Interarm blood pressure difference, cardiovascular risk and organ damage in type 2 diabetes

2015 ◽  
Vol 9 (4) ◽  
pp. e40-e41 ◽  
Author(s):  
Massimiliano Fedecostante ◽  
Francesco Spannella ◽  
Federico Giulietti ◽  
Maddalena Ricci ◽  
Marianna Pavani ◽  
...  
2019 ◽  
Vol 7 (1) ◽  
pp. e000787 ◽  
Author(s):  
Rianneke de Ritter ◽  
Simone J S Sep ◽  
Carla J H van der Kallen ◽  
Miranda T Schram ◽  
Annemarie Koster ◽  
...  

ObjectiveTo investigate whether adverse differences in levels of cardiovascular risk factors in women than men, already established when comparing individuals with and without diabetes, are also present before type 2 diabetes onset.Research design and methodsIn a population-based cohort study of individuals aged 40-75 years (n=3410; 49% women, 29% type 2 diabetes (oversampled by design)), we estimated associations with cardiometabolic and lifestyle risk factors of (1) pre-diabetes and type 2 diabetes (reference category: normal glucose metabolism) and (2) among non-diabetic individuals, of continuous levels of hemoglobin A1c (HbA1c). Age-adjusted sex differences were analyzed using linear and logistic regression models with sex interaction terms.ResultsIn pre-diabetes, adverse differences in cardiometabolic risk factors were greater in women than men for systolic blood pressure (difference, 3.02 mm Hg; 95% CI:−0.26 to 6.30), high-density lipoprotein (HDL) cholesterol (difference, −0.10 mmol/L; 95% CI: −0.18 to −0.02), total-to-HDL cholesterol ratio (difference, 0.22; 95% CI: −0.01 to 0.44), triglycerides (ratio: 1.11; 95% CI: 1.01 to 1.22), and inflammation markers Z-score (ratio: 1.18; 95% CI: 0.98 to 1.41). In type 2 diabetes, these sex differences were similar in direction, and of greater magnitude. Additionally, HbA1c among non-diabetic individuals was more strongly associated with several cardiometabolic risk factors in women than men: per one per cent point increase, systolic blood pressure (difference, 3.58 mm Hg; 95% CI: −0.03 to 7.19), diastolic blood pressure (difference, 2.10 mm Hg; 95% CI: −0.02 to 4.23), HDL cholesterol (difference, −0.09 mmol/L; 95% CI: −0.19 to 0.00), and low-density lipoprotein cholesterol (difference, 0.26 mmol/L; 95% CI: 0.05 to 0.47). With regard to lifestyle risk factors, no consistent pattern was observed.ConclusionOur results are consistent with the concept that the more adverse changes in cardiometabolic risk factors in women (than men) arise as a continuous process before the onset of type 2 diabetes.


2009 ◽  
Vol 59 (563) ◽  
pp. 428-432 ◽  
Author(s):  
Christopher E Clark ◽  
Colin J Greaves ◽  
Philip H Evans ◽  
Andy Dickens ◽  
John L Campbell

2020 ◽  
pp. 1-3
Author(s):  
Anand Jadhao ◽  
Saumya Naik ◽  
Megha Bhonde ◽  
Saurabh Mishra

In type 2 diabetes mellitus (DM-2), cardiovascular diseases are the important cause of mortality and morbidity. Regular monitoring of the diabetic condition is essential for the proper management of diabetes & effective controlling of diabetes-related complications. As the recording of IAD (Interarm blood pressure difference) is a simple procedure and it is also related to the vascular complication, it can be a vital indicator of the severity of diabetes. So, it is very important to study IAD concerning Complicated and Non-Complicated DM-2 which will be helpful for planning a better clinical management. In this cross-sectional study, we compare Interarm blood pressure difference in three groups i.e. Control, Non-Complicated DM-2 and Complicated DM-2 groups. There is a significant increase in systolic IAD in DM-2 group as compared to the control group, but no significant difference found between Non-Complicated and Complicated DM-2 groups.


2020 ◽  
Vol 17 (4) ◽  
pp. 147916412094591
Author(s):  
Ji Hyun Lee ◽  
Ye An Kim ◽  
Young Lee ◽  
Woo-Dae Bang ◽  
Je Hyun Seo

Background: The effect of interarm blood pressure difference on the development of diabetic retinopathy, proteinuria and chronic kidney disease remains unknown. We investigated to determine the impact of interarm blood pressure difference on the prevalence of diabetic retinopathy, proteinuria and chronic kidney disease in patients with type 2 diabetes. Methods: The study included 563 patients with diabetes, who were evaluated with a simultaneous bilateral blood pressure measurement. The cutoff values for interarm blood pressure difference were 5, 10 and 15 mmHg. Logistic regression analysis was used to explore the relation between interarm blood pressure difference and diabetic retinopathy, proteinuria and chronic kidney disease. Results: Diabetic patients with systolic interarm blood pressure difference ⩾5, ⩾10 and ⩾15 mmHg showed an increased risk of diabetic retinopathy [adjusted odds ratio = 1.48 (95% confidence interval = 1.01–2.18), odds ratio = 1.80 (95% confidence interval = 0.99–3.22), odds ratio = 2.29 (95% confidence interval = 1.00–5.23)] after adjustment. There were significant associations between interarm blood pressure difference ⩾5 and ⩾10 mmHg and proteinuria [odds ratio = 1.68 (95% confidence interval = 1.15–2.44), 1.89 (95% confidence interval = 1.05–3.37)]. Conclusion: The association between interarm blood pressure difference and the presence of diabetic retinopathy emerged even for systolic interarm blood pressure difference ⩾5 mmHg without interaction of systolic blood pressure. Systolic interarm blood pressure difference should be considered a surrogate marker for vascular complication in patients with type 2 diabetes.


Author(s):  
Dr. Amal Al Balushi ◽  
Dr Firdous Jahan ◽  
Dr. Maiya Al Jahdhami ◽  
Dr. Kamlesh Bhargava

Hypertension in patients with diabetes is a common problem; it increases the risk of cardiovascular, renal and ophthalmologic complications. Appropriate measurement of blood pressure is important, as the readings are the target of all pharmacological and non-pharmacological treatment. The aim of the present study was to observe the prev-alence of significant difference in blood pressure in the arms in type 2 Diabetics and to establish if there is association between inter-arm blood pressure difference (IAD) and cardiovascular risk. A cross sectional study conducted in 5 primary care health centers. BP measurements were done by automatic Omron 7 machine; the measure-ments were done two times with interchanging the instruments between two arms. Da-ta collection included demographic data (including, age, sex, body mass index (BMI), waist circumferences, duration of Diabetes, history of HTN, and smoking status).The data collection form also included entry of last biochemical investigations done in-cluding total cholesterol, LDL, HDL, triglyceride, glycosylated hemoglobin (HbA1c) and Cardiovascular risk (CV risk ) calculated by UKPDS engine version 2.0. Data was analyzed with SPSS (version 19). A total of 155 patients were studied. Mean age of patients was 55yrs. 22 participants (14.2, 95% CI=9.1-20.7) had systolic IAD >10 mmHg, 51 (33%, 95% CI=25.6-40.9) had a diastolic IAD >5 mmHg and 9 (5.8 %, 95% CI=2.7-10.7) had a diastolic difference >10 mmHg. In addition, the results showed statistically significant correlation between systolic interarm BP difference and duration of diabetes (P=0.025).There is significant diastolic interarm blood pres-sure difference in diabetic patients. Hence it is important to measure the blood pres-sure in both arms for patients with diabetes to treat hypertension in diabetics appropri-ately.


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