Pharmaceutical Technology in Europe

2021 ◽  
pp. 121441
Author(s):  
Juergen Siepmann ◽  
Abdul Basit ◽  
Thomas Rades
Keyword(s):  
Pharmaceutical Technology

Recent Advances in Novasome Formulation Technology

2014 ◽  
Vol 7 (2) ◽  
pp. 2407-2411
Author(s):  
J M Shah ◽  
N.H Shah ◽  
Hadiya P D
Keyword(s):  
Drug Delivery ◽  
Effective Means ◽  
Entrapment Efficiency ◽  
Bilayer Membrane ◽  
Water Soluble ◽  
Delivery Methods ◽  
Liposomal Drug ◽  
Pharmaceutical Technology ◽  
Insoluble Drugs ◽  
Novel Drug

Pharmaceutical technology has developed various newer modes of novel drug delivery aspects. Modifications in the previously existing drug delivery methods have led to various newly innovated technologies serving as a safe and effective means of improvement over the existing ones. Novasome technology is one of the new innovations of liposomes which have solved many of the problems related to liposomal drug delivery system. It offers a seven bilayer membrane which has the ability to incorporate both water soluble and insoluble drugs. It has an excellent entrapment efficiency which provides better medication. Formulation of novasomes is achieved in a high shear device. Due to its numerous advantages, novasomes have been used extensively in various fields like cosmetics, chemical, personal care, foods, pharmaceuticals and agrochemicals.

Ionic Liquids for Topical Delivery in Cancer

2020 ◽  
Vol 26 (41) ◽  
pp. 7520-7532 ◽  
Author(s):  
Ana Rita Dias ◽  
João Costa-Rodrigues ◽  
Cátia Teixeira ◽  
Cristina Prudêncio ◽  
Paula Gomes ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Clinical Applications ◽  
Great Promise ◽  
Topical Drug Delivery ◽  
Green Solvents ◽  
2Nd Generation ◽  
Windows Of Opportunity ◽  
Pharmaceutical Technology ◽  
Skin Cancers ◽  
Per Se

: The unique properties of ionic liquids make them quite appealing for diverse applications, from “green” solvents (1st generation ionic liquids) to finely tuned materials (2nd generation ionic liquids). A decade ago, a 3rd generation of ionic liquids emerged which is focused on their prospective clinical applications, either as drugs per se or as adjuvants in drug formulations. In recent years, research focused on the use of ionic liquids for topical drug delivery has been increasing and holds great promise towards clinical application against skin cancers. This article highlights the growing relevance of ionic liquids in medicinal chemistry and pharmaceutical technology, which is opening new windows of opportunity.

scholarly journals Utilization of Pharmaceutical Technology Methods for the Development of Innovative Porous Metasilicate Pellets with a Very High Specific Surface Area for Chemical Warfare Agents Detection

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1860
Author(s):  
Jiří Zeman ◽  
Sylvie Pavloková ◽  
David Vetchý ◽  
Adam Staňo ◽  
Zdeněk Moravec ◽  
...  
Keyword(s):  
Specific Surface ◽  
Surface Area ◽  
Specific Surface Area ◽  
Uv Light ◽  
Detection System ◽  
Chemical Warfare Agents ◽  
High Specific Surface Area ◽  
Ammonium Bicarbonate ◽  
Toxic Substances ◽  
Pharmaceutical Technology

Pharmaceutical technology offers various dosage forms that can be applied interdisciplinary. One of them are spherical pellets which could be utilized as a carrier in emerging second-generation detection tubes. This detection system requires carriers with high specific surface area (SSA), which should allow better adsorption of toxic substances and detection reagents. In this study, a magnesium aluminometasilicate with high SSA was utilized along with various concentrations of volatile substances (menthol, camphor and ammonium bicarbonate) to increase further the carrier SSA after their sublimation. The samples were evaluated in terms of physicochemical parameters, their morphology was assessed by scanning electron microscopy, and the Brunauer–Emmett–Teller (BET) method was utilized to measure SSA. The samples were then impregnated with a detection reagent o-phenylenediamine-pyronine and tested with diphosgene. Only samples prepared using menthol or camphor were found to show red fluorescence under the UV light in addition to the eye-visible red-violet color. This allowed the detection of diphosgene/phosgene at a concentration of only 0.1 mg/m3 in the air for samples M20.0 and C20.0 with their SSA higher than 115 m2/g, thus exceeding the sensitivity of the first-generation DT-12 detection tube.

scholarly journals Prospects for the Use of Medical Clays (Review)

2019 ◽  
Vol 8 (4) ◽  
pp. 27-31 ◽  
Author(s):  
A. V. Bondarev ◽  
E. T. Zhilyakova ◽  
N. B. Demina ◽  
E. Yu. Timoshenko
Keyword(s):  
Raw Materials ◽  
Chemical Compounds ◽  
Food Technology ◽  
Mineral Raw Materials ◽  
Promising Direction ◽  
Pharmaceutical Substances ◽  
Pharmaceutical Technology ◽  
New Directions ◽  
Scientific Significance ◽  
Cutaneous Application

Introduction. The article deals with the aspects of the use of Medical Clays in Pharmaceutical Technology. A review of the traditional areas of application of Medical Clay, as well as highlighting new directions.Text. One of the main problems of domestic industrial pharmacy is a narrow nomenclature of active pharmaceutical substances and excipients. Replenishment of the nomenclature occurs in two ways-through the synthesis of new chemical compounds or through the processing of natural raw materials of animal, plant or mineral origin. In the process of purification and processing of mineral raw materials, Medical Clays are obtained, which are now widely used as active pharmaceutical substances for the production of Enterosorbents, as well as auxiliary substances.Conclusion. A review of perspectives and areas of use of Medicinal Clays have shown that at present, Medical Clays used in the three traditional areas: cutaneous application, application per os, application in pharmaceutical and food technology. A promising direction is the use of Medical Clays as transport drug systems. The study of this information array and its generalization has undoubted practical and scientific significance in modern pharmaceutical technology. 

scholarly journals Smart polymers in drug delivery: a perspective in pharmaceutical technology

2019 ◽  
Vol 18 (2) ◽  
pp. 15-20
Author(s):  
E. V. Blynskaya ◽  
K. V. Alekseyev ◽  
D. V. Yudina ◽  
V. K. Alexseev ◽  
S. V. Tishkov ◽  
...  
Keyword(s):  
Dosage Forms ◽  
Smart Polymers ◽  
Solid Dosage Forms ◽  
Solid Dosage ◽  
Promising Tool ◽  
Pharmaceutical Technology ◽  
Polymer Properties ◽  
Wide Range ◽  
The World ◽  
Polymer Research

Polymers have already been recognized as promising materials in many areas of life including pharmaceutical technology. A wide range of polymer properties such as providing controlled release of APIs, enhancing permeation and protection of APIs from mucosal enzymes is now successfully using worldwide in producing soft and solid dosage forms. It is now recognized that a significant portion of the polymer research ongoing in the world is related with a new group of polymer properties such as «shape memory system» and “self-folding”. This review focuses on “smart” – polymers properties that could be a promising tool in developing smart delivery systems.

scholarly journals Influence of soft fInIshed pharmaproducts based on PENTAPHYLLOIDES FRUTICOSA l. on the course of wound process

2016 ◽  
Vol 1 (5) ◽  
pp. 129-132
Author(s):  
Ханхасыков ◽  
Sergey Khankhasykov ◽  
Хибхенов ◽  
Lopsondorzho Khibkhenov ◽  
Бальхаев ◽  
...  
Keyword(s):  
White Male ◽  
Biopsy Material ◽  
Drug Products ◽  
The Third ◽  
Pharmaceutical Technology ◽  
Male Wistar Rats ◽  
Soft Drug ◽  
Wound Healing Effect ◽  
Pentaphylloides Fruticosa ◽  
High Level

The aim of the work was to estimate a wound-healing effect of soft drug products from the Pentaphylloides fruticosa L. shoots on the model of planar skin-fascial wound. The liniment was developed with the use of the NanoDeBee 30 device and the ointment was developed with the use of pharmaceutical technology. Experiments were carried out on white male Wistar rats. The skin injury was simulated by inflicting planar wounds 2.0×2.0 cm in size. The 5%-liniment and 5% ointment from P. fruticosa were put on the wounds of the first and second experimental groups respectively. In the third group the wounds were treated with glycerin-vaseline ointment. Bioptate of the wound surface was taken on the 7th, 14th and 21st day. Histological preparations were studied using standard methods. Cell elements of the first group animals were displayed as fibroblasts and fibrocytes; it was noted high level of collagen organization that testified the effective staging of the wound process in this case. The amount of fibrocytes and fibroblasts and ratio between juvenile and mature forms of collagen-producing cells vary in the first and second groups. Biopsy material obtained from the animals of the third group only on the 21st day corresponded to the picture observed in animals of the 1st group on the 14th day. The findings of the study verify that the use of the product obtained on NanoDeBee device provides the earlier forming of the scar as compared with the ointment developed using pharmaceutical technology.

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