Two new phenolic acids and one new phenolic glycoside from Hyssopus cuspidatus Boriss and their anti-inflammatory activities

2021 ◽  
Vol 46 ◽  
pp. 15-20
Author(s):  
Xingyu Liu ◽  
Geng Wang ◽  
Chao Lv ◽  
Zhenbo Song ◽  
Yongli Bao ◽  
...  
Keyword(s):  
Phenolic Acids ◽  
Phenolic Glycoside ◽  
Anti Inflammatory

scholarly journals Phytochemicals and Biological Activity of Desert Date (Balanites aegyptiaca (L.) Delile)

Plants ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 32
Author(s):  
Hosakatte Niranjana Murthy ◽  
Guggalada Govardhana Yadav ◽  
Yaser Hassan Dewir ◽  
Abdullah Ibrahim
Keyword(s):  
Biological Activity ◽  
Middle East ◽  
Bioactive Compounds ◽  
Phenolic Acids ◽  
Tree Species ◽  
Indian Subcontinent ◽  
Therapeutic Agents ◽  
Root Bark ◽  
Balanites Aegyptiaca ◽  
Anti Inflammatory

Many underutilized tree species are good sources of food, fodder and possible therapeutic agents. Balanites aegyptiaca (L.) Delile belongs to the Zygophyllaceae family and is popularly known as “desert date”, reflecting its edible fruits. This tree grows naturally in Africa, the Middle East and the Indian subcontinent. Local inhabitants use fruits, leaves, roots, stem and root bark of the species for the treatment of various ailments. Several research studies demonstrate that extracts and phytochemicals isolated from desert date display antioxidant, anticancer, antidiabetic, anti-inflammatory, antimicrobial, hepatoprotective and molluscicidal activities. Mesocarp of fruits, seeds, leaves, stem and root bark are rich sources of saponins. These tissues are also rich in phenolic acids, flavonoids, coumarins, alkaloids and polysterols. Some constituents show antioxidant, anticancer and antidiabetic properties. The objective of this review is to summarize studies on diverse bioactive compounds and the beneficial properties of B. aegyptiaca.

scholarly journals Effects of Drying Methods on Antioxidant, Anti-Inflammatory, and Anticancer Potentials of Phenolic Acids in Lovage Elicited by Jasmonic Acid and Yeast Extract

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 662
Author(s):  
Urszula Złotek ◽  
Sławomir Lewicki ◽  
Anna Markiewicz ◽  
Urszula Szymanowska ◽  
Anna Jakubczyk
Keyword(s):  
Jasmonic Acid ◽  
Phenolic Acids ◽  
Yeast Extract ◽  
Syringic Acid ◽  
Epithelial Cell Line ◽  
Drying Methods ◽  
Simulated Digestion ◽  
Lipoxygenase Inhibition ◽  
Anti Inflammatory ◽  
Inhibition Ability

The study presents the effect of drying methods (traditional, convection, microwave, and freeze-drying) on the content and bioactivity (determined as antioxidative, anti-inflammatory, and antiproliferative potential) of potentially bioavailable fractions of phenolic acids contained in lovage elicited with jasmonic acid (JA) and yeast extract (YE) and in untreated control leaves. The highest amount of syringic acid was recorded in the convectionally dried lovage samples, while ethanolic extracts from lyophilized lovage had the highest content of protocatechuic and caffeic acids. The drying method significantly influenced the tested properties only in some cases. The traditional drying resulted in lower antioxidant potential, while convectional drying caused a reduction of the lipoxygenase inhibition ability of the samples after simulated digestion. Samples containing the control and elicited lovage leaves dried with convectional and traditional methods exhibited the highest cytotoxicity against a prostate cancer epithelial cell line.

scholarly journals In vitro Antioxidant, Anti-inflammatory, Anti-metabolic Syndrome, Antimicrobial, and Anticancer Effect of Phenolic Acids Isolated from Fresh Lovage Leaves [Levisticum officinale Koch] Elicited with Jasmonic Acid and Yeast Extract

Antioxidants ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 554
Author(s):  
Anna Jakubczyk ◽  
Urszula Złotek ◽  
Urszula Szymanowska ◽  
Kamila Rybczyńska-Tkaczyk ◽  
Krystyna Jęderka ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Jasmonic Acid ◽  
Phenolic Acids ◽  
Yeast Extract ◽  
In Vitro Digestion ◽  
Digestion Process ◽  
Simulated Digestion ◽  
Bioavailable Fraction ◽  
Anti Inflammatory

Lovage seedlings were elicited with jasmonic acid (JA) and yeast extract (YE) to induce the synthesis of biologically active compounds. A simulated digestion process was carried out to determine the potential bioavailability of phenolic acids. Buffer extracts were prepared for comparison. The ability to neutralize ABTS radicals was higher in all samples after the in vitro digestion, compared to that in the buffer extracts. However, the elicitation resulted in a significant increase only in the value of the reduction power of the potentially bioavailable fraction of phenolic acids. The effect of the elicitation on the activity of the potentially bioavailable fraction of phenolic acids towards the enzymes involved in the pathogenesis of the metabolic syndrome, i.e., ACE, lipase, amylase, and glucosidase, was analyzed as well. The in vitro digestion caused a significant increase in the ability to inhibit the activity of these enzymes; moreover, the inhibitory activity against alpha-amylase was revealed only after the digestion process. The potential anti-inflammatory effect of the analyzed extracts was defined as the ability to inhibit key pro-inflammatory enzymes, i.e., lipoxygenase and cyclooxygenase 2. The buffer extracts from the YE-elicited lovage inhibited the LOX and COX-2 activity more effectively than the extracts from the control plants. A significant increase in the anti-inflammatory and antimicrobial properties was noted after the simulated digestion.

scholarly journals Virtual Screening in Pharmacokinetics, Bioactivity, and Toxicity of the Amburana cearensis Secondary Metabolites

2021 ◽  
Vol 12 (6) ◽  
pp. 8471-8491
Keyword(s):  
Secondary Metabolites ◽  
Phenolic Acids ◽  
Stem Bark ◽  
New Drugs ◽  
Structure Property ◽  
In Vivo Models ◽  
Popular Medicine ◽  
Anti Inflammatory

Bioprospecting has contributed to the work of pharmaceutical chemists in the development and commercial disposal of new drugs. Currently, the pharmaceutical industry has emphasized drugs produced from bioactive compounds extracted from natural sources, based on popular medicine discussed in the literature, such as secondary metabolites isolated from the stem bark and seeds of the Amburana cearensis, rich in coumarin derivatives, flavonoids, and phenolic acids and is popularly used in the treatment of respiratory diseases and with anti-inflammatory and antioxidant bioactivity. This review is a study of the structure/activity and structure/property (SAR/SPA) relationship with the physicochemical properties calculated by the algorithms of the MarvinSketch software for the secondary metabolites of A. cearensis, as well as their correlation with in silico test values the SwissADME and admetSAR 2.0 servers and in vitro and in vivo models of the dataset from the PreADMET, GUSAR Online and PASS Online servers. The results showed that substances derived from coumarin, flavonoids, and phenolic acids have attributes of good permeability and low efflux, which favor their oral bioavailability, since phenolic heterosides, amburoside analogs, and biflavonoids are effective in local action as subcutaneous application, constituting promising antimicrobial, anti-inflammatory and antioxidant therapeutic actions in their proper administration routes.

scholarly journals Phytochemicals and Biological Activities of Garcinia morella (Gaertn.) Desr.: A Review

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5690
Author(s):  
Hosakatte Niranjana Murthy ◽  
Dayanand Dalawai ◽  
Yaser Hassan Dewir ◽  
Abdullah Ibrahim
Keyword(s):  
Organic Acids ◽  
Bioactive Compounds ◽  
Phenolic Acids ◽  
Biological Activities ◽  
Active Constituents ◽  
Evergreen Tree ◽  
Wide Range ◽  
Anti Inflammatory ◽  
Larvicidal Activities ◽  
Seed Extracts

Garcinia morella (Gaertn.) Desr. is an evergreen tree that yields edible fruits, oil, and resin. It is a source of “gamboge”, a gum/resin that has a wide range of uses. The fruits, leaves, and seeds of this tree are rich in bioactive compounds, including xanthones, flavonoids, phenolic acids, organic acids, and terpenoids. Evidence from different studies has demonstrated the antioxidant, antifungal, antiviral, hepatoprotective, anticancer, anti-inflammatory, antibacterial, and larvicidal activities of the fruit, leaf, and seed extracts of G. morella. This review summarizes the information on the phytochemicals of G. morella and the biological activities of its active constituents.

scholarly journals Effect of Extraction Solvent and Temperature on Polyphenol Profiles, Antioxidant and Anti-Inflammatory Effects of Red Grape Skin By-Product

Molecules ◽  
2021 ◽  
Vol 26 (18) ◽  
pp. 5454
Author(s):  
Giovanna Baron ◽  
Giulio Ferrario ◽  
Cristina Marinello ◽  
Marina Carini ◽  
Paolo Morazzoni ◽  
...  
Keyword(s):  
Phenolic Acids ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Extraction Yield ◽  
Water Extraction ◽  
Binary Solvent ◽  
Polyphenol Content ◽  
Grape Skin ◽  
Anti Inflammatory ◽  
Red Grape

A fully-detailed LC-MS qualitative profiling of red grape skin, extracted with a mixture of ethanol and water (70:30 v:v) has permitted the identification of 65 compounds which can be classified into the following chemical classes: organic and phenolic acids (14 compounds), stilbenoids (1 compound), flavanols (21 compounds), flavonols (15 compounds) and anthocyanins (14 compounds). The extraction yield obtained with water at different temperatures (100 °C, 70 °C, room temperature) was then evaluated and the overall polyphenol content indicates that EtOH:H2O solvent is the most efficient and selective for polyphenol extraction. However, by analyzing the recovery yield of each single polyphenol, we found that water extraction under heating conditions is effective (extraction yield similar or even better in respect to the binary solvent) for some polyphenolic classes, such as hydrophilic procyanidins, phenolic acids, flavonol glucosides and stilbenoids. However, according to their lipophilic character, a poor yield was found for the most lipophilic components, such as flavonol aglycones, and in general for anthocyanins. The radical scavenging activity was in accordance with the polyphenol content, and hence, much higher for the extract obtained with the binary solvent in respect to water extraction. All the tested extracts were found to have an anti-inflammatory activity in the R3/1 cell line with NF-kb reporter challenged with 0.01 µg/mL of IL-1α, in a 1 to 250 µg/mL concentration range. An intriguing result was that the EtOH:H2O extract was found to be superimposable with that obtained using water at 100 °C despite the lower polyphenol content. Taken together, the results show the bioactive potentialities of grape skin extracts and the possibility to exploit this rich industrial waste. Water extraction carried out by heating is an easy, low-cost and environmentally friendly extraction method for some polyphenol classes and may have great potential for extracts with anti-inflammatory activities.

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