Uncaria tomentosa extract (AC-11) improves pregnancy hypertension together with suppression of sFlt1 and sEng

Objectives This meta-analysis aimed to evaluate the effectiveness of HCQ in improving the maternal and fetal outcomes in pregnancies with SLE. Methods A literature search was conducted using PubMed, MEDLINE, EMBASE, and the Cochrane database for relevant English language articles, and Wanfang, CNKI and VIP for Chinese articles, from the databases’ inception to April 30, 2020. These studies compared the maternal and/or fetal outcomes between pregnant patients with SLE who were administered HCQ during pregnancy (HCQ+ group) and those who were not administered HCQ (HCQ− group). Two investigators extracted the data and assessed the quality using the Newcastle-Ottawa Scale (NOS) and GRADE criteria independently. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated. All statistical analyses were conducted using the Stata 12.0 software. Results Nine studies involving 1132 pregnancies were included in the study (3 case controls, 2 prospective cohorts, 4 retrospective cohorts). Preeclampsia, gestational hypertension, and prematurity were significantly lower in the HCQ+ group than in the HCQ− group (OR 0.35, 95% CI 0.21–0.59), (OR 0.41, 95% CI 0.19–0.89) and (OR 0.55, 95% CI 0.36–0.86), respectively. There were no significant differences in the rates of HELLP Syndrome (OR 0.88, 95% CI 0.19–3.96), gestational diabetes (OR 2.3, 95% CI 0.44–12.12), thrombotic events (OR 0.26, 95% CI 0.05–1.51), spontaneous abortion (OR 1.77, 95% CI 0.96–3.26), premature rupture of membranes (OR 0.58, 95% CI 0.24–1.39), oligohydramnios (OR 0.90, 95% CI 0.38–2.14), live birth (OR 1.22, 95% CI 0.60–2.47), stillbirth (OR 1.00, 95% CI 0.50–2.00), congenital malformation (OR 0.53, 95% CI 0.14–2.04), low birth weight (OR 0.77, 95% CI 0.43–1.39), intrauterine distress (OR 1.07, 95% CI 0.41–2.76,), intrauterine growth restriction (OR 0.57, 95% CI 0.06–5.43), or five-minute APGAR score <7 (OR 0.72, 95% CI 0.20–2.58) between the two groups. Conclusions HCQ treatment during pregnancy could reduce the risk of preeclampsia, pregnancy hypertension and prematurity in SLE patients. The certainty of evidence is high but majority of the studies included are retrospective studies and not randomized controlled trials. Therefore, the multidisciplinary management of pregnant patients with SLE should promote HCQ use, irrespective of disease activity or severity.

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Treatment with Uncaria tomentosa Promotes Apoptosis in B16-BL6 Mouse Melanoma Cells and Inhibits the Growth of B16-BL6 Tumours

Molecules ◽

10.3390/molecules26041066 ◽

2021 ◽

Vol 26 (4) ◽

pp. 1066

Author(s):

Ali Zari ◽

Hajer Alfarteesh ◽

Carly Buckner ◽

Robert Lafrenie

Keyword(s):

Tumour Size ◽

Melanoma Cells ◽

Tunel Staining ◽

Aqueous Extracts ◽

Ki 67 ◽

Uncaria Tomentosa ◽

Mouse Melanoma ◽

Anti Cancer

Uncaria tomentosa is a medicinal plant native to Peru that has been traditionally used in the treatment of various inflammatory disorders. In this study, the effectiveness of U. tomentosa as an anti-cancer agent was assessed using the growth and survival of B16-BL6 mouse melanoma cells. B16-BL6 cell cultures treated with both ethanol and phosphate-buffered saline (PBS) extracts of U. tomentosa displayed up to 80% lower levels of growth and increased apoptosis compared to vehicle controls. Treatment with ethanolic extracts of Uncaria tomentosa were much more effective than treatment with aqueous extracts. U. tomentosa was also shown to inhibit B16-BL6 cell growth in C57/bl mice in vivo. Mice injected with both the ethanolic and aqueous extracts of U. tomentosa showed a 59 ± 13% decrease in B16-BL6 tumour weight and a 40 ± 9% decrease in tumour size. Histochemical analysis of the B16-BL6 tumours showed a strong reduction in the Ki-67 cell proliferation marker in U. tomentosa-treated mice and a small, but insignificant increase in terminal transferase dUTP nick labelling (TUNEL) staining. Furthermore, U. tomentosa extracts reduced angiogenic markers and reduced the infiltration of T cells into the tumours. Collectively, the results in this study concluded that U. tomentosa has potent anti-cancer activity that significantly inhibited cancer cells in vitro and in vivo.

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Antimicrobial Activity of Isopteropodine

Zeitschrift für Naturforschung C ◽

10.1515/znc-2005-5-603 ◽

2005 ◽

Vol 60 (5-6) ◽

pp. 385-388 ◽

Cited By ~ 4

Author(s):

Rubén García ◽

Cesia Cayunao ◽

Ronny Bocic ◽

Nadine Backhouse ◽

Carla Delporte ◽

...

Keyword(s):

Antimicrobial Activity ◽

Antibacterial Activity ◽

Gram Positive ◽

Uncaria Tomentosa ◽

Gram Positive Bacteria

Bioassay-directed fractionation for the determination of antimicrobial activity of Uncaria tomentosa, has led to the isolation of isopteropodine (0.3%), a known Uncaria pentacyclic oxindol alkaloid that exhibited antibacterial activity against Gram positive bacteria.

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Risk of post-pregnancy hypertension in women with a history of hypertensive disorders of pregnancy: nationwide cohort study

BMJ ◽

10.1136/bmj.j3078 ◽

2017 ◽

pp. j3078 ◽

Cited By ~ 77

Author(s):

Ida Behrens ◽

Saima Basit ◽

Mads Melbye ◽

Jacob A Lykke ◽

Jan Wohlfahrt ◽

...

Keyword(s):

Cohort Study ◽

Hypertensive Disorders Of Pregnancy ◽

Pregnancy Hypertension ◽

Hypertensive Disorders ◽

History Of

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Monoterpenoid Oxindole Alkaloid Production by Uncaria tomentosa (Willd) D.C. Cell Suspension Cultures in a Stirred Tank Bioreactor

Biotechnology Progress ◽

10.1021/bp049608s ◽

2008 ◽

Vol 21 (3) ◽

pp. 786-792 ◽

Cited By ~ 10

Author(s):

Gabriela Trejo-Tapia ◽

Carlos M. Cerda-García-Rojas ◽

Mario Rodríguez-Monroy ◽

Ana C. Ramos-Valdivia

Keyword(s):

Cell Suspension ◽

Cell Suspension Cultures ◽

Suspension Cultures ◽

Stirred Tank ◽

Alkaloid Production ◽

Stirred Tank Bioreactor ◽

Uncaria Tomentosa

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In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism

Obstetrics and Gynecology International ◽

10.1155/2014/361727 ◽

2014 ◽

Vol 2014 ◽

pp. 1-10 ◽

Cited By ~ 3

Author(s):

Andreia Matos ◽

Alda Pereira da Silva ◽

Maria Clara Bicho ◽

Conceição Afonso ◽

Maria José Areias ◽

...

Keyword(s):

Cardiovascular Disease ◽

Cardiovascular Risk ◽

Genetic Polymorphism ◽

Premenopausal Women ◽

Predisposing Factor ◽

Peripheral Tissues ◽

Pregnancy Hypertension ◽

Nitric Oxide Metabolites ◽

Risk Biomarkers ◽

A Prospective Study

Preeclampsia (PE) may affect the risk for future cardiovascular disease. Haptoglobin (Hp), an acute phase protein with functional genetic polymorphism, synthesized in the hepatocyte and in many peripheral tissues secondary of oxidative stress of PE, may modulate that risk through the antioxidant, angiogenic, and anti-inflammatory differential effects of their genotypes. We performed a prospective study in 352 women aged35±5.48years, which 165 had previous PE, 2 to 16 years ago. We studied demographic, anthropometric, and haemodynamic biomarkers such as C-reactive protein (CRP), myeloperoxidase (MPO), and nitric oxide metabolites (total and nitrites), and others associated with liver function (AST and ALT) and lipid profile (total LDL and cholesterol HDL, non-HDL, and apolipoproteins A and B). Finally, we study the influence of Hp genetic polymorphism on all these biomarkers and as a predisposing factor for PE and its remote cardiovascular disease prognosis. Previously preeclamptic women either hypertensive or normotensive presented significant differences in those risk biomarkers (MPO, nitrites, and ALT), whose variation may be modulated by Hp 1/2 functional genetic polymorphism. The history of PE may be relevant, in association with these biomarkers to the cardiovascular risk in premenopausal women.

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Changes in chromosome structure, mitotic activity and nuclear DNA content from cells of Allium Test induced by bark water extract of Uncaria tomentosa (Willd.) DC

Journal of Ethnopharmacology ◽

10.1016/j.jep.2006.03.018 ◽

2006 ◽

Vol 107 (2) ◽

pp. 211-221 ◽

Cited By ~ 32

Author(s):

Mieczysław Kuraś ◽

Julita Nowakowska ◽

Elwira Śliwińska ◽

Radosław Pilarski ◽

Renata Ilasz ◽

...

Keyword(s):

Mitotic Activity ◽

Dna Content ◽

Nuclear Dna ◽

Chromosome Structure ◽

Water Extract ◽

Nuclear Dna Content ◽

Allium Test ◽

Uncaria Tomentosa

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Changes in Human Erythrocyte Membrane Exposed to Aqueous and Ethanolic Extracts from Uncaria tomentosa

Molecules ◽

10.3390/molecules26113189 ◽

2021 ◽

Vol 26 (11) ◽

pp. 3189

Author(s):

Piotr Duchnowicz ◽

Radosław Pilarski ◽

Jaromir Michałowicz ◽

Bożena Bukowska

Keyword(s):

Erythrocyte Membrane ◽

Human Erythrocyte ◽

Ethanolic Extract ◽

Blood Purification ◽

Human Erythrocyte Membrane ◽

Uncaria Tomentosa ◽

Erythrocyte Shape ◽

Ethanolic Extracts ◽

Erythrocyte Membrane Fluidity ◽

Erythrocyte Plasma Membrane

Uncaria tomentosa (Willd.) DC is a woody climber species originating from South and Central America that has been used in the therapy of asthma, rheumatism, hypertension, and blood purification. Our previous study showed that U. tomentosa extracts altered human erythrocyte shape, which could be due to incorporation of the compounds contained in extracts into the erythrocyte membrane. The aim of the present study was to determine how the compounds contained in U. tomentosa extracts incorporate into the human erythrocyte membrane. The study has assessed the effect of aqueous and ethanolic extracts from leaves and bark of U. tomentosa on the osmotic resistance of the human erythrocyte, the viscosity of erythrocyte interior, and the fluidity of erythrocyte plasma membrane. Human erythrocytes were incubated with the studied extracts in the concentrations of 100, 250, and 500 µg/mL for 2, 5, and 24 h. All extracts tested caused a decrease in erythrocyte membrane fluidity and increased erythrocyte osmotic sensitivity. The ethanolic extracts from the bark and leaves increased viscosity of the erythrocytes. The largest changes in the studied parameters were observed in the cells incubated with bark ethanolic extract. We consider that the compounds from U. tomentosa extracts mainly build into the outer, hydrophilic monolayer of the erythrocyte membrane, thus protecting the erythrocytes against the adverse effects of oxidative stress.

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