Internalization of particulate delivery systems by activated microglia influenced the therapeutic efficacy of simvastatin repurposing for neuroinflammation

2019 ◽  
Vol 570 ◽  
pp. 118690 ◽  
Author(s):  
Dharani Manickavasagam ◽  
Moses O. Oyewumi
Keyword(s):  
Therapeutic Efficacy ◽  
Delivery Systems ◽  
Activated Microglia ◽  
Particulate Delivery

Improved Therapeutic Efficacy of Topotecan Against A549 Lung Cancer Cells with Folate-targeted Topotecan Liposomes

2020 ◽  
Vol 21 (11) ◽  
pp. 902-909
Author(s):  
Jingxin Zhang ◽  
Weiyue Shi ◽  
Gangqiang Xue ◽  
Qiang Ma ◽  
Haixin Cui ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Lung Tumor ◽  
A549 Cells ◽  
Delivery Systems ◽  
Lung Cancer Cells

Background: Among all cancers, lung cancer has high mortality among patients in most of the countries in the world. Targeted delivery of anticancer drugs can significantly reduce the side effects and dramatically improve the effects of the treatment. Folate, a suitable ligand, can be modified to the surface of tumor-selective drug delivery systems because it can selectively bind to the folate receptor, which is highly expressed on the surface of lung tumor cells. Objective: This study aimed to construct a kind of folate-targeted topotecan liposomes for investigating their efficacy and mechanism of action in the treatment of lung cancer in preclinical models. Methods: We conjugated topotecan liposomes with folate, and the liposomes were characterized by particle size, entrapment efficiency, cytotoxicity to A549 cells and in vitro release profile. Technical evaluations were performed on lung cancer A549 cells and xenografted A549 cancer cells in female nude mice, and the pharmacokinetics of the drug were evaluated in female SD rats. Results: The folate-targeted topotecan liposomes were proven to show effectiveness in targeting lung tumors. The anti-tumor effects of these liposomes were demonstrated by the decreased tumor volume and improved therapeutic efficacy. The folate-targeted topotecan liposomes also lengthened the topotecan blood circulation time. Conclusion: The folate-targeted topotecan liposomes are effective drug delivery systems and can be easily modified with folate, enabling the targeted liposomes to deliver topotecan to lung cancer cells and kill them, which could be used as potential carriers for lung chemotherapy.

Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

2018 ◽  
Vol 14 (5) ◽  
pp. 432-439 ◽  
Author(s):  
Juliana M. Juarez ◽  
Jorgelina Cussa ◽  
Marcos B. Gomez Costa ◽  
Oscar A. Anunziata
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
The Body ◽  
Fickian Diffusion ◽  
Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

scholarly journals Enhanced topical delivery of dexamethasone by β-cyclodextrin decorated thermoresponsive nanogels

Nanoscale ◽  
2018 ◽  
Vol 10 (1) ◽  
pp. 469-479 ◽  
Author(s):  
M. Giulbudagian ◽  
S. Hönzke ◽  
J. Bergueiro ◽  
D. Işık ◽  
F. Schumacher ◽  
...  
Keyword(s):  
Topical Delivery ◽  
Delivery Systems ◽  
Penetration Enhancers ◽  
Particulate Delivery

Particulate delivery systems combined with conventional penetration enhancers show superiority in delivering dexamethasone into the viable skin layers.

Development and validation of an in vitro release method for topical particulate delivery systems

2015 ◽  
Vol 485 (1-2) ◽  
pp. 202-214 ◽  
Author(s):  
Maja Lusina Kregar ◽  
Marjana Dürrigl ◽  
Andrea Rožman ◽  
Želimir Jelčić ◽  
Biserka Cetina-Čižmek ◽  
...  
Keyword(s):  
In Vitro Release ◽  
Delivery Systems ◽  
Particulate Delivery ◽  
Development And Validation ◽  
Release Method ◽  
Vitro Release

Comparing the therapeutic efficacy of different amphotericin B-carrying delivery systems against visceral leishmaniasis

2018 ◽  
Vol 186 ◽  
pp. 24-35 ◽  
Author(s):  
Débora V.C. Mendonça ◽  
Vívian T. Martins ◽  
Daniela P. Lage ◽  
Daniel S. Dias ◽  
Patrícia A.F. Ribeiro ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Amphotericin B ◽  
Therapeutic Efficacy ◽  
Delivery Systems

The Application of High-Content Analysis in the Study of Targeted Particulate Delivery Systems for Intracellular Drug Delivery to Alveolar Macrophages

2011 ◽  
Vol 8 (4) ◽  
pp. 1100-1112 ◽  
Author(s):  
Ciaran Lawlor ◽  
Mary P. O’Sullivan ◽  
Neera Sivadas ◽  
Seonadh O’Leary ◽  
Paul J. Gallagher ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Content Analysis ◽  
Alveolar Macrophages ◽  
Delivery Systems ◽  
Intracellular Drug Delivery ◽  
High Content Analysis ◽  
Particulate Delivery

Particulate delivery systems for animal vaccines

Methods ◽  
2006 ◽  
Vol 40 (1) ◽  
pp. 118-124 ◽  
Author(s):  
Jean-Pierre Y. Scheerlinck ◽  
Deanne L.V. Greenwood
Keyword(s):  
Delivery Systems ◽  
Particulate Delivery

scholarly journals Nanotechnology-Based Topical Drug Delivery Systems for Management of Dandruff and Seborrheic Dermatitis: An overview

2020 ◽  
Vol 29 (1) ◽  
pp. 12-32
Author(s):  
Lena M. Thomas ◽  
Abeer H. Khasraghi
Keyword(s):  
Drug Delivery ◽  
Patient Compliance ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Seborrheic Dermatitis ◽  
Delivery Systems ◽  
Drug Formulation ◽  
Topical Drug Delivery ◽  
Skin Disorders ◽  
Common Skin

Dandruff and seborrheic dermatitis (SD) are common skin disorders affecting the scalp and extending to other body sites in the case of SD. They are associated with pruritus and scaling, causing an esthetical disturbance in the population affected.   Treatment of such conditions involves using a variety of drugs for long terms, thus optimizing drug formulation is essential to improve therapeutic efficacy and patient compliance. Conventional topical formulations like shampoos and creams have been widely used but their use is associated with disadvantages. To overcome such effects, novel topical nanotechnology-based formulations are currently under investigation. In the following article, we highlight recently published formulation approaches used to improve topical dandruff/SD therapy

The potential application of novel drug delivery systems for phytopharmaceuticals and natural extracts – current status and future perspectives

2020 ◽  
Vol 20 ◽  
Author(s):  
Mohamad Fawzi Mahomoodally ◽  
Nabeelah Sadeer ◽  
Mehtaab Edoo ◽  
Katharigatta N. Venugopala
Keyword(s):  
Drug Delivery ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Current Status ◽  
Novel Technologies ◽  
Alternative Drug ◽  
Low Toxicity ◽  
Novel Drug ◽  
Herbal Formulations

: Phytocompounds isolated from plants are well appraised for their broad pharmacological propensities in several pathologies. One key benefit of phytoconstituents is their relatively low toxicity and adverse effects. Nonetheless, poor solubility, permeation, and poor specificity at the target site tend to hinder its therapeutic efficacy. Hence, novel technologies for drug delivery systems are being developed via the use of various nanoformulation strategies to overcome these challenges and give uniform medication focusing at the dynamic site in desired concentration and improved therapeutic efficacy. Such approaches comprise of novel drug delivery systems (NDDS). The utilisation of herbal formulations for NDDS is more beneficious and advantageous as opposed to others. The utilisation of ethosome, liposome, emulsion, phytosomes, microsphere, and strong lipid nanoparticles of herbal formulation have improved the remedial impacts of plant extricates. With the utilisation of all these, directed delivery of the formulation is accomplished, because of which the formulation exhibits impact on the site, and the bioavailability of the formulation is likewise expanded. With these novel medication conveyance frameworks, the actives and concentrates which are utilised as part of natural formulations exhibit sustained release of formulation, enhancement in stability, improved therapeutic efficacy, and protection from toxicity. The primary motivation behind creating alternative drug delivery technologies is to expand the effectiveness of drug conveyance and safety in the process of drug conveyance and give more comfort to the patient. In this review, the importance of various phytocompounds in the delivery of drugs are highlighted as well as their importance in reducing the risk or diseases.

Sign in / Sign up

Export Citation Format

Share Document