P3-482: Alzheimer's disease patients’ cognitive functions are enhanced following a new non-invasive non-pharmacological treatment

2011 ◽  
Vol 7 ◽  
pp. S669-S669
Author(s):  
Niels Birbaumer
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Functions ◽  
Pharmacological Treatment ◽  
Non Invasive

A brief essay on non-pharmacological treatment of Alzheimer’s disease

2017 ◽  
Vol 28 (6) ◽  
pp. 587-597 ◽  
Author(s):  
Alberto Raggi ◽  
Domenica Tasca ◽  
Raffaele Ferri
Keyword(s):  
Quality Of Life ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Virtual Reality ◽  
Family Caregivers ◽  
Pharmacological Treatment ◽  
Complementary Therapies ◽  
Conclusive Evidence ◽  
Non Invasive

AbstractCurrent pharmacological therapies for Alzheimer’s disease (AD) do not modify its course and are not always beneficial. Therefore, the optimization of quality of life represents the best possible outcome achievable in all stages of the disease. Cognitive and behavioural rehabilitation represents the main therapeutic approach for this purpose, also in order to mitigate indirectly the burden of distress of family caregivers. The aim of this mini-review is to go through this theme by discussing cognitive activation, virtual reality and neuromodulation techniques. The practices summarized in this essay are not alternative but, often, complementary therapies to standardized pharmacological treatment. The present mini-review has found encouraging results but also the need for more conclusive evidence for all types of non-invasive/non-pharmacological treatment of AD.

scholarly journals ЭТИЧЕСКИЕ ПРЕПЯТСТВИЯ ПРИМЕНЕНИЯ КУКЛОТЕРАПИИ ПРИ ДЕМЕНЦИИ И БОЛЕЗНИ АЛЬЦГЕЙМЕРА

2020 ◽  
Vol 51 (3) ◽  
pp. 108-119
Author(s):  
Severina D. Koldman
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Older People ◽  
Cognitive Functions ◽  
Pharmacological Treatment ◽  
The Elderly ◽  
The Subject ◽  
Everyday Interaction

The article raises the question of the effectiveness and ethics of the method of doll therapy for older people suffering from a decrease in cognitive functions. The results of studies by sociologists and medical anthropologists, evidence of caring staff and relatives of people suffering from dementia and Alzheimer’s disease confirm that dolls make medication easier, improve mood and facilitate everyday interaction. The subject of discussion is the question of the ethics of the doll therapy in view of possible humiliation and dehumanization of older people. This study reveals the perception of doll therapy as a method of non-pharmacological treatment in caring for the elderly.

Effect Of Nhexane Extract Of Caryota No Seed On Markers Of Neurodegeneration And Fecundity In Drosophila Melanogaster

2020 ◽  
Vol 6 (5) ◽  
pp. 1-7
Author(s):  
Chinonye A Maduagwuna ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drosophila Melanogaster ◽  
Neurodegenerative Diseases ◽  
Cognitive Functions ◽  
The Elderly ◽  
Common Cause ◽  
Chronic Neuroinflammation

Study background: Chronic neuroinflammation is a common emerging hallmark of several neurodegenerative diseases. Alzheimer’s Disease (AD) is the most common cause of dementia among the elderly and is characterized by loss of memory and other cognitive functions.

scholarly journals Proteins and microRNAs are differentially expressed in tear fluid from patients with Alzheimer’s disease

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Aidan Kenny ◽  
Eva M. Jiménez-Mateos ◽  
María Ascensión Zea-Sevilla ◽  
Alberto Rábano ◽  
Pablo Gili-Manzanaro ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Unmet Need ◽  
Cost Effective ◽  
Specific Protein ◽  
Tear Fluid ◽  
Initiation Factor ◽  
Non Invasive ◽  
A Genome ◽  
Potential Biomarker

Abstract Alzheimer’s disease (AD) is characterized by a progressive loss of neurons and cognitive functions. Therefore, early diagnosis of AD is critical. The development of practical and non-invasive diagnostic tests for AD remains, however, an unmet need. In the present proof-of-concept study we investigated tear fluid as a novel source of disease-specific protein and microRNA-based biomarkers for AD development using samples from patients with mild cognitive impairment (MCI) and AD. Tear protein content was evaluated via liquid chromatography-mass spectrometry and microRNA content was profiled using a genome-wide high-throughput PCR-based platform. These complementary approaches identified enrichment of specific proteins and microRNAs in tear fluid of AD patients. In particular, we identified elongation initiation factor 4E (eIF4E) as a unique protein present only in AD samples. Total microRNA abundance was found to be higher in tears from AD patients. Among individual microRNAs, microRNA-200b-5p was identified as a potential biomarker for AD with elevated levels present in AD tear fluid samples compared to controls. Our study suggests that tears may be a useful novel source of biomarkers for AD and that the identification and verification of biomarkers within tears may allow for the development of a non-invasive and cost-effective diagnostic test for AD.

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