The epidemiological characteristics and genetic diversity of dengue virus during the third largest historical outbreak of dengue in Guangdong, China, in 2014

2016 ◽  
Vol 72 (1) ◽  
pp. 80-90 ◽  
Author(s):  
Jiufeng Sun ◽  
De Wu ◽  
Huiqiong Zhou ◽  
Huan Zhang ◽  
Dawei Guan ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Dengue Virus ◽  
The Third ◽  
Epidemiological Characteristics

scholarly journals Time to Harmonize Dengue Nomenclature and Classification

Viruses ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 569 ◽  
Author(s):  
Lize Cuypers ◽  
Pieter Libin ◽  
Peter Simmonds ◽  
Ann Nowé ◽  
Jorge Muñoz-Jordán ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Dengue Virus ◽  
Classification System ◽  
Formal Definition ◽  
Classification Procedure ◽  
Genotype 2 ◽  
Global Spread ◽  
Significant Burden ◽  
Definition Of ◽  
Epidemiological Characteristics

Dengue virus (DENV) is estimated to cause 390 million infections per year worldwide. A quarter of these infections manifest clinically and are associated with a morbidity and mortality that put a significant burden on the affected regions. Reports of increased frequency, intensity, and extended geographical range of outbreaks highlight the virus’s ongoing global spread. Persistent transmission in endemic areas and the emergence in territories formerly devoid of transmission have shaped DENV’s current genetic diversity and divergence. This genetic layout is hierarchically organized in serotypes, genotypes, and sub-genotypic clades. While serotypes are well defined, the genotype nomenclature and classification system lack consistency, which complicates a broader analysis of their clinical and epidemiological characteristics. We identify five key challenges: (1) Currently, there is no formal definition of a DENV genotype; (2) Two different nomenclature systems are used in parallel, which causes significant confusion; (3) A standardized classification procedure is lacking so far; (4) No formal definition of sub-genotypic clades is in place; (5) There is no consensus on how to report antigenic diversity. Therefore, we believe that the time is right to re-evaluate DENV genetic diversity in an essential effort to provide harmonization across DENV studies.

scholarly journals Nationwide Distribution of Dengue Virus Type 3 (DENV-3) Genotype I and Emergence of DENV-3 Genotype III during the 2019 Outbreak in Bangladesh

2021 ◽  
Vol 6 (2) ◽  
pp. 58
Author(s):  
Snigdha Rahman Titir ◽  
Shyamal Kumar Paul ◽  
Salma Ahmed ◽  
Nazia Haque ◽  
Syeda Anjuman Nasreen ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Secondary Infection ◽  
Capital City ◽  
Endemic Region ◽  
Genotype I ◽  
Genotype Iii ◽  
Two Samples ◽  
Dengue Virus Type 3 ◽  
Type 3 ◽  
Epidemiological Characteristics

Bangladesh is an endemic region of dengue fever and experienced an unprecedented large outbreak with more than 100,000 confirmed cases in 2019. To understand the prevalence of dengue antibody in patients and molecular epidemiological characteristics of dengue virus (DENV) in this outbreak, a total of 179 blood samples were collected from patients in 10 districts (seven divisions) covering nearly the whole country from August to December 2019. DENV NS-1 was detected in 162 samples, among which DENV-specific IgM was positive in 119 samples (73.5%), including 60.5% samples also positive for DENV-specific IgG. Sequencing of the partial C-prM gene and its phylogenetic analysis revealed predominance of DENV type 3 genotype I, accounting for 93% of samples examined. DENV-3 genotype III was identified in two samples from separate districts, and only one DENV-2 cosmopolitan genotype was found in the capital city, Dhaka. These findings suggest the predominance of DENV-3 genotype I and occurrence of DENV-3 genotype III, associated with increased incidence of recent secondary infection in Bangladesh in 2019.

scholarly journals Why and How to Switch to Genomic Selection: Lessons From Plant and Animal Breeding Experience

2021 ◽  
Vol 12 ◽  
Author(s):  
◽  
Aline Fugeray-Scarbel ◽  
Catherine Bastien ◽  
Mathilde Dupont-Nivet ◽  
Stéphane Lemarié
Keyword(s):  
Genetic Diversity ◽  
Genomic Selection ◽  
Plant Species ◽  
Animal Species ◽  
Animal Breeding ◽  
Breeding Cycle ◽  
Breeding Programs ◽  
The Third ◽  
Wide Range ◽  
Selection For

The present study is a transversal analysis of the interest in genomic selection for plant and animal species. It focuses on the arguments that may convince breeders to switch to genomic selection. The arguments are classified into three different “bricks.” The first brick considers the addition of genotyping to improve the accuracy of the prediction of breeding values. The second consists of saving costs and/or shortening the breeding cycle by replacing all or a portion of the phenotyping effort with genotyping. The third concerns population management to improve the choice of parents to either optimize crossbreeding or maintain genetic diversity. We analyse the relevance of these different bricks for a wide range of animal and plant species and sought to explain the differences between species according to their biological specificities and the organization of breeding programs.

scholarly journals EVALUATION OF GENETIC DIVERSITY IN CACAO COLLECTED FROM KOLAKA, SOUTHEAST SULAWESI, USING SSR MARKERS

2016 ◽  
Vol 16 (2) ◽  
pp. 71
Author(s):  
Rubiyo Rubiyo ◽  
Nur Kholilatul Izzah ◽  
Indah Sulistiyorini ◽  
Cici Tresniawati
Keyword(s):  
Genetic Diversity ◽  
Ssr Markers ◽  
Gel Electrophoresis ◽  
Genetic Similarity ◽  
Similarity Coefficient ◽  
Breeding Program ◽  
New Variety ◽  
Average Value ◽  
The Third ◽  
Ctab Method

Kolaka, which is located in Southeast Sulawesi, has long been known as one of cacao production centers in Indonesia. Therefore, many different cacao germplasms can be found in this region. The study aimed to evaluate genetic diversity and relationships of 12 cacao genotypes collected from Kolaka. Genomic DNA was extracted by using a modified CTAB method. Meanwhile, genetic diversity was analyzed based on 16 SSR markers, which then separated by 6% non-denaturing polyacryl-amide gel electrophoresis. The result showed that all of those markers, 14 markers exhibited polymorphism and subsequently used for data analysis using NTSYS and PowerMarker program. About 70 different alleles were generated from 12 cacao genotypes analyzed with an average of 5 alleles per locus. Average value of polymorphism information content (PIC) resulted in this study was 0.59. The cluster analysis using UPGMA method based on the genetic similarity coefficient revealed that all cacao genotypes were separated into three major groups. The first group consisted of five cacao genotypes, the second one held four cacao genotypes, whereas the third group contained three genotypes. This result indicates that three genotypes that clustered separately from the others could be used as a good clonal candidate for cacao breeding program. The information resulted from this present study would be useful for future cacao breeding program, especially in efforts to release a new variety.

scholarly journals Tracking dengue virus type 1 genetic diversity during lineage replacement in an hyperendemic area in Colombia

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0212947
Author(s):  
Mauricio A. Salvo ◽  
Matthew T. Aliota ◽  
Louise H. Moncla ◽  
Ivan D. Velez ◽  
Andrea I. Trujillo ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Dengue Virus ◽  
Virus Type ◽  
Hyperendemic Area

Neonate with haemophagocytic lymphohistiocytosis secondary to dengue infection: a case report

2016 ◽  
Vol 47 (3) ◽  
pp. 253-255 ◽  
Author(s):  
MV Krithika ◽  
Prakash Amboiram ◽  
Sneha M Latha ◽  
Binu Ninan ◽  
Febe Renjitha Suman ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Case Report ◽  
Virus Infection ◽  
Dengue Virus ◽  
Dengue Infection ◽  
Haemophagocytic Lymphohistiocytosis ◽  
Dengue Virus Infection ◽  
The Third ◽  
First Case

We report the first case of haemophagocytic lymphohistiocytosis (HLH) in a neonate secondary to primary Dengue virus infection. This neonate presented in the third week of life with fever, shock and hepatosplenomegaly and was diagnosed to have Dengue infection by serology and HLH was confirmed on bone marrow.

Further investigations of vegetative compatibility within Fusarium oxysporum f.sp. melonis

1990 ◽  
Vol 68 (6) ◽  
pp. 1245-1248 ◽  
Author(s):  
D. J. Jacobson ◽  
T. R. Gordon
Keyword(s):  
Genetic Diversity ◽  
North America ◽  
Fusarium Oxysporum ◽  
Vegetative Compatibility ◽  
Vegetative Compatibility Group ◽  
Culture Collections ◽  
Vegetative Compatibility Groups ◽  
The Third ◽  
Geographic Origins ◽  
Compatibility Group

One hundred and nineteen strains of Fusarium oxysporum f.sp. melonis were characterized by virulence and vegetative compatibility. One hundred and seven strains were placed in four previously reported vegetative compatibility groups: 0130, 0131, 0133, and 0134. Four strains were placed in three new vegetative compatibility groups, and the remaining eight strains were vegetatively self-incompatible. Two of the three new vegetative compatibility groups shared similar geographic origins and distribution with two previously reported vegetative compatibility groups; the third represented a more isolated infestation. All vegetatively self-incompatible isolates originated from culture collections; none have been recently isolated from nature. These newly characterized strains extend our knowledge of genetic diversity in F. oxysporum f.sp. melonis. All four F. oxysporum f.sp. melonis races exist in more than one vegetative compatibility group. European strains represent four vegetative compatibility groups, one of which is present in North America and another in the Middle East. The significance of this diversity is unknown, as are the phylogenetic relationships among strains in this forma specialis.

scholarly journals Características epidemiológicas da população brasileira e implicações à condução de pesquisas clínicas / Epidemiological characteristics of the Brazilian population and implications for the conduction of clinical research

2019 ◽  
Vol 64 (2) ◽  
pp. 142
Author(s):  
Marina De Carvalho Souza Ferreira ◽  
Luis Lopez Martinez
Keyword(s):  
Genetic Diversity ◽  
Clinical Trials ◽  
Clinical Research ◽  
Large Population ◽  
Population Sample ◽  
Target Population ◽  
Brazilian Population ◽  
Diverse Groups ◽  
Epidemiological Characteristics ◽  
Burden Of Diseases

Objetivo: A Pesquisa Clínica (PC) é um meio fundamental para a redução da carga de doenças mundialmente, proporcionando o desenvolvimento de terapias inovadoras, seguras e eficazes. Para tanto, necessita-se considerar que os participantes nela incluídos sejam representativos da população alvo do produto estudado, garantindo a confiabilidade e a capacidade de generalização dos resultados obtidos. Logo, a inclusão de grupos diversificados resulta, futuramente, em uma maior qualidade na prestação de assistência à saúde. Com isso, buscou-se caracterizar a população brasileira, gerando informações que possam ser relevantes e atrativas para a realização de PC no país, destacando-se a importância da diversidade genética na amostra populacional a ser alocada em PC. Material e Método: Levantamento através de bases de dados científicas e governamentais.  Resultados e Conclusão: A realização de PC no Brasil, além de representar oportunidades de benefícios econômicos, técnicos e estruturais para o país, possui a qualidade de incluir uma população numerosa, composta por uma grande variedade étnico-racial, podendo representar uma vantagem competitiva e estratégica na escolha de países para realização de estudos multicêntricos internacionais.Descritores: Pesquisa Clínica, Estudo Clínico, Epidemiologia, População, BrasilABSTRACTObjective: Clinical Research (CR) is a fundamental path to reduce the burden of diseases worldwide by providing the development of innovative, safe and effective therapies, mainly through clinical trials. Therefore, the design of a CR needs to consider that the participants included are representative of the target population of the studied product, guaranteeing the reliability and generalization of the results. Thus, the inclusion of diverse groups results in a higher quality in the provision of healthcare. Thereby, we sought to characterize the Brazilian population, generating information that may be relevant and attractive to the development of CR in that country, highlighting the importance of genetic diversity in the population sample to be allocated in CR. Material and Methods: Survey through scientific and governmental databases. Results and Conclusion: Brazil, in addition to providing economic, technical and structural benefits for the development of clinical research, has a large population and comprises a large ethnic-racial variety, which may represent a competitive and strategic advantage in the choice of countries to perform multicenter and international studies.Keywords:, Clinical Research, Clinical Study, Epidemiology, Population, Brazil

scholarly journals Regulatory options for exchange, use and conservation of animal genetic resources: a closer look at property right issues

2007 ◽  
Vol 41 ◽  
pp. 91-99 ◽  
Author(s):  
M.W. Tvedt ◽  
S.J. Hiemstra ◽  
A.G. Drucker ◽  
N. Louwaars ◽  
J.K. Oldenbroek
Keyword(s):  
Genetic Diversity ◽  
Genetic Resources ◽  
Genetic Material ◽  
Property Right ◽  
The Third ◽  
Animal Genetic Resources ◽  
Depth Analysis ◽  
Further Development

SummaryThree main areas for further development of policies or regulatory options for animal genetic resources (AnGR) were identified in a study on the exchange, use and conservation of AnGR (Hiemstra et al., 2006):1. how to halt the further erosion of genetic diversity and promote sustainable breeding and use,2. whether there is a need to further regulate the exchange of genetic material and3 how to balance different systems of property and use rights.This paper provides an in-depth analysis regarding the third challenge, that of addressing the problems and options available for balancing the different property right systems for AnGR.

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