Xanthan-Gelatin And Xanthan-Gelatin-Keratin Wound Dressings For Local Delivery Of Vitamin C

2021 ◽  
pp. 121436
Author(s):  
Gizem Cigdem Demir ◽  
Özge Erdemli ◽  
Dilek Keskin ◽  
Ayşen Tezcaner
Keyword(s):  
Vitamin C ◽  
Local Delivery ◽  
Wound Dressings

scholarly journals Highly Porous and Superabsorbent Biomaterial Made of Marine-Derived Polysaccharides and Ascorbic Acid as an Optimal Dressing for Exuding Wound Management

Materials ◽  
2021 ◽  
Vol 14 (5) ◽  
pp. 1211
Author(s):  
Vladyslav Vivcharenko ◽  
Michal Wojcik ◽  
Krzysztof Palka ◽  
Agata Przekora
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Wound Dressing ◽  
Human Fibroblasts ◽  
Healing Process ◽  
Wound Dressings ◽  
Wound Management ◽  
Matrix Metalloproteinase 2 ◽  
In Vitro Tests ◽  
Skin Damage

There are many modern wound dressings that have promising properties for repairing skin damage. However, due to various types of wounds and the problems they cause, there is still a great demand for new, effective healing strategies. The aim of this study was to create superabsorbent wound dressing made of marine-derived polysaccharides (agarose and chitosan) using the freeze-drying method. The secondary goal was its comprehensive evaluation for potential use as an external superabsorbent bandage for wounds with high exudation. Due to the well-known positive effect of ascorbic acid (vitamin C) on the healing process, biomaterial enriched with vitamin C was prepared and compared to the variant without the addition of ascorbic acid. It was shown that the produced foam-like wound dressing had a very porous structure, which was characterized by hydrophilicity, allowing a large amount of human fluids to be absorbed. According to in vitro tests on human fibroblasts, biomaterial was nontoxic and supportive to cell proliferation. Vitamin C-enriched dressing also had the ability to significantly reduce matrix metalloproteinase-2 production and to promote platelet-derived growth factor-BB synthesis by fibroblasts, which is desired during chronic wound treatment. The material has features of the eco-friendly wound care product since it was made of naturally-derived polysaccharides and was proved to be biodegradable. Importantly, despite degradable character, it was stable in the chronic and infected wound microenvironment, maintaining high integrity after 8-week incubation in the enzymatic solutions containing lysozyme and collagenases. The obtained results clearly showed that developed biomaterial possesses all necessary features of the external dressing for the management of exudate from both acute and chronic non-healing wounds.

scholarly journals Pressure Wounds and Skin Failure Secondary Scurvy. Prevention with Early Vitamin Micro Nutrient Supplements

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Kaminski MV
Keyword(s):  
Vitamin C ◽  
Collagen Fiber ◽  
Wound Care ◽  
Steel Wire ◽  
The Body ◽  
Wound Dressings ◽  
Cross Linking ◽  
Nutrient Supplements ◽  
Skin Tears ◽  
The Media

Skin is the largest organ of the body. The dermis is primarily collagen. A collagen deficit results in skin failure with thinning to the point of transparency and disruption. (pressure wounds). The media of blood vessels is also primarily collagen. Here a deficit causes capillary fragility and purpura. A collagen fiber is a triple strand of protein. Plates initially produce three strands of procollagen which twist around each other, first to the left, then right and left again. The result is a fiber more flexible and stronger than a steel wire of the same diameter. Strength is due to cross linking between fibers at the frequent amino acid proline and lysine positions after hydrogenation by vitamin C. It was observed that patients referred for pressure wound care had scurvy at the time of consult. Diagnosing a collagen, i.e. Vitamin C deficit during the admission skin assessment is straight forward by bed side observation for dermal atrophy, purpura or skin tears. If an ample profile of all micro-nutrients with 1 gm of vitamin C was started along with biofilm control and adequate wound dressings, the existing pressure wounds promptly improved and new wounds were prevented.

scholarly journals Effect of Vitamin C/Hydrocortisone Immobilization within Curdlan-Based Wound Dressings on In Vitro Cellular Response in Context of the Management of Chronic and Burn Wounds

2021 ◽  
Vol 22 (21) ◽  
pp. 11474
Author(s):  
Michal Wojcik ◽  
Paulina Kazimierczak ◽  
Vladyslav Vivcharenko ◽  
Malgorzata Koziol ◽  
Agata Przekora
Keyword(s):  
Vitamin C ◽  
Cellular Response ◽  
Type I Collagen ◽  
Therapeutic Potential ◽  
Bioactive Molecules ◽  
Wound Dressings ◽  
Type I ◽  
Burn Wounds ◽  
Dressing Materials

Bioactive dressings are usually produced using natural or synthetic polymers. Recently, special attention has been paid to β-glucans that act as immunomodulators and have pro-healing properties. The aim of this research was to use β-1,3-glucan (curdlan) as a base for the production of bioactive dressing materials (curdlan/agarose and curdlan/chitosan) that were additionally enriched with vitamin C and/or hydrocortisone to improve healing of chronic and burn wounds. The secondary goal of the study was to compressively evaluate biological properties of the biomaterials. In this work, it was shown that vitamin C/hydrocortisone-enriched biomaterials exhibited faster vitamin C release profile than hydrocortisone. Consecutive release of the drugs is a desired phenomenon since it protects wounds against accumulation of high and toxic concentrations of the bioactive molecules. Moreover, biomaterials showed gradual release of low doses of the hydrocortisone, which is beneficial during management of burn wounds with hypergranulation tissue. Among all tested variants of biomaterials, dressing materials enriched with hydrocortisone and a mixture of vitamin C/hydrocortisone showed the best therapeutic potential since they had the ability to significantly reduce MMP-2 synthesis by macrophages and increase TGF-β1 release by skin cells. Moreover, materials containing hydrocortisone and its blend with vitamin C stimulated type I collagen deposition by fibroblasts and positively affected their migration and proliferation. Results of the experiments clearly showed that the developed biomaterials enriched with bioactive agents may be promising dressings for the management of non-healing chronic and burn wounds.

French Panel Outlines Utility of Wound Dressings

2007 ◽  
Vol 38 (12) ◽  
pp. 6
Author(s):  
LEANNE SULLIVAN
Keyword(s):  
Wound Dressings

Striae Gravidarum, Vitamin C and Other Related Factors

2011 ◽  
Vol 81 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Rahime Bedir Findik ◽  
Nurcihan Karakurt Hascelik ◽  
Kadir Okhan Akin ◽  
Ayse Nurcan Unluer ◽  
Jale Karakaya
Keyword(s):  
Family History ◽  
Vitamin C ◽  
Pregnant Women ◽  
Smoking Status ◽  
Multiple Logistic Regression Analysis ◽  
Blood Levels ◽  
Significant Relation ◽  
Related Factors ◽  
Thigh Circumference ◽  
Striae Gravidarum

Background: Striae gravidarum, a clinical condition commonly seen in pregnant women, produces serious cosmetic problems and may lead to psychological problems. Aim: The present study investigated whether there was any relation between the presence of striae in primigravid pregnant women and blood vitamin C levels, and factors thought to contribute to the formation of striae such as family history, weight gained during pregnancy, smoking status, abdominal and thigh circumference, and age. Methods: Overall, 69 primigravid women attending routine antenatal follow-up and, using prophylactic iron and vitamin preparations, underwent investigation. All were pregnant 36 or more weeks. Scoring was based on striae examination and whether striae were present. The relation between the presence of striae, vitamin C blood levels, and other factors was investigated. Results and Conclusions: Multiple logistic regression analysis showed a significant relation between the presence of striae and blood vitamin C levels (p = 0.046) and between the presence of striae and family history (p = 0.023). No significant relation was found between the presence of striae and age, weight gained during pregnancy, abdominal and thigh circumference, or smoking status. It was concluded that further, more comprehensive studies on the issue are required.

The Relationship Between Antioxidant Nutrient Intake and Cataracts in Older People

2006 ◽  
Vol 76 (6) ◽  
pp. 359-366 ◽  
Author(s):  
Rodríguez-Rodríguez ◽  
Ortega ◽  
López-Sobaler ◽  
Aparicio ◽  
Bermejo ◽  
...  
Keyword(s):  
Vitamin C ◽  
Older People ◽  
Dietary Intake ◽  
Protective Effect ◽  
Elderly People ◽  
Nutrient Intake ◽  
Institutionalized Elderly ◽  
Weighing Method ◽  
The Relationship

This study investigated the relationship between the intake of antioxidant nutrients and the suffering of cataracts in 177 institutionalized elderly people (61 men and 116 women) aged ≥ 65 years. Dietary intake was monitored for 7 consecutive days using a "precise individual weighing" method. Subjects, who during their earlier years were exposed by their work to sunlight, had a greater risk of suffering cataracts (OR = 3.2; Cl: 1.1–9.3, P < 0.05) than those who worked indoors. A relationship was found between increased vitamin C intake and a reduced prevalence of cataracts (i.e., when comparing those above P95 for vitamin C intake with those below P5; (OR = 0.08; Cl: 0.01–0.75, P 0.05). Among subjects with cataracts, 12.1% had vitamin C intakes of < 61 mg/day (P10) and only 2.2% had intakes of > 183 mg/day (P95) (p < 0.01). Subjects who consumed > 3290 μg/day (P95) of lutein were less likely to have cataracts (OR = 0.086; Cl: 0.007–1.084; p < 0.05) than those whose consumption was < 256 μg/day (P5). In men, high intakes of zeaxanthin seemed to provide a protective effect against the problem (OR = 0.96; Cl: 0.91–0.99; p < 0.05). The results suggest an association exists between exposure to sunlight and the development of cataracts, and that vitamin C, lutein, and zeaxanthin offer some protection against this disorder.

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