scholarly journals The Relationship between Cortisol and the Hippocampal Volume in Depressed Patients – A MRI Pilot Study

2016 ◽  
Vol 22 ◽  
pp. 1106-1112 ◽  
Author(s):  
Theodor Moica ◽  
Adrian Gligor ◽  
Sorina Moica
2004 ◽  
Vol 19 (7) ◽  
pp. 438-440 ◽  
Author(s):  
Armin von Gunten ◽  
Maria A. Ron

AbstractThe relationship between severity of subjective memory impairment and volume of the hippocampus/amygdala complex was investigated in non-demented depressed patients and it was found to correlate with decreasing volume in the right hippocampus.


2021 ◽  
Vol 12 ◽  
Author(s):  
Vera Békés ◽  
Katie Aafjes-van Doorn ◽  
Daniel Spina ◽  
Alessandro Talia ◽  
Claire J. Starrs ◽  
...  

Despite many theoretical and clinical writings, the theorized connection between defense mechanisms and adult attachment in depressed patients has received little empirical attention. This is the first study to examine patients’ defense mechanisms in relation to their attachment in a clinical sample of depressed patients and also the first to use observer-rated measures for assessing both defense mechanisms and attachment. In this pilot study, we aimed to investigate the relationship between patients’ attachment and their use of defense mechanisms in psychotherapy sessions, as well as patterns of change over treatment. We conducted a secondary analysis of data from a randomized controlled trial of 30 patients receiving psychotherapy for major depression. Session transcripts were previously coded for defense mechanisms using the Defense Mechanisms Rating Scales, and depression severity data were collected by the clinician-rated HRSD-17 and the self-report BDI-II. Patients’ attachment was assessed in two transcripts, one in an early session and a second in a late session, using the novel observer-rated Patient Attachment Coding System. In contrast with expectations, in the early phase of therapy, preoccupied attachment-related characteristics were significantly positively related to overall defensive functioning and negatively related to Depressive immature defenses. In the late phase of treatment, preoccupied attachment-related characteristics were negatively correlated with Non-depressive immature defenses. Moreover, as expected, early-phase defense use was related to late phase attachment; specifically, early neurotic and immature Depressive and Non-depressive defenses predicted an increase in avoidant, whereas immature Non-depressive defenses predicted a decrease in preoccupied attachment-related characteristics over the course of treatment, after controlling for early attachment effects. The results imply a longitudinal relationship between defenses and change in attachment-related characteristics over the course of treatment in a depressed sample and warrant further research about the relationship between defenses and attachment during psychotherapy.


2011 ◽  
Vol 19 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Natalie Sachs-Ericsson ◽  
Kathryn Sawyer ◽  
Elizabeth Corsentino ◽  
Nicole Collins ◽  
David C. Steffens

BJPsych Open ◽  
2020 ◽  
Vol 6 (2) ◽  
Author(s):  
Konstantin F. Brückmann ◽  
Jürgen Hennig ◽  
Matthias J. Müller ◽  
Stanislava Fockenberg ◽  
Anne-Marthe Schmidt ◽  
...  

Summary Depression risk is associated with a late chronotype pattern often described as an ‘evening chronotype’. Fluctuations in mood over consecutive days have not yet been measured according to chronotype in in-patients with depression. A total of 30 in-patients with depression and 32 healthy controls matched for gender and age completed a chronotype questionnaire and twice-daily ratings on mood for 10 consecutive days (registered in the German Clinical Trials Register: DRKS00010215). The in-patients had Saturdays and Sundays as hospital-leave days. The relationship between chronotype and daily mood was mediated by the weekday–weekend schedule with higher levels of negative affect in the evening-chronotype patient subgroup at weekends. Results are discussed with respect to a probably advantageous standardised clinical setting with early morning routines, especially for patients with evening chronotypes.


2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 652-653
Author(s):  
Emily Urban-Wojcik ◽  
Soomi Lee ◽  
Susan Charles ◽  
David Almeida ◽  
Richard Davidson ◽  
...  

Abstract The hippocampus, implicated in learning, memory, and spatial navigation, is one of the few brain structures that demonstrates neurogenesis across the lifespan. Hippocampal volume (HV), then, may be a marker of exposure to and engagement with novel events and environments, which may in turn be related to cognitive functioning. The present study examined the relationship between HV and activity diversity (AD), which characterizes the range and evenness of participation in daily activities. In 52 participants who completed the daily-diary and neuroscience projects of the Midlife in the United States Refresher study, greater levels of AD across an 8-day period were related to greater HV averaged across the left and right hemispheres when adjusting for overall brain volume, total activity time, time between projects, and relevant sociodemographic variables, b=1128mm3, t(43)=2.54, p=.015. These findings may point to a mechanism through which AD has been related to better cognitive and mental health outcomes.


Life Sciences ◽  
2021 ◽  
pp. 119663
Author(s):  
Kyle J. Jaquess ◽  
Nathaniel Allen ◽  
Timothy J. Chun ◽  
Lucas Crock ◽  
Alexander A. Zajdel ◽  
...  

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