Chinese sumac (Rhus chinensis Mill.) fruits alleviate indomethacin-induced gastric ulcer in mice by improving oxidative stress, inflammation and apoptosis

2021 ◽  
pp. 114752
Author(s):  
Nan Ma ◽  
Yilin Sun ◽  
Junjie Yi ◽  
Linyan Zhou ◽  
Shengbao Cai
Keyword(s):  
Oxidative Stress ◽  
Gastric Ulcer ◽  
Rhus Chinensis

scholarly journals Gastroprotective effect of mucilage fraction from Solenostemma argel via cytoprotection and attenuation of oxidative stress, inflammation and apoptosis

2021 ◽  
Vol 10 (2) ◽  
pp. 232-240
Author(s):  
Riham A. El-Shiekh ◽  
Abeer Salama ◽  
Asmaa K. Al-Mokaddem ◽  
Essam A. Abdel-Sattar
Keyword(s):  
Oxidative Stress ◽  
Gastric Ulcer ◽  
High Performance ◽  
Angiotensin Converting Enzyme Inhibition ◽  
Cytotoxic Activities ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Anti Oxidant ◽  
Converting Enzyme Inhibition ◽  
Gross Examination

Introduction: Polysaccharides have numerous therapeutic values including immunity stimulation, angiotensin converting enzyme inhibition, wound healing, anti-diabetic and cytotoxic activities, in addition to their potent anti-oxidant properties. This work examined the gastroprotective and ulcer healing potential of mucilage fraction isolated from Solenostemma argel (Delile) Hayne (MFA) against ethanol-induced gastric ulcer in rats. Methods: Forty Sprague-Dawley rats were divided into five groups (n=8); normal control (I), ethanol control (II), 20 mg/kg Antodine pretreated rats (III), 100 mg/kg, and 200 mg/kg MFA pretreated rats, respectively (IV & V). All rats in groups II-V received single intragastric dose of ethanol (5 mL/kg) to induce gastric ulcer. Gastric mucosal injuries were assessed by stomach gross examination as well as histopathology, and immunohistochemistry of apoptotic markers. Also, several biochemical parameters including oxidative stress, proinflammatory cytokines, cytoprotective and cell proliferative biomarkers were measured. Results: High-performance liquid chromatography (HPLC) analysis of MFA revealed its composition of glucose, D-fucose and N-acetyl glucosamine as monosaccharaides, in addition to glucuronic and galacturonic acids. The data showed that MFA, 200 mg/kg had potent antioxidant, anti-inflammatory, cytoprotective, cell proliferative, and antiapoptotic activities which were better than Antodine. Conclusion: This study revealed that MFA had significant gastroprotective effects against ethanol-induced gastric injuries and could be a promising adjuvant therapy for ulcer treatment.

Anti-ulcerogenic effect of the methanol extract of Chasmanthera dependens (Hochst) stem on male Wistar rats

2018 ◽  
Vol 29 (4) ◽  
pp. 377-383 ◽  
Author(s):  
Stephanie Abiola Tijani ◽  
Samuel B. Olaleye ◽  
Ebenezer O. Farombi
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Gastric Ulcer ◽  
Gastric Mucosa ◽  
Antioxidant System ◽  
Methanol Extract ◽  
Histopathological Examination ◽  
Antioxidant Properties ◽  
Male Rats ◽  
Standard Drug

AbstractBackgroundOxidative stress and free radical-mediated processes have been implicated in the pathogenesis of indomethacin-induced gastric ulcer. This study investigated the ability of the methanol extract ofChasmanthera dependensto protect the gastric mucosal from oxidative damage induced by oral administration of indomethacin in rats.MethodsTheC. dependensstems were chopped into pieces, air-dried, and pulverized into powder. One kilogram of the powder was macerated in 1 L of methanol for 72 h. The mixture was filtered and evaporated using rotatory evaporator to obtain the extract ofC. dependens. Adult male rats were divided into eight groups of six animals per group and were pretreated orally with the methanol extract ofC. dependens(200, 400, and 800 mg/kg) or cimetidine (CIM), a standard drug (50 mg/kg), for 7 days. Gastric ulcer was induced orally with indomethacin. Ulcerogenic parameters, oxidative stress indices, and histopathological examination of the stomach were assessed to monitor the gastroprotective potential ofC. dependensstem.ResultsIndomethacin caused severe gastric mucosa damage and significant reduction in the gastric mucosa antioxidant system with concomitant increase in the level of lipid peroxidation. Pretreatment with the methanol extract ofC. dependensor CIM significantly reduced the formation of ulcer at the different doses administered. Similarly, pretreatments with the extract or CIM improved the antioxidant system, decreased acid output, lipid peroxidation, and improved the architecture of the gastric mucosa in ulcerated rats.ConclusionsThe results show the gastroprotective effect of the methanolic extract ofC. dependens, which may be attributed to its antioxidant properties.

scholarly journals Malvidin Protects against and Repairs Peptic Ulcers in Mice by Alleviating Oxidative Stress and Inflammation

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3312
Author(s):  
Felipe Leonardo Fagundes ◽  
Quélita Cristina Pereira ◽  
Melina Luzzi Zarricueta ◽  
Raquel de Cássia dos Santos
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Acetic Acid ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Defense Mechanisms ◽  
Ischemia Reperfusion ◽  
Peptic Ulcers ◽  
Anti Inflammatory ◽  
And Oxidative Stress

Peptic ulcer episodes cause damage to the stomach and intestine, with inflammatory cell infiltration and oxidative stress as the main players. In this study, we investigated the potential of anthocyanidin malvidin for preventive and curative peptic ulcer treatment. The anthocyanidin effects were examined in gastric ulcer mouse models induced by ethanol, non-steroidal anti-inflammatory drugs (NSAIDs), ischemia-reperfusion (IR), acetic acid and duodenal ulcer induced by polypharmacy. Expression levels of oxidative and inflammatory genes were measured to investigate the mechanism of anthocyanin activity. At a dose of 5 mg·kg−1, Malvidin prevented gastric ulcer induction by ethanol, NSAID and repaired the tissue after 6 days of IR. Moreover, the anthocyanidin accelerated the healing of acetic acid-induced ulcer, increased the gene expression of EGF and COX-1, and downregulated MMP-9. Anthocyanin treatment mitigated the effect of polypharmacy on inflammation and oxidative stress observed in the intestine. Additionally, the compound downregulated cytokine expression and TLR4 and upregulated HMOX-1 and IL-10, exhibiting protective activity in the mouse gut. Malvidin thus prevented gastric and duodenal ulcers due to prominent anti-inflammatory and antioxidative effects on the gastrointestinal tract that were related to gene expression modulation and an increase in endogenous defense mechanisms.

scholarly journals Study on the Influence of Free Radicals and Oxidative Stress on Peptic Ulcers

2019 ◽  
Vol 70 (9) ◽  
pp. 3254-3257
Author(s):  
Germaine Savoiu Balint ◽  
Emeric Toth ◽  
Mihaiela Andoni ◽  
Ioan Demeter ◽  
Claudia Borza ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gastric Ulcer ◽  
Gastric Carcinoma ◽  
Organ Bath ◽  
Vascular Endothelial ◽  
Peptic Ulcers ◽  
Antioxidant Treatment ◽  
And Oxidative Stress

It can be observed that oxidative stress initiates and aggravates many diseases, including peptic ulcers and gastric carcinoma. An increase in rat mucosal glandular lipid peroxidation (LPO) and superoxide dismutase (SOD) and a decrease in catalase (CAT) levels in gastric ulceration induced by cold retention stress were observed, whereas in patients with ulcerated clinical peptic and gastric carcinoma LPO serum is associated with a decrease in SOD and CAT. It was intended to determine the parameters of oxidative stress in the blood and brain in rats after induction of gastric ulcer, the effect of antioxidant treatment on these parameters and on the appearance of gastric ulcer, determination of correlation between oxidative stress and severity of gastric ulcer in rats and also evaluation of vascular endothelial function by in vitro studies in the organ bath, from rat aortic rings with gastric ulcer vs. normal and others under treatment vs. untreated.

scholarly journals Comparative Study of the Efficacy of Prebiotics and Probiotics as Dietary Supplements in Rats with Gastric Ulcer

2021 ◽  
pp. 137-145
Author(s):  
Ahmad Ali Al-garni ◽  
Fares K. Khalifa ◽  
Mustafa Adnan Zeyadi
Keyword(s):  
Oxidative Stress ◽  
Gastric Ulcer ◽  
Comparative Study ◽  
Gastrointestinal Disease ◽  
Gastric Injury ◽  
Health Issues ◽  
Potent Effect ◽  
Treatment Groups ◽  
Important Health ◽  
Healthy Control

Gastric ulcer is considered as main problem of gastrointestinal disease, presenting one of the most important health issues in all societies. This comparative study designed to explore the anti-ulcerogenic role of probiotics and prebiotics and to evaluate the most potent effect against gastric ulcer. Sixty rats were distributed into 6 groups : G1 Healthy control; G2 gastric ulcer (GU), ulcer was induced by four oral doses of Aspirin 200 mg/kg b.w./week ;G3 Prebiotics (PreB) administered orally group ( 0.5 g/day); G4 Probiotics (ProB) administered orally group ( 0.5 mg/day); G5 Prebiotics (Therapeutic): prebiotics was administered orally at dose ( 0.5g/day) for 30 days after induction of gastric ulcer (GU+PreB); G6 Probiotics (Therapeutic): probiotics was administered orally at dose ( 0.5mg/day) for 30 days after induction of gastric ulcer (GU+ProB). Oxidative stress parameters and inflammatory markers were measured. Results revealed that: aspirin caused gastric ulcer associated with increased MDA, TNF-α, IL-6, and IL-10 and decreased gastroprotective mediators SOD, GSH, CAT, and PGE2compared with control rats. Treatment with prebiotics or probiotics efficiently reduces gastric injury, oxidative stress and proinflammatory cytokines. Comparing treatment groups showed that, Probiotics as a therapeutic group was the most potent demonstrated a hopeful role against gastric ulcer.

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