scholarly journals Potential Combination of Tinospora crispa, Andrographis paniculata, Cinamomum burmanii, Syzygium polyanthum and Momordica charantia Extracts Against Intake of Glucose in Muscle Rats-Induced Diabetes Mellitus

2021 ◽  
Vol 2 (1) ◽  
pp. 68-72
Author(s):  
Rachmat Hidayat ◽  
Patricia Wulandari
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Secondary Metabolites ◽  
Protein Expression ◽  
Blood Sugar ◽  
Chronic Condition ◽  
Andrographis Paniculata ◽  
Glucose Intake ◽  
Sugar Regulation ◽  
Sugar Levels

Diabetes mellitus is a chronic condition that disturbs the body's blood sugarregulation. This disorder is characterized by a decrease in the ability of bodycells to intake glucose into cells. Due to the failure of cells in glucose intake,glucose buildup occurs in the extracellular, namely in the plasma. Thesemedicinal plants contain quite varied secondary metabolites, where theseplants are rich in flavonoids, alkaloids, terpenes and glycosides. The contentof these secondary metabolite compounds is believed to be rich in antioxidanteffects so that it has the effect of being able to suppress various oxidativestress conditions that cause damage to various organs due to blood sugardysregulation. The effect of Tinospora crispa, Andrographis paniculata,Cinamomum burmanii, Syzygium polyanthum and Momordica charantiaextracts on blood sugar levels and GLUT4 protein expression in muscle tissueshows the potential of the test extract's ability to improve blood glucose intaketo cells so as to maintain blood sugar regulation.

scholarly journals Effect of Noni Fruit Extract (Morinda citrifolia) on Glucose Intake to Diabetes Mellitus White Rat Muscle Tissue

2020 ◽  
Vol 1 (1) ◽  
pp. 9-16
Author(s):  
Patricia Wulandari
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Muscle Tissue ◽  
Morinda Citrifolia ◽  
Wild Plants ◽  
Fruit Extract ◽  
White Rats ◽  
Glucose Intake ◽  
Sugar Regulation ◽  
Sugar Levels

Noni fruit (Morinda citrifolia) is one of the most common plants inIndonesia. This plant is often found in various regions in Indonesia, where theseplants are often in the form of shrubs or wild plants that grow in yards orplantations. This study aims to assess the effect of noni (Morinda citrifolia) fruitextract on blood sugar levels and the expression of GLUT4 protein in muscletissue which shows the potential of the test extract's ability to improve bloodglucose intake to cells so that it can maintain blood sugar regulation. Thisresearch was an experimental study that used white rats as research subject.Induction of diabetes was done by injecting alloxan at a dose of 110 mg/kg BWintraperitoneally; then the white rats were given 10% glucose to drink. Alloxan-induced white rats showed a very significant increase in blood sugar levels,where the use of the drug metformin was able to reduce blood sugar levelssignificantly. In white rats induced with diabetes mellitus, there was a decreasein GLUT4 levels in muscle tissue. The administration of metformin drugs or nonifruit extracts shows the ability to increase levels of GLUT4 protein. In conclusion,noni fruit extract affects lowering blood sugar levels in diabetes mellitus whiterats by increasing glucose intake to cells and tissues.

scholarly journals THE EFFECTS OF CORN FLOUR WITH TEMPEH FLOUR SUPPLEMENTATION FEEDING IN DIABETES MELLITUS WISTAR RATS TOWARD BLOOD GLUCOSE LEVEL

2017 ◽  
Vol 4 (2) ◽  
pp. 24
Author(s):  
Fatifa Asmarani ◽  
Bambang Wirjatmadi ◽  
Merryana Adriani
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Sugar ◽  
Wistar Rats ◽  
Control Group ◽  
Standard Diet ◽  
Corn Flour ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Sugar Levels

Background: Diabetes mellitus (DM) is metabolic disorder syndrome characterized by hyperglycemia due to deficiency of insulin secretion. Patients of diabetic patients increases each year, so it needs proper handling. Corn flour is a source of carbohydrates with a low glycemic index to help reduce the rise in blood sugar levels. In addition, supplementation with tempeh flour containing isoflavones act to protect cells from free radical thereby inhibiting damage cells. Fiber in tempeh affect blood glucose levels because it slows the absorption of glucose.Objective: To determine the effect supplementation of corn flour with tempeh flour on blood sugar levels in diabetes mellitus Wistar rats.Methods: The study was true experimental design with Pre-posttest control group design, samples were 20 male Wistar rats aged 2-3 months were then divided into 4 groups (T0, T1, T2, T3.) T0 was injected with alloxan as 30 mg / 150 grams of BB rats are subsequently treated with standard diet; T1 was dministered by standard diet 50% + 50% corn flour; T2 was administered by standard diet 50% + 30% + corn flour tempeh flour 20%; and T3 was administered by standard diet of corn flour 50% + 15% + 35% tempeh flour for 2 weeks. Blood glucose levels were measured with a glucose kit (GOD FS). Research data were analyzed by One Way ANOVA followed by Tukey's Post Hoc test p-value <0.05.Results: There were significant differences on blood sugar levels in all groups (p = 0.000): control group (only dietary standards), T1 (administered by standard diet 50% + corn flour 50%), T2 (administered by a standard diet 50% + cornstarch 30% tempeh flour + 20%) and T3 (administered by standard diet of corn flour 50% + 15% + 35% tempeh flour).Conclusion: corn flour with tempeh flour supplementation effect on decresing of blood sugar levels.

scholarly journals EFFECT OF HESPERETIN TREATMENT ON BLOOD GLUCOSE LEVEL, SPERMATOZOA QUALITY, AND SPERMATOZOA QUANTITY IN ALLOXAN-INDUCED DIABETIC MICE

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Nerdy Nerdy ◽  
Linta Meliala ◽  
Bunga Rimta Barus ◽  
Puji Lestari ◽  
Selamat Ginting ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Sugar ◽  
Normal Control ◽  
Normal Control Group ◽  
Optimum Dose ◽  
Control Group ◽  
Testicular Weight ◽  
Significant Difference ◽  
Sugar Levels

Male infertility has occurred rapidly in the last few decades, primarily in developing countries. An antioxidant, hesperetin is a flavonoid that is found in abundance in orange peels. The aims of this research were to determine the effect of hesperetin on blood sugar levels, spermatozoaquality, and spermatozoa quantity. The research structure included induction of diabetes mellitus and treatment for 8 weeks, followed bydetermination of blood sugar levels, spermatozoa quality, and spermatozoa quantity. Hesperetin has the ability to restore blood sugar levels, spermatozoa quantity, seminiferous tubules diameter, and testicular weight, volume, and germinal epithelial layer thickness with significant difference from the normal control group. Hesperetin did not fully restore spermatozoa motility, viability, and morphology with significant difference from the normal control group, nor from the positive control group. However, overall, hesperetin decreased blood glucose levels, increased spermatozoa quantity, and improved the spermatozoa quality in alloxan-induced diabetes mellitus mice. Dose-dependent activity was observed with the optimum dose at 200 mg/kg body weight.

scholarly journals HUBUNGAN KECEMASAN DENGAN KADAR GLUKOSA DARAH PENDERITA DIABETES MELLITUS DI WILAYAH KERJA PUSKESMAS SUMBERSARI BANTUL KEC. METRO SELATAN KOTA METRO

2017 ◽  
Vol 2 (1) ◽  
pp. 5
Author(s):  
Ludiana Ludiana
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Standard Deviation ◽  
Blood Sugar ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
The World ◽  
Patients With Diabetes ◽  
Sugar Levels ◽  
The Relationship

Diabetes mellitus is a chronic metabolic disorder marked increase in blood glucose. According to the World Health Organization (WHO) in 2013 the incidence of diabetes mellitus in the world reached 347 million people in Indonesia alone ranks among the seven countries with the highest diabetes prevalence of 7.6 million people. Among the causes of the increase in blood glucose levels in diabetics is due to psychological factors, namely anxiety. In the pre-survey results in Puskesmas Sumbersari Bantul note that from 8 patients with diabetes mellitus, there are 6 people experiencing anxiety and 2 do not complain any signs of anxiety. The purpose of this study was to determine the relationship of anxiety with blood glucose levels of diabetics mellitus in Puskesmas Sumbersari Bantul District of South Metro City. The type quantitative research, form design used is cross sectional. The population in this study are patients with diabetes mellitus in Puskesmas Sumbersari Bantul District of South Metro totaling 408 samples taken as many as 41 people. The analysis in this study using the test Person Product Moment. Statistical analysis showed that anxiety patients with diabetes mellitus are at an average score of 27.44 with a standard deviation of 4.353 and the average blood sugar levels of people with diabetes mellitus are at 339.78 mg / dL with a standard deviation of 74.742. In the Person Product Moment test results proved no relationship anxiety with blood sugar levels of people with diabetes mellitus (p-value = 0.000 <a 0.05). Pearson correlation results obtained value of 0.817 towards a positive correlation with the strength of the relationship is very strong. Conclusions research shows there is an anxiety relationship with blood glucose levels of diabetics mellitus.

scholarly journals Potential Effects of Alkaloid vindolicine Substances in Tapak Dara Leafs (Catharanthus roseus (L.) G. Don) in Reducing Blood Glucose Levels

2019 ◽  
Vol 2 (4) ◽  
Author(s):  
Agung B S Satyarsa
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Sugar ◽  
Catharanthus Roseus ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Sugar Levels

Diabetes mellitus is a degenerative disease that commonly found and related to an unhealthy lifestyle and genetic factors. Current management of diabetes mellitus includes control of blood sugar levels and prevention of complications. Recent studies found that many phytochemicals have the potential to control blood sugar levels in patients with diabetes. Alkaloid substances from leaves of Tapak Dara have an effect on decreasing blood glucose. This review article aims to describe the potential effects of the Alkaloid vindolicine from Tapak Dara leaves (Catharanthus Roseus L.) in reducing blood glucose levels in patients with type 2 diabetes mellitus. The activity of vindolicine alkaloid against ? cells in previous studies has shown to improve ? cells activity and induce insulin secretion thus preventing further hyperglycemia. In addition, the vindolicine alkaloid also has a role in activating pancreatic ?-TC6 cells and carrying out an immediate reaction in blood vessels. As conclusion, further research is needed to prove the maximum effect of the utilization of tread leaf extract as well as the toxicity test to determine the toxic effects of the alkaloid substances in the tread leaf. Keywords: Type 2 Diabetes Mellitus, Vindolicine Alkaloid, Tapak Dara, blood glucoselevels

scholarly journals Effect of Bay Leaf Extract (Syzygium polyanthum) on Blood Sugar Regulation via GLUT4 Protein Regulation in White Rat Muscle Tissue Induced Aloxan

2020 ◽  
Vol 1 (1) ◽  
pp. 24-31
Author(s):  
Rachmat Hidayat ◽  
Lusia Hayati
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Muscle Tissue ◽  
Leaf Extract ◽  
Negative Control ◽  
Diabetes Group ◽  
White Rats ◽  
Target Blood Glucose ◽  
Sugar Regulation ◽  
Sugar Levels

Diabetes mellitus is a chronic condition that disturbs the body's bloodsugar regulation. Bay leaves contain entirely various secondary metabolites,where this plant is rich in flavonoids, alkaloids, terpenes and glycosides. Thisstudy aims to assess the effect of bay leaf extract (Syzygium polyanthum) onblood sugar levels and the expression of GLUT4 protein in muscle tissue. A totalof 30 white rats (Rattus norvegicus) Wistar strain obtained from the EurekaResearch Laboratory (Palembang, Indonesia) weighing between 200 - 250 grams.Bay leaf simplicia was obtained from the Tawangmangu Herbal Research Center,Karanganyar, Indonesia. After 1 week of adaptation, the mice were randomlydivided into the following six groups, each containing 5 animals: Normal controlgroup, diabetes group (negative control), diabetes + metformin group (Met; 45mg / kg), Diabetes + BLE (75 mg/kg), diabetes + BLE group (150 mg / kg) anddiabetes + BLE group (300 mg/kg). Alloxan-induced white rats showed a verysignificant increase in blood sugar levels, where the use of the drug metforminwas able to reduce blood sugar levels significantly even though they had notreached the target blood glucose target of less than 200 mg / dL. The treatmentwith bay leaf extract was able to reduce blood sugar levels significantly. Theadministration of metformin drugs or bay leaf extract showed the ability toincrease the level of GLUT4 protein. In conclusion, bay leaf extract affectsreducing blood sugar levels in diabetes mellitus white rats by increasing glucoseintake to cells and tissues.

LONGER MASTICATION CYCLES TEND TO LOWER POST-PRANDIAL BLOOD SUGAR LEVELS

2021 ◽  
Vol 1 (Volume 1 No 1) ◽  
pp. 11-18
Author(s):  
Ike Rahmawaty Ali ◽  
Siska Nia Irasanti
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Experimental Study ◽  
Blood Glucose ◽  
Blood Sugar ◽  
Hormone Secretion ◽  
Insulin Level ◽  
Statistical Calculation ◽  
Sugar Levels ◽  
Male Faculty

Diabetes Mellitus (DM) is a metabolic syndrome occurred because of the lack of insulin hormone secretion or some factors disturbing insulin hormone or both of them. The mastication cycle is one of the factors related to the increasing in blood glucose. The research aims to analyse the relation between mastication cycle and DM risk factor on Faculty of Medicine students, Universitas Islam Bandung. The methodology was an experimental study. The subjects were 18 male Faculty of Medicine, Unisba, who fulfil the inclusive and exclusive criteria. First, scanning was conducted to know DM risk by questioners. Those students were divided into three groups of mastication cycle (15,30,45 cycle). Each group consisted of six students. The result showed that the tendency of average blood sugar was lower in the group with 45 cycles of mastication, compared to 30 and 15 cycles (86.5 vs 89.5 vs 92 mg/dL). However, according to a statistical calculation, there was no significant relationship between the mastication cycle and blood glucose (P =0.413; P>0.05). The average blood insulin level of 45 times the mastication cycle was the lowest compared to 30 and 15 mastication cycles (2.44 vs 2.97 vs 3.58 µg/ml). The result was that the mastication cycle was longer than the initial insulin release to work in the cell more effectively. In conclusion, DM needs to do more cycle in mastication food to maintain glucose in the blood.

scholarly journals Effectiveness of Giving Muntingia Calabura Leaves and Muntingia Calabura Fruit (Muntingia Calabura L) on Blood Sugar Levels In Type 2 Diabetes Mellitus Patients: Literature Review

2021 ◽  
Vol 10 (1) ◽  
pp. 20
Author(s):  
Konita Shafira ◽  
Abu Bakar ◽  
Erna Dwi Wahyuni
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Sugar ◽  
Metabolic Diseases ◽  
Polar Compounds ◽  
Flavonoid Compound ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Sugar Levels ◽  
Muntingia Calabura

Introduction : Diabetes Mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia caused by abnormalities in insulin secretion, thus impacting on blood glucose levels. Calabura muntingia leaves are traditionally used as an alternative medicine because they contain flavonoid compounds which have anti-diabetic properties. In general, it is known that how to make traditional medicine is by boiling it, where the solvent only uses water so that the polar compounds will be attracted. The purpose of this study is to explain effectiveness the effect of administration between calabura muntingia leaves and calabura muntingia fruit through a review of studies related to blood sugar levelsin the last ten years.Method : Search for journals or articles using Scopus, Proquest, and Scholar indexed databases using appropriate keywords. The Center for Review and Dissemination and The Joanna Briggs Institute was used to assess the quality of the study. The framework used for the review is PICOS and the inclusion criteria used are English and Indonesian journals published in 2010 to 2020. Data analysis and tabulation are carried out in articles or journals. Title, abstract, full text and methodology are assessed to determine the eligibility of the article or journal.Results : Six hundred and forty-one articles were identified, there were eleven articles that fit the research criteria. The leaves of muntingia calabura and fruit of muntingia calabura contain flavonoids and saponins which can reduce blood sugar levels. A flavonoid compound that is thought to have activity in reducing blood glucose levels is quercetin.Conclusion : The form of extract, infusion, juice and stew did not change the content of the calabura muntingia plant.

scholarly journals Pemberian Kue Kering Tepung Ubi Jalar Ungu DenganTepung Tempe Terhadap Gula Darah Sewaktu Pada Penderita Diabetes Mellitus Type 2 Di Rumah Sakit dr. Tadjuddin Chalid Makassar

2018 ◽  
Vol 25 (1) ◽  
pp. 33
Author(s):  
Nurhayati Muslimin ◽  
Lydia Fanny ◽  
Manjilala Manjilala
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Sugar ◽  
Sweet Potato ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type ◽  
Wilcoxon Test ◽  
Sweet Potatoes ◽  
Sugar Levels

Diabetes Mellitus (DM) is a collection of symptoms that arise in someone who has increased blood sugar levels (Glucose) due to lack of insulin hormone. The content in purple and tempe sweet potatoes has high amylose fiber content, and low IG improves insulin sensitivity, decreases glucose uptake rate, and is useful in controlling blood glucose so as to reduce the risk of complications in people with diabetes mellitus type 2 .This study aims to determine the effect of pastry cake flour sweet potato purple and tempe powder to blood sugar levels in patients with diabetes mellitus Type 2 in dr. Tajuddin Chalid Makassar.This study is an analytical study with Pre-Experiments by looking at blood glucose levels in the subjects who suffer from diabetes mellitus type 2 with the number of samples senbanyak 12 respondents. The result of data analysis of the effect of sweet potato pie cake and tempe powder to Diabetes Mellitus Type 2 patients was analyzed using SPSS with Wilcoxon test. The presentation of data is presented in tabular and narrative form.The results show Asymp.Sig (2-tailed) is 0.005. Because Asymp.Sig (2-tailed) is worth 0.005 which means There is effect of cake pastry sweet potato purple powder and tempe powder to blood sugar while in patient of Diabetes Mellitus Type 2 in dr. Tadjuddin Chalid Makassar.It is advisable to control blood sugar regularly at least once a month, physical exercise such as doing regular physical activity at least 3 times a week, and multiply the activities at home. Should counseling about Diabetes Mellitus type 2 Related to the recommended foodstuffs and is not recommended for people with Diabetes Mellitus (DM) type 2.

scholarly journals Effects of acupressure therapy period towards blood sugar level in type 2 diabetes mellitus patients at Lumajang acupressure clinic

2021 ◽  
Vol 5 (1) ◽  
pp. 61
Author(s):  
Anung Putri Illahika ◽  
Hean Safira
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Sugar ◽  
T Test ◽  
Diabetic Patients ◽  
Health Practitioner ◽  
Before And After ◽  
Sugar Levels ◽  
Analytic Design ◽  
Type Two Diabetes

Abstract  Diabetes Mellitus is a worldwide metabolic disease and becomes a challenge for the health practitioner. Unfortunately, less than half of these diabetic individuals are aware of their conditions, and less than 1% of those receiving medical treatment achieve their therapeutic targets. Acupressure is an alternative method that is believed to be an effective way of treating diabetic patients with reducing symptoms and complications. This research aims to discover the effect of period acupressure therapy on blood sugar levels in type two diabetes mellitus patients in Lumajang Acupressure Clinic. It uses an observational analytic design with pre-test and post-test approach. It involved 36 participants who were split into two groups and contained 18 participants for each group. The first group received acupressure therapy for three weeks, while the second group received eight weeks. Both groups underwent acupressure at the San Yin Jiao (SP-6) acupoint for 20 minutes three times a week. All participants in both groups had their blood glucose checked before and after acupressure therapy. The results showed that the two groups were significantly different for the paired t-test and the independent t-test. The acupressure therapy period has an effect on decreasing blood sugar levels in type two diabetes mellitus patients at Lumajang acupressure clinic. Keywords             : Acupressure, the period of therapy, blood glucose level, type two diabetes mellitusCorrespondence   : [email protected]

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