A bibliometric analysis of preclinical trials of Andrographis paniculata (Burm.f.) Nees in diabetes mellitus

2021 ◽  
Author(s):  
Fitriana Hayyu Arifah ◽  
Agung Endro Nugroho ◽  
Abdul Rohman ◽  
Wawan Sujarwo
Keyword(s):  
Diabetes Mellitus ◽  
Bibliometric Analysis ◽  
Andrographis Paniculata ◽  
Preclinical Trials

scholarly journals Evaluation of Antidiabetic Activity of Gymnema sylvestre and Andrographis paniculata in Streptozotocin Induced Diabetic Rats

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Prem Kumar ◽  
Sudha Rani ◽  
B Arunjyothi ◽  
P. Chakrapani ◽  
A Rojarani
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Low Cost ◽  
Diabetic Rats ◽  
Andrographis Paniculata ◽  
Antidiabetic Activity ◽  
Gymnema Sylvestre ◽  
Streptozotocin Induced Diabetes ◽  
Oxidative Effect

Diabetes mellitus is a difficult metabolic disorder that has seriously impact the human health and quality of life. Medicinal plants are being used to control diabetes However, they are not entirely effective and no one has ever been reported to have fully recovered from diabetes. Many plants have been used for the management of diabetes mellitus in various traditional systems of medicine worldwide as they are a great source of biological constituents and many of them are known to be effective against diabetes. Medicinal plants with antihyperglycemic activities are being more desired, owing to lesser sideeffects and low cost. Streptozotocin was induced to all groups of rats at dosage of 35 -55mg/kg except for the normal. Streptozotocin induced diabetes in sprague dawly rats were used to study antidiabetic activity of methonolic extract of two medicinal plants Gymnema sylvestre,Andrographis paniculata methanolic leaf extract was administered orally in graded doses of 30 mg/kg,50mg /kg sprague dawly rats Gymnema sylvestre at a dose of 30mg/kg and Andrographis paniculata at a dose of 50mg/kg showed significant anti-hyperglycemic and anti-oxidative effect which was evident from the 1st week of treatment.

scholarly journals Aktivitas Antidiabetes Kombinasi Ekstrak Etanol Daun Andrographis Paniculata dan Vernonia Amygdalina

2017 ◽  
Vol 7 (2) ◽  
pp. 104
Author(s):  
Nyayu Fitriani ◽  
Kamalia Layal ◽  
Kamila Kamila
Keyword(s):  
Diabetes Mellitus ◽  
Andrographis Paniculata ◽  
Control Group ◽  
Vernonia Amygdalina ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
Test Control

Diabetes mellitus merupakan sekelompok penyakit metabolik yang ditandai dengan hiperglikemia kronik yang diakibatkan oleh defek pada sekresi insulin, aksi insulin atau keduanya. Daun Andrographis paniculata dan Vernonia amygdalina merupakan tanaman yang dapat digunakan sebagai pengendali kadar gula dalam darah. Penelitian ini bertujuan untuk mengetahui efektivitas kombinasi ekstrak kedua daun dibandingkan dengan acarbose dalam menurunkan kadar gula darah postprandial tikus diabetes. Penelitian ini adalah penelitian eksperimental, dengan pre dan post test control group design. Tikus diinduksi dengan aloksan kemudian diobati dengan kombinasi ekstrak dengan dosis yang berbeda selama 7 hari. Sebanyak 25 ekor tikus dibagi dalam 5 kelompok, yaitu kelompok yang diberikan aquadest (kontrol negatif); acarbose 75mg/kgBB (kontrol positif), kombinasi ekstrak etanol daun Andrographis paniculata 500mg/kgBB dan daun Vernonia amygdalina 100mg/kgBB; kombinasi ekstrak etanol daun Andrographis paniculata 1000mg/kgBB dan daun Vernonia amygdalina 200mg/kgBB; dan kombinasi ekstrak etanol daun Andrographis paniculata 2000mg/kgBB dan daun Vernonia amygdalina 400mg/kgBB. Analisis data kadar gula darah tikus menggunakan uji T- berpasangan dan PostHoc. Hasil penelitian didapatkan bahwa tidak terdapat perbedaan bermakna antara semua kombinasi ekstrak daun Andrographis paniculata dan daun Vernonia amygdalina dengan acarbose dalam menurunkan kadar gula darah postprandial tikus wistar yang diinduksi aloksan (p>0,05). Dari penelitian ini dapat disimpulkan bahwa kombinasi ekstrak etanol daun Andrographis paniculata dan daun Vernonia amygdalina efektif dalam menurunkan kadar gula darah postprandial tikus diabetes.

Bibliometric analysis of diabetes mellitus research output from Middle Eastern Arab countries during the period (1996–2012)

2014 ◽  
Vol 101 (1) ◽  
pp. 819-832 ◽  
Author(s):  
Waleed M. Sweileh ◽  
Sa’ed H. Zyoud ◽  
Samah W. Al-Jabi ◽  
Ansam F. Sawalha
Keyword(s):  
Diabetes Mellitus ◽  
Bibliometric Analysis ◽  
Research Output ◽  
Middle Eastern ◽  
Arab Countries ◽  
Middle Eastern Arab

scholarly journals A Bibliometric Analysis of the Top 30 Most-cited Articles in Gestational Diabetes Mellitus Literature (1946-2019)

Cureus ◽  
2019 ◽  
Author(s):  
Pulwasha M Iftikhar ◽  
Fatima Ali ◽  
Mohammed Faisaluddin ◽  
Azadeh Khayyat ◽  
Maribel De Gouvia De Sa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Bibliometric Analysis

scholarly journals Sambiroto (Andrographis paniculata) dan Bioaktivitasnya

2020 ◽  
Vol 3 (1) ◽  
pp. 76-84
Author(s):  
Marina Silalahi
Keyword(s):  
Diabetes Mellitus ◽  
Andrographis Paniculata ◽  
On Line

Andrographis paniculata (AP) merupakan spesies dalam famili Acanthaceae yang telah lama digunakan sebagai bahan jamu oleh masyarakat lokal Indonesia. Untuk mengetahuai bioaktivitas AP dilakukan studi literatur atau review artikel ilmiah baik yang terbit secara on-line maupun offline, sehingga diperoleh informasi yang konfrehensip untuk mendukung pemanfaatannya sebagai obat. AP mudah ditemukan di pekarangan sebagai tanaman hias maupun sebagai bahan obat. Sebagai obat tradisional AP digunakan sebagai obat demam, influensa, diabetes mellitus, diuretika, analgesik. Andrographolide merupakan senyawa marker yang digunakan sebagai sediaan atau ramuan yang mengandung AP. Hasil bioessay menunjukkan bahwa Ap memiliki aktivitas sebagai anti mikroba, anti plasmodium, anti kanker, anti diabetes mellitus, anti inflamasi dan hepatoprotektor. Pemanfaatan AP sebagai anti mikroba khususnya Plasmodium perlu dikaji lebih lanjut sehingga dapat digunakan sebagai alternatif obat malaria.

scholarly journals Antidiabetic Activity Test of Sambiloto Capsules (Andrographis paniculata) with Glibenclamide on White Male Mice DDY Strain

2020 ◽  
pp. 19-26
Author(s):  
Monik Krisnawati
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
White Male ◽  
Andrographis Paniculata ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Male Mice ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Paired T Test

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia and metabolic abnormality of carbohydrates, fats, and proteins caused by decreased insulin sensitivity. Glibenclamid as a synthesis drug or traditional medicine such as Sambiloto Capsule could use for diabetes mellitus. Hereditary, people have been using decoction of Sambiloto’s leaves to prevent cold, influenza, fevers, jaundice. The bitterness of Sambiloto (Andrographis paniculata) was also believed to cure diabetes. The purpose of this research was to compare between Sambiloto capsule with Glibenclamid on white male mices DDY strain. The research method was an experimental study using pre and post test control group design, using 15 white male mices DDY strain which were given a glucose load and divided into 3 groups. Negatif control group (CMC Na), positive control group (Glibenclamid), and test group (Sambiloto Capsules). The results blood glucose level of this research was analyzed using Paired T-test and with the 95 % convidence level. The comparison test of antidiabetes activity between Sambiloto Capsule and Glibenklamid on white male mice DDY strain showed that the Sambiloto Capsule had antidiabetic activity viewed from the average decline in blood glucose levels. The degradation of blood glucose levels in Glibenklamid group was faster than Sambiloto Capsule group indicated by the statistical analysis using Paired T-test with the significance level smaller than 0,05 and showed by T-value was great than T-tabel. Conclusion of the research showed that the activity Sambiloto Capsules anti diabetic.

scholarly journals Potential Combination of Tinospora crispa, Andrographis paniculata, Cinamomum burmanii, Syzygium polyanthum and Momordica charantia Extracts Against Intake of Glucose in Muscle Rats-Induced Diabetes Mellitus

2021 ◽  
Vol 2 (1) ◽  
pp. 68-72
Author(s):  
Rachmat Hidayat ◽  
Patricia Wulandari
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Secondary Metabolites ◽  
Protein Expression ◽  
Blood Sugar ◽  
Chronic Condition ◽  
Andrographis Paniculata ◽  
Glucose Intake ◽  
Sugar Regulation ◽  
Sugar Levels

Diabetes mellitus is a chronic condition that disturbs the body's blood sugarregulation. This disorder is characterized by a decrease in the ability of bodycells to intake glucose into cells. Due to the failure of cells in glucose intake,glucose buildup occurs in the extracellular, namely in the plasma. Thesemedicinal plants contain quite varied secondary metabolites, where theseplants are rich in flavonoids, alkaloids, terpenes and glycosides. The contentof these secondary metabolite compounds is believed to be rich in antioxidanteffects so that it has the effect of being able to suppress various oxidativestress conditions that cause damage to various organs due to blood sugardysregulation. The effect of Tinospora crispa, Andrographis paniculata,Cinamomum burmanii, Syzygium polyanthum and Momordica charantiaextracts on blood sugar levels and GLUT4 protein expression in muscle tissueshows the potential of the test extract's ability to improve blood glucose intaketo cells so as to maintain blood sugar regulation.

scholarly journals In Silico Preclinical Trials: Methodology and Engineering Guide to Closed-Loop Control in Type 1 Diabetes Mellitus

2009 ◽  
Vol 3 (2) ◽  
pp. 269-282 ◽  
Author(s):  
Stephen D. Patek ◽  
B. Wayne Bequette ◽  
Marc Breton ◽  
Bruce A. Buckingham ◽  
Eyal Dassau ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
In Silico ◽  
Closed Loop ◽  
Closed Loop Control ◽  
Loop Control ◽  
Preclinical Trials ◽  
Trials Methodology

scholarly journals Mesenchymal stem cells for diabetes mellitus treatment: new advances

2017 ◽  
Vol 4 (1) ◽  
pp. 1062 ◽  
Author(s):  
Loan Thi-Tung Dang ◽  
Ngoc Kim Phan ◽  
Kiet Dinh Truong
Keyword(s):  
Diabetes Mellitus ◽  
Stem Cells ◽  
Clinical Trials ◽  
Mesenchymal Stem Cells ◽  
Diabetes Mellitus Type 1 ◽  
Successful Isolation ◽  
Preclinical Trials ◽  
Diabetes Mellitus Treatment

Mesenchymal stem cells (MSCs) are the most widely used stem cells of the human body due to ease of successful isolation and expansion for many years. In particular, from 2012 until now, MSCs have been widely clinically used to treat various diseases, including graft versus host disease (GVHD), Crohn’s disease, and knee osteoarthritis. In this review, the applications of MSCs in diabetes will be reviewed and discussed. Diabetes mellitus type 1, also known as Type 1 diabetes (T1DM), is an autoimmune disease in which immune cells attack the beta cells in islets of Langerhans (pancreatic islets). Although type 2 diabetes (T2DM) is considered to be a disease related to insulin resistance, several recent studies have shown some relation of immune dysfunction in this disease. Therefore, MSC transplantation may be a beneficial treatment for both T1DM and T2DM. MSC transplantation in preclinical trials and clinical trials for T1DM and T2DM have shown a moderate to significant improvement in diabetes without adverse side effects. In this review, we will discuss some of the updates from preclinical and clinical trials of MSC transplantation for diabetes.

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