Impact of setting up a bone and joint infection referral center on arthroscopic treatment of septic arthritis of the knee and shoulder: Retrospective study

Background: Septic arthritis in paediatric age group poses a significant clinical problem. Common sites are hip and knee joint. There are several orthopaedic literatures available on septic arthritis of the hip and knee joint, however, literature on epidemiology, causative organisms and outcome of septic arthritis of the ankle are very few.Methods: We conducted a retrospective study at a tertiary hospital with an aim to evaluate the incidence, causative pathogen, outcome and to identify differences, if any, between clinical features and laboratory findings of these patients when compared to those with hip and knee joint infection.Results: 47 children were diagnosed with septic arthritis, of which, 14 had septic arthritis of the ankle. Mean age was 5.2 years (8 months - 12 years). 13 children had undergone joint aspiration as a primary procedure. 50% (7) children had positive culture. Streptococcus pyogenes was the commonest causative organism in our cohort (29%) followed by Staphylococcus aureus. Mean follow-up was 36 months (16 - 56 months). 13 children (93%) had good clinical outcome. 1 child developed early arthritis.Conclusions: Septic arthritis of the ankle is a serious condition. Even-though the joint is superficial, diagnosing it clinically can be difficult due to less pronounced symptoms. This can lead to delay in establishing the diagnosis and commencing treatment, hence, it is imperative to have a high index of suspicion. We found early joint aspiration followed by a course of antibiotics to be an effective regimen in management of this devastating condition.

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S. caprae, S. capitis and S. lugdunensis: a pathogenic role in bone and joint infection?

10.26226/morressier.56d6be71d462b80296c970da ◽

2016 ◽

Author(s):

Marion Grare

Keyword(s):

Joint Infection ◽

Pathogenic Role ◽

Bone And Joint Infection

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Clinical features and prognosis of prosthetic joint infection caused by Staphylococcus lugdunensis - a multi-center retrospective study

10.26226/morressier.56d6be71d462b80296c970be ◽

2016 ◽

Author(s):

Piseth Seng

Keyword(s):

Retrospective Study ◽

Clinical Features ◽

Prosthetic Joint Infection ◽

Joint Infection ◽

Staphylococcus Lugdunensis ◽

Prosthetic Joint

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322. Evaluation of the BioFire® Bone and Joint Infection (BJI) Panel for the Detection of Microorganisms and Antimicrobial Resistance Genes in Synovial Fluid Specimens

Open Forum Infectious Diseases ◽

10.1093/ofid/ofaa439.518 ◽

2020 ◽

Vol 7 (Supplement_1) ◽

pp. S233-S234

Author(s):

Corrin Graue ◽

Bryan H Schmitt ◽

Amy Waggoner ◽

Frederic Laurent ◽

Lelia Abad ◽

...

Keyword(s):

Antimicrobial Resistance ◽

Synovial Fluid ◽

Resistance Genes ◽

Clinical Care ◽

Joint Infection ◽

High Morbidity ◽

Bone And Joint Infection ◽

Microbiological Methods ◽

Antimicrobial Resistance Genes ◽

Wide Range

Abstract Background Bone and Joint Infections (BJIs) present with non-specific symptoms that may include pain, swelling, and fever and are associated with high morbidity and significant risk of mortality. BJIs can be caused by a variety of bacteria and fungi, including anaerobes and microorganisms that can be challenging to culture or identify by traditional microbiological methods. Clinicians primarily rely on culture to identify the pathogen(s) responsible for infection. The BioFire® Bone and Joint Infection (BJI) Panel (BioFire Diagnostics, Salt Lake City, UT) is designed to detect 15 gram-positive bacteria (including seven anaerobes), 14 gram-negative bacteria (including one anaerobe), two yeast, and eight antimicrobial resistance (AMR) genes from synovial fluid specimens in about an hour. The objective of this study was to evaluate the performance of an Investigational Use Only (IUO) version of the BioFire BJI Panel compared to various reference methods. Methods Remnant synovial fluid specimens, which were collected for routine clinical care at 13 study sites in the US and Europe, underwent testing using an IUO version of the BioFire BJI Panel. Performance of this test was determined by comparison to Standard of Care (SoC) consisting of bacterial culture performed at each study site according to their routine procedures. Results A total of 1544 synovial fluid specimens were collected and tested with the BioFire BJI Panel. The majority of specimens were from knee joints (77.9%) and arthrocentesis (79.4%) was the most common collection method. Compared to SoC culture, overall sensitivity was 90.2% and specificity was 99.8%. The BioFire BJI Panel yielded a total of 268 Detected results, whereas SoC yielded a total of 215 positive results for on-panel analytes. Conclusion The BioFire BJI Panel is a sensitive, specific, and robust test for rapid detection of a wide range of analytes in synovial fluid specimens. The number of microorganisms and resistance genes included in the BioFire BJI Panel, together with a reduced time-to-result and increased diagnostic yield compared to culture, is expected to aid in the timely diagnosis and appropriate management of BJIs. Disclosures Benjamin von Bredow, PhD, BioFire (Grant/Research Support) Jennifer Dien Bard, PhD, BioFire Diagnostic (Consultant, Scientific Research Study Investigator) Bart Kensinger, PhD, BioFire Diagnostics (Employee) Benedicte Pons, PhD, bioMerieux SA (Employee) Corinne Jay, PhD, bioMerieux SA (Employee)

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An automated real‐time PCR assay for synovial fluid improves the preoperative etiological diagnosis of periprosthetic joint infection and septic arthritis

Journal of Orthopaedic Research® ◽

10.1002/jor.24959 ◽

2020 ◽

Author(s):

Fan Yang ◽

Hyonmin Choe ◽

Naomi Kobayashi ◽

Taro Tezuka ◽

Masatoshi Oba ◽

...

Keyword(s):

Synovial Fluid ◽

Septic Arthritis ◽

Real Time ◽

Periprosthetic Joint Infection ◽

Real Time Pcr ◽

Joint Infection ◽

Pcr Assay ◽

Etiological Diagnosis

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Bone and Joint Infections among Hematopoietic Stem Cell Transplant Recipients

Journal of Bone and Joint Infection ◽

10.7150/jbji.38120 ◽

2019 ◽

Vol 4 (5) ◽

pp. 209-215

Author(s):

Cybele Lara Abad ◽

Vania Phuoc ◽

Prashant Kapoor ◽

Pritish K. Tosh ◽

Irene G. Sia ◽

...

Keyword(s):

Stem Cell ◽

Septic Arthritis ◽

Hematopoietic Stem Cell ◽

Joint Infection ◽

Cell Transplant ◽

Hematopoietic Stem ◽

Joint Infections ◽

Bone And Joint Infections ◽

Prosthetic Joint ◽

Increased Risk

Abstract. Background: Hematopoietic stem cell transplantation (HSCT) recipients are at increased risk for infection. This study describes bone and joint infections (BJI) among HSCT recipients.Methods: We reviewed 5861 patients who underwent HSCT at Mayo Clinic, Rochester, MN from January 1, 2005 through January 1, 2015 for study inclusion. BJI was defined as native septic arthritis, prosthetic joint infection, osteomyelitis, and orthopedic implant infection. All adults with BJI after HSCT were included in the analysis.Results: Of 5861 patients, 33 (0.6%) developed BJI. Native joint septic arthritis was the most common BJI occurring in 15/33 (45.4%) patients. Patients were predominantly male (24/33, 72.7%), with median age of 58 (range 20-72) years. BJI was diagnosed a median of 39 (range 1-114) months after allogeneic (14/33, 42.4%) or autologous (19/33, 57.6%) HSCT. Organisms were recovered via tissue (24/27, 88.9%), synovial fluid (13/17, 76.5%), and/or blood cultures (16/25, 64%). Most underwent surgical debridement (23/33, 69.7%). Patients were followed a median of 78.3 months (range 74-119). Therapy was unsuccessful in 4/33 (12.1%), with death related to the underlying BJI in two (50%). Failure occurred a median of 3.4 (0.1-48.5) months from diagnosis. At last follow up, 7/33 (21.2%) patients were alive. Median overall survival was 13 months (0.07-70.6).Conclusion: BJI among HSCT recipients is infrequent. The most common infection is native joint septic arthritis. Pathogens appear similar to patients without HSCT. Treatment involving surgical-medical modalities is successful, with most patients surviving >1 year after BJI.

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