Biomimetic pH responsive amphiphilic polymers: Solution property dependent antifungal mechanism

2021 ◽  
pp. 104937
Author(s):  
Lakshmi Priya Datta ◽  
Triparna Mukherjee ◽  
Tapan Kumar Das
Keyword(s):  
Amphiphilic Polymers ◽  
Ph Responsive ◽  
Solution Property ◽  
Antifungal Mechanism

Degradable polycaprolactone nanoparticles stabilized via supramolecular host–guest interactions with pH-responsive polymer-pillar[5]arene conjugates

2020 ◽  
Vol 11 (12) ◽  
pp. 1985-1997
Author(s):  
Peng Wei ◽  
Fabian H. Sobotta ◽  
Carolin Kellner ◽  
Damiano Bandelli ◽  
Stephanie Hoeppener ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Amphiphilic Polymers ◽  
Ph Responsive ◽  
Responsive Polymer ◽  
New Generation

Smart nano-carriers such as micelles, vesicles or nanoparticles constructed from amphiphilic polymers promise a new generation of drug delivery systems featuring localized and controlled release.

scholarly journals Versatile Encapsulation Technology Based on Tailored pH-Responsive Amphiphilic Polymers: Emulsion Gels and Capsules

Langmuir ◽  
2017 ◽  
Vol 33 (49) ◽  
pp. 14020-14028
Author(s):  
Clémentine Locatelli-Champagne ◽  
Jean-Marc Suau ◽  
Olivier Guerret ◽  
Charlotte Pellet ◽  
Michel Cloitre
Keyword(s):  
Amphiphilic Polymers ◽  
Ph Responsive

Novel pH-Responsive Triply Hydrophilic Block Copolymer with Reversible Micellization Property

2011 ◽  
Vol 181-182 ◽  
pp. 88-91 ◽  
Author(s):  
Xin De Tang ◽  
Ye Chen ◽  
Fa Qi Yu ◽  
Mei Shan Pei
Keyword(s):  
Drug Delivery ◽  
Ionic Strength ◽  
Block Copolymer ◽  
Solvent Polarity ◽  
Amphiphilic Polymers ◽  
Water Soluble ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Stimuli-responsive water-soluble and amphiphilic polymers have attracted much attention because their micelles can be produced or destroyed by changing the temperatute, pH, ionic strength, and solvent polarity. In this work, a triply hydrophilic block copolymer of poly (ethylene glycol) and poly (methacrylic acid-co-dimethylamine ethyl methacrylate) [PEO-P(MAA-co-DMAEMA)] was synthesized and characterized. The copolymer system is believed to have the potential for drug delivery applications due to the biocompatibility of MAA and DMAEMA.

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

In Vitro Evaluation of pH Responsive Doxazosin Loaded Mesoporous Silica Nanoparticles: A Smart Approach in Drug Delivery

2016 ◽  
Vol 13 (4) ◽  
pp. 574-581 ◽  
Author(s):  
Arijit Guha ◽  
Nikhil Biswas ◽  
Kaustav Bhattacharjee ◽  
Piu Das ◽  
Ketousetuo Kuotsu
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Responsive ◽  
In Vitro Evaluation

A fast response, large deformation, excellent mechanical pH-responsive polyacrylonitrile/polyimide bilayer film

Polymer ◽  
2020 ◽  
Vol 191 ◽  
pp. 122271
Author(s):  
Xu Wang ◽  
Chengyong He ◽  
Longbo Luo ◽  
Daiqiang Chen ◽  
Xiangyang Liu ◽  
...  
Keyword(s):  
Large Deformation ◽  
Fast Response ◽  
Bilayer Film ◽  
Ph Responsive

Electrophoretic deposition of GHK-Cu loaded MSN-chitosan coatings with pH-responsive release of copper and its bioactivity

2019 ◽  
Vol 104 ◽  
pp. 109746 ◽  
Author(s):  
Cui Ning ◽  
Jing Jiajia ◽  
Li Meng ◽  
Qi Hongfei ◽  
Wu Xianglong ◽  
...  
Keyword(s):  
Electrophoretic Deposition ◽  
Ph Responsive
Sign in / Sign up

Export Citation Format

Share Document