Training With Cognitive Aerobic Exercise in Older Adults at Risk of Cognitive Decline

2019 ◽  
Author(s):  
Keyword(s):  
Older Adults ◽  
At Risk ◽  
Cognitive Decline ◽  
Aerobic Exercise

scholarly journals Trait mindfulness is associated with less amyloid, tau, and cognitive decline in individuals at risk for Alzheimer's disease

2021 ◽  
Author(s):  
Cherie Strikwerda-Brown ◽  
Hazal Ozlen ◽  
Alexa Pichet Binette ◽  
Marianne Chapleau ◽  
Natalie Marchant ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Cognitive Decline ◽  
Protective Factor ◽  
Present Moment ◽  
Trait Mindfulness ◽  
Cognitive Assessments ◽  
Positron Emission

Mindfulness, defined as the ability to engage in non-judgmental awareness of the present moment, has been associated with an array of health benefits. Mindfulness may also represent a protective factor for Alzheimer's disease (AD). Here, we tested the potential protective effect of trait mindfulness on cognitive decline and AD pathology in older adults at risk of AD dementia. Measures of trait mindfulness, longitudinal cognitive assessments, and AB- and tau- positron emission tomography (PET) scans were collected in 261 nondemented older adults with a family history of AD dementia from the PREVENT-AD observational cohort study. Multivariate partial least squares analyses were used to examine relationships between combinations of different facets of trait mindfulness and (1) cognitive decline, (2) AB, and (3) tau. Higher levels of trait mindfulness, particularly mindful nonjudgment, were associated with less cognitive decline, AB, and tau. Trait mindfulness may represent a psychological protective factor for AD dementia.

The Association of Positive and Negative Affect and Exercise Self-Efficacy in Older Adults

2003 ◽  
Vol 11 (2) ◽  
pp. 265-274 ◽  
Author(s):  
Glenn V. Ostir ◽  
Jiska Cohen-Mansfield ◽  
Suzanne Leveille ◽  
Stefano Volpato ◽  
Jack M. Guralnik
Keyword(s):  
Older Adults ◽  
At Risk ◽  
Muscle Strength ◽  
Negative Affect ◽  
Positive Affect ◽  
Aerobic Exercise ◽  
Self Efficacy ◽  
Odds Ratio ◽  
Positive And Negative Affect ◽  
Independent Association

This study investigated whether positive or negative affect has an independent association with exercise self-efficacy. Participants (N= 324) age 75-85 were classified as high or at-risk performers, and three exercise-self-efficacy items (scored 1-10) were assessed. For at-risk performers, positive affect was significantly associated with confidence in the ability to perform strength and flexibility (b= 0.83,SE= 0.23,p= .001) and aerobic exercise (b= 0.59,SE= 0.28,p= .04) and with the perception that exercise would not worsen preexisting symptoms (b= 0.73,SE= 0.24,p= .001). Among high performers, nonsignificant associations were found for positive and negative affect and exercise-self-efficacy. For at-risk performers, higher positive affect was associated with an increased odds ratio of 2.72 for scoring 10 on the muscle strength and flexibility item, 4.08 on the aerobic item, and 2.94 on the item assessing preexisting symptoms. The results suggest that improving at-risk older adults’ positive affect might increase their participation in exercise.

scholarly journals Evaluating PROMIS(®) applied cognition items in a sample of older adults at risk for cognitive decline

2017 ◽  
Vol 247 ◽  
pp. 39-42 ◽  
Author(s):  
Molly Howland ◽  
Curtis Tatsuoka ◽  
Kathleen A. Smyth ◽  
Martha Sajatovic
Keyword(s):  
Older Adults ◽  
At Risk ◽  
Cognitive Decline

scholarly journals Hearing aids to support cognitive functions of older adults at risk of dementia: the HearCog trial- clinical protocols

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Dona M. P. Jayakody ◽  
Osvaldo P. Almeida ◽  
Andrew H. Ford ◽  
Marcus D. Atlas ◽  
Nicola T. Lautenschlager ◽  
...  
Keyword(s):  
Older Adults ◽  
At Risk ◽  
Hearing Loss ◽  
Cognitive Decline ◽  
Hearing Aids ◽  
Trial Registration ◽  
Control Group ◽  
Age Related ◽  
Randomised Controlled ◽  
The Impact

Abstract Background Globally, about 50 million people were living with dementia in 2015, with this number projected to triple by 2050. With no cure or effective treatment currently insight, it is vital that factors are identified which will help prevent or delay both age-related and pathological cognitive decline and dementia. Observational data have suggested that hearing loss is a potentially modifiable risk factor for dementia, but no conclusive evidence from randomised controlled trials is currently available. Methods The HearCog trial is a 24-month, randomised, controlled clinical trial aimed at determining whether a hearing loss intervention can delay or arrest the cognitive decline. We will randomise 180 older adults with hearing loss and mild cognitive impairment to a hearing aid or control group to determine if the fitting of hearing aids decreases the 12-month rate of cognitive decline compared with the control group. In addition, we will also determine if the expected clinical gains achieved after 12 months can be sustained over an additional 12 months and if losses experienced through the non-correction of hearing loss can be reversed with the fitting of hearing aids after 12 months. Discussion The trial will also explore the cost-effectiveness of the intervention compared to the control arm and the impact of hearing aids on anxiety, depression, physical health and quality of life. The results of this trial will clarify whether the systematic correction of hearing loss benefits cognition in older adults at risk of cognitive decline. We anticipate that our findings will have implications for clinical practice and health policy development. Trial registration Australian and New Zealand Clinical Trials Registry (ANZCTR: 12618001278224), registered on 30.07.2018.

scholarly journals Efficacy of simultaneous aerobic exercise and cognitive training in subjective cognitive decline: study protocol for randomized controlled trial of the Exergames Study

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Dereck Salisbury ◽  
Tom Plocher ◽  
Fang Yu
Keyword(s):  
Older Adults ◽  
Randomized Controlled Trial ◽  
Cognitive Decline ◽  
Aerobic Exercise ◽  
Cognitive Training ◽  
Aerobic Fitness ◽  
Controlled Trial ◽  
Moderate Intensity ◽  
Subjective Cognitive Decline ◽  
Randomized Controlled

Abstract Background Subjective cognitive decline (SCD) is an early manifestation of Alzheimer’s disease (AD) and offers a therapeutic window where interventions have strong potential to prevent or delay the progression of AD. Aerobic exercise and cognitive training represent two promising interventions for AD prevention, but their synergistic effect has yet to be assessed in persons with SCD. Methods/design The purpose of this single-blinded, 3-parallel group randomized controlled trial is to test the synergistic efficacy of an exergame intervention (simultaneous moderate-intensity aerobic cycling and cognitive training) on cognition and aerobic fitness in community-dwelling older adults with SCD. The Exergames Study will randomize 96 participants on a 2:1:1 allocation ratio to 3-month exergame, cycling only, or attention control (stretching). Primary outcomes include global cognition and aerobic fitness, which will be assessed at baseline and after 3 months. The specific aims of the Exergames Study are to (1) determine the efficacy of the exergame in older adults with SCD and (2) assess the distraction effect of exergame on aerobic fitness. Data will be analyzed using ANOVA following intention-to-treat. Discussion This study will test the synergistic effects of exergame on cognition and aerobic fitness. It has the potential to advance prevention research for AD by providing effect-size estimates for future trials. Trial registration ClinicalTrials.gov NCT04311736. Registered on 17 March 2020.

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