Keyword(s):

Tertiary Care Hospital ◽

Tertiary Care ◽

Total Duration ◽

Hospital Setting ◽

Surgical Site Infections ◽

The Body ◽

Brand Names ◽

Surgical Patients ◽

Care Hospital ◽

Prescription Pattern

Background: Antimicrobials are used for prophylaxis and treatment of infections which occur following surgical procedures, to reduce the morbidity and mortality associated with surgical site infections (SSIs). A surgical site infection is an infection that occurs after surgery in the part of the body where the surgery took place. These are infections of the tissues, organs, or spaces exposed by surgeons during performance of an invasive procedure.Methods: A prospective, non-interventional, observational study in tertiary care hospital for duration of 9 months. Sample size was 330.Results: The prescription pattern shows that nitroimidazoles were the most commonly prescribed group of antimicrobials in 72% of patients followed by penicillins (58%) and cephalosporins (42%). Metronidazole (72%), amoxicillin and clavulanic acid (51.21%) ceftriaxone (20.90%) were most commonly prescribed antimicrobials in these groups. Two antimicrobials were prescribed in 47% patients with nitroimidazole and penicillins being the most commonly prescribed combination of antimicrobial. Three antimicrobials were prescribed in 25% patients and four antimicrobials in 8% patients. This shows trend towards polypharmacy. About 82% of antimicrobials were prescribed by brand names and 64% of total antimicrobials prescribed from outside the hospital pharmacy source. About 12.42% of patients changed antimicrobial therapy after culture and sensitivity report.Conclusions: Total duration, number of anti-microbial used was more in clean-contaminated, contaminated, dirty wound surgeries as compare to clean wound surgeries. Our study provides a framework for continuous prescription audit of antimicrobials in a hospital setting and thus can help in rational use of antimicrobials in post-operative surgical patients.

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Detection of Oxacillin (Methicillin)-resistant Staphylococcus aureus Isolated from a Tertiary-care Hospital, Georgetown, Guyana

Microbiology Research Journal International ◽

10.9734/mrji/2019/v29i630182 ◽

2020 ◽

pp. 1-7

Author(s):

Paul Cheddie ◽

Drovashti Seepersaud ◽

Tereasia Ramlochan

Keyword(s):

Staphylococcus Aureus ◽

Tertiary Care Hospital ◽

Methicillin Resistance ◽

Tertiary Care ◽

Hospital Setting ◽

Tertiary Hospital ◽

Care Hospital ◽

Prevalence Survey ◽

Methicillin Resistant ◽

Broth Microdilution Method

Background and Aim: Methicillin-resistant Staphylocccus aureus (MRSA) continues to be a major problem globally. Previous data had suggested that the prevalence of MRSA infections in the tertiary hospital setting was 51%. The aim of this study was to conduct a point prevalence survey of MRSA infections occurring at a tertiary-care hospital in Georgetown, Guyana, and to determine to what extent methicillin-resistance was occurring among Staphylococcus aureus isolates utilising the minimum inhibitory concentration (MIC) data. Study Design: This study was based on a prospective, analytical design. Place and Duration of Study: Microbiology department, Georgetown Public Hospital Corporation (GPHC), and Department of Medical Technology, University of Guyana, between May 2019 and July 2019. Methodology: A total of 101 consecutive, non-repetitive, laboratory-identified MRSA and methicillin-susceptible Staphylococcus aureus (MSSA) isolates were tested using an oxacillin broth microdilution method. Results: We found that 65.4% of Staphylococcus aureus were oxacillin (methicillin) resistant with a majority of the isolates being high level oxacillin resistant strains (i.e., MICs > 256 μg/ml) (84.85%). Most of the resistant isolates were collected from patients admitted to medical and surgical wards. Conclusion: Methicillin-resistance continues to be a major problem in the hospital setting and conventional techniques are unlikely to identify all of the potentially resistant isolates.

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SARS-CoV-2 antibody seroprevalence and stability in a tertiary care hospital-setting

10.1101/2020.09.02.20186486 ◽

2020 ◽

Author(s):

Samreen Siddiqui ◽

Salwa Naushin ◽

Shalini Pradhan ◽

Archa Misra ◽

Akansha Tyagi ◽

...

Keyword(s):

General Population ◽

Tertiary Care Hospital ◽

Venous Blood ◽

Tertiary Care ◽

Hospital Setting ◽

Care Hospital ◽

Asymptomatic Individuals ◽

The Stability ◽

Roche Diagnostics ◽

Cumulative Prevalence

Background: SARS-CoV-2 infection has caused 64,469 deaths in India, with 7, 81, 975 active cases till 30th August 2020, lifting it to 3rd rank globally. To estimate the burden of the disease with time it is important to undertake a longitudinal seroprevalence study which will also help to understand the stability of anti SARS-CoV-2 antibodies. Various studies have been conducted worldwide to assess the antibody stability. However, there is very limited data available from India. Healthcare workers (HCW) are the frontline workforce and more exposed to the COVID-19 infection (SARS-CoV-2) compared to the community. This study was conceptualized with an aim to estimate the seroprevalence in hospital and general population and determine the stability of anti SARS-CoV-2 antibodies in HCW. Methods: Staff of a tertiary care hospital in Delhi and individuals visiting that hospital were recruited between April to August 2020. Venous blood sample, demographic, clinical, COVID-19 symptoms, and RT-PCR data was collected from all participants. Serological testing was performed using the electro-chemiluminescence based assay developed by Roche Diagnostics, in Cobas Elecsys 411. Seropositive participants were followed- upto 83 days to check for the presence of antibodies. Results: A total of 780 participants were included in this study, which comprised 448 HCW and 332 individuals from the general population. Among the HCW, seroprevalence rates increased from 2.3% in April to 50.6% in July. The cumulative prevalence was 16.5% in HCW and 23.5% (78/332) in the general population with a large number of asymptomatic individuals. Out of 74 seropositive HCWs, 51 were followed-up for the duration of this study. We observed that in all seropositive cases the antibodies were sustained even up to 83 days. Conclusion: The cumulative prevalence of seropositivity was lower in HCWs than the general population. There were a large number of asymptomatic cases and the antibodies developed persisted through the duration of the study. More such longitudinal serology studies are needed to better understand the antibody response kinetics.

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ANALYSIS OF APPLICABILITY OF TOOLS OF INVENTORY CONTROL AND KNOWLEDGE OF HOSPITAL PHARMACISTS ON METHODS OF INVENTORY IN THE CENTRAL PHARMACY OF A TERTIARY CARE HOSPITAL

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2019v11i8.32390 ◽

2019 ◽

pp. 11-16

Author(s):

SAI ASHWINI R. ◽

SAI CHOWDRY B. ◽

SAI SANNIHITHA B. ◽

SENTHIL RAJ V. ◽

VANITHA RANI N. ◽

...

Keyword(s):

Inventory Control ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Hospital Setting ◽

Unit Price ◽

Care Hospital ◽

Inventory Analysis ◽

Hospital Pharmacists ◽

Abc Analysis ◽

Structured Questionnaire

Objective: A study was conducted to analyse the applicability of the tools of inventory control of drugs, and the awareness of hospital pharmacists on the inventory tools in the central pharmacy of a tertiary care hospital. Methods: Always Better Control (ABC) and High Moderate Low (HML) analysis were carried out for 4057 drugs purchased in the central pharmacy during the financial year of 2017-2018. The drugs were classified as A, B and C category based on their annual usage value and as Category High (H), Moderate (M) and low (L) drugs based on their unit price respectively. The knowledge of the 80 hospital pharmacists on the tools of inventory control was assessed using a structured questionnaire. Results: Based on ABC analysis, of 4057 drugs, 330 drugs were classified under “A” category accounting to 8.13% of the total number of drugs purchased which was 70.91 % of total annual consumption in money value. The category “B” consisted of 667 drugs accounting to 16.44% of the total number of drugs which was 20.01% of total annual money consumption. Category “C” had 3060 drugs which accounted to 75.42% of the total number of drugs purchased which reflected on 9.01% of annual money consumption. Based on HML analysis, 440 drugs (10%) had a unit price above Rs. 500 and were classified under ‘H’ category. The drugs with unit price between Rs.500 and Rs.100 were grouped as ‘M’ items. There were 695 drugs (17.13%) in ‘M’ category. The ‘L’ category consisted of 2922 drugs (72.02%) with their unit price below Rs.100. Of 80 pharmacists, 84 % had good overall knowledge on the inventory control tools and 59 participants were willing to acquire additional training on inventory control techniques. Conclusion: The study explained the need for the application of ABC and HML analysis, and the involvement of hospital pharmacists in the regular implementation of inventory analysis towards effective management of Pharmacy stores in a hospital setting.

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