scholarly journals Physico-chemical properties of the water-soluble C70-tris-malonic solutions

2015 ◽  
Vol 211 ◽  
pp. 487-493 ◽  
Author(s):  
Olga S. Manyakina ◽  
Konstantin N. Semenov ◽  
Nikolay A. Charykov ◽  
Natalia M. Ivanova ◽  
Viktor A. Keskinov ◽  
...  
Keyword(s):  
Chemical Properties ◽  
Water Soluble ◽  
Physico Chemical

Amorphous and Crystalline Particulates: Challenges and Perspectives in Drug Delivery

2017 ◽  
Vol 23 (3) ◽  
pp. 350-361 ◽  
Author(s):  
Hisham Al-Obaidi ◽  
Mridul Majumder ◽  
Fiza Bari
Keyword(s):  
Crystal Engineering ◽  
Drug Carrier ◽  
Solid Dispersions ◽  
Chemical Properties ◽  
Pharmaceutical Product ◽  
Water Soluble ◽  
Amorphous Form ◽  
Physico Chemical ◽  
Water Soluble Drugs ◽  
Amorphous Drug

Crystalline and amorphous dispersions have been the focus of academic and industrial research due to their potential role in formulating poorly water-soluble drugs. This review looks at the progress made starting with crystalline carriers in the form of eutectics moving towards more complex crystalline mixtures. It also covers using glassy polymers to maintain the drug as amorphous exhibiting higher energy and entropy. However, the amorphous form tends to recrystallize on storage, which limits the benefits of this approach. Specific interactions between the drug and the polymer may retard this spontaneous conversion of the amorphous drug. Some studies have shown that it is possible to maintain the drug in the amorphous form for extended periods of time. For the drug and the polymer to form a stable mixture they have to be miscible on a molecular basis. Another form of solid dispersions is pharmaceutical co-crystals, for which research has focused on understanding the chemistry, crystal engineering and physico-chemical properties. USFDA has issued a guidance in April 2013 suggesting that the co-crystals as a pharmaceutical product may be a reality; but just not yet! While some of the research is still oriented towards application of these carriers, understanding the mechanism by which drug-carrier miscibility occurs is also covered. Within this context is the use of thermodynamic models such as Flory-Huggins model with some examples of studies used to predict miscibility.

scholarly journals Status and Speciation of Silicon and Its Interaction with Physico-Chemical Properties

2021 ◽  
pp. 1-11
Author(s):  
Isaiah Ufuoma Efenudu ◽  
Ehi Robert Orhue ◽  
Ogochukwu Jennifer Ikeh ◽  
Michael Aimiesomon Erhayimwen ◽  
Blessing James
Keyword(s):  
Organic Matter ◽  
Acidic Medium ◽  
Soil Depth ◽  
Chemical Properties ◽  
Water Soluble ◽  
Sequential Fractionation ◽  
Soil Redox ◽  
Parent Materials ◽  
Physico Chemical ◽  
Negative Effect

The effectiveness of three different extractants soil mixtures—HCl, HCl + H2S04, and DTPA-TEA, in order to determine Si from soil and the forms of Silicon as influenced by different parent materials under acidic medium. Seven forms of Silicon; namely water soluble, specifically adsorbed, oxides bound, organic matter bound, exchangeable, residual, total viz sequential fractionation. Extractable Si value established in this study was (50.0 mg kg-1), indicating negative effect on plant physiology. The physico-chemical properties decreased significantly with increase in soil depth vs soil parent materials. In addition, the forms of Si in the parent materials decreased in the pattern RES, bound residual fractions > EXC, soluble & exchangeable fractions > OM, organic matter fraction. Among the properties the silt fraction, pH & OM significantly and positively correlated with the forms of silicon, with negative correlation vs clay which maybe due to silicon adsorption by clayey fraction of the soil (redox). Therefore the soil maybe be maintained and conserved for farming activities.

scholarly journals Impact of Resistant Maltodextrin Addition on the Physico-Chemical Properties in Pasteurised Orange Juice

Foods ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1832
Author(s):  
Elías Arilla ◽  
Marta Igual ◽  
Javier Martínez-Monzó ◽  
Pilar Codoñer-Franch ◽  
Purificación García-Segovia
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Orange Juice ◽  
Chemical Properties ◽  
Water Soluble ◽  
Soluble Solids ◽  
Soluble Fibre ◽  
Physico Chemical ◽  
Resistant Maltodextrin

Resistant maltodextrin (RMD) is a water-soluble fibre that can be fermented in the colon and exert prebiotic effects. Therefore, its addition to food and beverage products could be beneficial from both technological and nutritional viewpoints. However, to date, most studies have focused on the stability of the prebiotic fibre rather than its impact in the original food matrices. Therefore, this work aimed to evaluate the addition of RMD on the physico-chemical properties of pasteurised orange juice (with and without pulp). °Brix, pH, acidity, particle size distribution, density, turbidity, rheology, and colour were measured in orange juices with increasing RMD concentrations (2.5, 5, and 7.5%). Control samples without RMD were also prepared. RMD added soluble solids to the orange juice, affecting the °Brix, density, turbidity, and rheology. Slight colour differences were observed, and lower citric acid content was achieved because of orange juice replacement with RMD. Differences in particle size distribution were exclusively because of pulp content. Further studies are needed to elucidate if potential consumers will appreciate such physico-chemical changes in organoleptic terms.

scholarly journals HPMA-Based Polymer Conjugates for Repurposed Drug Mebendazole and Other Imidazole-Based Therapeutics

Polymers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 2530
Author(s):  
Martin Studenovský ◽  
Anna Rumlerová ◽  
Libor Kostka ◽  
Tomáš Etrych
Keyword(s):  
Chemical Properties ◽  
Drug Repurposing ◽  
Water Soluble ◽  
Biologically Active ◽  
Lysosomal Hydrolases ◽  
Polymer Carrier ◽  
Design Synthesis ◽  
Polymer Conjugates ◽  
Synthetic Strategy ◽  
Physico Chemical

Recently, the antitumor potential of benzimidazole anthelmintics, such as mebendazole and its analogues, have been reported to have minimal side effects, in addition to their well-known anti-parasitic abilities. However, their administration is strongly limited owing to their extremely poor solubility, which highly depletes their overall bioavailability. This study describes the design, synthesis, and physico-chemical properties of polymer-mebendazole nanomedicines for drug repurposing in cancer therapy. The conjugation of mebendazole to water-soluble and biocompatible polymer carrier was carried out via biodegradable bond, relying on the hydrolytic action of lysosomal hydrolases for mebendazole release inside the tumor cells. Five low-molecular-weight mebendazole derivatives, differing in their inner structure, and two polymer conjugates differing in their linker structure, were synthesized. The overall synthetic strategy was designed to enable the modification and polymer conjugation of most benzimidazole-based anthelmintics, such as albendazole, fenbendazole or albendazole, besides the mebendazole. Furthermore, the described methodology may be suitable for conjugation of other biologically active compounds with a heterocyclic N-H group in their molecules.

scholarly journals Physico-chemical and Proximate Analysis of Poly Herbal Formula- Palakalyana Ghrita

2018 ◽  
Vol 4 (3) ◽  
pp. 132-134
Author(s):  
Kariyakeranage Chandi Perera ◽  
◽  
Menuka Arawwawala ◽  
Sumeda Wijeratne ◽  
Deepal Mathew ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Fatty Acids ◽  
Unsaturated Fatty Acids ◽  
Saturated Fatty Acids ◽  
Chemical Properties ◽  
Capric Acid ◽  
Ash Content ◽  
Water Soluble ◽  
Herbal Formula ◽  
Physico Chemical

Background: Standardization is necessary in order to assess the quality of herbal formulations. Palakalyana Ghrita (PKG) is an herbal formula used in Ayurveda medical system to enhance fertility and immunity in both genders which consists nineteen medicinal plants with cow’s ghee and milk. As per available literature PKG formula has not been standardized although it is a commonly used drug by traditional practitioners. Therefore, this study was carried out to evaluate the physio-chemical properties, nutrition composition and possible toxic elements and microorganisms of PKG formula. Methodology: Physico-chemical properties tested include refractive index, total ash content, acid in soluble ash content, water soluble ash content, moisture content, acid value, peroxide value, saponification value. Carbohydrate, protein, fatty acid, vitamin and mineral composition were assessed as nutritional parameters of PKG. Heavy metals and microorganisms were tested using standard protocols. Results: Unsaturated fatty acids namely Palmitoleic acid (0.26%), Oleic acid (40.36%) and Linoleic acid (9.19%) and saturated fatty acids; Capric acid (0.63%), Myristic acid (1.68%) Pentadecyclic acid (0.23%) Palmitic acid (42.25%) Margaric acid ((0.26%) and Stearic acid (4.85%) were present in the PKG formulation. The percentages of carbohydrate, protein and fat content of PKG were 0.04±0.0, 98.8±0.2 and 0.7 ± 0.0 respectively. Heavy metals and microbes were not detected. Conclusion: Results obtained could be utilized as references standard for quality assurance of PKG.

Standardization and Phytochemical screening of Carica papaya seeds

2021 ◽  
pp. 4540-4546
Author(s):  
Varsha Singh ◽  
Aleza Rizvi ◽  
Udaivir Singh Sara
Keyword(s):  
Physicochemical Parameters ◽  
Plant Secondary Metabolites ◽  
Chemical Properties ◽  
Fluorescence Analysis ◽  
Water Soluble ◽  
Correct Identification ◽  
Phytochemical Screening ◽  
Physico Chemical ◽  
Hexane Extracts ◽  
Phytochemical Studies

The present work focus to evaluate the physicochemical and preliminary phytochemical studies on the seeds of family Caricaceae. The plants resources which are used in pharmaceutical formulation standardization was carried out on the basis of organoleptic properties, physical characteristics, and physico-chemical properties. Different Physicochemical parameters ash values, extractive values, loss on drying, foreign matter, fluorescence analysis, and pH were evaluated. Macroscopical characteristics and Physicochemical parameters like total ash, acid insoluble ash and water soluble ash were found to be 83.7%, 71.7% and 61.5% w/w respectively. Hexane, ethyl acetate, ethanol and water soluble extractive values (hot)were 7.6%, 11.6%, 27.4%, 37.5%w/w respectively. The pH of 1% and 10% aqueous solution was found to be 3.57 and 3.78 respectively. Preliminary phytochemical screening showed the presence of Tannins, Proteins and amino acids, Glycosides, Phenolic compounds, Carbohydrates, Saponins, Alkaloids and Flavonoids. Thin layer chromatographic studies also had been done on ethanolic and hexane extracts. HPTLC fingerprinting is a valuable method for the quantitative determination of phytochemicals present in plant extract. These studies aim to investigating referential information for correct identification and standardization of this plant secondary metabolites.

scholarly journals Synthesis and physico-chemical properties of the first water soluble Cu(ii)@hemicryptophane complex

2015 ◽  
Vol 13 (7) ◽  
pp. 2157-2161 ◽  
Author(s):  
Aline Schmitt ◽  
Solène Collin ◽  
Christophe Bucher ◽  
Vincent Maurel ◽  
Jean-Pierre Dutasta ◽  
...  
Keyword(s):  
Chemical Properties ◽  
Closed Shell ◽  
Water Soluble ◽  
Physico Chemical ◽  
Enzyme Model

A water-soluble metallo-enzyme model featuring a copper(ii) site encaged in a closed-shell cavity of a hemicryptophane has been synthesized and studied.

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