Biological Synthesis of Titanium Dioxide Nanoparticles from Plants and Microorganisms and their Potential Biomedical Applications

Abstract Metal oxide nanoparticles (NPs) have found a variety of applications in numerous industrial, medical, and environmental fields s, attributable to recent advances in the nanotechnology field. Titanium dioxide nanoparticles (TiO2-NPs) have gained importance as metal oxide NPs due to their potential in various fields, particularly nanomedicine and other biomedicine fields. Several studies have confirmed that NPs produced via the biosynthesis route using natural resources have significant advantages such as fewer toxic contaminants, less subsequent complex chemical synthesis, environmental friendliness, cost-effectiveness, and stability when compared to NPs produced by conventional methods, and its production with controlled shapes and sizes. Therefore, considerable effort is being expended to implement biological synthesis methods with these proven advantages. TiO2-NPs can be made using a variety of biological, chemical, and physical methods. Physicochemical methods are costly, emit high levels of toxic chemicals into the atmosphere, and consume a lot of energy. On the other hand, the biological approach is an environmentally safe, cost-effective, dependable, convenient, and easy way to synthesize TiO2-NPs. In this review, the bio-mediated synthesis, as well as various biomedical applications of TiO2-NPs, were discussed.

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A Coronopus didymus based eco-benign synthesis of Titanium dioxide nanoparticles (TiO2 NPs) with enhanced photocatalytic and biomedical applications

Inorganic Chemistry Communications ◽

10.1016/j.inoche.2021.109179 ◽

2021 ◽

pp. 109179

Author(s):

Khalil ur Rehman ◽

Umber Zaman ◽

Kamran Tahir ◽

Dilfaraz Khan ◽

Noor Saeed Khattak ◽

...

Keyword(s):

Titanium Dioxide ◽

Biomedical Applications ◽

Titanium Dioxide Nanoparticles ◽

Tio2 Nps ◽

Benign Synthesis

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Biosynthesis, Antimicrobial and Cytotoxic Effects of Titanium Dioxide Nanoparticles Using Vigna unguiculata Seeds

International Journal of Pharmacognosy and Phytochemical Research ◽

10.25258/ijpapr.v9i1.8047 ◽

2017 ◽

Vol 9 (1) ◽

Cited By ~ 1

Author(s):

Ankita Chatterjee ◽

M. Ajantha ◽

Aishwarya Talekar ◽

N. Revathyr ◽

Jayanthi Abraham

Keyword(s):

Titanium Dioxide ◽

Metal Nanoparticles ◽

Vigna Unguiculata ◽

Titanium Dioxide Nanoparticles ◽

Cost Effective ◽

Biological Synthesis ◽

Osteosarcoma Cell ◽

Cowpea Seeds ◽

Clinical Pathogens ◽

Physical And Chemical

Background: Physical and chemical methods of synthesizing metal nanoparticles have been on the focus for the last decade as it has been broadly exploited by researchers. Biological synthesis of metal nanoparticles was found to be easy and economical. The wide applications of titanium dioxide in various fields have drawn attention for biosynthesis of titanium dioxide nanoparticles. Cowpea seeds are easily available and rich in protein as well as high in antioxidant which enhances the good characteristics of the nanoparticles synthesized using it. Methods: In the present investigation the nanoparticles are synthesized using Vigna unguiculata (cowpea) seeds extract. 0.1 mM titanium dioxide was mixed with cowpea seeds extract for the preparation of the nanoparticles. The characterization of nanoparticles was done by Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). Antibacterial activity of the titanium dioxide nanoparticles was checked against clinical pathogens followed by antioxidant study and cytotoxicity assay by 2, 2- diphenyl-1-picryl-hydrazyl-hydrate (DPPH) assay and [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] (MTT) assay respectively. Results: The oval shaped biologically synthesized nanoparticles were effective against most of the clinical pathogens. The observance of peak at 418 cm-1 confirms the synthesis of titanium dioxide nanoparticles. The titanium nanoparticles were highly antioxidant in nature and cytotoxic on MG63 osteosarcoma cell lines. Conclusion: The biological method of preparation of nanoparticles proved to be easy and cost effective. The nanoparticles synthesized can be further used in research for anticancer treatments

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Comments on:“In vitro and in vivo pharmacokinetics and toxicity evaluation of curcumin incorporated titanium dioxide nanoparticles for biomedical applications”

Chemico-Biological Interactions ◽

10.1016/j.cbi.2017.09.009 ◽

2017 ◽

Vol 277 ◽

pp. 145

Author(s):

Nuggehally R. Srinivas

Keyword(s):

Titanium Dioxide ◽

Biomedical Applications ◽

Titanium Dioxide Nanoparticles ◽

Toxicity Evaluation ◽

In Vivo Pharmacokinetics

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Synthesis of Chitosan Beads Incorporating Graphene Oxide/Titanium Dioxide Nanoparticles for In Vivo Studies

Molecules ◽

10.3390/molecules25102308 ◽

2020 ◽

Vol 25 (10) ◽

pp. 2308

Author(s):

Carlos David Grande Tovar ◽

Jorge Iván Castro ◽

Carlos Humberto Valencia ◽

Paula A. Zapata ◽

Moisés A. Solano ◽

...

Keyword(s):

Titanium Dioxide ◽

Graphene Oxide ◽

Photoelectron Spectroscopy ◽

Biomedical Applications ◽

Titanium Dioxide Nanoparticles ◽

Healing Process ◽

Antimicrobial Property ◽

In Vivo Studies ◽

Cell Regeneration

Scaffold development for cell regeneration has increased in recent years due to the high demand for more efficient and biocompatible materials. Nanomaterials have become a critical alternative for mechanical, thermal, and antimicrobial property reinforcement in several biopolymers. In this work, four different chitosan (CS) bead formulations crosslinked with glutaraldehyde (GLA), including titanium dioxide nanoparticles (TiO2), and graphene oxide (GO) nanosheets, were prepared with potential biomedical applications in mind. The characterization of by FTIR spectroscopy, X-ray photoelectron spectroscopy (XRD), thermogravimetric analysis (TGA), energy-dispersive spectroscopy (EDS) and scanning electron microscopy (SEM), demonstrated an efficient preparation of nanocomposites, with nanoparticles well-dispersed in the polymer matrix. In vivo, subdermal implantation of the beads in Wistar rat′s tissue for 90 days showed a proper and complete healing process without any allergenic response to any of the formulations. Masson′s trichrome staining of the histological implanted tissues demonstrated the presence of a group of macrophage/histiocyte compatible cells, which indicates a high degree of biocompatibility of the beads. The materials were very stable under body conditions as the morphometry studies showed, but with low resorption percentages. These high stability beads could be used as biocompatible, resistant materials for long-term applications. The results presented in this study show the enormous potential of these chitosan nanocomposites in cell regeneration and biomedical applications.

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A comparative study of metal oxide nanoparticles embryotoxicity using the embryonic stem cell test

BioNanoMaterials ◽

10.1515/bnm-2013-0008 ◽

2013 ◽

Vol 14 (1-2) ◽

pp. 61-64 ◽

Cited By ~ 1

Author(s):

Lucia Vecchione ◽

Micol Massimiani ◽

Antonella Camaioni ◽

Luna Sifrani ◽

Andrea Magrini ◽

...

Keyword(s):

Zinc Oxide ◽

Titanium Dioxide ◽

Metal Oxide ◽

Biomedical Applications ◽

Titanium Dioxide Nanoparticles ◽

Metal Oxide Nanoparticles ◽

Embryonic Stem ◽

Oxide Nanoparticles ◽

Cell Test

AbstractMany in vitro studies demonstrated that metal oxide nanoparticles like zinc oxide and titanium dioxide are versatile platforms for industrial and biomedical applications. In this paper, investigation of the embryotoxic potential of these nanoparticles using the Embryonic stem Cells Test (EST) was evaluated. The EST is a validated in vitro toxicity test used to predict embryotoxicity of soluble chemical compounds, which only recently has been applied to nanoparticles, demonstrating its suitability also in nanotoxicology. Through such test, we were able to classify zinc oxide nanoparticles as not embryotoxic, while titanium dioxide nanoparticles appeared to be weakly embryotoxic.

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