TCT-850 Patients undergoing PCI via the femoral artery in a default radial centre have very high BARC bleeding rates and subsequent bleeding 30 day and 1 year mortality

Aim. To study the prevalence of carotid (CA) and femoral artery (FA) atherosclerosis among Russian population, mainly in middle age group, using a representative sample of one of the Central Russian regions.Material and methods. The analysis included participants of the ATEROGEN-Ivanovo study (sub-study of the ESSE-RF conducted in the Ivanovo region) aged 40-67 years, who were invited for CA and FA ultrasound to assess plaque presence. A total 1102 people were examined, which was >80% of the original sample.Results. The age of subjects was 54 [48; 60] years (men, 28%). Only 11,2% of participants took statins; 30,9% had low cardiovascular risk (CVR), 35,6% — moderate CVR, 21,8% — high CVR, and 11,8% — very high CVR. The incidence of at least one plaque in CA or FA was 73,6%. The prevalence of CA atherosclerosis was 76,4% in men and 59,1% in women, FA atherosclerosis — 54,9% and 28,3%, respectively. Furthermore, plaques were detected already at the age of 40. The incidence of plaques significantly increased with age, with the exception of carotid atherosclerosis in men, a significant increase in the incidence of which stopped at 45 years of age.Conclusion. Among the Ivanovo population aged 40-67 with a predominance of low-to-moderate CVR patients, there is a high prevalence of carotid and femoral atherosclerosis, which indicates a high potential for using ultrasound for diagnosing subclinical atherosclerosis in assessing CVR in people of this age range.

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OP0122 SUBCLINICAL ATHEROSCLEROSIS OF FEMORAL ARTERIES IN RHEUMATOID ARTHRITIS. AN ULTRASOUND STUDY

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.2378 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 80.1-81

Author(s):

J. Medina ◽

F. Aramburu ◽

C. González Montagut ◽

D. Sánchez ◽

E. Loza

Keyword(s):

Rheumatoid Arthritis ◽

Cardiovascular Risk ◽

Femoral Artery ◽

Disease Risk ◽

Subclinical Atherosclerosis ◽

Cardiovascular Disease Risk ◽

Carotid Plaques ◽

Femoral Arteries ◽

Eular Recommendations ◽

Very High

Background:Cardiovascular morbidity and mortality is increased in patients with rheumatoid arthritis (RA). This cannot be entirely explained by traditional risk factors. Inflammation and autoimmunity may play a role in the cardiovascular risk excess. Subclinical atherosclerosis is associated with a risk comparable to established coronary heart disease. In RA it has been investigated by carotid artery ultrasound and carotid atherosclerotic plaques are more prevalent in RA patients than controls. EULAR recommendations for cardiovascular disease risk management consider that carotid ultrasound may be part of the risk evaluation in patients with RA. Recent studies in general population have shown that plaques in femoral arteries are more common and are associated with higher cardiovascular risk.Objectives:To study the usefulness of femoral artery ultrasound for the detection of subclinical atherosclerosis and its ability to improve cardiovascular risk assessment in RA patients.Methods:Cross-sectional observational study of prevalence in 140 RA patients aged 40 to 65 years. Subclinical atherosclerosis was evaluated by carotid and femoral artery ultrasound.Results:Atherosclerotic plaques were found in 86.4% of RA patients (60.7% in carotid arteries and 78.6% in femoral arteries). Patients with plaques were older and more frequently past or present tobacco users. Femoral plaques were larger and more numerous than the carotid plaques and people with plaques in both locations had more extensive subclinical atherosclerotic disease (table). Only 7.9% of RA patients were considered as having very high cardiovascular risk by clinical factors, after carotid ultrasound this increased to 57.1% and after femoral ultrasound to 86.4%.Conclusion:Ultrasound examinations of the femoral artery in addition to the carotid artery increased the detection of subclinical atherosclerosis and determine a group of patients with higher intensity of atherosclerotic disease. Examinations of both arteries allowed a greater number of RA patients previously considered to have low to moderate cardiovascular risk to be classified as very high cardiovascular risk.References:[1]Agca R, Heslinga SC, Rollefstad S, Heslinga M, McInnes IB, Peters MJL, et al. EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update. Ann Rheum Dis. 2017 Jan;76(1):17–28.[2]Ambrosino P, Lupoli R, Di Minno A, Tasso M, Peluso R, Di Minno MND. Subclinical atherosclerosis in patients with rheumatoid arthritis. A meta-analysis of literature studies. Thromb Haemost. 2015 May;113(5):916–30.[3]Laclaustra M, Casasnovas JA, Fernández-Ortiz A, Fuster V, León-Latre M, Jiménez-Borreguero LJ, et al. Femoral and Carotid Subclinical Atherosclerosis Association With Risk Factors and Coronary Calcium: The AWHS Study. J Am Coll Cardiol. 2016 Mar 22;67(11):1263–74.TableOnly carotid plaquesn= 11Only femoral plaquesn= 36Femoral and carotid plaquesn= 74Number of carotid plaques per patient1,3 ± 0,5-2,5 ±2,0*Carotid plaques size (mm)1,63 ±0,20-2,08 ±0,69*Number of femoral plaques per patient-2,3 ±1,73,7 ± 2,9**Femoral plaque size (mm)-2,20 ± 0,593,10 ± 1,10**Total number of plaques per patient1,3 ± 0,52,3 ± 1,7*6,2 ± 4,3***†Results in mean ± sd. *p<0,05 vs only carotid plaques. **p<0,05 vs only femoral plaques. ***p<0,05 vs only carotid plaques and only femoral plaques.Disclosure of Interests:Julio Medina: None declared, Francisco Aramburu: None declared, Carmen González Montagut: None declared, Dolores Sánchez: None declared, Estíbaliz Loza Grant/research support from: Roche, Pfizer, Abbvie, MSD, Novartis, Gebro, Adacap, Astellas, BMS, Lylly, Sanofi, Eisai, Leo, Sobi

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Grculation of microparticles of lymphocytic origin at critical ischemia of the lower extremities

Medical Immunology (Russia) ◽

10.15789/1563-0625-com-1796 ◽

2020 ◽

Vol 22 (2) ◽

pp. 319-326

Author(s):

Y. S. Vinnik ◽

S. S. Dunayevskaya ◽

D. A. Antyufriyeva

Keyword(s):

Blood Pressure ◽

Correlation Coefficient ◽

Arterial Blood Pressure ◽

Negative Correlation ◽

Femoral Artery ◽

Lower Extremities ◽

Critical Ischemia ◽

Arterial Blood ◽

Circulating Microparticles ◽

Very High

Great scientific interest to problems of obliterating atherosclerosis of vessels of the lower extremities is caused by increase in incidence of this pathology and multidisciplinary approach in diagnostics and treatment the research objective: to study interrelations between quantity of the circulating microparticles of lymphocytic origin and development of critical ischemia of the lower extremities. The executed research belonged to cohort prospective researches. Two studied groups were created: 1st group included 75 patients with ischemia IIB degrees on Pokrovsky—Fontaine's classification. The 2nd group included 75 patients with clinical manifestations of critical ischemia. Also, the group of control of 75 almost healthy faces which do not have symptoms of obliterating diseases of vessels of the lower extremities was created. For objectification of assessment of degree of ischemia measured anklebone’s arterial blood pressure, the anklebone-humeral index, toe’s arterial blood pressure, Transcutaneous tension of oxygen in foot fingers. For blood-groove assessment in arteries of the lower extremities used ultrasonic doppler sonography of arteries of the lower extremities and the KT-angiography. The research was conducted at arrival of the patient in a hospital prior to therapy. Lymphocytes and the circulating microparticles defined according to the standard protocol. At almost healthy faces the number of the circulating microparticles of lymphocytic origin made of control group 385 (260479) on 100 lymphocytes. In 1st group this indicator was twice higher and made 728 (654-836) (p1 = 0.002). In the 2nd group it was 5 times higher, than in group of control and authentically differed from an indicator of 1st group (1570 (1124-2120) (p1< 0.001, p2 = 0.002) the Correlation coefficient between number of the circulating microparticles and anklebone’s arterial blood pressure rS = -0.82 (p = 0.003), Correlation between the anklebone-humeral index and number of microparticles was equal to rS = -0.92 (p < 0.001). Toe’s arterial blood pressure had average force negative correlation with number of microparticles. The transcutaneous tension of oxygen and number of microparticles had a correlation coefficient equal rS = -0.89 (p = 0.002). The correlation coefficient between a gleam of the general femoral artery and number of microparticles of lymphocytic origin made rS = -0.44 (p = 0.016). A correlation coefficient between a gleam of a superficial femoral artery and number of microparticles of rS = -0.64 (p = 0.002). Negative correlations of number of microparticles with the kept gleam of a popliteal artery — rS = -0.79 (p < 0.001), and a back tibial artery — rS = -0.86 were high, (p < 0.001). Very high negative correlation coefficient was between the kept gleam of a lobby tibial and number of microparticles of lymphocytic origin of rS = -0.91 (p = 0.003). The revealed high and very high correlation bonds between number of the circulating microparticles of lymphocytic origin and indicators of a condition of an arterial blood-groove of the lower extremities, and the kept gleam of arteries of the lower extremities allow to speak about the prospects of use of microparticles as pathogenetic marker of critical ischemia of the lower extremities.

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Very High Resolution Analysis of the Dynamics of a Coronal Plasmoid

International Astronomical Union Colloquium ◽

10.1017/s0252921100026117 ◽

1994 ◽

Vol 144 ◽

pp. 593-596

Author(s):

O. Bouchard ◽

S. Koutchmy ◽

L. November ◽

J.-C. Vial ◽

J. B. Zirker

Keyword(s):

High Resolution ◽

Solar Eclipse ◽

Total Solar Eclipse ◽

Field Of View ◽

Small Field ◽

High Resolution Analysis ◽

Ccd Observations ◽

Resolution Analysis ◽

Very High ◽

Small Field Of View

AbstractWe present the results of the analysis of a movie taken over a small field of view in the intermediate corona at a spatial resolution of 0.5“, a temporal resolution of 1 s and a spectral passband of 7 nm. These CCD observations were made at the prime focus of the 3.6 m aperture CFHT telescope during the 1991 total solar eclipse.

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Monte Carlo Algorithms for Moments of Transition Arrays

International Astronomical Union Colloquium ◽

10.1017/s0252921100107468 ◽

1988 ◽

Vol 102 ◽

pp. 79-81

Author(s):

A. Goldberg ◽

S.D. Bloom

Keyword(s):

Monte Carlo ◽

State Vector ◽

Basis Vector ◽

Collective State ◽

Dispersion Characteristics ◽

Dipole Strength ◽

The Third ◽

Monte Carlo Algorithms ◽

Third Moment ◽

Very High

AbstractClosed expressions for the first, second, and (in some cases) the third moment of atomic transition arrays now exist. Recently a method has been developed for getting to very high moments (up to the 12th and beyond) in cases where a “collective” state-vector (i.e. a state-vector containing the entire electric dipole strength) can be created from each eigenstate in the parent configuration. Both of these approaches give exact results. Herein we describe astatistical(or Monte Carlo) approach which requires onlyonerepresentative state-vector |RV> for the entire parent manifold to get estimates of transition moments of high order. The representation is achieved through the random amplitudes associated with each basis vector making up |RV>. This also gives rise to the dispersion characterizing the method, which has been applied to a system (in the M shell) with≈250,000 lines where we have calculated up to the 5th moment. It turns out that the dispersion in the moments decreases with the size of the manifold, making its application to very big systems statistically advantageous. A discussion of the method and these dispersion characteristics will be presented.

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Decomposition of the metastable beta titanium alloy Ti-15-3

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100075117 ◽

1983 ◽

Vol 41 ◽

pp. 264-265

Author(s):

Y. L. Chen ◽

S. Fujlshiro

Keyword(s):

Low Cost ◽

High Strength ◽

Alpha Phase ◽

Thick Sheet ◽

Omega Phase ◽

Beta Titanium Alloy ◽

Beta Titanium ◽

Beta Matrix ◽

Metastable Beta ◽

Very High

Metastable beta titanium alloys have been known to have numerous advantages such as cold formability, high strength, good fracture resistance, deep hardenability, and cost effectiveness. Very high strength is obtainable by precipitation of the hexagonal alpha phase in a bcc beta matrix in these alloys. Precipitation hardening in the metastable beta alloys may also result from the formation of transition phases such as omega phase. Ti-15-3 (Ti-15V- 3Cr-3Al-3Sn) has been developed recently by TIMET and USAF for low cost sheet metal applications. The purpose of the present study was to examine the aging characteristics in this alloy.The composition of the as-received material is: 14.7 V, 3.14 Cr, 3.05 Al, 2.26 Sn, and 0.145 Fe. The beta transus temperature as determined by optical metallographic method was about 770°C. Specimen coupons were prepared from a mill-annealed 1.2 mm thick sheet, and solution treated at 827°C for 2 hr in argon, then water quenched. Aging was also done in argon at temperatures ranging from 316 to 616°C for various times.

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Deformation Replication

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100068394 ◽

1970 ◽

Vol 28 ◽

pp. 280-281

Author(s):

J. Temple Black

Keyword(s):

Cutting Speed ◽

Machining Process ◽

Depth Of Cut ◽

Rake Face ◽

Orthogonal Machining ◽

Aluminum Chips ◽

Before And After ◽

Materials Used ◽

Glass Knife ◽

Very High

Tool materials used in ultramicrotomy are glass, developed by Latta and Hartmann (1) and diamond, introduced by Fernandez-Moran (2). While diamonds produce more good sections per knife edge than glass, they are expensive; require careful mounting and handling; and are time consuming to clean before and after usage, purchase from vendors (3-6 months waiting time), and regrind. Glass offers an easily accessible, inexpensive material ($0.04 per knife) with very high compressive strength (3) that can be employed in microtomy of metals (4) as well as biological materials. When the orthogonal machining process is being studied, glass offers additional advantages. Sections of metal or plastic can be dried down on the rake face, coated with Au-Pd, and examined directly in the SEM with no additional handling (5). Figure 1 shows aluminum chips microtomed with a 75° glass knife at a cutting speed of 1 mm/sec with a depth of cut of 1000 Å lying on the rake face of the knife.

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Electron Microscopy in Molecular Biology

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100060027 ◽

1967 ◽

Vol 25 ◽

pp. 2-3

Author(s):

Cecil E. Hall

Keyword(s):

Electron Microscopy ◽

Molecular Biology ◽

Noise Level ◽

Molecular Structures ◽

Material Structure ◽

The Arts ◽

Shadow Casting ◽

Electron Image ◽

High Degree ◽

Very High

The visualization of organic macromolecules such as proteins, nucleic acids, viruses and virus components has reached its high degree of effectiveness owing to refinements and reliability of instruments and to the invention of methods for enhancing the structure of these materials within the electron image. The latter techniques have been most important because what can be seen depends upon the molecular and atomic character of the object as modified which is rarely evident in the pristine material. Structure may thus be displayed by the arts of positive and negative staining, shadow casting, replication and other techniques. Enhancement of contrast, which delineates bounds of isolated macromolecules has been effected progressively over the years as illustrated in Figs. 1, 2, 3 and 4 by these methods. We now look to the future wondering what other visions are waiting to be seen. The instrument designers will need to exact from the arts of fabrication the performance that theory has prescribed as well as methods for phase and interference contrast with explorations of the potentialities of very high and very low voltages. Chemistry must play an increasingly important part in future progress by providing specific stain molecules of high visibility, substrates of vanishing “noise” level and means for preservation of molecular structures that usually exist in a solvated condition.

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Use of LaB6 for a High Quality, Small Energy Spread Beam in an Electron Velocity Spectrometer

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100092633 ◽

1976 ◽

Vol 34 ◽

pp. 534-535 ◽

Cited By ~ 1

Author(s):

P. E. Batson ◽

C. H. Chen ◽

J. Silcox

Keyword(s):

High Temperature ◽

Energy Resolution ◽

Electron Velocity ◽

Electronic Excitations ◽

Small Energy ◽

Small Intensity ◽

Good Energy ◽

Spectrometer System ◽

Electron Energy Loss ◽

Very High

Electron energy loss experiments combined with microscopy have proven to be a valuable tool for the exploration of the structure of electronic excitations in materials. These types of excitations, however, are difficult to measure because of their small intensity. In a usual situation, the filament of the microscope is run at a very high temperature in order to present as much intensity as possible at the specimen. This results in a degradation of the ultimate energy resolution of the instrument due to thermal broadening of the electron beam.We report here observations and measurements on a new LaB filament in a microscope-velocity spectrometer system. We have found that, in general, we may retain a good energy resolution with intensities comparable to or greater than those available with the very high temperature tungsten filament. We have also explored the energy distribution of this filament.

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Some aspects of the defect structure in an austenitic stainless steel

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100108714 ◽

1978 ◽

Vol 36 (1) ◽

pp. 314-315

Author(s):

R. Gonzalez ◽

L. Bru

Keyword(s):

Stainless Steel ◽

Austenitic Stainless Steel ◽

Cellular Structures ◽

Total Strain Amplitude ◽

Total Deformation ◽

Density Of Dislocations ◽

Planar Arrays ◽

Stacking Fault Tetrahedra ◽

Distribution Of Dislocations ◽

Very High

The analysis of stacking fault tetrahedra (SFT) in fatigued metals (1,2) is somewhat complicated, due partly to their relatively low density, but principally to the presence of a very high density of dislocations which hides them. In order to overcome this second difficulty, we have used in this work an austenitic stainless steel that deforms in a planar mode and, as expected, examination of the substructure revealed planar arrays of dislocation dipoles rather than the cellular structures which appear both in single and polycrystals of cyclically deformed copper and silver. This more uniform distribution of dislocations allows a better identification of the SFT.The samples were fatigue deformed at the constant total strain amplitude Δε = 0.025 for 5 cycles at three temperatures: 85, 293 and 773 K. One of the samples was tensile strained with a total deformation of 3.5%.

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