Stable trait-like individual differences in salivary uric acid (SUA): Relations to gender and body mass index

Experimental studies suggest that periostin is involved in tissue repair and remodeling. The study aimed to evaluate serum periostin concentration as potential biomarker in pediatric patients with primary hypertension (PH). We measured serum periostin, blood pressure, arterial damage, biochemical, and clinical data in 50 children with PH and 20 age-matched healthy controls. In univariate analysis, children with PH had significantly lower serum periostin compared to healthy peers (35.42 ± 10.43 vs. 42.16 ± 12.82 [ng/mL], p = 0.038). In the entire group of 70 children serum periostin concentration correlated negatively with peripheral, central, and ambulatory blood pressure, as well as with aortic pulse wave velocity (aPWV). In multivariate analysis, periostin level significantly correlated with age (β = −0.614, [95% confidence interval (CI), −0.831–−0.398]), uric acid (β = 0.328, [95%CI, 0.124–0.533]), body mass index (BMI) Z-score (β = −0.293, [95%CI, −0.492–−0.095]), high-density lipoprotein (HDL)-cholesterol (β = 0.235, [95%CI, 0.054–0.416]), and triglycerides (β = −0.198, [95%CI, −0.394–−0.002]). Neither the presence of hypertension nor blood pressure and aPWV influenced periostin level. To conclude, the role of serum periostin as a biomarker of elevated blood pressure and arterial damage in pediatric patients with primary hypertension is yet to be unmasked. Age, body mass index, uric acid, and lipid concentrations are key factors influencing periostin level in pediatric patients.

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Prognostic significance of serum uric acid in outpatients with chronic heart failure is complex and related to body mass index: Data from the IN-CHF Registry

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/j.numecd.2010.08.007 ◽

2012 ◽

Vol 22 (5) ◽

pp. 442-448 ◽

Cited By ~ 9

Author(s):

S. Baldasseroni ◽

R. Urso ◽

A.P. Maggioni ◽

F. Orso ◽

G. Fabbri ◽

...

Keyword(s):

Heart Failure ◽

Body Mass Index ◽

Uric Acid ◽

Chronic Heart Failure ◽

Serum Uric Acid ◽

Body Mass ◽

Prognostic Significance ◽

Index Data ◽

Body Mass Index Data

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Serum uric acid as a predictor of future hypertension: Stratified analysis based on body mass index and age

Preventive Medicine ◽

10.1016/j.ypmed.2016.07.007 ◽

2016 ◽

Vol 90 ◽

pp. 201-206 ◽

Cited By ~ 18

Author(s):

Yuki Yokoi ◽

Takahisa Kondo ◽

Naoki Okumura ◽

Keiko Shimokata ◽

Shigeki Osugi ◽

...

Keyword(s):

Body Mass Index ◽

Uric Acid ◽

Serum Uric Acid ◽

Body Mass ◽

Stratified Analysis

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Abstract 3147: Uric Acid Independently Predicted Acute Coronary Syndrome in a Large Cohort of Ethnic Chinese

Circulation ◽

10.1161/circ.118.suppl_18.s_1103 ◽

2008 ◽

Vol 118 (suppl_18) ◽

Author(s):

Shao-Yuan Chuang ◽

Jonathan Jiunn-Horng Chen ◽

Chih-Cheng Wu ◽

Wen-Harn Pan

Keyword(s):

Body Mass Index ◽

Acute Coronary Syndrome ◽

Uric Acid ◽

Total Cholesterol ◽

Body Mass ◽

Ethnic Chinese ◽

Coronary Syndrome ◽

Group 4 ◽

Group 3 ◽

Group 2

Few studies examine the association between serum uric acid (SUA) and acute coronary syndrome (ACS). We aimed to investigate the association between SUA and ACS in a prospective study of ethnic Chinese. Enrolled were 128569 adults ≥ 20 yrs from 4 MJ Health Checkup Clinics in Taiwan during 1994 –1996, excluding those with heart disease, stroke, renal disease and cancer disease. All physical examination, biochemical test and structured questionnaire were executed in standardized central labs. ACS was defined by main ICD-9 of 410 – 414 from claim data of National Health Insurance for hospitalization and from Death certification registry. Cox proportional hazard model was used to estimate the hazard ratios (HRs) between levels of SUA and ACS events. A total of 2049 subjects (Men: 1239/Women: 810) developed ACS during the period from baseline to Dec.31.2002. Men had higher ACS incidence than women (2.84 vs. 1.61 per 1000 person-years [PY]; p < .0001). Independent risk factors of ACS unfolded from this study included age, male sex, waist circumference, body mass index, triglycerides, total-cholesterol, hypertension, diabetes, uric acid, and current smoking. The crude incidences of ACS were 1.27, 2.06, 3.27 and 4.61 per 1000 PY in that order for four consecutive SUA groups (group1: <5.0 mg/dl; group 2: 5.0 – 6.9 mg/dl; group 3: 7.0 – 8.9 mg/dl; group 4: ≥9.0 mg/dl) (p-value for trend <.0001). Compared to group1, the multi-variate adjusted HRs (95% Confidence intervals) were 1.14 (0.92, 1.42) for group 2, 1.38 (1.10, 1.72) for group 3 and 1.38 (1.10, 1.72) for group 4 among men, and 1.03 (0.87, 1.22), 1.30 (1.05, 1.62) and 1.43 (0.99, 2.05) among women after adjusting for age, systolic/diastolic BP, body mass index, triglycerides, total cholesterol, diabetes, smoking, alcohol drinking, physical activity, and occupation. One standard deviation increase in SUA corresponded to around 30% ACS risk increase in women (HR=1.33; 1.04 –1.70) and 60% in men (HR=1.59; 1.25–2.03). Baseline SUA level independently predicts the development of ACS and should be considered as a potential risk factor of ACS.

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Nonlinear relationship between serum uric acid and body mass index: a cross-sectional study of a general population in coastal China

Journal of Translational Medicine ◽

10.1186/s12967-019-02142-9 ◽

2019 ◽

Vol 17 (1) ◽

Author(s):

Hui Zhou ◽

Zhen Liu ◽

Zhong Chao ◽

Yeqing Chao ◽

Lidan Ma ◽

...

Keyword(s):

Body Mass Index ◽

Uric Acid ◽

General Population ◽

Serum Uric Acid ◽

Body Mass ◽

Large Scale ◽

Cross Sectional ◽

Men And Women ◽

Nadir Point ◽

Coastal China

Abstract Background Conflicting evidence exists on the relationship between body mass index (BMI) and serum uric acid (SUA). Therefore, we aimed to evaluate the SUA–BMI relationship in a large-scale epidemiological survey in coastal China. Methods This survey was conducted among the general population in the coastal region of China from September 2014 to January 2015. SUA Levels were measured by the automatic Sysmex Chemix-180 biochemical analyzer. Results A total of 6098 men (BMI: 24.58 ± 3.74 kg/m2) and 7941 women (24.56 ± 3.64 kg/m2) were included in this study. A stronger positive BMI-SUA association was found for men than women (all P-values < 0.05). The piecewise linear spline models indicated a U-shaped relationship of SUA-BMI association for both men and women; and the lowest turning points were at 19.12 kg/m2 for men and 21.3 kg/m2 for women. When BMIs were lower than the nadir point, each 1 kg/m2 increase in BMI related to a 7.74-fold (95% CI − 14.73, − 0.75) reduction for men and 2.70-fold reduction (− 4.47, − 0.94) for women in SUA levels. Once the BMI was higher than the nadir point, each 1 kg/m2 increase in BMI was related to a 5.10-fold (4.44, 5.77) increment for men and 3.93-fold increment (3.42, 4.43) for women in SUA levels. The regression coefficient differences between the two stages were 12.84 (5.66, 20.03) for men and 6.63 (4.65, 8.61) for women. Conclusions A U-shaped relationship between BMI and SUA was found for both men and women; the association was stronger for men than women.

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