The potential application of novel drug delivery systems for phytopharmaceuticals and natural extracts – current status and future perspectives

2020 ◽  
Vol 20 ◽  
Author(s):  
Mohamad Fawzi Mahomoodally ◽  
Nabeelah Sadeer ◽  
Mehtaab Edoo ◽  
Katharigatta N. Venugopala
Keyword(s):  
Drug Delivery ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Current Status ◽  
Novel Technologies ◽  
Alternative Drug ◽  
Low Toxicity ◽  
Novel Drug ◽  
Herbal Formulations

: Phytocompounds isolated from plants are well appraised for their broad pharmacological propensities in several pathologies. One key benefit of phytoconstituents is their relatively low toxicity and adverse effects. Nonetheless, poor solubility, permeation, and poor specificity at the target site tend to hinder its therapeutic efficacy. Hence, novel technologies for drug delivery systems are being developed via the use of various nanoformulation strategies to overcome these challenges and give uniform medication focusing at the dynamic site in desired concentration and improved therapeutic efficacy. Such approaches comprise of novel drug delivery systems (NDDS). The utilisation of herbal formulations for NDDS is more beneficious and advantageous as opposed to others. The utilisation of ethosome, liposome, emulsion, phytosomes, microsphere, and strong lipid nanoparticles of herbal formulation have improved the remedial impacts of plant extricates. With the utilisation of all these, directed delivery of the formulation is accomplished, because of which the formulation exhibits impact on the site, and the bioavailability of the formulation is likewise expanded. With these novel medication conveyance frameworks, the actives and concentrates which are utilised as part of natural formulations exhibit sustained release of formulation, enhancement in stability, improved therapeutic efficacy, and protection from toxicity. The primary motivation behind creating alternative drug delivery technologies is to expand the effectiveness of drug conveyance and safety in the process of drug conveyance and give more comfort to the patient. In this review, the importance of various phytocompounds in the delivery of drugs are highlighted as well as their importance in reducing the risk or diseases.

Effect of NDDS on Polyherbal Formulation

2021 ◽  
pp. 106-148
Author(s):  
Sandeep Onkar Waghulde ◽  
Nilofar A. Khan ◽  
Nilesh Gorde
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Therapeutic Potential ◽  
Polymeric Nanoparticles ◽  
Delivery Systems ◽  
Plant Materials ◽  
Ancient Times ◽  
Reduced Toxicity ◽  
Novel Drug ◽  
Herbal Formulations

In India, in ancient times, people used plant materials to make drug polyherbal formulations. Herbal drugs have enormous therapeutic potential which can be explored through various beneficial drug delivery systems and novel drug delivery systems. Great advancement has been made in the uses of plant therapeutics on the development of novel herbal formulations like polymeric nanoparticles, nanocapsules, liposomes, phytosomes, nanoemulsions, microsphere, transferosomes, and ethosomes. These formulations have reported having various advantages over the traditional formulations such as improved solubility and bioavailability, reduced toxicity, controlled drug delivery, protections of plant actives from degradation. Also, having the drug targeting properties with improved selectivity, drug delivery, and effectiveness with dose reduction not only increases the safety but also patient compliance.

NANO-CARRIER BASED DRUG DELIVERY SYSTEMS CONTAINING BIOACTIVE FROM CARICA PAPAYA FOR ANTI-DIABETIC ACTIVITY

2021 ◽  
Vol 11 (6) ◽  
pp. 9-15
Author(s):  
Rima Ramesh Patil
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Carica Papaya ◽  
Polymeric Nanoparticles ◽  
Delivery Systems ◽  
Patient Comfort ◽  
Synthetic Drugs ◽  
Therapeutic Benefits ◽  
Alternative Drug ◽  
Novel Drug

Significant progress has been achieved in the creation of novel drug delivery systems based on herbal bioactive in recent years. Herbal formulations for novel drug delivery systems are more efficient and have more benefits than other alternatives. Papaya (Carica papaya Linn) is very popular for its nutritious as well as therapeutic benefits all over the world. Carica papaya is a tropical and subtropical fruit that is used as a vegetable and in herbal medicine to treat a variety of ailments. The rising prevalence of diabetes, along with the harsh side effects of some synthetic drugs, has prompted an increase in the search for natural alternatives. Liposomes, phytosomes, ethosomes microspheres, nano-capsules, transferosomes, polymeric nanoparticles, nano-emulsions, and nano-emulsions have all been developed using bioactive and plant extracts. The primary motivation for the advancement of alternative drug delivery is to improve drug delivery quality and safety while also providing greater patient comfort.

Enhancing the Therapeutic Efficacy of Flavonoids as Anticancer Drugs Through Novel Drug Delivery Systems

2021 ◽  
pp. 207-229
Author(s):  
Anamika Basu
Keyword(s):  
Drug Delivery ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Fruits And Vegetables ◽  
Delivery Systems ◽  
Inorganic Nanoparticles ◽  
Therapeutic Uses ◽  
Different Types ◽  
Traditional Drug ◽  
Novel Drug

Flavonoids are a group of heterocyclic compounds that are well-known for their anti-cancer activity. Fruits and vegetables are the main dietary sources of flavonoids. Several mechanisms have been proposed for the effect of flavonoids to combat cancer. But before considering the flavonoids as chemotherapeutic drugs for cancer, a number of problems still need to be addressed before their therapeutic uses. Solubility may play a major role in the therapeutic efficacy of flavonoids. Bioavailability of flavonoids are also affected by several other factors. Nanotechnology is the most efficient tool to solve the problems of solubility, stability, and oral bioavailability. Nanotechnology-based drug delivery has several benefits compared to the traditional drug delivery systems. Different types of nano delivery systems are used for producing nanomedicines such as lipid-based nanomedicines, polymer-based nanomedicines, and inorganic nanoparticles. Different types of flavonoids encapsulated nanoparticles have been developed to improve their effectiveness against different types of cancer.

scholarly journals Phytosomes: A Promising Strategy for Enhanced Therapeutic Beneϐits of Phytochemicals

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 3157-3163
Author(s):  
Kamal Saroha ◽  
Parul Waliyan ◽  
Rakesh Pahwa ◽  
Shweta Pal ◽  
Inderbir Singh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Herbal Extract ◽  
Herbal Extracts ◽  
Promising Strategy ◽  
Pharmacodynamic Profile ◽  
Novel Drug ◽  
Herbal Formulations ◽  
Phytochemical Constituent

Phytosomes are phytochemical based novel drug delivery systems that lead to better absorption, greater bioavailability in addition to improved therapeutic efficacy of numerous phytoconstituents. It is a supremely advanced form of herbal formulations which contains the active phytoconstituent of herbal extract bound by phospholipid molecule. Additionally, these also act as vesicular systems for various fascinating and significant phytoactive. The phytosomes technique produces remarkable minute spheres or tiny cells, which is helpful in the protection of active phytochemical constituent from destruction by the gastric environment. Furthermore, phytosomes also reveal efficient pharmacokinetic as well as pharmacodynamic profile compared to conventional herbal extracts. The current manuscript is a cogent attempt to review the potential pharmacological benefits of herbal extracts by forming an impressive and successful phytophospholipid complex.  Salient attributes, as well as promising and imperative applications of phytosomes, are illustrated in the manuscript. Recent advances in research endeavours, along with major inferences on effective phytosomal drug delivery systems, have also been highlighted.

scholarly journals Recent development in novel drug delivery systems for delivery of herbal drugs: An updates

2021 ◽  
Vol 8 (2) ◽  
pp. 008-018
Author(s):  
Prajakta N. Dongare ◽  
Anuja S. Motule ◽  
Mahesh R. Dubey ◽  
Manisha P. More ◽  
Prerna A. Patinge ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Herbal Medicines ◽  
Delivery Systems ◽  
Therapeutic Effects ◽  
Herbal Drugs ◽  
Active Components ◽  
Novel Drug ◽  
Herbal Formulations

In the recent years, herbal medicines have gained worldwide attention of peoples and researchers due to their esthetic value, more patient’s compliance and prominent therapeutic effects. Novel drug delivery systems for delivery of herbal drugs possesses several advantages over conventional formulations. It includes enhancement of solubility, bioavailability, and protection from toxicity, etc. The herbal drugs can be used in a more upright course with enhanced efficacy by incorporating them into suitable dosage forms. This can be achieved by designing novel drug delivery systems for such drugs. Such systems are polymeric nanoparticles, nanocapsules, phytosomes, animations, microsphere, etc. The present article highlights the current condition of the development of novel herbal formulations and summarizes their type of active components, biological activity, and applications of novel formulations.

Novel Nano Carriers for the Treatment of Progressive Auto Immune Disease Rheumatoid Arthritis

2020 ◽  
Vol 26 ◽  
Author(s):  
Ritu Mishra ◽  
Swati Gupta
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Autoimmune Disease ◽  
Drug Delivery Systems ◽  
Clinical Manifestations ◽  
Adaptive Immune Response ◽  
Delivery Systems ◽  
Current Therapy ◽  
Genetic And Environmental Factors ◽  
Novel Drug

Background: Rheumatoid arthritis (RA) is the most common occurring progressive, autoimmune disease, affecting 1% of the population and the ratio of affected women is three times as compared to men in most developing countries. Clinical manifestations of RA are the presence of anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF) in blood, tendered joints and soreness of the muscles. Some other factors which may lead to chronic inflammation are genetic and environmental factors as well as adaptive immune response. Several conventional drugs are available for the treatment of RA but have their own drawbacks which can be overcome by the use of novel drug delivery systems. : The objective of the present review is to focus on the molecular pathogenesis of the disease and its current conventional treatment with special reference to the role of novel drug delivery systems encapsulating anti rheumatic drugs and herbal drugs in passive and receptor mediated active targeting against RA. On reviewing the conventional and current therapeutics agains RA, we conclude that, although the current therapy for the treatment of RA is capable enough, yet more advances in the field of targeted drug delivery will sanguinely result in effective and appropriate treatment of this autoimmune disease.

Provesicles as Novel Drug Delivery Systems

2015 ◽  
Vol 16 (4) ◽  
pp. 344-364 ◽  
Author(s):  
Zerrin Bayindir ◽  
Nilufer Yuksel
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Novel Drug

Improved Therapeutic Efficacy of Topotecan Against A549 Lung Cancer Cells with Folate-targeted Topotecan Liposomes

2020 ◽  
Vol 21 (11) ◽  
pp. 902-909
Author(s):  
Jingxin Zhang ◽  
Weiyue Shi ◽  
Gangqiang Xue ◽  
Qiang Ma ◽  
Haixin Cui ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Lung Tumor ◽  
A549 Cells ◽  
Delivery Systems ◽  
Lung Cancer Cells

Background: Among all cancers, lung cancer has high mortality among patients in most of the countries in the world. Targeted delivery of anticancer drugs can significantly reduce the side effects and dramatically improve the effects of the treatment. Folate, a suitable ligand, can be modified to the surface of tumor-selective drug delivery systems because it can selectively bind to the folate receptor, which is highly expressed on the surface of lung tumor cells. Objective: This study aimed to construct a kind of folate-targeted topotecan liposomes for investigating their efficacy and mechanism of action in the treatment of lung cancer in preclinical models. Methods: We conjugated topotecan liposomes with folate, and the liposomes were characterized by particle size, entrapment efficiency, cytotoxicity to A549 cells and in vitro release profile. Technical evaluations were performed on lung cancer A549 cells and xenografted A549 cancer cells in female nude mice, and the pharmacokinetics of the drug were evaluated in female SD rats. Results: The folate-targeted topotecan liposomes were proven to show effectiveness in targeting lung tumors. The anti-tumor effects of these liposomes were demonstrated by the decreased tumor volume and improved therapeutic efficacy. The folate-targeted topotecan liposomes also lengthened the topotecan blood circulation time. Conclusion: The folate-targeted topotecan liposomes are effective drug delivery systems and can be easily modified with folate, enabling the targeted liposomes to deliver topotecan to lung cancer cells and kill them, which could be used as potential carriers for lung chemotherapy.

Current Perspectives on Novel Drug Delivery Systems and Therapies for Management of Prostate Cancer: An Inclusive Review

2017 ◽  
Vol 18 (11) ◽  
Author(s):  
Rohit R. Bhosale ◽  
H. V. Gangadharappa ◽  
Umme Hani ◽  
Riyaz Ali M. Osmani ◽  
Rudra Vaghela ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Novel Drug
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