scholarly journals Hypoxia related long non-coding RNAs in ischemic stroke

2021 ◽  
Author(s):  
Jiawei Yao ◽  
Yiming Du ◽  
Junsi Liu ◽  
Ilgiz Gareev ◽  
Guang Yang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Non Coding Rnas

LncRNAs a New Target for Post-Stroke Recovery

2020 ◽  
Vol 26 (26) ◽  
pp. 3115-3121
Author(s):  
Jun Yang ◽  
Jingjing Zhao ◽  
Xu Liu ◽  
Ruixia Zhu
Keyword(s):  
Ischemic Stroke ◽  
Microglial Activation ◽  
Vital Role ◽  
Stroke Recovery ◽  
Biological Processes ◽  
Current Development ◽  
Post Stroke ◽  
Cascade Processes ◽  
Non Coding Rnas ◽  
Neuron Injury

LncRNAs (long non-coding RNAs) are endogenous molecules, involved in complicated biological processes. Increasing evidence has shown that lncRNAs play a vital role in the post-stroke pathophysiology. Furthermore, several lncRNAs were reported to mediate ischemia cascade processes include apoptosis, bloodbrain barier breakdown, angiogenesis, microglial activation induced neuroinflammation which can cause neuron injury and influence neuron recovery after ischemic stroke. In our study, we first summarize current development about lncRNAs and post-stroke, focus on the regulatory roles of lncRNAs on pathophysiology after stroke. We also reviewed genetic variation in lncRNA associated with functional outcome after ischemic stroke. Additionally, lncRNA-based therapeutics offer promising strategies to decrease brain damage and promote neurological recovery following ischemic stroke. We believe that lncRNAs will become promising for the frontier strategies for IS and can open up a new path for the treatment of IS in the future.

Abstract 110: Carotid Plaque Instability is Associated with an Increase in the Serum Ratio of circularRNA-284 to microRNA-221

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Hernan Bazan ◽  
Ashton Brooks ◽  
Daniel Lightell ◽  
T. Cooper Woods
Keyword(s):  
Ischemic Stroke ◽  
Sensitivity And Specificity ◽  
Carotid Plaque ◽  
Plaque Rupture ◽  
Serum Levels ◽  
Circular Rna ◽  
Cerebrovascular Event ◽  
Asymptomatic Group ◽  
Plaque Instability ◽  
Non Coding Rnas

Introduction: Atherosclerotic cap thinning and plaque instability occur as a result of a decrease in vascular smooth muscle cell proliferation, which is partly regulated by alterations in the expression of non-coding RNAs in the arterial wall. We recently reported that miR-221 expression in the carotid plaque shoulder is reduced immediately following a carotid-related ischemic cerebrovascular event and returns to normal levels after seven days. We hypothesized that changes in the expression of non-coding RNAs within carotid plaques are reflected in the serum of asymptomatic and acutely symptomatic patients with carotid disease. Methods: Serum levels of microRNA (miR) -221 and a circular RNA with potential binding sites for miR-221 (circR-284), were measured using real-time polymerase chain reaction in 41 patients undergoing carotid endarterectomy. Patients were grouped into those who were asymptomatic and those with an acute ischemic cerebrovascular event within the previous 5 days (urgent). Results: miR-221 was significantly lower (0.25 ± 0.11 vs. 1.00 ± 0.31, p = 0.01) while circR-284 was significantly elevated (2.96 ± 1.16 vs. 1.00 ± 0.37, p = 0.06) in the serum of the urgent compared to the asymptomatic group. Serum levels of these RNAs alone did not exhibit favorable sensitivity and specificity for use as a biomarker indicative of carotid-related ischemic stroke. The ratio of serum circR-284:miR-221, however, was significantly elevated in the urgent group [11.7 ± 0.48 vs. 1.0 ± 0.6, p = 0.0002 (Figure, A)]. Furthermore, receiver operator curve analysis of circR-284:miR-221 ratio demonstrated favorable sensitivity and specificity (Figure, B) for detecting carotid plaque rupture and ischemic stroke. Conclusions: Increases in the ratio of serum circR-284:miR-221 has potential as a diagnostic biomarker of carotid-related ischemic stroke. This data also supports the use and development of functionally related pairs of circulating non-coding RNAs as biomarkers.

scholarly journals Non-Coding RNA in Acute Ischemic Stroke: Mechanisms, Biomarkers and Therapeutic Targets

2018 ◽  
Vol 27 (12) ◽  
pp. 1763-1777 ◽  
Author(s):  
Sheng-Wen Wang ◽  
Zhong Liu ◽  
Zhong-Song Shi
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Neural Development ◽  
Therapeutic Targets ◽  
Circular Rnas ◽  
Non Coding Rna ◽  
Non Coding Rnas ◽  
Cerebral Ischemic ◽  
Functional Rnas ◽  
The Brain

Non-coding RNAs (ncRNAs) are a class of functional RNAs that regulate gene expression in a post-transcriptional manner. NcRNAs include microRNAs, long non-coding RNAs and circular RNAs. They are highly expressed in the brain and are involved in the regulation of physiological and pathophysiological processes, including cerebral ischemic injury, neurodegeneration, neural development, and plasticity. Stroke is one of the leading causes of death and physical disability worldwide. Acute ischemic stroke (AIS) occurs when brain blood flow stops, and that stoppage results in reduced oxygen and glucose supply to cells in the brain. In this article, we review the latest progress on ncRNAs in relation to their implications in AIS, as well as their potential as diagnostic and prognostic biomarkers. We also review ncRNAs acting as possible therapeutic targets in future precision medicine. Finally, we conclude with a brief discussion of current challenges and future directions for ncRNAs studies in AIS, which may facilitate the translation of ncRNAs research into clinical practice to improve clinical outcome of AIS.

Non-coding RNAs in Ischemic Stroke: Roles in the Neuroinflammation and Cell Death

2020 ◽  
Vol 38 (3) ◽  
pp. 564-578 ◽  
Author(s):  
Meng Lu ◽  
Xingang Dong ◽  
Zhenqiang Zhang ◽  
Weifeng Li ◽  
Seyed Esmaeil Khoshnam
Keyword(s):  
Cell Death ◽  
Ischemic Stroke ◽  
Non Coding Rnas

scholarly journals Long non-coding RNAs in ischemic stroke

2018 ◽  
Vol 9 (3) ◽  
Author(s):  
Mei-Hua Bao ◽  
Vivian Szeto ◽  
Burton B. Yang ◽  
Shu-zhen Zhu ◽  
Hong-Shuo Sun ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Non Coding Rnas

The role of non-coding RNAs in neuroprotection and angiogenesis following ischemic stroke

2019 ◽  
Vol 35 (1) ◽  
pp. 31-43 ◽  
Author(s):  
Elaheh Heydari ◽  
Masoumeh Alishahi ◽  
Farhoodeh Ghaedrahmati ◽  
William Winlow ◽  
Seyed Esmaeil Khoshnam ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Non Coding Rnas

scholarly journals Emerging Impact of Non-coding RNAs in the Pathology of Stroke

2021 ◽  
Vol 13 ◽  
Author(s):  
Soudeh Ghafouri-Fard ◽  
Zeinab Shirvani-Farsani ◽  
Bashdar Mahmud Hussen ◽  
Mohammad Taheri ◽  
Noormohammad Arefian
Keyword(s):  
Ischemic Stroke ◽  
Differential Expression ◽  
High Mortality ◽  
Animal Studies ◽  
Mortality And Morbidity ◽  
Human Experiments ◽  
Risk Patients ◽  
Non Coding Rnas ◽  
Assessment Of Evidence ◽  
The Impact

Ischemic stroke (IS) is an acute cerebral vascular event with high mortality and morbidity. Though the precise pathophysiologic routes leading to this condition are not entirely clarified, growing evidence from animal and human experiments has exhibited the impact of non-coding RNAs in the pathogenesis of IS. Various lncRNAs namely MALAT1, linc-SLC22A2, linc-OBP2B-1, linc_luo_1172, linc-DHFRL1-4, SNHG15, linc-FAM98A-3, H19, MEG3, ANRIL, MIAT, and GAS5 are possibly involved in the pathogenesis of IS. Meanwhile, lots of miRNAs contribute in this process. Differential expression of lncRNAs and miRNAs in the sera of IS patients versus unaffected individuals has endowed these transcripts the aptitude to distinguish at risk patients. Despite conduction of comprehensive assays for evaluation of the influence of lncRNAs/miRNAs in the pathogenesis of IS, therapeutic impacts of these transcripts in IS have not been clarified. In the present paper, we review the impact of lncRNAs/miRNAs in the pathobiology of IS through assessment of evidence provided by human and animal studies.

Long Noncoding RNAs as Diagnostic and Therapeutic Targets for Ischemic Stroke

2019 ◽  
Vol 25 (10) ◽  
pp. 1115-1121 ◽  
Author(s):  
Qianwen Wang ◽  
Xu Liu ◽  
Ruixia Zhu
Keyword(s):  
Ischemic Stroke ◽  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Therapeutic Targets ◽  
Therapeutic Approaches ◽  
Ischemic Disease ◽  
Diagnosis And Prognosis ◽  
Protein Encoding ◽  
Non Coding Rnas

LncRNAs (long non-coding RNAs) are endogenous molecules lacking protein-encoding capacity, which have been identified as key regulators of ischemic stroke. Increasing evidence suggests that lncRNAs play critical roles in several aspects of ischemic stroke, including atherosclerosis, dyslipidemia, hypertension, and diabetes mellitus. Hence, lncRNAs may further broaden our understanding of stroke pathogenesis. Altered lncRNA expression has been found in rodent focal cerebral ischemia models and oxygen–glucose deprived mouse brain microvascular endothelial cells as well as stroke patients. LncRNAs are considered to be promising biomarkers for the diagnosis and prognosis of cerebral ischemia. Here, we have reviewed the latest advances in lncRNA-based therapeutic approaches for ischemic disease. Accordingly, we summarize the current understanding of lncRNAs and ischemic stroke, focusing on the regulatory role of lncRNAs in ischemic stroke, as well as their potential as biomarkers and therapeutic targets in cerebral ischemia.

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