scholarly journals Evaluating PROMIS(®) applied cognition items in a sample of older adults at risk for cognitive decline

2017 ◽  
Vol 247 ◽  
pp. 39-42 ◽  
Author(s):  
Molly Howland ◽  
Curtis Tatsuoka ◽  
Kathleen A. Smyth ◽  
Martha Sajatovic
Keyword(s):  
Older Adults ◽  
At Risk ◽  
Cognitive Decline

scholarly journals Trait mindfulness is associated with less amyloid, tau, and cognitive decline in individuals at risk for Alzheimer's disease

2021 ◽  
Author(s):  
Cherie Strikwerda-Brown ◽  
Hazal Ozlen ◽  
Alexa Pichet Binette ◽  
Marianne Chapleau ◽  
Natalie Marchant ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Cognitive Decline ◽  
Protective Factor ◽  
Present Moment ◽  
Trait Mindfulness ◽  
Cognitive Assessments ◽  
Positron Emission

Mindfulness, defined as the ability to engage in non-judgmental awareness of the present moment, has been associated with an array of health benefits. Mindfulness may also represent a protective factor for Alzheimer's disease (AD). Here, we tested the potential protective effect of trait mindfulness on cognitive decline and AD pathology in older adults at risk of AD dementia. Measures of trait mindfulness, longitudinal cognitive assessments, and AB- and tau- positron emission tomography (PET) scans were collected in 261 nondemented older adults with a family history of AD dementia from the PREVENT-AD observational cohort study. Multivariate partial least squares analyses were used to examine relationships between combinations of different facets of trait mindfulness and (1) cognitive decline, (2) AB, and (3) tau. Higher levels of trait mindfulness, particularly mindful nonjudgment, were associated with less cognitive decline, AB, and tau. Trait mindfulness may represent a psychological protective factor for AD dementia.

scholarly journals Hearing aids to support cognitive functions of older adults at risk of dementia: the HearCog trial- clinical protocols

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Dona M. P. Jayakody ◽  
Osvaldo P. Almeida ◽  
Andrew H. Ford ◽  
Marcus D. Atlas ◽  
Nicola T. Lautenschlager ◽  
...  
Keyword(s):  
Older Adults ◽  
At Risk ◽  
Hearing Loss ◽  
Cognitive Decline ◽  
Hearing Aids ◽  
Trial Registration ◽  
Control Group ◽  
Age Related ◽  
Randomised Controlled ◽  
The Impact

Abstract Background Globally, about 50 million people were living with dementia in 2015, with this number projected to triple by 2050. With no cure or effective treatment currently insight, it is vital that factors are identified which will help prevent or delay both age-related and pathological cognitive decline and dementia. Observational data have suggested that hearing loss is a potentially modifiable risk factor for dementia, but no conclusive evidence from randomised controlled trials is currently available. Methods The HearCog trial is a 24-month, randomised, controlled clinical trial aimed at determining whether a hearing loss intervention can delay or arrest the cognitive decline. We will randomise 180 older adults with hearing loss and mild cognitive impairment to a hearing aid or control group to determine if the fitting of hearing aids decreases the 12-month rate of cognitive decline compared with the control group. In addition, we will also determine if the expected clinical gains achieved after 12 months can be sustained over an additional 12 months and if losses experienced through the non-correction of hearing loss can be reversed with the fitting of hearing aids after 12 months. Discussion The trial will also explore the cost-effectiveness of the intervention compared to the control arm and the impact of hearing aids on anxiety, depression, physical health and quality of life. The results of this trial will clarify whether the systematic correction of hearing loss benefits cognition in older adults at risk of cognitive decline. We anticipate that our findings will have implications for clinical practice and health policy development. Trial registration Australian and New Zealand Clinical Trials Registry (ANZCTR: 12618001278224), registered on 30.07.2018.

scholarly journals Diet May Moderate the Relationship Between Arterial Stiffness and Cognitive Performance in Older Adults

2021 ◽  
pp. 1-14
Author(s):  
Sarah Gauci ◽  
Lauren M. Young ◽  
David J. White ◽  
Jeffery M. Reddan ◽  
Annie-Claude Lassemillante ◽  
...  
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
At Risk ◽  
Arterial Stiffness ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Diet Quality ◽  
Glucose Control ◽  
Verbal Learning ◽  
The Relationship

Background: Cognitive decline is influenced by various factors including diet, cardiovascular disease, and glucose control. However, the combined effect of these risk factors on cognitive performance is yet to be fully understood. Objective: The current study aimed to explore the inter-relationship between these risk factors and cognitive performance in older adults at risk of future cognitive decline. Methods: The sample comprised 163 (Age: M = 65.23 years, SD = 6.50) participants. Food Frequency Questionnaire data was used to score diet quality and adherence to the Western Style Diet (WSD) and Prudent Style Diet (PSD). Glucose control was gauged by serum levels of glycated hemoglobin (HbA1c) and arterial stiffness was measured using carotid to femoral pulse wave velocity. Cognitive performance was assessed using two subtests of the Swinburne University Computerized Cognitive Assessment Battery (SUCCAB) and Rey’s Verbal Learning Test (RVLT). Results: Diet quality, adherence to the WSD or PSD, and glucose control were not significantly related to cognitive outcomes. However, a significant negative association was found between arterial stiffness and the spatial working memory subtest of SUCCAB (β= –0.21, p <  0.05). Arterial stiffness also significantly interacted with the PSD to impact total recall (F change (1,134) = 5.37, p <  0.05) and the composite score of RVLT (F change (1,134) = 4.03, p <  0.05). Conclusion: In this sample of older adults at risk of cognitive decline, diet alone was not found to predict cognitive performance; however, it was found to moderate the relationship between arterial stiffness and cognition.

Amyloid Burden and Depressive Symptom Trajectories in Older Adults at Risk of Developing Cognitive Decline

2021 ◽  
Vol 82 (5) ◽  
Author(s):  
Ismael Conejero ◽  
Jonathan Dubois ◽  
Laure-Anne Gutierrez ◽  
Julien Delrieu ◽  
Christophe Arbus ◽  
...  
Keyword(s):  
Older Adults ◽  
At Risk ◽  
Depressive Symptom ◽  
Cognitive Decline ◽  
Amyloid Burden ◽  
Symptom Trajectories
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