pH, temperature and reduction multi-responsive polymeric microspheres as drug delivery system for anti-tumor drug: Effect of middle hollow layer between pH and reduction dual-responsive cores and temperature sensitive shells

2017 ◽  
Vol 74 ◽  
pp. 238-245 ◽  
Author(s):  
Jiagen Li ◽  
Jin Zeng ◽  
Xu Jia ◽  
Lei Liu ◽  
Tingting Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Effect ◽  
Temperature Sensitive ◽  
Polymeric Microspheres ◽  
Dual Responsive

A Smart Drug Delivery System Based on Thermo-Responsive Polymer Gated Au NRs@SiO2 Nano-Platform

2021 ◽  
Vol 16 (7) ◽  
pp. 1029-1036
Author(s):  
Hongzhu Wang ◽  
Mengxun Chen ◽  
Liping Song ◽  
Youju Huang
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Photothermal Therapy ◽  
Drug Loading ◽  
Temperature Sensitive

A key challenge for nanoparticles-based drug delivery system is to achieve manageable drug release in tumour cell. In this study, a versatile system combining photothermal therapy and controllable drug release for tumour cells using temperature-sensitive block copolymer coupled Au NRs@SiO2 is reported. While the Au NRs serve as hyperthermal agent and the mesoporous silica was used to improve the drug loading and decrease biotoxicity. The block copolymer acted as “gatekeeper” to regulate the release of model drug (Doxorubicin hydrochloride, DOX). Through in vivo and in vitro experiments, we achieved the truly controllable drug release and photothermal therapy with the collaborative effect of the three constituents of the nanocomposites. The reported nanocomposites pave the way to high-performance controllable drug release and photothermal therapy system.

scholarly journals Reactive oxygen species and enzyme dual-responsive biocompatible drug delivery system for targeted tumor therapy

2020 ◽  
Vol 324 ◽  
pp. 330-340 ◽  
Author(s):  
Ning Zhao ◽  
Bingbing Ding ◽  
Ying Zhang ◽  
Jessica L. Klockow ◽  
Ken Lau ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Therapy ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Dual Responsive

Pickering nano-emulsions stabilized by solid lipid nanoparticles as a temperature sensitive drug delivery system

Soft Matter ◽  
2019 ◽  
Vol 15 (40) ◽  
pp. 8164-8174 ◽  
Author(s):  
Sidy Mouhamed Dieng ◽  
Nicolas Anton ◽  
Patrick Bouriat ◽  
Oumar Thioune ◽  
Papa Mady Sy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Environmental Impact ◽  
Drug Delivery System ◽  
Delivery System ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Temperature Sensitive ◽  
Solid Lipid ◽  
System P

The development of biomaterials with low environmental impact has seen increased interest in recent years.

scholarly journals Microsponge as an Emerging Technique in Novel Drug Delivery System

2021 ◽  
Vol 11 (1) ◽  
pp. 171-182
Author(s):  
Payal D Borawake ◽  
Arumugam Kauslya ◽  
Jitendra V Shinde ◽  
Rajashree S Chavan
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Product Performance ◽  
Topical Drug Delivery ◽  
Polymeric Microspheres ◽  
Current Review ◽  
Improved Stability ◽  
Novel Drug

Numbers of developments are implemented in drug delivery system to achieve the goals of optimized efficacy, cost effectiveness of therapy. One of the latest, novel and highly evolving technologies is microsponge drug delivery system which gives controlled release and site specific delivery of active ingredients. They are highly cross linked, porous and polymeric microspheres with size range of 5-300µm. This system is emerging as valuable option for topical delivery of drugs due to characteristics like decreased side effects, improved stability, better formulation flexibility, superior product performance. It is having number of applications in oral, topical, ocular and biopharmaceuticals delivery. The current review describes microsponge technology and details of the formulation methods, evaluation, programmable release mechanisms and applications.   Keywords: Microsponges; Controlled release; Quasi emulsion solvent diffusion; Programmable drug release; Oral administration; Topical drug delivery.

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